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Oxygen and Iron-and Steelmaking:Best Friends and Arch-Enemies

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Journal of Iron and Steel Research International 2011年第S2期18卷 16-27页

作者： BOOM rob Materials innovation institute M2i Department of Materials Science and EngineeringDelft University of TechnologyDelftThe Netherlands

Ironmaking is the art of removal the arch-enemy oxygen from iron ore by means of carbon reduction and thus producing hot *** is the art of removing carbon from liquid hot metal by means of best friend pure oxygen,followed by alloying and deoxidation-where oxygen returns to be the ***-metallic particles in steel such as oxides can have a detrimental effect on the steel product properties in terms of formability,strength and surface *** overview of the battle for clean steel production is given based on the experience of the author in industry as well as university research.

关键词： ironmaking carbon-oxygen equilibrium steelmaking deoxidation tundish metallurgy casting clean steel

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成功的线下零售商做对了什么

Mechanical circulatory support in cardiogenic shock and post-myocardial infarction mechanical complications

商业评论 2024年第10期 102-107页

作者：罗布·安杰尔石小竹南安普顿大学商学院

过去十年,许多线下零售商都一直在挣扎图存.源源不断的媒体信息与行业分析也给零售渠道大泼冷水,说这段时期实体店倒闭的速度更甚于2008年经济大衰退的高峰期.这场所谓的"零售业末日大劫"中,一大批零售企业纷纷倒下,包括好妈妈(Motherca...

过去十年,许多线下零售商都一直在挣扎图存.源源不断的媒体信息与行业分析也给零售渠道大泼冷水,说这段时期实体店倒闭的速度更甚于2008年经济大衰退的高峰期.这场所谓的"零售业末日大劫"中,一大批零售企业纷纷倒下,包括好妈妈(Mothercare)、百思买(Best Buy)和玩具反斗城等零售巨头.其中,百思买今年3月宣布计划在年底前关闭10到15家门店;玩具反斗城2017年申请破产,2018年关闭在美所有门店,目前正试图卷土重来,在美国商城(Mall of America)等地点开设体验式门店.

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Journal of Geriatric Cardiology 2022年第2期19卷 130-136页

作者： Daniel rob Jan Bělohlávek nd Department of Medicine-Department of Cardiovascular Medicine First Faculty of MedicineCharles University and General University HospitalPragueCzech Republic

Despite advanced therapies,the mortality of patients with myocardial infarction(MI)complicated by cardiogenic shock(CS)remains around 50%.Mechanical complications of MI are rare nowadays but associated with high mortality in patients who present with *** treatment strategies and mechanical circulatory support(MCS)devices have been increasingly used to improve the grim prognosis of refractory *** article discusses current evidence regarding the use of MCS in MI complicated by CS,ventricular septal rupture,free wall rupture and acute mitral *** selection should be tailored according to the cause and severity of *** MCS initiation and multidisciplinary team cooperation is mandatory for good *** associated bleeding remains a major complication and an obstacle to better *** prospective randomized trials will improve current knowledge regarding MCS indications,timing,and patient selection in the coming years.

关键词： mortality infarction rupture

RNA interference with DNA polymerase and synthesis

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Science China Chemistry 2014年第7期57卷 954-960页

作者： ABDUR rob GAN JianHua HUANG Zhen Department of Chemistry Georgia State University

RNA can catalyze and participate in many chemical and biochemical reactions. Non-coding RNAs （ncRNA） can regulate cellular transcription and translation reactions. We have demonstrated biochemically that RNA can also interfere with DNA polymerization via transforming DNA polymerase into deoxyribonucleoside triphosphate diphosphatase （dNTP-DPase）. RNA, even with six nucleotides, can transform DNA polymerase into dNTP-DPase, and the dNTP-DPase activity causes the hydrolysis of dNTPs into dNMPs and pyrophosphate. Moreover, we have found that DNA polymerases from several families generally have similar RNA-dependent dNTP-DPase activity. We have also observed that in the presence of RNA, when the dNTP concentrations are relatively low, and that the dNTP-DPase activity can deplete dNTPs and interfere with DNA polymerization Thus, we have discovered for the first time that in the presence of RNA, DNA polymerase can behave as a diphosphatase and inhibit DNA synthesis when dNTP quantity is low. These in vitro observations might imply a plausible role of RNA in vivo, such as suppressing DNA synthesis during a resting phase （Go） of the cell cycle, when RNA quantity is high and dNTP quantity is low.

关键词： RNA interference alternative activity of DNA polymerase non-coding RNA deoxyribonucleoside triphosphatediphosphatase DNA polymerization and synthesis

Synthetic lethal approaches to target cancers with loss of PTEN function

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Genes & Diseases 2023年第6期10卷 2511-2527页

作者： Ayse Ertay rob MEwing Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3 ) into phosphatidylinositol 4,5-bisphosphate (PIP2 ). The function of PTEN is regulated by different mechanisms and inactive PTEN results in aggressive tumor phenotype and tumorigenesis. Identifying targeted therapies for inactive tumor suppressor genes such as PTEN has been challenging as it is difficult to restore the tumor suppressor functions. Therefore, focusing on the downstream signaling pathways to discover a targeted therapy for inactive tumor suppressor genes has highlighted the importance of synthetic lethality studies. This review focused on the potential synthetic lethality genes discovered in PTEN-inactive cancer types. These discovered genes could be potential targeted therapies for PTEN-inactive cancer types and may improve the treatment response rates for aggressive types of cancer.

关键词： Cancer PTEN Synthetic lethality Tumour suppressor gene WDHD1

Fundamentals about onset and progressive disease character of type 2 diabetes mellitus

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World Journal of Diabetes 2020年第5期11卷 165-181页

作者： rob NM Weijers Teaching Hospital Onze Lieve Vrouwe GasthuisAmsterdam 1090Netherlands

ResearchGate is a world wide web for scientists and researchers to share papers,ask and answer questions,and find *** one of the more than 15 million members,the author uploads research output and reads and responds to some of the questions raised,which are related to type 2 *** that way,he noticed a serious gap of knowledge of this disease among medical professionals over recent *** main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology,which can be helpful for the scientific understanding of the molecular nature of type 2 *** fill up the shortcomings in the curricula of medical education,and to familiarize the medical community with a new concept of the onset of type 2 diabetes,items are discussed like:Insulin resistance,glucose effectiveness,insulin sensitivity,cell membranes,membrane flexibility,unsaturation index(UI;number of carboncarbon double bonds per 100 acyl chains of membrane phospholipids),slowdown principle,effects of temperature acclimation on phospholipid membrane composition,free fatty acids,energy transport,onset of type 2 diabetes,metformin,and *** on the reviewed data,a new model is presented with proposed steps in the development of type 2 diabetes,a disease arising as a result of a hypothetical hereditary anomaly,which causes hyperthermia in and around the *** is counterbalanced by the slow-down principle,which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl *** accompanying reduction in the UI lowers membrane flexibility,promotes a redistribution of the lateral pressure in cell membranes,and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT *** events will set up a reduction in transmembrane glucose ***,a new blood glucose regulation syst

关键词： ATP Free fatty acid Glucose transporter Membrane flexibility Metformin Slow-down principle Type 2 diabetes Unsaturation index

On ethics,the pursuit of knowledge,truth and status in the hallowed halls of academe

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Integrative Zoology 2013年第3期8卷 223-231页

作者： John S.BUCKERIDGE rob WATTS Earth&Oceanic Systems Group RMIT UniversityMelbourneVictoriaAustralia

Advancement in academe is largely on the basis of research output;that is,refereed journal *** paper first explores pressures on academics,especially emerging researchers,when English is not a first *** assess why,when faculty members rush to improve their station that they may elect to circumvent ethical protocols to accelerate their promotion and *** resulting unethical behavior includes plagiarism and forms of duplication such as *** is then given to the wider implications of both plagiarism and the theft of intellectual property,and the role these have played in the development of individuals,the university and society.

关键词： ethics plagiarism promotion publication social evolution

Degradation analysis of A^2/O combined with AgNO3 + K2FeO4 on coking wastewater

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Chinese Journal of Chemical Engineering 2018年第7期26卷 1555-1560页

作者： Pengyu Zhu Kaijin Zhu rob Puzey Xiaoli Ren School of Engineering University of HullCottingham RoadHullthe United Kingdom Department of Environmental Engineering Taiyuan Institute of TechnologyTaiyuan 030008China

In this work, a coking wastewater was selected and a biochemical Az/O treatment device for fractional degradation was designed and employed. After each stage of the treatment, the products were analyzed through gas chromatography-mass spectroscopy （GC-MS） to determine their composition. Finally, AgNO3 ＋ K2FeO4 was used as an advanced deep catalytic oxidation treatment. It was concluded from the analysis that cyclic organics could be degraded and the chemical oxygen demand （COD） was controlled within 50 mg. L-1, in line with the target value, Meanwhile, the spectra obtained from the GC-MS were in accordance with the conclusions reached based on the COD. The research results showed that all hard-degradable organics in coking wastewater could be eliminated through the A2/O bio-membrane treatment and the advanced treatment of making use of K2FeO4 as an oxidant and Ag＋ as a catalyst, the catalytic efficiency with Ag＋ as a catalyst of K2FeO4 was very high. Ag＋ could evidently improve the oxidation capacity of K2FeO4 to wastewater in its short stability time, and this is an important innovation.

关键词： Coking wastewater Biochemical treatment AgNO3 + K2FeO4 catalytic oxidation Cyclic organics Degradation characteristics

Organelle Structures: Bridging Strategy and Technological Processes

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厦门大学学报（自然科学版） 2002年第S1期41卷 249-251页

作者： rob Dekkers Section Production Technology and Organisation

The shifting requirements as imposed on operations ma nagement require adjusting and tailoring the organisational structure to meet ma rket demands. However, translating these requirements directly into hierarchical structure will not ensure the integration of processes across organisational un its and guarantee desirable performance. Therefore, management and management li terature wonders: · How should we connect processes to the external environment within a strategi c framework · Which organisational structures do meet performance requirements · Which choices and freedom do we have within organisational structures · How and when do we implement organisational structures That the hierarchical structure does not meet as such the performance requiremen ts nor did it relate to these became already clear during case studies performed in the ’70s. The conclusion was drawn that organisational changes should affect working processes before they proof to be viable. This required the development of new approach through empirical studies and base d on literature. This led to the development of the organelle structure. The org anelle structure should connect to the strategy and the product flow. Thereto, a decision model has been developed for revealing these relations and the practic al implication. During a number of case studies this methodology has been refined and includes t he strategic choice between variants for the organelle structure with their own performance capabilities; we distinguish about 20 variants ranging between the f unctional organisation and the product flow organisation. These ranges of choice s however can be connected to different order entry points, stemming from logist ic concepts. This extends the performance to improved lead-times and improved c ontrol. Strategic choices relate the organelle structure to external performance criteria dictated by product/market-combinations: · lead-time · quality · costs and internal choices for performance crit

关键词： link Bridging Strategy and Technological Processes Organelle Structures