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NUOVI SITI MESOLITICI IN PROVINCIA DI UDINE

Natural Disaster Reduction in China 1989年第1期 251-287页

作者： ALDO CANDUSSIO ALESSANDROFERRARI UMBERTOFERRARI ANTONIO MESSORI ANDREA PESSINA ODDONE PEZ FRANCO QUAGLIARO roberto tosone e BRUNO TULLIO Società Gruppo Naturalisti Spilamberto Modena. Dipartimento

Ricerche di superficie hanno portato all’individuazione di 5 siti preistorici riferibili alMesolitco. Tre stazioni (Fornaci De Mezzo; Corno-Ripudio; Cassacco) si collocano nella fascia collinarea nord di Udine nell’anfiteatro morenico del Tagliamento, ai margini di antichi bacini inframoreniciora prosciugati. Fornaci De Mezzo ha restituito un’industria di tipo Sauveterriano, forse riferibile allafase antica (prima metà del decimo millennio BP). Corno-Ripudio presenta invece caratteri che potrebbe-ro indicate una fase antica del Castelnoviano, qui attestato da due armature trapezoidali. A Cassaccosono invece numerosi i Trapezi e le tipiche lame denticolate castelnoviane. Due i siti rinvenuti nell’areadella bassa pianura friulana: Porpetto e Bertiolo. II primo ha restituito pochi elementi del MesoliticoRecente, mentre il secondo parrebbe attribuibile, con riserve, al Mesolitico Antico o alia fase finale dell’E-pigravettiano ltalico. Discovery of Mesolithic sites in the Province of Udine (Northern Italy). ArchaeologicalSurveys carried out in the Province of Udine led to the discovery of five Mesolithic sites. Three ofthese stations (Fornaci De Mezzo, Corno-Ripudio and Cassacco) lie along the shores of small basinsof the morainic arc of the river Tagliamento. Fornaci De Mezzo produced a Sauveterrian industry proba-bly to be attributed to the first half of the tenth millennium BP. Corno-Ripudio, which yielded twotrapezoidal points, might belong to the Early Castelnovian. Cassacco gave many trapezes and notchedbladelets of Castelnovian type. Two sites were also discovered in the Friuli plain, namely Porpetto andBertiolo. The first gave a few Late Mesolithic artefacts, while the second is to be attributed to the EarlyMesolithic or to the Final Epigravettian.

关键词：切创八价瓜州刃口户口

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Antiviral therapy for hepatitis C: Has anything changed for pregnant/lactating women?

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World Journal of Hepatology 2016年第12期8卷 557-565页

作者： Anna Maria Spera Tarek Kamal Eldin Grazia tosone Raffaele Orlando Department of Clinical Medicine and Surgery Section of Infectious Diseases University of Naples Federico II

Hepatitis C virus(HCV) affects about 3% of the world'spopulation, with the highest prevalence in individuals under 40. The prevalence in pregnant women varies with geographical distribution(highest in developing countries). Prevalence also increases in sub-populations of women at high risk for blood-transmitted infections. HCV infection in pregnancy represents a non-negligible problem. However, most of the past antiviral regimens cannot be routinely offered to pregnant or breastfeeding women because of their side effects. We briefly reviewed the issue of treatment of HCV infection in pregnant/breastfeeding women focusing on the effects of the new direct-acting antivirals on fertility, pregnancy and lactation in animal studies and on the potential risk for humans based on the pharmacokinetic properties of each drug. Currently, all new therapy regimens are contraindicated in this setting because of lack of sufficient safety information and adequate measures of contraception are still routinely recommended for female patients of childbearing potential.

关键词： Hepatitis C virus infection Breastfeeding woman Antiviral therapy Pregnancy category Directacting antivirals

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Vertical hepatitis C virus transmission:Main questions and answers

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World Journal of Hepatology 2014年第8期6卷 538-548页

作者： Grazia tosone Alberto Enrico Maraolo Silvia Mascolo Giulia Palmiero Orsola Tambaro Raffaele Orlando Department of Clinical Medicine and Surgery Section of Infectious Diseases University of Naples Federico Ⅱ 80131 Napoli Italy

Hepatitis C virus(HCV) affects about 3% of the world's population and peaks in subjects aged over 40 years. Its prevalence in pregnant women is low(1%-2%) in most western countries but drastically increases in women in developing countries or with high risk behav-iors for blood-transmitted infections. Here we review clinical, prognostic and therapeutic aspects of HCV in-fection in pregnant women and their offspring infected through vertical transmission. Pregnancy-related im-mune weakness does not seem to affect the course of acute hepatitis C but can affect the progression of chronic hepatitis C. In fact, postpartum immune res-toration can exacerbate hepatic inflammation, thereby worsening the liver disease, particularly in patients with liver cirrhosis. HCV infection increases the risk of gestational diabetes in patients with excessive weight gain, premature rupture of membrane and caesarean delivery. Only 3%-5% of infants born to HCV-positive mothers have been infected by intrauterine or perinatal transmission. Maternal viral load, human immunode-ficiency virus coinfection, prolonged rupture of mem-branes, fetal exposure to maternal infected blood con-sequent to vaginal or perineal lacerations and invasive monitoring of fetus increase the risk of viral transmis-sion. Cesarean delivery and breastfeeding increases the transmission risk in HCV/human immunodeficiency virus coinfected women. The consensus is not to offer antivi-ral therapy to HCV-infected pregnant women because it is based on ribavirin(pregnancy category X) because of its embryocidal and teratogenic effects in animal spe-cies. In vertically infected children, chronic C hepatitis is often associated with minimal or mild liver disease and progression to liver cirrhosis and hepatocarcinoma is lower than in adults. Infected children may be treated after the second year of life, given the adverse effects of current antiviral agents.

关键词： Hepatitis C infection Pregnancy Vertical transmission Antiviral therapy Prevention

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先天性心脏病患儿肝素效应与凝血酶抑制因子水平的临床检测

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麻醉与镇痛 2008年第2期4卷 23-30页

作者： Nina A. Guzzetta Bruce E. Miller Kathy Todd Fania Szlam, MMSc Renee H. Moore Keith K. Brosius Elizabeth C. Wilson Anna M. Cohen Steven R. tosone 陈蕾(译) 徐美英(校) Department of Anesthesiology Emory University School of Medicine Cardiac Research Department Children's Healthcare of Atlanta at Egleston Department of Biostatistics Emory University Atlanta Georgia 不详

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2M）]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1... 详细信息

本研究观察了体外循环（CPB）下行心脏手术的先天性心脏病患儿3种凝血酶抑制因子[抗凝血酶Ⅲ（ATⅢ）、肝素辅助因子Ⅱ（HCⅡ）、α-2-巨球蛋白（α2M）]水平与临床不同检测肝素效应方法间的关系。118例患儿分为6个年龄组：〈1个月龄．1～3个月龄，3—6个月龄，6～12个月龄，12～24个月龄，〉10岁。测定基础ATⅢ、HCⅡ、α2M数值。同时测定白陶土法活化凝血时间（k-ACT）、硅藻土法活化凝血时间（c-ACT）的基础值并在应用标准剂量400U／kg肝素3分钟后再次测定k-ACT和c-ACT。计算每例患儿应用肝素前、后ACT的差值和肝素量-效关系。给予肝素后k-ACT较c-ACT的变异性小。与既往在成人中证实的结果不同，ATⅢ以及其他凝血酶抑制因子与肝素效应的临床检测间无正性相关；而且〈1个月龄组患儿不仅ATⅢ、HCⅡ水平低．α2M水平也较低。研究结果对肝素是否能在新生儿体外循环手术中发挥充分的抗凝效应提出了疑义，并对ACT延长作为反映抗凝程度的精确性提出了挑战。

关键词：肝素辅助因子Ⅱ 抗凝血酶Ⅲ 先天性心脏病临床检测抑制因子患儿活化凝血时间水

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