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Management of urethral atrophy after implantation of artificial urinary sphincter:what are the weaknesses?

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Asian Journal of Andrology 2020年第1期22卷 60-63页

作者： Nathaniel H Heah ronny BW Tan Department of Urology Tan Tock Seng Hospital308433 Singapore A dvanced Urology Mount Elizabeth Hospital228510 Singapore

The use of artificial urinary sphincter(AUS)for the treatment of stress urinary incontinence has become more prevalent,especially in the“prostate-specific antigen(PSA)-era”,when more patients are treated for localized prostate *** first widely accepted device was the AMS 800,but since then,other devices have also entered the *** efficacy has increased with improvements in technology and technique,and patient satisfaction is high,AUS implantation still has inherent risks and complications of any implant surgery,in addition to the unique challenges of urethral complications that may be associated with the ***,the unique nature of the AUS,with a control pump,reservoir,balloon cuff,and connecting tubing,means that mechanical complications can also arise from these individual *** article aims to present and summarize the current literature on the management of complications of AUS,especially urethral *** conducted a literature search on PubMed from January 1990 to December 2018 on AUS complications and their *** review the various potential complications and their *** complications are either mechanical or nonmechanical *** complications usually involve malfunction of the *** complications include infection,urethral atrophy,cuff erosion,and *** exist especially in the management of urethral atrophy,with both tandem implants,transcorporal cuffs,and cuff downsizing all postulated as potential *** complications from AUS implants are not common,knowledge of the management of these issues are crucial to ensure care for patients with these *** studies are needed to further evaluate these techniques.

关键词： artificial urinary sphincter artificial urinary sphincter complications tandem cuffs transcorporal cuffs urethral atrophy

role of nuclear factor kappa B in central nervous system regeneration

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Neural Regeneration Research 2014年第7期9卷 707-711页

作者： Christian Engelmann Falk Weih ronny Haenold Leibniz Institute for Age Research-Fritz Lipmann Institute

Activation of nuclear factor kappa B （NF-κB） is a hallmark of various central nervous system （CNS） pathologies. Neuron-specific inhibition of its transcriptional activator subunit RelA, also referred to as p65, promotes neuronal survival under a range of conditions, i.e., for ischemic or excitotoxic insults. In macro- and microglial cells, post-lesional activation of NF-κB triggers a growth-permissive program which contributes to neural tissue inflammation, scar formation, and the expression of axonal growth inhibitors. Intriguingly, inhibition of such inducible NF-~B in the neuro-glial compartment, i.e., by genetic ablation of RelA or overexpression of a trans- dominant negative mutant of its upstream regulator IκBa, significantly enhances functional recovery and promotes axonal regeneration in the mature CNS. By contrast, depletion of the NF-κB subunit p50, which lacks transcriptional activator function and acts as a transcriptional repressor on its own, causes precocious neuronal loss and exacerbates axonal degeneration in the lesioned brain. Collectively, the data imply that NF-κB orchestrates a multicellular pro- gram in which κB-dependent gene expression establishes a growth-repulsive terrain within the post-lesioned brain that limits structural regeneration of neuronal circuits. Considering these subunit-specific functions, interference with the NF-κB pathway might hold clinical potentials to improve functional restoration following traumatic CNS injury.

关键词： nuclear factor kappa B RelA p65 p50 central nervous system injury axonal regeneration neural regeneration

High-Tc superconductor Fe（Se,Te） monolayer:an intrinsic,scalable and electrically tunable Majorana platform

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National Science Review 2022年第3期9卷 11-18页

作者： Xianxin Wu Xin Liu ronny Thomale Chao-Xing Liu Institut für Theoretische Physik und Astrophysik Julius-Maximilians-Universit?t Würzburg School of Physics Huazhong University of Science and Technology Wuhan National High Magnetic Field Center Huazhong University of Science and Technology Department of Physics the Pennsylvania State University

Iron-based superconductors have been identified as a novel platform for realizing Majorana zero modes（MZMs） without heterostructures, due to their intrinsic topological properties and high-Tc superconductivity. In the two-dimensional limit, the FeTe;1-x;Se;x;monolayer, a topological band inversion has recently been experimentally observed. Here, we propose to create MZMs by applying an in-plane magnetic field to the FeTe;1-x;Se;x;monolayer and tuning the local chemical potential via electric *** to the anisotropic magnetic couplings on edges, an in-plane magnetic field drives the system into an intrinsic high-order topological superconductor phase with Majorana corner modes. Furthermore, MZMs can occur at the domain wall of chemical potentials at either one edge or certain type of tri-junction in the two-dimensional bulk. Our study not only reveals the FeTe;1-x;Se;x;monolayer as a promising Majorana platform with scalability and electrical tunability and within reach of contemporary experimental capability,but also provides a general principle to search for realistic realization of high-order topological superconductivity.

关键词： high-order topological superconductivity Majorana zero modes iron-based superconductors

Homeodomain leucine-zipper proteins and their role in synchronizing growth and development with the environment

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Journal of Integrative Plant Biology 2014年第6期56卷 518-526页

作者： ronny Brt Marc Cabedo Yakun Xie Stephan Wenkel Center for Plant Molecular Biology University of Tübingen Germany Leibniz Institute of Plant Genetics and Crop Plant Research GaterslebenGermany

The Arabidopsis （Arabidopsis thaliana L.） genome encodes for four distinct classes of homeodomain leucinezipper （HD-ZIP） transcription factors （HD-ZIPI to HD-ZIPIV）, which are all organized in multi-gene families. HD-ZIP transcription factors act as sequence-specific DNA-binding proteins that are able to control the expression level of target genes. While HD-ZIPI and HD-ZIPII proteins are mainly associated with environmental responses, HD-ZIPIII and HD- ZIPIV are primarily known to act as patterning factors. Recent studies have challenged this view. It appears that several of the different HD-ZlP families interact genetically to align both morphogenesis and environmental responses, most likely by modulating phytohormone-signaling networks.

关键词： Transcription factors homeodomain leucine zipper auxin light signaling water stress abscisic acid leaf development REVOLUTA KANADI microRNA

Performance of GPS and IMU sensor fusion using unscented Kalman filter for precise i-Boat navigation in infinite wide waters

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Geodesy and Geodynamics 2023年第3期14卷 265-274页

作者： Mokhamad Nur Cahyadi Tahiyatul Asfihani ronny Mardiyanto Risa Erfianti Department of Geomatics Engineering Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Research Center of Marine and Earth Science-Technology Directorate of Research and Community ServiceInstitut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Mathematics Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia Department of Electrical Engineering Institut Teknologi Sepuluh NopemberSurabaya 60111Indonesia

The Unmanned Surface Vehicle(USV)navigation system needs an accurate,firm,and reliable performance to avoid obstacles,as well as carry out automatic movements during *** Global Positioning System(GPS)is often used in these systems to provide absolute position ***,the GPS measurements are affected by external conditions such as atmospheric bias and multipath *** leads to the inability of the stand-alone GPS to provide accurate positioning for the USV *** of the solutions to correct the errors of this sensor is by conducting GPS and Inertial Measurement Unit(IMU)*** IMU sensor is complementary to the GPS and not affected by external ***,it accumulates noise as time ***,this study aims to determine the fusion of the GPS and IMU sensors for the i-Boat navigation system,which is a USV developed by Institut Teknologi Sepuluh Nopember(ITS)*** the Unscented Kalman filter(UKF),sensor fusion was carried out based on the state equation defined by the dynamic and kinematic mathematical model of ship motion in 6 degrees of *** the performance of this model was tested through several simulations using different combinations of attitude measurement *** scenarios were conducted in the simulations:attitude measurement inclusion and exclusion(Scenarios I and II,respectively).The results showed that the position estimation in Scenario II was better than in Scenario I,with the root Mean Square Error(RMSE)value of 0.062 *** simulations showed that the presence of attitude measurement data caused a decrease in the fusion *** UKF simulation with eight measurement parameters(Scenarios A,B and C)and seven measurement parameters(Scenarios D,E and F),as well as analytical attitude movement,indicated that yaw data had the largest noise accumulation compared to roll and pitch.

关键词： GPS IMU Fusion sensor 6 DOF USV motion Unscented Kalman filte

The impact of aging on cardiac remodeling in chronic mitral regurgitation

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Journal of Geriatric Cardiology 2023年第10期20卷 748-755页

作者： David Leibowitz Donna Zwas ronen Beeri ronny Alcalai Israel Gotsman Heart Institute Hadassah Medical Center and Faculty of MedicineHebrew University of JerusalemJerusalemIsrael

BACKGroUND Chronic mitral regurgitation(MR)is a volume overload state that causes dilatation of the left sided cardiac *** presence of significant dilatation is considered an indication for mitral valve intervention,however,aging may affect left ventricular(LV)remodeling independently of valvular *** objective of this study was to examine age-related changes in cardiac remodeling in a broad population of patients with chronic *** Consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory were *** were categorized into none/mild,moderate or severe *** purposes of analysis of differences with aging,the population was divided into groups above and below 70 years of age and standard echocardiographic measurements were compared between the *** A total of 3492 subjects with at least moderate MR(mean age:76 years,52%female)were included in the study and compared to 18,250 subjects with none or mild *** patients had significantly smaller LV end-diastolic diameters and volumes and significantly larger left atrial(LA)volumes when compared to the younger *** volume index increased in both age groups as MR severity increased,while LV end-diastolic volume increased with increasing MR only in the younger *** Cardiac remodeling in chronic MR is significantly influenced by *** based recommendations of timing of mitral valve interventions in asymptomatic MR patients,based on assessment of LA and LV remodeling,may need to take age into account.

关键词： remodeling mitral cardiac

Ultrahigh numerical aperture meta-fibre for flexible optical trapping

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Light(Science & Applications) 2021年第4期10卷 589-599页

作者： Malte Plidschun Haoran Ren Jisoo Kim ronny Forster Stefan A.Maier Markus A.Schmidt Leibniz Institute of Photonic Technology 07745 JenaGermany Abbe Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Chair in Hybrid Nanosystems Nanoinstitute MunichLMU Munchen80539 MunchenGermany Department of Physics Imperial College LondonLondon SW72AZUK Otto Schott Institute of Material Research FSU Jena07745 JenaGermany

Strong focusing on diffraction-limited spots is essential for many photonic applications and is particularly relevant for optical trapping;however,all currently used approaches fail to simultaneously provide flexible transportation of light,straightforward implementation,compatibility with waveguide circuitry,and strong ***,we demonstrate the design and 3D nanoprinting of an ultrahigh numerical aperture meta-fibre for highly flexible optical *** into account the peculiarities of the fibre environment,we implemented an ultrathin meta-lens on the facet of a modified single-mode optical fibre via direct laser writing,leading to a diffraction-limited focal spot with a recordhigh numerical aperture of up to NA≈*** unique capabilities of this flexible,cost-effective,bio-and fibre-circuitrycompatible meta-fibre device were demonstrated by optically trapping microbeads and bacteria for the first time with only one single-mode fibre in combination with diffractive *** study highlights the relevance of the unexplored but exciting field of meta-fibre optics to a multitude of fields,such as bioanalytics,quantum technology and life sciences.

关键词： optical waveguide fibre

Impact of spatiotemporal land-use and land-cover changes on surface urban heat islands in a semiarid region using Landsat data

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International Journal of Digital Earth 2021年第2期14卷 250-270页

作者： Ehsan Kamali Maskooni Hossein Hashemi ronny Berndtsson Peyman Daneshkar Arasteh Mohammad Kazemi Department of Watershed Management and Engineering University of HormozganBandar-AbbasIran Centre for Middle Eastern Studies&Division of Water Resources Engineering Lund UniversityLundSweden Water Science and Engineering Faculty of Agriculture and Natural ResourcesImam Khomeini International UniversityQazvinIran

Many factors are involved in urban heat island development,such as lack of green spaces,improper choice of building materials,densification,and other human *** aim of this research was to quantify the effects of land-use/land-cover(LU/LC)changes on urban land surface temperature(LST)during a 25-year period(1993–2018)for the semiarid Shiraz City in southern Iran using Landsat data(TM,ETM+,and OLI/TIRS)and machine learning *** main LU/LC classes,such as orchard,vegetation,bare surface,asphalt cover,and built-up areas,were identified using a support vector machine *** images were used to retrieve normalized difference vegetation index(NDVI)and normalized difference built-up index(NDBI).The results showed that the mean LST over the entire study domain increased considerably between 1993 and 2018,due to urbanization,decrease of green areas,and increasing industrial ***-up areas increased considerably by 25.8%from 80 to 100.6 km^(2) between 1993 and 2018,while vegetation cover decreased dramatically by 69.3%.Mean LST increased from 38.4 to 40.2℃ during the 25-year period with a significant increase of 3.9℃ between 2013 and *** addition,the Urban heat island Ratio Index(URI)displayed a substantial upward trend during the 25-year period.

关键词： Urbanization urban heat island land use land cover semiarid population density

Tumour lysis syndrome:A rare acute presentation of locally advanced testicular cancer--Case report and review of literature

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Asian Journal of Urology 2016年第1期3卷 49-52页

作者： Marcus Chow Arianto Yuwono ronny Tan Department of Urology Tan Tock Seng HospitalSingapore

Tumour lysis syndrome(TLS)is a potentially fatal complication of malignancy or its *** uncommon syndrome comprises laboratory findings of hyperuricaemia,hypocalcaemia,hyperkalaemia and hyperphosphataemia.A literature search revealed a total of eight patients,with testicular cancer,who had *** these patients had metastatic *** present a unique case of a 47-year-old gentleman we saw in clinic,who presented with a rapidly growing right groin mass and acute breathlessness,and discuss the diagnosis and management of *** is extremely rare in testicular cancer but necessitates the awareness of *** can occur spontaneously in testicular *** lysis in a rapidly proliferating germ cell tumour is a possible *** prompt identification and institution of management for TLS is crucial to improve clinical outcomes.

关键词： Tumour lysis syndrome Testicular cancer Testicular malignancy