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Metabolic and cardiovascular benefits with combination therapy of SGLT-2 inhibitors and GLP-1 receptor agonists in type 2 diabetes

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World Journal of Cardiology 2022年第6期14卷 329-342页

作者： Awadhesh Kumar Singh ritu Singh Department of Diabetes and Endocrinology G.D Hospital and Diabetes InstituteKolkata 700013India Department of Reproductive Endocrinology G.D Hospital and Diabetes InstituteKolkata 700013India

Both GLP-1 receptor agonists(GLP-1RA)and SGLT-2 inhibitors(SGLT-2I)are newer classes of anti-diabetic agents that lower HbA1c moderately and decrease body weight and systolic blood pressure(SBP)*** therapy with GLP-1RA plus SGLT-2I have shown a greater reduction in HbA1c,body weight,and SBP compared to either agent alone without any significant increase in hypoglycemia or other side *** several agents from each class of these drugs have shown an improvement in cardiovascular(CV)and renal outcomes in their respective cardiovascular outcome trials(CVOT),combination therapy is theoretically expected to have additional CV and renal *** this comprehensive opinion review,we found HbA1c lowering with GLP-1RA plus SGLT-2I to be less than additive compared to the sum of HbA1c lowering with either agent alone,although body weight lowering was nearly additive and the SBP lowering was more than *** additional meta-analysis of CV outcomes with GLP1RA plus SGLT-2I combination therapy from the pooled data of five CVOT found a similar reduction in three-point major adverse cardiovascular events compared to GLP-1RA or SGLT-2I alone,against ***,a greater benefit in reduction of heart failure hospitalization with GLP-1RA plus SGLT-2I combination therapy was noted in the pooled meta-analysis of two randomized controlled *** adequately powered trials can confirm whether additional CV or renal benefit is truly exerted by GLP-1RA plus SGLT-2I combination therapy.

关键词： GLP-1 receptor agonists SGLT-2 inhibitors Combination therapy,Metabolic outcomes Cardiovascular outcomes Renal outcomes

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A Note on the Operator Equation Generalizing the Notion of Slant Hankel Operators

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Analysis in Theory and Applications 2016年第4期32卷 387-395页

作者： Gopal Datt ritu Aggarwal Department of Mathematics PGDAV College University of Delhi Department of Mathematics University of Delhi

The operator equation λMz^-X = XMzk, for k ≥ 2,λ∈ C, is completely solved. Further, some algebraic and spectral properties of the solutions of the equation are discussed.

关键词： Hankel operators slant Hankel operators generalized slant Toeplitz operators generalized slant Toeplitz operators spectrum of an operator.

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Synthesis and electroluminescence properties of tris-[5-choloro-8-hydroxyquinoline]aluminum Al(5-Clq)_3

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Journal of Semiconductors 2015年第6期36卷 35-38页

作者： Rahul Kumar Parag Bhargava ritu Srivastava Priyanka Tyagi Indian Institute of Technology Bombay National Physical Laboratory

A new electroluminescent material tris- [5-choloro-8-hydroxyquinoline] aluminum has been synthesized and characterized. Solution of this material AI（5-Clq）3 in toluene showed absorption maxima at 385 nm which was attributed to the moderate energy （π-π＊） transitions of the aromatic rings. The photoluminescence spectrum of AI（5-Clq）3 in toluene solution showed a peak at 522 nm. This material shows thermal stability up to 400 ℃. The structure of the device is ITO/0.4 wt%F4-TCNQ doped α-NPD （35 nm） / AI（5-Clq）3 （30 nm） / BCP （6 nm）/ Alq3 （30 nm） / LiF （1 nm） / A1 （150 nm）. This device exhibited a luminescence peak at 585 nm （CIE coordinates, x = 0.39, y = 0.50）. The maximum luminescence of the device was 920 Cd/m2 at 25 V. The maximum current efficiency of OLED was 0.27 Cd/A at 20 V and maximum power efficiency was 0.04 lm/W at 18 V.

关键词： organometallic compounds chemical synthesis vapour deposition photoluminescence spectroscopy electrical properties luminescence

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Emergence of non-albicans Candida species and antifungal resistance in intensive care unit patients

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 455-460页

作者： Ravinder Kaur Megh Singh Dhakad ritu Goyal Rakesh Kumar Department of Microbiology Lady Hardinge Medical College and Associated Hospitals Department of Microbiology Maulana Azad Medical College and Associated Lok Nayak Hospitals Department of Obstetrics and Gynaecology Maulana Azad Medical College and Associated Lok Nayak Hospitals Department of Anaesthesiology Maulana Azad Medical College and Associated Lok Nayak Hospitals

Objective: To evaluate the epidemiology of candidiasis and the antifungal susceptibility profile of Candida species isolated from the intensive care unit(ICU) ***: The study used a qualitative descriptive design. Relevant samples depending on organ system involvement from 100 ICU patients were collected and *** and speciation of the isolates was conducted by the biochemical *** susceptibility testing was carried out as per CLSI-M27-A3 ***: Ninety Candida isolates were isolated from the different clinical samples: urine(43.3%), tracheal aspirate(31.1%), urinary catheter(12.2%), endotracheal tube(7.8%),abdominal drains(3.3%), sputum(2.2%). The incidence of candidiasis caused by nonalbicans Candida(NAC) species(63.3%) was higher than Candida albicans(36.7%).The various NAC species were isolated as: Candida tropicalis(41.1%), Candida glabrata(10%), Candida parapsilosis(6.7%), Candida krusei(3.3%) and Candida kefyr(2.2%). The overall isolation rate of Candida species from samples was 53.3%. Antifungal susceptibility indicated that 37.8% and 7.8% of the Candida isolates were resistant to fluconazole and amphotericin B, ***: Predominance of NAC species in ICU patients along with the increasing resistance being recorded to fluconazole which has a major bearing on the morbidity and management of these patients and needs to be further worked upon.

关键词： Antifungal resistance Candida species Colonization Intensive care unit patients

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Environmental hypoxia:A threat to the gonadal development and reproduction in bony fishes

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Aquaculture and Fisheries 2022年第5期7卷 572-582页

作者： Nirmalendu Saha Debaprasad Koner ritu Sharma Biochemical Adaptation Laboratory Department of ZoologyNorth-Eastern Hill UniversityShillong793022India

Vast stretches of open water bodies are gradually becoming hypoxic as a result of depletion of oxygen levels mainly due to various human anthropogenic *** problem of hypoxic stress on the fish population is likely to be exacerbated soon since the aquatic hypoxic environment is continuously spreading over vast areas *** recent years,various harmful effects of hypoxia to bony fishes have been reported,such as the restriction of energy-consuming metabolic processes,arrest of the growth of ovary and testes that are associated with endocrine disruption,loss of sperm and egg quality,inhibition of fertilization,hatching success,and also the reduction of larval survivability,thereby impairment of overall reproductive and developmental processes in *** of the brain-pituitary-gonad axis,and certain enzymes related to steroidogenesis and vitellogenesis in fish have also been reported as the primary targets for an endocrine malfunction during ***-sensitive downregulation of key genes responsible for controlling sex hormones’synthesis has been documented in certain bony ***,continuous exposure to hypoxia was reported to induce early expression of pro-apoptotic/tumor suppressor p53 genes,thereby causing immense cell death in hypoxic ***,the cellular responses to long-term hypoxia exposure and the degree of reproductive impairments in bony fishes are still not adequate to figure out the actual underlying *** present review intends to highlight the current knowledge about the detrimental impact of chronic/acute hypoxia at different stages of fish reproduction and the associated underlying molecular mechanisms.

关键词： Sex hormones Endocrine disruption Gametogenesis Gonadal development Fish reproduction HPG-Axis

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Antioxidant activity and phenol and flavonoid contents of eight medicinal plants from Western Nepal

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Journal of Traditional Chinese Medicine 2014年第5期34卷 584-590页

作者： Lalita Subedi Sunita Timalsena Pabitra Duwadi ritu Thapa Anita Paudel Kalpana Parajuli Department of Pharmaceutical Sciences School of Health and Allied SciencesPokhara University

OBJECTIVE: The purpose of this study was to evaluate the antioxidant activity, phenolic and flavonoids contents of selected medicinal plants form the Western region of ***: The antioxidant activity of selected medicinal plants were determined by using 2, 2-diphenyl-1-picrylhydrazyl radical scavenging activity; total ferric ion reducing ability through spectroscopic analysis. The content of total phenols was determined using Folin-Ciocalteu reagent, whereas Aluminum chloride colorimetric method was used for flavonoid ***: Extracts of Syzygium Operculatus(87%),Astilbe Rivularis(83%) and Mallotus Philippnensis(88%) showed significant free radical scavenging activity with effective concentration(EC50) close to that of ascorbic acid. Syzygium Operculatus(96%),Astilbe Rivularis(97%) and Mallotus Philippnensis(97%) had potent reducing power in concentration dependent fashion. Those plant extract with higher free radical scavenging and ferric reducing effect also showed the greater content of both phenols and flavonoids, suggesting the correlation between polyphenolic content and antioxidant activity. Those plant extracts which showed better antioxidant activity assays, also demonstrated higher total phenol and flavonoid contents. These three plants showed the presence of higher amount of phenols and ***: This study may provide the scientific basis for the traditional use of those plants and may provide valuable idea for further research.

关键词： Plants, medicinal Antioxidants 2, 2-di-phenyl-l-picrylhydrazyl Phenol Flavonoids

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Synthesis of N1-3-{（4-Substituted aryl-3-chloro-2-oxo- azetidine）-iminocarbamyl}-propyl-6-nitroindazole Derivatives and Their Biological Significance

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Chinese Journal of Chemistry 2011年第8期29卷 1745-1752页

作者： Samadhiya, Pushkal Sharma, ritu Srivastava, Santosh K. Srivastava, Savitri D. Synthetic Organic Chemistry Laboratory Department of Chemistry Dr. H. S. Gour University (A Central Univer- sity) Sagar M.P. 470003 India

Synthesis of N1-3-{（4-substitute daryl-3-chloro-2-oxo-azetidine）-iminocarbamyl}-propyl-6-nitroindazole 4a-- 4s was conducted by a conventional method. All the compounds were synthesized and characterized by IR, 1H NMR, 13C NMR, FAB-Mass techniques and chemical methods. All the final synthesized compounds were evaluated for their antimicrobial activity and antitubercular activity with MIC values against some selected microorganisms.

关键词： synthesis 6-nitroindazole 2-azetidinone biological activity

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Synthesis and Biological Study of Some 4-oxo-Thiazolidine Derivatives of 2-Aminothiazole

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Chinese Journal of Chemistry 2011年第5期29卷 1001-1010页

作者： Samadhiya Pushkal Sharma ritu Srivastava Santosh K. Srivastava Savitri D. Synthetic Organic Chemistry Laboratory Department of Chemistry Dr. H.S. Gour University (A Central University) Sagar M.P. 470003 India

Conventional and microwave assisted synthesis of new series of N-[2-{2-（substituted phenyl）-4-oxo- 5-（substituted benzylidene）-1,3-thiazolidine}-iminoethyl]-2-aminothiazole 5a-Sin have been developed. The cycloaddition reaction of thioglycolic acid with N-{2-（substituted benzylidenehydrazino）-ethyl}-2-aminothiazole 3a--3m in the presence of anhydrous ZnC12 afforded new heterocyclic compounds N-[2-{2-（substituted phenyl）- 4-oxo-l,3-thiazolidine}-iminoethyl]-2-aminothiazole 4a---4m. The later product on treatment with several selected substituted aromatic aldehydes in the presence of C2HsONa undergoes Knoevenagel reaction to yield 5a--Sin. The structures of compounds 1, 2, 3a--3m, 4a---4m and 5a--Sm were confirmed by IR, IH NMR, 13C NMR, FAB-Mass and chemical analysis. All above compounds were screened for their antimicrobial activities against some selected bacteria and fungi and antituberculosis study against M. tuberculosis.

关键词： conventional microwave synthesis 2-aminothiazole 4-oxo-thiazolidine antimicrobial antitubercular

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Colloidal lead-free Cs_(2)AgBiBr_(6)double perovskite nanocrystals:Synthesis,uniform thin-film fabrication,and application in solution-processed solar cells

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Nano Research 2021年第4期14卷 1126-1134页

作者： Razi Ahmad Gautam Virender Nutan Dinesh Singh Govind Gupta Udit Soni Sameer Sapra ritu Srivastava Advanced Materials and Devices Metrology Division CSIR-National Physical LaboratoryDr.K.S.Krishnan RoadNew Delhi-110012India Indian Reference Materials Division CSIR-National Physical LaboratoryDr.K.S.Krishnan RoadNew Delhi-110012India Department of Biotechnology TERI School of Advanced studiesNew Delhi 110070India Department ofChemistryy Indian Institute of Technology Delhi New Delhi 110016India Regional Centre of Advanced Technologies and Materials Faculty of SciencePalacky University OlomoucSlechtitelu 2778371 OlomoucCzech Republic

Recently developed lead-free double perovskite nanocrystals(NCs)have been proposed for the possible application in solutionprocessed optoelectronic ***,the optoelectronic applications of double perovskite NCs have been hampered due to the structural and chemical instability in the presence of polar ***,we report a facile strategy for the synthesis and purification of Cs_(2)AgBiBr_(6)double perovskite NCs that remained stable even after washing with polar *** is realized with our efficient colloidal route to synthesize Cs_(2)AgBiBr_(6)NCs that involve stable and strongly coordinated precursor such as silvertrioctyl phosphine complex together with bismuth neodecanoate,which leads to a significantly improved chemical and colloidal *** layer-by-layer solid-state ligand exchange technique,a compact and crack-free thin film of Cs_(2)AgBiBr_(6)NCs were ***,perovskite solar cells consisting of Cs_(2)AgBiBr_(6)as an absorber layer were fabricated and tested.

关键词： double perovskite nanocrystals colloidal and chemical stability thin film solar cells

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L-Proline catalyzed one-pot multi-component synthesis of 2-(1,3-diphenyl-1H-pyrazol-4-yl)quinazolin-4(3H)-one derivatives and their biological studies

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Chinese Chemical Letters 2014年第5期25卷 741-744页

作者： Hemal B. Mehta Bharat C. Dixit ritu B. Dixit Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences Chemistry Departments V. P. and R. P. T. P Science CollegeAffiliated to Sardar Patel University

A new series of quinazolin-4（3H）-one derivatives containing a（1 3-diphenyl-1H-pyrazol-4-yl） core with substituents at the 2-position and aromatic or heteroaromatic substituents at the 3-position were synthesized using an L-proline catalyzed one-pot multi-component reaction *** the synthesized compounds were characterized and screened for their antimicrobial,antifungal and anti-tubercular activities.

关键词： Quinazolin-4(3H)-one Pyrazole L-Proline Antimicrobial Antifungal Anti-tubercular activity

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