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Declining Rate o. o.erative Vaginal Deliveries in Nigeria

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o.en Jo.rnal o. o.stetrics and Gyneco.o.y 2018年第3期8卷 175-184页

作者： o.echukwu Bo.aventure anozie Lawani Lucky o.aheni Fidelis A. o.u Ro.inso. Chukwudi o.o. Emeka o.we o.ah Justus N. Eze Jo.nbo.co.E. Mamah o.io.a G. Asiegbu rita o. anozie Department o. o.stetrics & Gynaeco.o.y Federal Teaching Hospital Abakaliki Abakaliki Nigeria Department o. Paediatrics Federal Teaching Hospital Abakaliki Abakaliki Nigeria Department o. o.stetrics & Gynaeco.o.y Ebonyi State University Abakaliki Nigeria Department o. Radio.o.y Federal Teaching Hospital Abakaliki Abakaliki Nigeria

Backgro.nd: The applicatio. o. invasive o.stetric pro.edures has an end po.nt o. reducing the Caesarean sectio. rate. The declining rate o. use o. these pro.edures is o.e o. the reaso.s fo. increasing Caesarean sectio. rates in o.r enviro.ment. o.jective: The aim o. the study was to.determine the practice o. o.erative vaginal deliveries amo.g o.stetricians practicing in Nigeria and to.evaluate the reaso.s fo. no.-use o. these pro.edures. Metho.o.o.y: It was a questio.naire based study. The questio.naires were administered to.practitio.ers o. o.stetrics in the vario.s centres in Nigeria. Data was co.lated and analyzed with Epi-Info.statistical so.tware versio. 7.0 (Center fo. Disease Co.tro. and Preventio., USA), and co.clusio.s were drawn by means o. descriptive statistics. Results: A to.al o. 1200 questio.naire were distributed but 1104 were returned and used fo. analysis. This gave a respo.se rate o. 92%. The age distributio. o. the respo.dents sho.ed that the 20 - 30 year age gro.p had the least number o. respo.dents 22 (2%) while 41 - 50 age gro.p had the highest number o. respo.dents 486 (4%). The majo.ity o. the respo.dents were males 839 (76%). In terms o. duratio. o. practice, 449 (40.7%) o. the respo.dents had mo.e than 6 years duratio. o. practice while 256 (23.2) had practiced fo. less than 3 years. Tertiary centres had highest number o. respo.dents 71.8%. The distributio. o. the respo.dents acco.ding to.the geo.o.itical zo.es in Nigeria are;So.th-East (57.6%), So.th-So.th (19.6%), So.th West (11.4%), No.th-West (4.9%), No.th-East (3.8%), No.th-Central (2.7%). The practice o. these pro.edures amo.g respo.dents were: External cephalic versio. (68.0%), Symphysio.o.y (41.7), Fo.ceps delivery (68.8%), Destructive delivery (60.1%), Vaginal breech delivery (85.5%), Vacuum extractio. (84.8%). Reaso.s fo. the no.-use included: Risk o. perinatal/maternal mo.bidity and mo.tality greater than benefit (25.7%), Lack o. equipment (22.4%), Lack o. skills (16.6%), Declin

关键词： Invasive o.stetric Pro.edures Decline Nigeria

A review o. the scale-up o. high-shear wet granulatio. pro.esses and the impact o. pro.ess parameters

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Particuo.o.y 2024年第9期92卷 180-195页

作者： Ana rita Alves Marta Filipe Simões Sérgio.Simões Jo.o.Go.es University o. Co.mbra CERESDepartment of Chemical EngineeringFaculty of Sciences and TechnologyRua Sílvio Lima3030-790CoimbraPortugal Bluepharma-Indústria Farmacêutica São Martinho do BispoCoimbra3045-016Portugal Faculty o. Pharmacy University of CoimbraAzinhaga de Santa Comba3000-548CoimbraPortugal

Wet granulatio. is o.e o. the mo.t impo.tant agglo.eratio. pro.esses,and high-shear granulatio.(HSG)o.e o. the mo.t emplo.ed techno.o.ies in the pharmaceutical *** mo.t critical pro.ess parameters o. HSG are discussed in this *** main co.cern in scaling up the wet granulatio. pro.ess is the differences between scales,which prevent the particles fro. having the same experience acro.s all *** scale-up o. wet granulatio. pro.esses is co.mo.ly divided into.two.catego.ies:engineering and attribute-based *** engineering-based scale-up appro.ch is a strategy based o. dimensio.al analysis and an attribute-based suppo.ted o. the principles o.“equifinality”,where pro.ess variables are adjusted to.o.tain equivalent granule *** wo.k presents the effect o. different HSG pro.ess parameters o. the scale-up,as well as the use o. pro.ess analytical to.ls(PAT)and mo.elling *** aim is to.review applied scale-up appro.ches in HSG and discuss benefits and *** is pro.en why the scale-up fo. o.al so.id pharmaceutical pro.ucts is still co.sidered a ho. to.ic and a very challenging task fo. develo.ment and engineering teams.

关键词： High-shear wetgranulatio. Parametric-based Attribute-based Physics-based mo.elling Impeller design Scale-up

Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Emerging ro.e o. liquid bio.sy in rat sarco.a virus mutated metastatic co.o.ectal cancer:A case repo.t

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Wo.ld Jo.rnal o. Gastro.ntestinal o.co.o.y 2024年第1期16卷 234-243页

作者： Jo.o.Gramaça Isabel Go.es Fernandes Caro.ina Trabulo.Jo.na Go.çalves rita Gameiro.do. Santo. Adriano.Baptista Idília Pina Centro.Ho.pitalar Barreiro.Mo.tijo Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal Medical o.co.o.y Unit Centro Hospitalar Barreiro MontijoSetúbalBarreiro 2830-003Portugal

BACKGRo.ND In patients with metastatic co.o.ectal cancer(mCRC),the treatment o.tio.s are limited and have been pro.ed to.be affected by rat sarco.a virus(RAS)mutatio.al *** RAS wild-type(wt)patients,the co.binatio. o. antiepidermal gro.th facto. recepto.(EGFR)mo.o.lo.al antibo.ies with chemo.herapy(CT)is mo.e effective than CT *** the o.her hand,RAS-mutated patients are no. eligible fo. treatment with anti-EGFR *** SUMMARY Eleven patients with initially RAS-mutated mCRC were fo.lo.ed fro. diagno.is to.May *** the time o. cell-free DNA determinatio.,five patients had undergo.e o.e CT line,five patients had undergo.e two.CT lines,and o.e patient had undergo.e three CT lines(all in co.binatio. with bevacizumab).At the seco.d and third treatment lines[seco.d line(2L),third line(3L)],patients with neo.RAS wt received a co.binatio. o. CT and *** neo.RAS wt patients treated with anti-EGFR,o.r findings indicated an increase in pro.ressio.-free survival fo. bo.h 2L and 3L(14.5 mo.P=0.119 and 3.9 mo.P=0.882,respectively).Regarding 2L o.erall survival,we registered a slight increase in neo.RAS wt patients treated with anti-EGFR(33.6 mo.vs 32.4 mo.P=0.385).At data cut-o.f,two.patients were still alive:A RAS-mutated patient undergo.ng 3L treatment and a neo.RAS wt patient who.received 2L treatment with anti-EGFR(o.go.ng).Co.CLUSIo. o.r case series demo.strated that mo.ito.ing RAS mutatio.s in mCRC by liquid bio.sy may pro.ide an additio.al treatment line fo. neo.RAS wt patients.

关键词： Metastatic co.o.ectal cancer Rat sarco.a virus mutatio.al status Liquid bio.sy Rat sarco.a virus wild-type Neo.rat sarco.a virus wild-type Anti-epidermal gro.th facto. recepto. therapy Case repo.t

Reductio. Disco.o.atio. o. Reactive Dyed Co.to. Waste and Chemical Recycling via Io.ic Liquid

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Jo.rnal o. Renewable Materials 2024年第9期12卷 1557-1571页

作者： Aline Ferreira Knihs Larissa Klen Aragão.Miguel Angelo.Granato.Andrea Cristiane Krause Bierhalz rita de Cassia Siqueira Curto.Valle Department o. Textile Engineering Federal University of Santa CatarinaBlumenau89036-256Brazil

The textile industry generates large vo.umes o. waste thro.gho.t its pro.uctio. *** o. this waste is co.o.ed,therefo.e,disco.o.atio. is an impo.tant step to.ard recycling and reusing this *** study fo.used o. the chemical reductive disco.o.atio. o. textile waste co.po.ed o. co.to. dyed with reactive *** experimental design demo.strated the significant influence o. the co.centratio. o. reducing agent and time o. reactio. o. the degree o. whiteness o. the co.to. *** co.centratio. o. the alkaline agent was no. significant in the *** o.timizatio. o. the reactio. co.ditio.s lead to.Berger degree o. 50.5±*** disco.o.ed co.to. was chemically recycled thro.gh disso.utio. in io.ic liquid 1-ethyl-3-methylimidazo.ium chlo.ide and regeneratio. in film fo.m in *** micro.tructure o. the regenerated cellulo.e films was evaluated by Scanning Electro. Micro.co.y(SEM)indicating co.plete disso.utio. and unifo.m *** disco.o.atio. pro.ess reduced the po.ymerizatio. degree and crystallinity index o. the co.to. fibers but retained the cellulo.e I *** disso.utio. and cellulo.e regeneratio. pro.ess results in transparent films with an amo.pho.s *** thermal behavio.,evaluated by thermo.ravimetric analysis,indicated that residues and regenerated film presented a main deco.po.itio. *** maximum deco.po.itio. rate temperature o. the regenerated films was appro.imately 40℃lo.er than the co.to. fibers,which co.relates well with the reductio. in po.ymerizatio. degree and amo.pho.s *** general,the study demo.strated that textile co.to. waste dyed with reactive dyes can be chemically disco.o.ed to.fo.m transparent and amo.pho.s films,co.tributing to.the develo.ment o. sustainable strategies fo. the textile industry.

关键词： Reactive dyed co.to. waste reactive disco.o.atio. io.ic liquid disso.utio. and regeneratio. recycling and reusing

Artificial intelligence in detectio. o. small bo.el lesio.s and their bleeding risk:A new step fo.ward

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2024年第18期30卷 2482-2484页

作者： Silvia Co.ca Giuseppina Po.tillo.Giuseppe Grande rita Co.igliaro Gastro.ntero.o.y and Endo.co.y Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Gastro.ntero.o.y and Endo.co.y Unit Presidio Ospedaliero San Giuseppe Moscati(AversaCE)-ASL CasertaCaserta 81100Italy Department o. Gastro.ntero.o.y and Digestive Endo.co.y Azienda Ospedaliero Universitaria di ModenaModena 41121Italy

The present letter to.the edito. is related to.the study with the title“Auto.atic detectio. o. small bo.el(SB)lesio.s with different bleeding risk based o. deep learning mo.els”.Capsule endo.co.y(CE)is the main to.l to.assess SB diseases but it is a time-co.suming pro.edure with a significant erro. *** develo.ment o. artificial intelligence(AI)in CE co.ld simplify physicians’*** no.el deep learning mo.el by Zhang et al seems to.be able to.identify vario.s SB lesio.s and their bleeding risk,and it co.ld pave the way to.next perspective studies to.better enhance the diagno.tic suppo.t o. AI in the detectio. o. different types o. SB lesio.s in clinical practice.

关键词： Capsule endo.co.y Small bo.el Artificial intelligence Bleeding risk Vascular lesio.s

Ammo.ia and greenho.se gas distributio. in a dairy barn during warm perio.s

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Fro.tiers o. Agricultural Science and Engineering 2024年第3期11卷 428-441页

作者： Pro.videnza rita D’URSo.Claudia ARCIDIACo.o.Gio.anni CASCo.E Department o. Agriculture Food and EnvironmentUniversity of CataniaVia S.Sofia n.100Catania 95123Italy

This research aimed to.quantify co.centratio.s o. ammo.ia(NH3),carbo. dio.ide(Co.(2))and methane(CH_(4)),estimate emissio.s,and analyze the facto.s influencing them during warm perio.s in an o.en dairy barn equipped with two.co.ling systems in a Mediterranean climate *** distributio. within the barn was o.served to.vary bo.h vertically and ho.izo.tally,with the highest gas co.centratio.s o.served in the central area o. the ***_(3),CH_(4)and Co.(2)ranged in 1.7–7.4,7–18,560–724μg·g^(–1),*** ventilatio. thro.gh o.enings and the o.eratio. o. co.ling systems induced changes in indo.r micro.limate co.ditio.s,influencing co. behavio. and,co.sequently,gas *** co.centratio.s were the highest at air velo.ities belo. 0.5 m·s^(–1).The highest co.centratio. o. NH_(3)was o.served when the temperature-humidity index(THI)was>72 and≤78;and Co.(2)and CH_(4)co.centratio.s were the highest with THI≥72 and decreased with THI≤***_(3)co.centratio.s when barn management included three daily milkings were higher than tho.e measured when barn management was based o. two.daily milkings,and lo.er fo. CH_(4)and Co.(2).NH_(3)and CH_(4)emissio.s were the highest during barn cleaning,while the lo.est NH_(3)emissio.s o.curred during activity o. the co.s(i.e.,feeding,walking).

关键词： Ammo.ia greenho.se gas enviro.mental mo.ito.ing co.s’behavio. barn management ho.sing system climatic parameters

Syndecans in Alzheimer's disease:patho.enetic mechanisms and po.ential therapeutic targets

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Neural Regeneratio. Research 2025年第9期20卷 2594-2595页

作者： Carmela rita Balistreri Ro.erto.Mo.astero Cellular Molecular and Clinical Pathological LaboratoryDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoPalermoItaly Memo.y and Parkinso.’s disease Center Policlinico“Paolo Giaccone”PalermoDepartment of BiomedicineNeuroscience and Advanced Diagnostics(Bi.N.D.)University of PalermoVia La Loggia 1PalermoItaly

With increasing age,humans beco.e mo.e susceptible to.the o.set o. neuro.egenerative diseases(NDs),and amo.g these,Alzheimer's disease(AD)is the mo.t frequent(Nico.etti et al.,2023).NDs are primarily characterized by neuro.al lo.s and atro.hy,but also.by lesio.s invo.ving the cerebral and/o. cardio.ascular system(Balistreri,2021).Lesio.s such as macro.nfa rcts,micro.nfarcts,hemo.rhages,white matter lesio.s,athero.clero.is,and arterio.o.clero.is have also.been significantly described in the preclinical stages o. co.nitive impairment characterizing NDs(Mariani et al.,2007).

关键词： Alzheimer cardio.ascular

Identifying the validity do.ain o. machine learning mo.els in building energy systems

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Energy and AI 2024年第1期15卷 328-341页

作者： Martin Rätz Patrick Henkel Phillip Sto.fel rita Streblo. Dirk Müller RWTH Aachen University E.ON Energy Research CenterInstitute for Energy Efficient Buildings and Indoor ClimateMathieustraβe 10Aachen52074Germany

The building secto. significantly co.tributes to.climate *** impro.e its carbo. fo.tprint,applicatio.s like mo.el predictive co.tro. and predictive maintenance rely o. system ***,the high mo.eling effo.t hinders practical *** learning mo.els can significantly reduce this mo.eling *** ensure a machine learning mo.el’s reliability in all o.erating states,it is essential to.kno. its validity *** states o.tside the validity do.ain might lead to.extrapo.atio.,resulting in unpredictable *** paper addresses the challenge o. identifying extrapo.atio. in data-driven building energy system mo.els and aims to.raise kno.ledge abo.t *** that,a no.el appro.ch is pro.o.ed that calibrates no.elty detectio. algo.ithms to.ards the machine learning *** no.elty detectio. algo.ithms are identified thro.gh a literature review and a benchmark test with 15 candidates.A subset o. five algo.ithms is then evaluated o. building energy ***,o. two.dimensio.al data,displaying the results with a no.el visualizatio. *** o. mo.e co.plex multi-dimensio.al use *** metho.o.o.y perfo.ms well,and the validity do.ain co.ld be *** visualizatio. allo.s fo. a pro.o.nd analysis and an impro.ed understanding o. the fundamental effects behind a machine learning mo.el’s validity do.ain and the extrapo.atio. regimes.

关键词： Extrapo.atio. detectio. Validity do.ain No.elty detectio. Machine learning Artificial neural netwo.k Data-driven mo.el predictive co.tro. Building energy systems