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Assessment of Safety and Effectiveness of Glaritus®(Wockhardt’s Insulin Glargine) in a Prospective, Multi-Centric Post Marketing Observational Study in Nepalese Having Type 2 Diabetes Mellitus

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Open Journal of Endocrine and Metabolic Diseases 2019年第2期9卷 21-33页

作者： Ansumali Joshi Bhojraj Adhikari Basant Tamrakar Gaurav Puppalwar Agam Shah rishi Jain Kathmandu Diabetes & Thyroid Centre Pvt. Ltd. Kathmandu Nepal Pushpanjali Hospital Bharatpur Nepal Fishtail Hospital & Research Centre Pvt. Ltd. Pokhara Nepal Medical Affairs Wockhardt Ltd. Mumbai India

Background: Nepal is one of the fastest urbanizing countries in South Asia and is facing the consequences of urban lifestyle leading to obesity and metabolic syndrome. Type 2 diabetes mellitus (T2DM) is currently a high-burden disease in Nepal with a prevalence of 8.4%. Of these 8% - 18% patients are on insulin and 42% patients were reported to have uncontrolled diabetes in the past year. This suggests a need for better therapy options in terms of efficacy and safety. The current study was designed to investigate the effects of Insulin glargine-based therapy in Nepalese with T2DM who could not achieve adequate glycemic control with oral and non-glargine-insulin therapy. Methods: This is a prospective, multi-centric, single arm and post marketing observational study to assess the safety and effectiveness of Glaritus®(Wockhardt’s Insulin Glargine) in 52 T2DM patients from 3 (three) different study sites in Nepal (Bharatpur, Kathmandu and Pokhra) from September 2015 to December 2016. The primary objective of the study was to evaluate the safety of Glaritus®, mainly in terms of hypoglycemia, renal function tests and liver function tests. The secondary objectives were to evaluate the effectiveness of Glaritus®in terms of percentage of patients achieving HbA1c goal of less than 7%, mean changes in HbA1c & fasting plasma glucose (FPG) levels from baseline till the end of study. Results: 3.85% of subjects experienced hypoglycemia during first 3 months of therapy whereas 1.92% had similar experience in next 3 months of therapy. The mean HbA1c values reduced from 9.16% to 7.15% at the end of study. 21.05% of the enrolled subjects achieved the goal of HbA1c ®was well tolerated by the study patients. Conclusion: In patients with type 2 diabetes mellitus inadequately controlled on oral hypoglycemic agents and/or insulin, initiation with Glaritus®significantly improved glycemic control with good tolerability and acceptability. This analysis in T2DM Nepalese pa

关键词： Insulin Glargine Type 2 Diabetes Nepalese Patients Hypoglycemia Basal Insulin HbA1c Fasting Plasma Glucose Post Marketing Surveillance

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高龄胆石症患者LC与OC前后心肌酶、肌钙蛋白T、C反应蛋白变化的对比研究

高龄胆石症患者LC与OC前后心肌酶、肌钙蛋白T、C反应蛋白变化的对...

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作者：哈克（rishi Ram Dhakal）广西医科大学

学位级别：硕士

目的:了解电视腹腔镜胆囊切除术(LC)对老年患者心脏的影响,评价该手术在老年患者中的安全性。方法:选择61例老年胆石症病人,其中腹腔镜胆囊切除术31例(LC组),开腹胆囊切除术30例(OC组)。检测这些病人的术前、术中及术后不同时段的血清... 详细信息

目的:了解电视腹腔镜胆囊切除术(LC)对老年患者心脏的影响,评价该手术在老年患者中的安全性。方法:选择61例老年胆石症病人,其中腹腔镜胆囊切除术31例(LC组),开腹胆囊切除术30例(OC组)。检测这些病人的术前、术中及术后不同时段的血清肌酸激酶(CK)及其同工酶(CK-MB)、乳酸脱氢酶(LDH)、血清谷草转氨酶(AST)、乳酸脱氢酶同功酶(LD-1)、血清α-羟丁酸脱氢酶(HBDH)、心肌钙蛋白T(cTnT),C反应蛋白,并进行归纳和巩固分析。比较两组病人的相关指标的差异情况。结果:OC组的CK、CK-MB、LDH、AST、LD-1、cTnT及CRP术后各个时段与术前比较有统计学差异(P0.05)。结论:手术可以引起老年人心肌酶,心肌钙蛋白T发生变化,但LC及OC术均未发现患者出现严重的心肌损伤结果。LC与OC比较结果表明LC对心功能的影响与OC相似。C反应蛋白OC组24h后明显高于LC组表明LC对老年人患者的创伤小于OC者。

关键词：老年人胆石症胆囊切除术二氧化碳气腹心肌酶肌钙蛋白T C反应蛋白

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Time Varying Deceleration Parameter in f(R, T) Gravity

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Journal of Applied Mathematics and Physics 2021年第5期9卷 847-855页

作者： rishi Kumar Tiwari Sushil Kumar Mishra Sateesh Kumar Mishra Değ er Sofuoğ lu Department of Mathematics Government Model Science College Rewa India Department of Mathematics Kashi Naresh Govt. P. G. College Gyanpur India Department of Physics Istanbul University Istanbul Turkey

In the present study, a homogeneous and anisotropic LRS Bianchi type I universe model is considered in f(R, T) theory of gravity. In order to find an exact solution of the field equations of the model, the model presented is based on a unique condition of periodically time varying deceleration parameter. The physical and geometrical characteristics of the universe model have been studied. It has been shown that the model has point-type singularity and all the cosmological parameters possess periodic time behavior. The model has a cyclic expansion history, for example, the model starts with the decelerating expansion, and later it transits to an accelerating phase of expansion and then goes to super-exponential phase of expansion in a period.

关键词： Periodic Deceleration Parameter f(R T) Gravity Bianchi Type-I Universe

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Molecular cloning and characterization of two differentially expressed Cellulose synthase gene isoforms in Leucaena leucocephala: A pulp yielding tree species

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Advances in Bioscience and Biotechnology 2012年第1期3卷 92-100页

作者： rishi K. Vishwakarma Sameer Srivastava Somesh Singh Bashir M. Khan Plant Tissue Culture Division National Chemical Laboratory Maharashtra India

Leucaena leucocephala is fast growing leguminous tree species, acclimatized to variety of soil and climatic conditions. It is widely used for pulp production in India. Pulp mainly consists of cellulose, which is a simple polymer of unbranched β-1, 4-linked glucan chains. The polymerization of glucose residues into a β-1, 4-linked backbone is catalysed by the enzyme cellulose synthase (CesA). Here, cDNAs encoding CesA genes from Leucaena were isolated and characterized. The two complete cDNAs of 3.228 kb and 3.222 kb encoding CesA gene from L. leucocephala were designated as Ll-7CesA (FJ871987) and Ll-8CesA (GQ267555) respectively. In-silico studies showed that Ll-7CesA has 95.2% identities and Ll- 8CesA has 95.8% identities with Acacia mangium CesA2. Phylogenetic analysis revealed significant similarity with known dicot CesA genes. The deduced amino acid sequence of both CesA genes contained the conserved D, D, D, QxxRW motif, eight membrane spanning regions and a putative zinc binding domain, which are characteristic of glycosyltransferases. DNA blot analysis suggested, CesA gene to be in multiple copies in Leucaena genome. Semi quantitative and quantitative real-time PCR expression analysis of Ll-7CesA gene showed more expression in stem than leaf and not detected in root where as Ll-8CesA gene was expressed more in stem than leaf and root. Overall Ll-8CesA was expressed in all tested tissues and could be involved in active cellulose biosynthesis.

关键词： Cellulose Biosynthesis Cellulose Synthase Expression Analysis Leucaena leucocephala Tree Species

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Comparison of intravitreal ranibizumab and bevacizumab for the treatment of macular edema secondary to retinal vein occlusion

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 86-91页

作者： Alex Yuan Baseer U.Ahmad David Xu rishi P.Singh Peter K.Kaiser Daniel F.Martin Jonathan E.Sears Andrew P.Schachat Justis P.Ehlers Vitreoretinal Service Cole Eye InstituteCleveland Clinic The Retina Institute

AIMTo compare the efficacy of ranibizumab and bevacizumab for macular edema due to retinal vein occlusion (RVO).

关键词： macular edema retinal vein occlusion bevacizumab ranibizumab optical coherence tomography

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数字信号控制器实现嵌入式语音应用

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电子产品世界 2006年第8期 76-76页

作者： rishi Vasuki Microchip Technology

在通信领域,改善话音质量和提高话音传输速度是一直以来的要求.在其他市场领域,如消费电子和汽车行业,语音识别正快速成为用户和终端产品交流的标准方法.传统上,这些市场应用主要由集成了数字信号处理器(DSP)和微控制器(MCU)的系统来实... 详细信息

在通信领域,改善话音质量和提高话音传输速度是一直以来的要求.在其他市场领域,如消费电子和汽车行业,语音识别正快速成为用户和终端产品交流的标准方法.传统上,这些市场应用主要由集成了数字信号处理器(DSP)和微控制器(MCU)的系统来实现.MCU过去用来录音、回放声音以及控制用户操作.DSP严格用作数字解码引擎,处理记录下来的语音.最近出现了一种新的产品,叫做数字信号控制器(DSC).

关键词：语音应用 DSC DSP 累加器加法器数字信号控制器

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Effect of Semecarpus anacardium fruits on reproductive function of male albino rats

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Asian Journal of Andrology 2003年第2期5卷 121-124页

作者： Arti Sharma Pramod Kumar Verma V.P.Dixit Department of Zoology Raj Rishi Colloge A/war (Raj) 301001 IndiaReproductive Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 IndiaReproductive Physiology Section Department of Zoology University of Rajasthan Jaipur-302 004 India

Aim: To evaluate the effect of an ethanolic extract of Semecarpus anacardium fruits on spermatogenesis in albino rats. Methods: Male albino rats were fed with a 50 % ethanolic extract of Semecarpus anacardium fruit at 100 mg·***-1, 200 mg·kg-1·day-1 and 300 mg·kg-1·day-1 for 60 days. Fertility test was performed after 60 days of treatment. Sperm motility and density were observed in the cauda epididymis. Biochemical and histological analyses of the blood and reproductive organs were done. Recovery of fertility was followed to evaluate the reversibility of drug action. Results: S. anacardium fruit extract administration resulted in spermatogenic arrest in albino rats. The sperm motility and density was reduced significantly. The RBC and WBC counts, haemoglobin, haematocrit, blood sugar and urea were found to be within the normal range in the whole blood. The protein, cholesterol and glycogen in the testes and the fructose in the seminal vesicle were significantly decreased after the treatment. The fruit extract feeding caused marked reduction in the number of primary spermatocytes, secondary spermatocytes and spermatids. The number of mature Leydig cells was also decreased and degenerating cells increased proportionately. Conclusion: 5. anacardium fruit extract causes spermatogenic arrest in albino rats.

关键词： Semecarpus anacardium spermatogenesis androgen spermatocytes Leydig cells

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数字信号控制器支持嵌入式语音应用

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世界电子元器件 2007年第5期 29-30页

作者： rishi Vasuki Microchip数字信号控制器部

改善话音质量和加快话音传输速度一直是电信行业的要求。在消费电器和汽车等其他市场领域，语音识别也在迅速成为最终产品的标准人机接口方法。传统上，这些市场中的应用系统往往同时使用数字信号处理器（DSP）和单片机（MCU）。单片机... 详细信息

改善话音质量和加快话音传输速度一直是电信行业的要求。在消费电器和汽车等其他市场领域，语音识别也在迅速成为最终产品的标准人机接口方法。传统上，这些市场中的应用系统往往同时使用数字信号处理器（DSP）和单片机（MCU）。单片机用于录制和播放话音，同时控制用户交互过程。DSP则严格作为数字计算引擎用来处理录制的话音。

关键词：数字信号控制器语音识别应用系统嵌入式数字信号处理器话音质量电信行业传输速度

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Influence of spectral distribution on accommodation-vergence and reading performance

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Annals of Eye Science 2017年第1期2卷 127-132页

作者： Shiva Ram Male rishi Bhardwaj Chiranjib Majumder School of Medical Sciences University of HyderabadTelanganaIndia R J N School of Optometry GwaliorMadhya PradeshIndia

Background:To assess the influence of different spectral energy distribution on accommodation,vergence and reading ***:A Randomized experimental study was conducted after getting the approval of the Ethical Committee of University of *** participants with an age group of 18-21 years was integrated,out of which 50%was male and 50%was *** with emmetropia and no history of ocular pathology were included in the *** point of accommodation(NPA)&near point of convergence(NPC)was measured with the help of royal air force(RAF)ruler followed by near visual task of a readability ***:A statistically significant result was obtained when reading rate,reading speed and NPC was compared among different spectral distribution of light(P<0.001)except NPA(P=0.43).Post hoc analysis showed a significant difference(P<0.001)when tungsten was compared with fluorescent light(FLOU),compact fluorescent light(CFL),and light emitting diode(LED)for reading rate,reading speed and *** there is no noteworthy difference exist when fluorescent was compared with CFL for reading rate(P=0.530)&reading speed(P=0.595).Similarly,LED also showed no considerable difference when compared with CFL(P=0.682)and fluorescent(P=0.490)for *** NPA was assessed within the group LED showed insignificant difference with CFL(P=0.205)and fluorescent(P=0.275)similar like fluorescent and tungsten(P=0.482).Conclusions:This study concluded that reading performance(reading rate and reading speed)and NPC has a significance change if we use inappropriate lighting during visual *** will cause visual fatigue and strain after sustained near *** addition,tungsten spectral energy influences the convergence which can also show an impact on reading and near visual tasks because of its brightness and *** reading and working under this lighting can cause convergence disorders and visual fatigue.

关键词： Accommodation convergence reading rate reading speed readability spectral distribution correct word per minute(CWPM)

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Evaluation of Drought Tolerant Rice Cultivars Using Drought Tolerant Indices under Water Stress and Irrigated Condition

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American Journal of Climate Change 2019年第2期8卷 228-236页

作者： Mandeep Adhikari Nav Raj Adhikari Subarna Sharma Janmajaya Gairhe rishi Ram Bhandari Sakshi Paudel Department of Plant Breeding Institute of Agriculture and Animal Science Tribhuvan University Kirtipur Nepal Department of Biological Sciences Mississippi State University Starkville Mississippi State USA Department of Soil Science and Agri-Engineering Institute of Agriculture and Animal Science Tribhuvan University Kirtipur Nepal Department of Entomology and Plant Pathology Auburn University Auburn Alabama USA Prithu Technical College Institute of Agriculture and Animal Science Tribhuvan University Dang Nepal

Drought is the most critical abiotic factor reducing rice yield in rainfed and drought prone areas. Majority of rice cultivated area in south Asia are under rainfed, where water stress at any of the critical growth stage causes sharp decline in yield. Research was conducted in western Nepal at farmers field around the close vicinity of Regional Agriculture Research Center (RARS) Nepalgunj. Ten different rice cultivars were evaluated under drought stress and non-stress condition during the year 2017 to identify superior stress tolerant cultivars. Different drought tolerance indices like stress tolerance (TOL), Stress tolerance index (STI), Stress susceptibility index (SSI), were tested in screening superior rice cultivars. Significant reduction in mean grain yield was observed under drought stress in all rice cultivars under the study. The rice cultivars with high STI values and low TOL and SSI were identified as superior drought tolerant cultivars. Based on results of different tolerance indices, Sukha series of rice, Sukha Dhan 1-6 and Radha-4 showed low TOL and SSI and high STI values and were identified as drought tolerant cultivars. The present study reveals that selection based on drought tolerance indices can be an efficient tool in identification of superior drought tolerant cultivars with higher yield and stability.

关键词： Rice Drought Stress Drought Tolerance Indices Drought Tolerant Cultivars

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