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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 18-19页

作者： Koivusalo A. Pakarinen M. rintala r.j. 刘凯 Children' s Hospital Department of Paediatric SurgeryUniversity of Helsinki00290 HelsinkiFinland

Introduction: In antegrade colonic enema (ACE) appendicostomy,cecal fixation on the inside of the abdominal wall and cecal wrap around the base of the appendix are often performed as an antireflux procedure. Whether cecal fixation and wrap and fixation (FW) are necessary is not known. In a retrospective study,we compared laparoscopic and open procedure with FW (LACEfw+ and OACEfw+ ) with laparoscopic procedure without FW (LACEfw-). Materials and Methods: Between 1997 and 2004,44 consecutive patients underwent an ACE appendicostomy for fecal incontinence. Eleven patients (1997-2000) had OACEfw+ ,14 patients (2001 to 2003) had LACEfw+ ,and nineteen (2003-2004) had LACEfw-. The primary disorders included meningomyelocele (n=17),imperforate anus (n=12),sacral agenesis (n=1),presacral teratoma (n=1),osteosarcoma (n=1),diastematomyelia (n=1),tuberose sclerosis (n=1),Hirschsprung’ s disease (n=2),Down syndrome-associated refractory constipation (n=1)-,jacobsen syndrome (n=1),and chronic constipation (n=1). Twenty-eight patients had undergone previous abdominal surgery. Operative time,theatre time,length of hospitalization,and complications related with procedure and stoma were compared among the 3 groups. results: Age and age-adjusted body mass index did not differ statistically among the 3 groups. One LACEfw+ and 2 LACEfw-were converted. The median operative time was 38 minutes (range,23-65 minutes) for OACEfw+ ,78 minutes (50-135 minutes) for LACEfw+ ,and 40 minutes (25-120 minutes) for LACEfw-(P re time for OACEfw+ was 71 minutes (range,50-107 minutes),for LACEfw+ 123 minutes (range,70-173 minutes),and for LACEfw+ 75 minutes (57-160 minutes) (P range,3-8 days) for OACEfw+ ,5 days (4-6 days) for LACEfw+ ,and 4 days (2-9 days) for LACEfw-(P revisions were required in 6 of 10 patients with open ACE,7 of 14 patients with LACEfw+ ,and 2 of 19 patients with LACEfw-; stomal leak

关键词：结肠灌洗顺行性造口术脊髓脊膜膨出骶前畸胎瘤肛门闭锁脊髓纵裂造口并发症阑尾根部大便失

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维普期刊数据库

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经肛门内镜下直肠成形术:无瘘管形成的肛门闭锁患者的一种新型个体化手术方法

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 17-18页

作者： Pakarinen M.P. Baillie C. Koivusalo A. rintala r.j. 刘凯 Children's Hospital Section of Pediatric SurgeryUniversity of HelsinkiStenbckinkatu 11 PoBox 28100029-HUSHelsinkiFinland

Background/Aim: Imperforate anus without fistula consists of a spectrum of defects with variable distance between the rectal pouch and the perineum. We have developed a novel surgical approach for individual man agement of these patients based on precise knowledge of the level of the anomaly. Methods: All consecutive patients with imperforate anus without fistula between 2002 and 2004 had sigmoidostomy performed after having failed to pass meconium in the first 24 hours. The upper pouch was intraluminally visualized using retrograde endoscopy through the sigmoidmucous fistula. The distal termination of the rectum was clearly identified as by convergence of the anal columns. Bright translumination of the endoscope light from the rectum to the anal dimple within the external sphincter indicated a low malformation amenable to transanal proctoplasty. The rectum was incised from below under endoscopic visual control. Poor translumination indicated a higher defect,in which case,the operation was converted to standard posterior sagittal anorectoplasty. results: Seven patients (6 boys) were identified. Four patients (3 boys) completed transanal endoscopic-assisted proctoplasty. In all cases,the convergence of anal columns indicating rectal termination was right above the anal pit at the site of the maximal external sphincter squeeze. In 3 patients,the operation was converted to posterior sagittal anorectoplasty after verification of a higher anomaly by endoscopy. There were no operative complications. The median follow-up was 3 months (range,1-26 months). All patients have an appropriate size anus and regular bowel actions. Conclusions: Transanal endoscopic-assisted proctoplasty allows safe and anatomical reconstruction of the anorectum,as well as contemporaneous closure of the sigmoidostomy in a significant proportion of patients with imperforate anus without fistula,avoiding the potential complications associated with the open posterior sagittal approach.

关键词：肛门闭锁肠成形术个体化手术下直直肠盲端瘘管形成肛凹管成形术畸形程度肛门外括约肌

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先天性袋状结肠被纵向剪开可用于阴道重建

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世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 46-46页

作者： Wester T. Lckgren G. Christofferson r. rintala r.j. 朱新菊 Department of Paediatric Surgery University Children's HospitalSE-751 85 UppsalaSweden

Congenital pouch colon(CPC)is a rare malformation in which the distal part o f a shortened colon forms a dilated *** is associated with an anorectal ma *** report 2 patients with CPC,one with a cloaca and one with vestib ular fistula and vaginal *** is the first description of CPC,vestibular fistula,and vaginal *** purpose of this report was to demonstrate tha t the pouch can be split longitudinally-in analogy with Bianchi’s intestinal l engthening procedure [Bianchi *** loop lengthening:a technique for in creasing small intestinal length.j Pediatr Surg 1980;15:145-51]-to create a v agina and to reconstruct the anorectum with preserved blood supply.

关键词：阴道重建先天性结肠肛门直肠畸形阴道闭锁血液供应直肠肛门 CPC 前庭瘘延长术

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Downregulating activated epidermal growth factor receptor has no effect on rBM5 expression

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Chinese Medical journal 2012年第13期125卷 2378-2381页

作者： Twinkle j. Masilamani Nina D. rintala-Maki WANG Ke Leslie C. Sutherland Tumor Biology Group Regional Cancer Program of the Sudbury Regional Hospital Sudbury Ontario Canada P3E 5J1 Biomolecular Sciences Program Laurentian University Sudbury Ontario Canada P3E 5J1 Departments of Chemistry/Biochemistry and Biology Laurentian University Sudbury Ontario Canada P3E 5J1 Department of respiratory Medicine Second Affiliated Hospital ofJilin University Changchun Jilin 130000 China Medical Sciences Division Northern Ontario School of Medicine Laurentian and Lakehead Universities Canada Faculty of Medicine University of Ottawa Canada

Background We were interested in determining how the tumor suppressor gene rBM5 is regulated in lung cancers. Previous studies suggested that the gene expression is related to histological subtype and smoking exposure, since in small cell lung cancers the rBM5 gene is deleted whereas in non-small cell lung carcinomas （NSCLC） rBM5 expression is reduced. Of particular interest was the recent finding that in lung adenocarcinomas, a histological subtype of NSCLC, smoking exposure correlated with mutational activity in the transforming growth factor alpha （TGF-c~） signaling pathway. Lung adenocarcinomas from smokers were associated with activating KrAS mutations, whereas lung adenocarcinomas from never-smokers were associated with activating epidermal growth factor receptor （EGFr） mutations. We hypothesized that inhibition of rBM5 in lung adenocarcinomas is achieved indirectly via these activating mutations. The objective of the research described herein was to determine if EGFr activation and rBM5 expression are negatively correlated. Methods EGFr expression in the lung adenocarcinoma cell line NCI-H1975 was inhibited using small interfering rNA. rBM5 expression was examined by real-time quantitative polymerase chain reaction and Western blotting. results reduced EGFr expression did not correlate with any change in rBM5 expression at either the rNA or protein level. Conclusion These results suggest that rBM5 expression is not directly regulated by EGFr in non-smoker related lung adenocarinomas, and that some other mechanism operates to inhibit either the expression or function of this potential tumour suppressor in lung cancers that retain the rBM5 gene.

关键词： adenocarcinoma epidermal growth factor receptor rBM5 gene expression

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远端有瘘管的食管闭锁修补术后常规术后扩张是否优于症状出现后扩张——欧洲两小儿外科中心的结果比较

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世界核心医学期刊文摘（儿科学分册） 2005年第4期1卷 51-52页

作者： Koivusalo A. Turunen P. rintala r. j. N. M. A. Bax 肖莉 Willhelmina Children's Hospital University Medical Center Utrecht The Utrecht Netherlands

背景/目的:确定对远端有瘘管的食道闭锁(EADF),在修补术后进行常规扩张是否比保守观察,仅当症状出现时才扩张的效果好。方法:回顾在欧洲两个小儿外科中心100例EADF患儿的手术纪录[A(n=63),B(n=37)]。在A中心,吻合口扩张术只对有症状的... 详细信息

背景/目的:确定对远端有瘘管的食道闭锁(EADF),在修补术后进行常规扩张是否比保守观察,仅当症状出现时才扩张的效果好。方法:回顾在欧洲两个小儿外科中心100例EADF患儿的手术纪录[A(n=63),B(n=37)]。在A中心,吻合口扩张术只对有症状的病例实施,然而在B中心。

关键词：食管闭锁小儿外科扩张术常规扩张吻合口术后并发症 atresia dilatation 气管软化 anastomosis

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