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基因对于儿童肥胖的影响在小于胎龄儿童中或不重要

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基因对于儿童肥胖的影响在小于胎龄儿童中或不重要

Making connections with cell surface auxin signaling

作者： Dug Yeo Han rinki murphy Angharad R Morgan 郭婧张帆

小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,...

小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,研究与成人肥胖相关的常见基因变异是否会与小于胎龄儿出生后生长加速有关。研究者将547名欧洲儿童(228名小于胎龄儿和319名适于胎龄儿)进行基因分型,他们被分为共计37个单核苷酸多态性(SNPs)候选基因。重复测量儿童的BMI,并以Z评分法评估肥胖程度,使

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Molecular Plant 2024年第4期17卷 522-524页

作者： Angus S.murphy University of Maryland College ParkMDUSA

The discovery and characterization of the nuclear AUX-indole-3-acetic acid(IAA)-TIR1/AFB auxin co-receptor complex in the model plant Arabidopsis at the outset of the 21st century was a hallmark event in biological *** decades of subsequent discovery demonstrated the central role of the nuclear auxin perception mechanism in virtually every stage of Viridiplantae *** auxin receptors were also shown to be essential for later stages of differential hypocotyl,coleoptile,and root tropisms,but the most rapid responses were found to persist in Arabidopsis mutants lacking important components of the receptor mechanism(Napier,2021;Peer and murphy,2022).In particular,rapid cellular elongation observed in tropic growth or after experimental application of auxin is mediated by H+extrusion across the plasma membrane(PM).The resulting apoplastic acidification activates extensin proteins that loosen cell walls to allow for turgor-driven cellular *** initial events occur in a time frame that precludes nuclear signaling and now can be clearly attributed to a cell surface auxin co-receptor complex and downstream signaling intermediaries.

关键词： Arabidopsis surface walls

Insights into optimizing exosome therapies for acute skin wound healing and other tissue repair

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Frontiers of Medicine 2024年第2期18卷 258-284页

作者： Tianjing Sun Mo Li Qi Liu Anyong Yu Kun Cheng Jianxing Ma Sean murphy Patrick Michael McNutt Yuanyuan Zhang Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Department of Nephrology Affiliated Hospital of Zunyi Medical UniversityZunyi563003China Division of Pharmacology and Pharmaceutical Sciences School of PharmacyUniversity of Missouri-Kansas CityKansas CityMO64108USA Department of Biochemistry Wake Forest University School of MedicineWinston-SalemNC27157USA Wake Forest Institute of Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC27109USA

Exosome therapy holds great promise as a novel approach to improve acute skin wound *** review provides a comprehensive overview of the current understanding of exosome biology and its potential applications in acute skin wound healing and ***,small extracellular vesicles secreted by various stem cells,have emerged as potent mediators of intercellular communication and tissue *** advantage of exosome therapy is its ability to avoid potential risks associated with stem cell therapy,such as immune rejection or stem cells differentiating into unwanted cell ***,further research is necessary to optimize exosome therapy,not only in the areas of exosome isolation,characterization,and engineering,but also in determining the optimal dose,timing,administration,and frequency of exosome ***,optimization of exosome therapy is critical for the development of more effective and safer exosome-based therapies for acute skin wound healing and other diseases induced by cancer,ischemia,or *** review provides valuable insights into the potential of exosome therapy and highlights the need for further research to optimize exosome therapy for clinical use.

关键词： exosomes stem cells therapeutic impact skin wound healing

Predictors of the placebo response in a nutraceutical randomized controlled trial for depression

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Journal of Integrative Medicine 2024年第1期22卷 46-53页

作者： Rosemary Arnold Jenifer murphy-Smith Chee H.Ng David Mischoulon Gerard J.Byrne Chad A.Bousman Con Stough Michael Berk Jerome Sarris Professorial Unit the Melbourne ClinicDepartment of PsychiatryUniversity of MelbourneRichmond 3121Australia Depression Clinical and Research Program Department of PsychiatryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02115USA Faculty of Medicine Discipline of PsychiatryCentre for Clinical ResearchRoyal Brisbane&Women’s HospitalHerstonthe University of QueenslandBrisbane 4006Australia Departments of Medical Genetics PsychiatryPhysiology&Pharmacology and Community Health SciencesUniversity of CalgaryCalgaryAB T2N 1N4Canada Department of Psychiatry the University of MelbourneMelbourne 3052Australia Centre for Human Psychopharmacology Swinburne UniversityMelbourne 3122Australia The Institute for Mental and Physical Health and Clinical Translation School of MedicineBarwon HealthDeakin UniversityGeelong 3220Australia The Centre of Excellence in Youth Mental Health the University of MelbourneParkville 3052Australia Florey Institute of Neuroscience and Mental Health the University of MelbourneParkville 3052Australia NICM Health Research Institute Western Sydney UniversityWestmeadNSW 2145Australia

Objective The placebo response in depression studies is the change in symptoms amongst those who receive an inactive *** well-designed randomized controlled trials(RCTs)of depression have a high proportion of placebo responders,with little understanding as to *** present study assesses characteristics associated with the placebo response in a nutraceutical trial with a large proportion of placebo *** This is a secondary analysis of a nutraceutical depression RCT which identified no overall treatment benefit relative to placebo(n=69 in placebo group).We investigated participant characteristics such as socio-demographics,clinical features,and recruitment methods,and their association with the placebo *** genetic polymorphisms were also *** response was measured based on change in Montgomery-Asberg Depression Rating Scale *** association of these hypothesis-driven variables of interest and the placebo response was examined using linear mixed effects *** Greater levels of education,particularly pursuing post-high school education,better self-reported general health,marriage/de facto,greater improvement in the first trial week,and more failed antidepressant therapies in the current depressive episode were associated with greater placebo *** increased placebo response was not found in those recruited via social media nor in those with concomitant antidepressant *** nucleotide polymorphisms from the tryptophan hydroxylase 1(TPH1)gene(A779C and A218C)were weakly associated with greater placebo response,although the evidence was attenuated after accounting for multiple *** This is,to our knowledge,the first study within nutraceutical research for depression to assess the association between participant characteristics and variation in the placebo *** variables appeared to predict the placebo *** findings may encourage future trial design

关键词： Randomized controlled trial Placebo Depression Nutraceutical Psychiatry

基因对于儿童肥胖的影响在小于胎龄儿童中或不重要

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营养健康新观察 2013年第1期 51-51页

作者： Dug Yeo Han rinki murphy Angharad R Morgan 郭婧张帆

小于胎龄儿在日后的生活中面临着更高的患肥胖症和代谢性疾病的风险,目前认为这种风险主要与小于胎龄儿出生后生长加速有关。研究人员对奥克兰出生体重协作研究项目中的小于胎龄儿和适于胎龄儿做了研究,测量并计算这些儿童的BMI-Z评分,... 详细信息

关键词：小于胎龄儿生长加速儿童肥胖出生后成人肥胖代谢性疾病肥胖程度重复测量评分法单核苷酸多

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Wishing

小学生时代（大嘴英语） 2024年第7期 66-67页

作者： Maggie murphy Gina Lorena Maldonado(图) 不详

Spherical Functions on Fuzzy Lie Group

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Advances in Pure Mathematics 2024年第4期14卷 185-195页

作者： murphy E. Egwe Samuel S. Sangodele Department of Mathematics University of Ibadan Ibadan Nigeria

Let G be a locally compact Lie group and its Lie algebra. We consider a fuzzy analogue of G, denoted by called a fuzzy Lie group. Spherical functions on are constructed and a version of the existence result of the Hel... 详细信息

关键词： Fuzzy Spherical Function Fuzzy Lie Group Fuzzy Manifolds

Groupoid Approach to Ergodic Dynamical System of Commutative von Neumann Algebra

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Advances in Pure Mathematics 2024年第3期14卷 167-184页

作者： Nicholas O. Okeke murphy E. Egwe Physical and Mathematical Sciences Dominican University Ibadan Nigeria Department of Mathematics University of Ibadan Ibadan Nigeria

Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bounded functions L∞(X, μ) on X. We confirm that the commutative von Neumann algebras M⊂B(H), with H=L2(X, μ), are unitary equivariant to the maximal ideals of the commutative algebra C(X). Subsequenly, we use the measure groupoid to formulate the algebraic and topological structures of the commutative algebra C(X) following its action on M(X) and define its representation and ergodic dynamical system on the commutative von Neumann algebras of M of B(H) .

关键词： Measure Groupoid Groupoid Equivalence Ergodic Action Convolution Algebra von Neumann Algebra Generalized Space

Production of chitosan-based composite film reinforced with lignin-rich lignocellulose nanofibers from rice husk

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Journal of Bioresources and Bioproducts 2024年第2期9卷 174-184页

作者： Hye Jee Kang Yeon Ju Lee Jin Kyoung Lee Irnia Nurika Sri Suhartini Deokyeong Choe Dong Hyun Kim Hoon Choi Natasha P.murphy Ho Yong Kim Young Hoon Jung School of Food Science and Biotechnology Kyungpook National UniversityDaegu 41566Republic of Korea CPR S&T Co. Ltd.Gunpo 15880Republic of Korea Department of Agroindustrial Technology Faculty of Agricultural TechnologyUniversitas BrawijayaMalang 65145Indonesia Renewable Resources and Enabling Sciences Center National Renewable Energy LaboratoryGoldenCO 80401United States Center for Bio-based Chemistry Korea Research Institute of Chemical TechnologyUlsan 44429Republic of Korea

Lignocellulosic nanofibers(LCNFs),implying lignin-containing cellulose fibers,maintain the prop-erties of both lignin and cellulose,which are hydrophobic and hydrophilic,*** pres-ence of hydrophobic lignin in LCNFs is expected to be an economical and attractive option that can improve the thermal and mechanical properties of ***,this study was conducted to produce lignin-rich LCNFs from sugar-rich waste obtained from rice husks after acidic *** LCNFs were produced from the lignin-rich solid fractions obtained after pretreatment and enzymatic hydrolysis,which were then incorporated as an additive into a chitosan-based *** variations in lignin content in the range of approximately 50.6%-66.8%in differently obtained LCNFs gave significantly different optical strengths and mechanical *** controllable processes may allow for customized film ***,the glucose-rich liquid fractions obtained after pretreatment and enzymatic hydrolysis were used as a substrate for ethanol fermentation to achieve total utilization of rice husk biomass *** conclusion,the lignin-rich biomass fraction holds promise as a suitable material for chitosan-LCNF film and has the potential to increase the economic feasibility of the biomaterial industry.

关键词： Rice husk Lignocellulose nanofiber Lignin-based material Chitosan film Upcycling