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The biogenic silica variation and paleoproductivity evolution in the eastern Indian Ocean during the past 20 000 a

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Acta Oceanologica Sinica 2019年第1期38卷 78-84页

作者： Yonghang Xu Liang Wang Zhikun Lai Xiaohui Xu Feng Wang Shengfa Liu Xuefa Shi Rainer Arief Troa rina Zuraida Eko Triarso Marfasran Hendrizan Laboratory of Ocean and Coast Geology Third Institute of Oceanography Ministry of Natural Resources Laboratory for Marine Geology Pilot National Laboratory for Marine Science and Technology (Qingdao) Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of Oceanography Ministry of Natural Resources Marine Research Center Agency of Research and Human Resources for Marine and Fisheries Marine Geological Institute Agency for Research and Development for Energy and Mineral Resources Research Center for Geotechnology Indonesia Institute of Sciences

The biogenic silica of sediment samples from Core CJ01-185 which is collected from the eastern India Ocean off the Sunda Strait is analyzed to evaluate the impact of the opening of the Sunda Strait on a paleoproductivity evolution. The new results indicate that the biogenic silica mass values of Core CJ01-185 show the lowest 0.86% in the last glacial period, and reach its maxima of 1.89% in the late Holocene. Furthermore, the biogenic silica mass accumulation rate(MARBSi) values also vary with much higher during the late Holocene than during the last glaciation. The input of additional terrigenous materials from the Java Sea has enhanced the paleoproductivity and increased the biogenic silica mass and MARBSi values after the opening of the Sunda Strait. It is suggested that the paleoproductivity in the study area is mainly influenced by the southeast monsoon and upwelling before the opening of the Sunda Strait. However, the paleoproductivity is dominated by the terrigenous materials input other than by the southeast monsoon or upwelling in the Holocene.

关键词： biogenic silica paleoproductivity Sunda Strait eastern India Ocean

Quantification of atorvastatin in human plasma by liquid chromatography tandem mass spectrometry and its application for bioequivalence study of three formulations

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 66-67页

作者： Yahdiana Harahap Santi Purnasari Harmita rina Rahmawati Krisnasari Dian Pratami Witri Sansris Siti Fatriyah Laboratory of Bioavailability and Bioequivalence Faculty of Pharmacy Universitas Indonesia

Atorvastatin, a chemical ([R-(R*, R*)]-2-(4-fluorophenyl)-b,ddihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]1 H-pyrole-1-heptanoic acid), is a synthetic HMG-Co A (3-hydroxy-3-methylglutaryl-coenzyme A)reductase inhibitor. It has been shown to be remarkably efficacious in decreasing the level of cholesterol and triglyceride(1)In order to quantify the level of atorvastatin in plasma, it needs a sensitive, rapid and selective method.

关键词： Atorvastatin Simvastatin LC-MS/MS

Unusual Seismic Activities in Northwestern Madagascar Using:Spot Them All

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Journal of Geological Resource and Engineering 2020年第3期8卷 80-89页

作者： Jaona Andriamampandry rina Andrianasolo Tahina Rakotoarisoa Institute and Observatory of Geophysics of Antananarivo Antananarivo UniversityAmbohidempona-AntananarivoMadagascar

Spot Them All,is the first localization software developed by the Laboratoire de Seismologie et Infrason *** objective of this study is to validate results obtained from the software by comparing them with bulletin published by GFZ and the revised event bulletin of the CTBTO from April 2018 to November *** May 15th,2018 around 15:48,an unusual seismic event of magnitude 5.9 was detected in northwest of Madagascar with thousands of *** program Spot Them All collects data from IRIS,GEOFON,DASE,IMS,Africa Array network on *** showed that earthquake location obtained using STA is consistent with the other two international ***,199 earthquakes of magnitude greater than 4 were detected by the IMS,39 by the GEOFON network while 937 by *** is fixed at 10 km in the GFZ’s bulletin and at 0 km in the CTBTO’s ***’s bulletin shows more constrain on events’depth,ranging from 0 to 135 km and they are located between latitudes 11.84°S and 14.18°S,and longitudes 44.8°E and 46.78°*** collected from different researches showed that a magma is propagating from Moho depth to the ***,a new mountain of about 800 m high and 5 km wide is raising above the seafloor.

关键词： Spot Them All earthquakes Northwestern of Madagascar new mountain

Systematic review of suicide in economic recession

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World Journal of Psychiatry 2015年第2期5卷 243-254页

作者： Mayowa Oyesanya Javier Lopez-Morinigo rina Dutta Department of Psychological Medicine King’s College London School of Medicine King’s College London Department of Psychosis Studies Institute of Psychiatry King’s College London Department of Psychological Medicine Institute of Psychiatry King’s College London

AIM: To provide a systematic update of the evidence concerning the relationship between economic recession and ***: A keyword search of Ovid Medline, Embase, Embase Classic, PsycI NFO and PsycA RTICLES was performed to identify studies that had investigated the association between economic recession and suicide. RESULTS: Thirty-eight studies met predetermined selection criteria and 31 of them found a positive association between economic recession and increased suicide rates. Two studies reported a negative association, two articles failed to find such an association, and three studies were inconclusive. CONCLUSION: Economic recession periods appear to increase overall suicide rates, although further research is warranted in this area, particularly in low income countries.

关键词： Economic recession Suicide Unemployment Time series Systematic review

Functional Recovery of Axonal Injury Induced by Gelatin-Hydrogel Film and PRP: An Initial Study in Rats

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Journal of Biomedical Science and Engineering 2015年第3期8卷 160-169页

作者： Retno Ardhani rina Susilowati Ika Dewi Ana Dental Biomedical Sciences Department Faculty of Dentistry Universitas Gadjah Mada Yogyakarta Indonesia Histology and Cell Biology Department Faculty of Medicine Universitas Gadjah Mada Yogyakarta Indonesia

In today’s society, axonal regeneration is considered very important because of high incidence of nerve injuries. The injury may cause vast damage of extracellular matrix leading to the condition wherein cell lost their environment to live. In this situation, new strategies by the introduction of scaffold to function as synthetic extracellular matrix are needed. In the field of tissue engineering, a large variety of carriers and matrices have been utilized as a scaffold to direct axonal growth. In this study, a new strategy by the combined application of gelatin hydrogel film and Platelet Rich Plasma (PRP) to induce functional recovery of sciatic nerve crushed injury was investigated in Wistar rat model. Assessment of motorist and sensory functions were done to evaluate the recovery processes. It was found that the application of gelatin hydrogel film with controlled release manner combined with PRP results faster axonal regeneration. Further research by different injury model and other investigation factors are needed to confirm the effectiveness of the strategy.

关键词： Tissue Engineering Functional Recovery Axonal Injury Gelatin Hydrogel PRP

基于青色荧光蛋白和FAM标记核酸的荧光能量共振转移分析PUF蛋白与其目标核酸的互作

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基于青色荧光蛋白和FAM标记核酸的荧光能量共振转移分析PUF蛋白与...

作者： Fidiniaina rina Juliana 浙江师范大学

学位级别：硕士

在细胞内,各种生物分子之间的相互作用,对于调节、维持细胞的正常生长、发育、繁殖具有非常重要的意义。F?rster或荧光共振能量转移(fluorescence resonance energy transfer,FRET)是一种物理现象,需要在一对分子之间发生非辐射能量转移... 详细信息

在细胞内,各种生物分子之间的相互作用,对于调节、维持细胞的正常生长、发育、繁殖具有非常重要的意义。F?rster或荧光共振能量转移(fluorescence resonance energy transfer,FRET)是一种物理现象,需要在一对分子之间发生非辐射能量转移,这取决于距离以及光子从供体到受体荧光色团的发射和再吸收。这种能量转移的效率高度依赖于供体和受体荧光团的选择,荧光蛋白是最流行的荧光色团之一,可以与不同的蛋白质分子形成融合蛋白,有机荧光色团可用来标记目标核酸序列。FRET技术可以用来分析蛋白质之间相互作用,以及蛋白质与其他分子之间的相互作用。PUF蛋白家族是一种高度保守的蛋白,属于广泛的真核细胞RNA结合蛋白家族,它们通过与靶标m RNA的3’非翻译区(UTR)结合并调节其降解来调节靶标m RNA的生命周期。不同的PUF蛋白具有称为RNA结合支架或PUF蛋白结构域的特异性结合位点,可调节靶RNA的表达。在长期进化过程中,PUF蛋白的结合特异性,调控和靶标等在真核生物中出现了多样化现象。科学家已经分析出PUF蛋白氨基酸序列与识别核苷酸序列的对应关系,为人工设计PUF蛋白并应用于识别结合特定RNA序列奠定了基础。在本研究中,我们首先通过绿色荧光蛋白序列基因的64、65、66和72位的定点突变设计了一种新的蓝绿色荧光蛋白mutCFP,并分析了其发射光谱。此mutCFP在490nm波长处产生一个单峰发射光谱,这与普通青色荧光蛋白在476nm和500nm波长处具有双峰发射光谱有所不同,mutCFP可作为FAM荧光色团FRET的荧光供体。构建PUF3-mutCFP融合蛋白表达载体,并纯化融合蛋白,分析其与目标核苷酸的互作。PUF3蛋白可以结合12个寡核苷酸(GATCGGCAGCGA),我们在其编码序列的3’端连接mutCFP编码序列,并在大肠杆菌胞内表达此融合蛋白。经分离、纯化获得此融合蛋白PUF3-mutCFP。我们设计、合成在6-FAM标记与PUF识别位点之间有不同长度腺苷酸的寡核苷酸链,并以融合蛋白PUF3-mutCFP中的mutCFP作为荧光供体,6-FAM作为荧光受体进行FRET分析。结果我们发现与15、20和25个腺苷酸相比,当FAM和靶序列之间有9个连接腺苷酸时,PUF3与目标寡核苷酸具有最高亲和力(K=163.3 nM)。而与6、8和10个寡核苷酸相比,PUF3对12个寡核苷酸靶序列具有最高亲和力(K=44.3 nM)。用FRET技术进一步研究了pH,甘油和还原剂对PUF3和目标寡核苷酸链互作的影响。通过解离常数测定分析,发现PUF3和目标寡核苷酸链的亲和力受到这些因素的影响,且在pH8,20%甘油和2 m M DTT的条件下具有更强的亲和力。本研究利用FRET技术分析PUF3与目标寡核苷酸链的互作条件,如6-FAM标记与PUF识别位点之间间隔核苷酸链长度的影响,并评估不同pH、甘油和还原剂等对其相互作用的潜在影响。总之,本研究建立了一个RNA结合蛋白与目标核苷酸链互作的互作分析体系,为体外分析其生物大分子之间的互作、深入探究它们体内的互作功能建立的一定基础。

关键词：荧光共振能量转移 RNA结合蛋白蛋白核酸互作青色荧光蛋白 PUF蛋白

Risk Assessment of Retrograde Intramedullary Nailing for Proximal Humeral Fracture

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Journal of Biomedical Science and Engineering 2019年第5期12卷 277-284页

作者： rina Sakai Uchino Masataka Kazuhiro Yoshida Masanobu Ujihira Department of Biomedical Engineering and Technology School of Allied Health Sciences Kitasato University Sagamihara Japan Department of Orthopedic Surgery Hakujikai Memorial General Hospital Tokyo Japan

In proximal humeral fracture except AO classification 11A1, fixations with a locking plate and nails are recommended. We performed mechanical tests to investigate whether retrograde intramedullary nailing has fixation stability comparable to those of anterograde intramedullary nailing and locking plate which achieve clinically favorable outcomes. In retrograde intramedullary nailing, a nail entry point is made in the diaphysis, for which reduction of stiffness of the humerus is of concern. Thus, we investigated the influence of a nail entry point made in the diaphysis on humeral strength. Retrograde intramedullary nailing had fixation stability against bending and a force loaded in the rotation direction comparable to those of anterograde intramedullary nail and locking plate. Displacement by the main external force loaded on the humerus, compressive load, was less than half in the bone fixed by retrograde intramedullary nailing compared with that in the bone fixed with a locking plate, showing favorable fixation stability. It was clarified that stiffness of the humerus against rotation and a load in the compression direction is not reduced by a nail entry point made by retrograde intramedullary nailing.

关键词： Proximal Humeral Fracture Retrograde Intramedullary Nailing Anterograde Intramedullary Nailing Locking Plate Internal Fixation

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柬埔寨政府利用世界银行信贷的绩效研究

柬埔寨政府利用世界银行信贷的绩效研究

作者： Em rina（李永庆）云南大学

学位级别：硕士

回顾柬埔寨与世界银行合作的20年,正是柬埔寨进入到新知识经济时期(90年代中期至今),处于经济腾飞的阶段,这期间世界银行的信贷援助对于刚刚渡过经济恶化时期的柬埔寨来说,发挥了重要的作用。本文在梳理国际援助的相关文献后发现,柬埔... 详细信息

回顾柬埔寨与世界银行合作的20年,正是柬埔寨进入到新知识经济时期(90年代中期至今),处于经济腾飞的阶段,这期间世界银行的信贷援助对于刚刚渡过经济恶化时期的柬埔寨来说,发挥了重要的作用。本文在梳理国际援助的相关文献后发现,柬埔寨关于这方面的研究比较少,而且仅有的文献也是从国际政治视角或发展经济学方面来考虑的,缺乏相应的实证研究。世界银行对柬埔寨信贷援助绩效问题的研究是前所未有的,这是对以前缺乏的文献的补充,也是为以后如何更有效的利用世界银行信贷政策提供一种借鉴。本文拟从世界银行的信贷政策作为出发点,在现有的信贷政策理论的基础之上,对世界银行现行的信贷政策进行研究,然后通过计量模型等统计方法反映和说明现行的信贷政策对柬埔寨产生的积极的作用,同时结合实际情况深入分析当前存在的问题并提出相应的解决问题的建议。其中,介绍了信贷政策的演变过程和未来的发展方向,以及对现有的信贷政策的评析,同时还结合信贷政策的最前沿的理论,阐述了当前学者对信用贷款的方式、手段以及积极的作用等方面的理论成果;同时,相关学者还针对相应的数据显示,结合理论提出了世界银行提供信贷业务对发展中国家所带来的积极的影响,主要包括了为发展中国家提供了充沛的资金、良好的环境以及先进的技术为发展国内经济提供基础;信贷政策存在的问题主要指受援国外债规模、具体情况和推行的政治理念等问题。其次是针对柬埔寨利用世界银行信贷的现状和效果进行实证分析,主要介绍了柬埔寨接受世行信贷援助的现状及取得的成果,并利用正确的国际前沿的援助分类模型,来保证合理有效的模型数据采集依据;然后将柬埔寨国内的受援部门包括农业、政府管理、环境、卫生和教育作为自变量,利用Eviews7.2软件对模型进行回归分析以及相关变量和总体的显著性检验,结果发现该模型以绝对数值通过了t检验和F检验,不但保证了该模型是准确的,还证明了其的合理性;最后对回归模型中各个受援部门进行经济性分析,得出世行的信贷援助对柬埔寨的总体发展具有显著性的作用的结论,并提出部分受援部门出现负效应的实证结论,并进一步分析出现负效应的各方面原因。文中最后通过绩效分析的方法全面剖析了世行在柬埔寨的信贷援助效果并反映出其存在的信贷水平、贷款管理系统、投入分配和市场机制等问题,提出相应的政策建议,包括降低信贷风险、建立有效的贷款管理系统、优化受援产业结构和积极参与国际合作等方面。文中在进行绩效分析的基础上,不仅提到世行对柬埔寨经济增长的巨大贡献,还分析了柬埔寨利用世行信贷政策存在的问题的各方面原因,以及提出如何更有效利用世行贷款的四点建议。

关键词：柬埔寨世界银行信贷政策绩效分析存在的问题

Validation of Metformin Hydrochloride in Human Plasma by HPLC-Photo Diode Array （PDA） for Application of Bioequivalence Study

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Journal of Life Sciences 2012年第1期6卷 20-27页

作者： Yahdiana Harahap Krisnasari Dianpratami Mahi Wulandari rina Rahmawati Department of Pharmacy University of Indonesia Depok Jakarta 16424 Indonesia

A sensitive and specific high performance liquid chromatography （HPLC） method was developed and validated for the simultaneous determination of metformin hydrochloride （HCI） in human plasma. The HPLC method consists of isocratic eluation with a mixture of 60% buffer （10 mM sodium dihyrogenphosphate-10 mM sodium dodecyl sulphate） and 40% acetonitrile with final pH 7.0 with flow rate of 1.0 mL/min on a Kromasil~ Akzo Nobel RP-18 （4.6 mm ID ~ 250 mm, 5 ~tm） column at an ambient temperature. Photo diode array detection was performed in program mode at 234 rim. The analyte and diazepam as internal standard （IS） were extracted from plasma using 10% trichloroacetic acid. The assay was linear over the therapeutic concentration range of 20-2,500 ng/mL for metformin HCI with correlation coefficient of r = 0.9999. Limit of quantitation was 20 ng/mL. The results obtained for intraJinter day accuracy and precision complied very well with the generally accepted criteria for bio-analytical assay. The method was applied to bioequivalence （BE） study of metformin HCI in healthy Indonesian volunteers after treatment with 750 mg XR metformin HCI. This BE study shows that the two formulations are equivalent so that they were therapeutically interchangeable for each other.

关键词： Metformin HCl diazepam HPLC sodium dodecyl sulphate (SDS) photo diode array (PDA) detector bioequivalence(BE) study.