检索结果-南通市图书馆

IDO1 in cancer: a Gemini of immune checkpoints

Cellular & Molecular Immunology 2018年第5期15卷 447-457页

作者： Lijie Zhai Erik Ladomersky Alicia Lenzen Brenda Nguyen ricky patel Kristen L Lauing Meijing Wu Derek A Wainwright Department of Neurological Surgery Northwestern University Department of Pediatrics Northwestern University Division of Hematology Oncology and Stem Cell TransplantationNorthwestern University Ann&Robert H.Lurie Children’s Hospital of Chicago Northwestern University Department of Medicine-Hematology/Oncology Northwestern University Department of Microbiology-Immunology Northwestern University Department of MedicineDivision of Hematology and Oncology Northwestern UniversityBrain Tumor InstituteNorthwestern University Robert H.Lurie Comprehensive Cancer Center of Northwestern University Northwestern UniversityChicagoIL 60611USA

Indoleamine 2,3-dioxygenase 1(IDO1)is a rate-limiting metabolic enzyme that converts the essential amino acid tryptophan(Trp)into downstream catabolites known as ***,numerous studies have demonstrated that IDO1 is highly expressed in multiple types of human *** studies have further introduced an interesting paradox:while single-agent treatment with IDO1 enzyme inhibitor has a negligible effect on decreasing the established cancer burden,approaches combining select therapies with IDO1 blockade tend to yield a synergistic benefit against tumor growth and/or animal subject *** the high expression of IDO1 among multiple cancer types along with the lack of monotherapeutic efficacy,these data suggest that there is a more complex mechanism of action than previously *** to the dual faces of the astrological Gemini,we highlight the multiple roles of IDO1 and review its canonical association with IDO1-dependent tryptophan metabolism,as well as documented evidence confirming the dispensability of enzyme activity for its immunosuppressive *** gene transcript levels for IDO1 highlight its strong association with T-cell infiltration,but the lack of a universal prognostic significance among all cancer ***,ongoing clinical trials are discussed with consideration of IDO1-targeting strategies that enhance the efficacy of immunotherapy for cancer patients。

关键词： glioblastoma glioma IDO immunosuppression kynurenine immunotherapy melanoma Treg

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

成为教练的上一站

引用

电子竞技 2024年第8期 76-77页

作者： ricky 不详

前不久,在哈维·阿隆索率领勒沃库森队史首次加冕德甲冠军后,我看到了一个有趣的数据统计。即所有转型成为主教练的退役球员中,有42%的人在球员时代踢的是中场的位置,而这其中后腰位置的球员又占据了大多数。同样是踢球,为什么中场和后... 详细信息

前不久,在哈维·阿隆索率领勒沃库森队史首次加冕德甲冠军后,我看到了一个有趣的数据统计。即所有转型成为主教练的退役球员中,有42%的人在球员时代踢的是中场的位置,而这其中后腰位置的球员又占据了大多数。同样是踢球,为什么中场和后腰能够产出更多的名帅?球员时期同样踢后腰,去年率曼城夺得三冠王的瓜迪奥拉给出了这样的解答,“当你是一名前锋,主要考虑的事情就是进球。但当你是一名中场,必须随时知道整个球场上发生着什么,自己的位置应该在哪里,这些会让你对比赛有着更多的了解。”

关键词：阿隆索勒沃库森德甲数据统计进球教练球员

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ranking Modules for Integrate Testing Based on PageRank Algorithm

引用

Chinese Journal of Electronics 2017年第5期26卷 993-998页

作者： SUN Qi Krishna ricky MONIZ YUAN Yuyu Key Laboratory of Trustworthy Distributed Computing and Service(BUPT) Ministry of EducationBeijing University of Posts and Telecommunications

The testing industry need to prioritize the limited resources and focus on testing modules whose failure is mostly likely to cause *** paper discusses a method that can rank modules in a software package for integrate testing using the PageR ank *** this algorithm,a sequences of random walks iteratively can find a high likelihood of encountering a node,which is interpreted as it being an important performance *** experiment result prove that the proposed method actually can be used to prioritize testing of specific modules when testing resource are scarce.

关键词： Software testing Integrate testing PageRank algorithm Testing prioritize

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Introduction to the Special Issue on Optical Coherence Tomography(OCT)

引用

Journal of Innovative Optical Health Sciences 2021年第1期4卷 1-2页

作者： Zhihua Ding Peng Li Ruikang(ricky)Wang State Key Laboratory of Modern Optical Instrumentation College of Optical Science&Engineering Zhejiang University HangzhouZhejiang Province310027P.R.China Department of Bioengineering University of Washington SeattleWA 98195-5061USA

Optical Coherence Tomography(OCT)is one of the fastest developing medical imaging technologies that enables non-invasive and non-contact cross-sectional volumetric imaging by detecting the in-terference formed between... 详细信息

关键词： Optical mirror sectional

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cluster-Based Advantages in the Innovation Process： The Diffusion of Nanotechnology in Two Chinese Cities

引用

Frontiers of Business Research in China 2012年第1期6卷 25-54页

作者： ricky Leung Department of Health Management and Informatics University of Missouri Columbia MO65212 USA

Researchers have shown that ＂cluster＂ is a more useful unit of analysis than ＂nation＂ in innovation studies. Clusters are characterized by interconnected organizations, shared resources and frequent knowledge flows. Within national boundaries, multiple clusters with different relative advantages may coexist, and exhibit very different innovation patterns. Yet, in studies of innovation in emerging economies, there remains little attention on cluster-based advantages, and how these advantages generate distinct patterns of innovation. To bridge this gap, this study analyzes the diffusion patterns of nanotechnology in two Chinese clusters--Beijing and Shanghai. With different relative advantages, the diffusion of nanotechnology has been oriented by different levels of ＂imitation＂ and ＂innovation＂ forces in the two Chinese clusters. This study applies the Bass Model to quantify imitation and innovation forces, and compare the resultant diffusion patterns of nanotechnology in the two clusters with other technologies. Supplementary qualitative data is also provided to show how Chinese scientists perceive their relative advantages in different clusters. Among other things, the findings suggest that scientists of emerging economies favor the learning-by-doing principle while utilizing external networks.

关键词： clusters emerging economies diffusion of innovation technology management China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Trichosanthin can spontaneously penetrate phospholipid monolayer under acid condition

引用

Chinese Science Bulletin 1999年第20期44卷 1892-1895页

作者： ricky N.S.Wong Biological Department Hong Kong Baptist UniversityHong KongChina

Tianhuafen is a kind of traditional Chinese medicine for abortion, which has long been used in China. The basic protein trichosanthin (TCS) is responsible for such activity. As a ribosome inactivating protein (RIP), trichosanthin removes A4304 in the 28s rRNA via the N-glycosidase activity and inactivates the ribosome. However, it remains unclear how TCS

关键词： trichosanthin (TCS) lipid monolayer critical insertion pressure.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spacing optimization of high power LED arrays for solid state lighting

引用

Journal of Semiconductors 2011年第1期32卷 45-49页

作者： Y.Sing Chan S.W.ricky Lee Electronic Packaging Laboratory Center for Advanced Microsystems Packaging Hong Kong University of Science and Technology

This paper provides an analytical approach to determine the optimum pitch by utilizing a thermal resistance network, under the assumption of constant luminous efficiency. This work allows an LED array design which is mounted on a printed circuit board （PCB） attached with a heat sink subject to the natural convection cooling. Being validated by finite element （FE） models, the current approach can be shown as an effective method for the determination of optimal component spacing in an LED array assembly for SSL.

关键词： high power LED thermal resistance network finite element modeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Calculation of terminal velocity in transitional flow for spherical particle

引用

International Journal of Mining Science and Technology 2015年第2期25卷 311-317页

作者： Zhang Lei Honaker ricky Liu Wenli Men Dongpo Chen Jinxiang School of Chemical and Environmental Engineering China University of Mining & Technology Department of Mining Engineering University of Kentucky

The terminal velocity has been widely used in extensive fields, but the complexity of drag coefficient expression leads to the calculation of terminal velocity in transitional flow （1 〈 Re ≤ 1000） with much more difficulty than those in laminar flow （Re ≤ 1） and turbulent flow （Re ≥ 1000）. This paper summarized and compared 24 drag coefficient correlations, and developed an expression for calculating the terminal velocity in transitional flow, and also analyzed the effects of particle density and size, fluid density and viscosity on terminal velocity. The results show that 19 of 24 previously published correlations for drag coefficient have good prediction performance and can be used for calculating the terminal velocity in the entire transitional flow with higher accuracy. Adapting two dimensionless parameters （w＊, d＊）, a proposed explicit correlation, w＊=-25.68654 × exp （-d＊/77.02069）＋ 24.89826, is attained in transitional flow with good performance, which is helpful in calculating the terminal velocity.

关键词： Transitional flow Drag coefficient Terminal velocity Spherical particle Calculation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Open science as a better gatekeeper for science and society: a perspective from neurolaw

引用

Science Bulletin 2018年第23期63卷 1529-1531页

作者： Chuan-Peng Hu Xiaoming Jiang ricky Jeffrey Xi-Nian Zuo Deutsches Resilienz Zentrum (DRZ) & Neuroimaging Center (NIC) University Medical Center of the Johannes Gutenberg University Department of Psychology Tongji University Language Center International Campus Zhejiang University CAS Key Laboratory of Behavioral Science Institute of Psychology the Chinese Academy of Sciences

In 2011,a court near Milan,Italy,reduced the sentence of a convicted murderer from life to 20years in jail,after considering results from neuroimaging and genetic *** tests had been used to convince the judge that the trial's female defendant,Stefania Albertani,was suffering from partial mental illness (http:// ***/news/2011/09]italian_court_reduces_murde_s. html).The structural MRI images showed that Albertani's grey matter volume was different from the average volume of a randomly-selected group -10healthy women with no history of mental or neurological disorders -in brain areas including the anterior cingulate gyrus (ACC)and *** expert testimony concluded that "these alterations (of brain structures)have to be considered in causal relation to the psychiatric symptomatology of the murderer."

关键词： Open science society neuroimaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contents of four active components in different commercial crude drugs and preparations of Danshen (Salvia miltiorrhiza)

引用

Acta Pharmacologica Sinica 2002年第12期23卷 110-115页

作者： Susan Wai Sum LEUNG,Yaw Loong SIOW,ricky Ying Keung MAN Department of Pharmacology Faculty of Medicine University of Hong Kong 21 Sassoon Road Hong Kong China Department of Pharmacology Faculty of Medicine University of Hong Kong 21 Sassoon Road Hong Kong China Department of Pharmacology Faculty of Medicine University of Hong Kong 21 Sassoon Road Hong Kong China Department of Pharmacology University of Hong Kong 21 Sassoon Road Hong Kong China

AIM: To detect the contents of four active components of Salvia miltiorrhiza in various commercially available danshen crude drugs and preparations. METHODS: Commercially available danshen crude drugs from different sources, as well as danshen pills and intravenous injection preparations containing danshen alone or in combination with other herbs were collected. The composition of these danshen samples was analyzed using HPLC. Specifically, the amounts of magnesium tanshinoate B (MTB), danshensu, isotanshinone IIA, and ctyptotanshinone were determined. In some of these samples, the content of MTB was further confirmed by liquid chromatography-tandem mass spectrometer (LC-MS)/MS method. RESULTS: There were great variations in the amount of the four active ingredients in the commercially available danshen crude drugs and drug preparations in this study. The amount of MTB was the highest among the four components measured in the crude drugs. However, the amounts of MTB in all danshen preparations were much

关键词： Salvia miltiorrhiza magnesium tanshinoate B (MTB) high pressure liquid chromatography

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：