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Science China Life Sciences 2024年

作者： Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shuzhen Huang richard H.Finnell Fanyi Zeng Shanghai Institute of Medical Genetics Shanghai Children's Hospital Shanghai Jiao Tong University School of Medicine Department of Histo-Embryology Genetics and Developmental Biology Shanghai Jiao Tong University School of Medicine NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction Engineering Center for Precision Environmental Health Baylor College of Medicine School of Pharmacy Macau University of Science and Technology

Autosomal recessive spinocerebellar ataxias（SCARs） are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation（c.1A>G, p.M1V） in the AFG3L2 start codon. The proband's genotype included heterozygous mutations of the compound AFG3L2(p.[M1V]; [R632X]（c.[1A>G];[1894.C>T]）), which were inherited from the father（c.1A>G, p.M1V） and mother（c.1894C>T, p.R632X）. Functional studies performed on hiPSCs（human induced pluripotent stem cells） generated from the patients and HEK293T cells showed that the mutations impair mitochondrial function and the unbalanced expression of AFG3L2 mRNA and protein levels. Furthermore, this novel mutation resulted in the degradation of the protein and the reduction of the stability of the AFG3L2 protein, and MCU（mitochondrial calcium uniporter） complex mediated Ca2+overload.

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Fetal MRI Artifacts: Semi-Supervised Generative Adversarial Neural Network for Motion Artifacts Reducing in Fetal Magnetic Resonance Images

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Journal of Computer and Communications 2024年第6期12卷 210-225页

作者： Ítalo Messias Félix Santos Gilson Antonio Giraldi Heron Werner Junior Bruno richard Schulze National Laboratory for Scientific Computing Rio de Janeiro Brazil Biodesign Laboratory Dasa/PUC-Rio Rio de Janeiro Brazil

This study addresses challenges in fetal magnetic resonance imaging (MRI) related to motion artifacts, maternal respiration, and hardware limitations. To enhance MRI quality, we employ deep learning techniques, specifically utilizing Cycle GAN. Synthetic pairs of images, simulating artifacts in fetal MRI, are generated to train the model. Our primary contribution is the use of Cycle GAN for fetal MRI restoration, augmented by artificially corrupted data. We compare three approaches (supervised Cycle GAN, Pix2Pix, and Mobile Unet) for artifact removal. Experimental results demonstrate that the proposed supervised Cycle GAN effectively removes artifacts while preserving image details, as validated through Structural Similarity Index Measure (SSIM) and normalized Mean Absolute Error (MAE). The method proves comparable to alternatives but avoids the generation of spurious regions, which is crucial for medical accuracy.

关键词： Fetal MRI Artifacts Removal Deep Learning Image Processing Generative Adversarial Networks

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感恩记录

疯狂英语（初中天地） 2024年第1期 21-24页

作者： richard Edwards 不详

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享... 详细信息

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享受生命的美好,发现感恩的力量。

关键词：感恩享受生命用心记录

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文化、道德、行为等与会计行业相关的事项

新理财（公司理财） 2024年第1期 76-78页

作者： richard Crump 不详

当我们作出正确决策时,要从各个角度去考虑,并非所有事情都像合规处理一样有明确的界限。道德分析,金融道德学副教授、Tezos基金会首席财务官和瑞银集团首席运营官埃尔科·菲奥莱(Ecelco Fiole)认为,金融从业人员面临的一个问题是,他们... 详细信息

当我们作出正确决策时,要从各个角度去考虑,并非所有事情都像合规处理一样有明确的界限。道德分析,金融道德学副教授、Tezos基金会首席财务官和瑞银集团首席运营官埃尔科·菲奥莱(Ecelco Fiole)认为,金融从业人员面临的一个问题是,他们接受的道德决策培训非常有限,面对道德困境时,只能运用个人的道德观念来进行评判,不能客观、公平地分析与判断。

关键词：金融从业人员会计行业道德决策道德分析道德困境道德观念首席运营官正确决策

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Function and Application Progress of Probiotics in Food

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Agricultural Biotechnology 2024年第4期13卷 63-64,69页

作者： Junpeng ZHAO richard Avoi Azman Bin Atil@Azmi Jiao CHEN Ling YUN Tangshan Food and Drug Comprehensive Inspection and Testing Center Tangshan 063000China Hebei Agricultural Products Quality and Safety Testing Technology Innovation Center Tangshan 063000China Tangshan Institute of Industrial Technology for Functional Agricultural Products Tangshan 063000China Universiti Malaysia Sabah Faculty of Medicine and Health SciencesMalaysia Guizhou Forerunner College Guiyang 550000China Tangshan Center for Disease Prevention and Control Tangshan 063000China

Probiotics have a long history of use in human production and *** the gradual deepening of the research on the functions of probiotics,their various nutritional and health benefits for the human body have also become increasingly *** research shows that probiotics can regulate intestinal flora,and improve immunity and even the symptoms of some ***,in the food industry,the application of probiotics from traditional fermented foods to functional foods has become more and more *** this paper,the research progress of nutritional function and application of probiotics in food at home and abroad was reviewed,in order to provide some reference for the safe application of probiotics in food.

关键词： Probiotics Physiological function Food Development and application

Determination of 14 Organophosphorus Pesticide Residues in Mutton by Gel Permeation Chromatography-Gas Chromatography-Mass Spectrometry(GPC-GC-MS)

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Agricultural Biotechnology 2024年第3期13卷 28-30,33页

[Objectives]This study was conducted to purify mutton samples by gel permeation chromatography(GPC).[Methods]Fourteen organophosphorus pesticide residues in samples were qualitatively and quantitatively analyzed by gas chromatography-mass spectrometry(GC-MS)in selective ion scanning mode(SIM).[Results]The organophosphorus pesticide standard solutions showed good linearity in the mass concentration range of 0.1-10.0μg/ml with correlation coefficients(r)not lower than 0.999,and the detection limits(S=3 N)ranged from 0.01 to 0.05 mg/*** average recovery values were in the range of 80.2%-99.7%,with relative standard deviations(RSDs,n=3)in the range of 1.8%-6.3%,at the addition levels of 0.5,1.0 and 2.0 mg/kg.[Conclusions]The method is simple,sensitive and accurate,and can be used for the determination of organophosphorus pesticide residues in mutton.

关键词： Mutton Gas chromatography-mass spectrometry Gel permeation chromatography Organophosphorus Pesticide residue

Evaluation of the Reproduction Parameters of “Lohmann Brown” Strain Chickens Fed with Cajanus cajan Leaf Meal in the Republic of Congo

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Open Journal of Animal Sciences 2024年第3期14卷 234-248页

作者： richard Missoko Mabeki Alexis Jonas Ognika Dora Chérita Ekou Nathalie Myreille Ockoyi Parisse Akouango Laboratory of Animal Production and Biodiversity National School of Agronomy and Forestry Marien Ngouabi University Brazzaville Republic of the Congo Department of Animal Production and Health Marien Ngouabi University Brazzaville Republic of the Congo

The objective of this study was to evaluate the reproductive parameters of “Lohmann Brown” strain chickens fed on Cajanus cajan leaves and to assess the viability of the chicks after hatching. 40 hens of the “Lohmann Brown” strain fed on Cajanus cajan leaf flour laid 219 eggs divided into four batches depending on the rate of incorporation of Cajanus cajan leaf flour in the rations (0%, 5%, 10% and 15%) were trained and introduced into the incubator. Results: the incubator indicates a hatching temperature of 38˚C to 37.2˚C and relative humidity of 60% to 70%. Hatching performance shows that: The 15% batch recorded the highest fertility rate 86.95% compared to 26.88% of the control batch. The CC 15% batch recorded the highest hatching rate 36.87. The lowest rate (17.18%) was recorded in the control batch (CC 0%). The highest embryonic mortality rate was recorded in the CC 15% batch. The lowest rate in the CC 10% batch. Concerning unfertilized eggs, the highest rate is 72.20% (CC 0%), and the lowest are (12.03%;57.42% and 66.66%) recorded in CC batches. 15%, CC 5% and CC 10% respectively. For the shell mortality rate, the highest is 18.58% recorded in the CC 15% batch. The lowest shell mortality rate is 2.07%, obtained in the control batch (CC 0%);the dust mortality rate was 0% for all chicks. The study seems to indicate that the incorporation of Cajanus cajan leaf meal up to 15% into the reproduction type ration in hens does not cause any harmful effects on the reproduction performance of laying hens.

关键词： Egg Incubation Hatching Fertility Mortality Viability

Clay Materials for Ceramics Application from N’Djamena in the Chad Republic: Mineralogical, Physicochemical and Microstructural Characterization

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Journal of Materials Science and Chemical Engineering 2024年第2期12卷 31-48页

作者： Ndjolba Madjihingam Djoda Pagore Jacques richard Mache Bebbata Warabi Bertin Pagna Kagonbe Patrick Mountapmbeme Kouotou Department of Civil Engineering National Advanced School of Engineering University of Maroua Maroua Cameroon Department of Mining Engineering School of Geology and Mining Engineering University of Ngaoundere Meiganga Cameroon Local Materials Authority Promotion (MIPROMALO) Yaoundé Cameroon Department of Environmental Sciences Advanced School of Agriculture Forestry Water and Environment University of Ebolowa Ebolowa Cameroon

Herein, we report some characteristics of the clayey materials (CMs) collected from Kaliwa (C1), Kabé (C2) and Malo (C3) district in N’Djamena (Chad). Three samples were characterized applying XRF, XRD, FTIR, SEM. In addition, TGA/DSC were performed to control decomposition/mass loss and show phase transitions respectively of CMs. Geochemical analysis by XRF reveals the following minerals composition: SiO2 (~57% - 66%), Al2O3 (~13% - 15%), Fe2O3 (~6% - 10%), TiO2 (~1% - 2%) were the predominant oxides with a reduced proportion in C1, and (~7%) of fluxing agents (K2O, CaO, Na2O). Negligible and trace of MgO (~1%) and P2O5 was noted. The mineralogical composition by XRD shows that, C1, C2 and C3 display close mineralogy with: Quartz (~50%), feldspar (~20%) as non-clay minerals, whereas clays minerals were mostly kaolinite (~15%), illite (~5%) and smectite (~10%). FTIR analysis exhibits almost seemingly similar absorption bands characteristic of hydroxyls elongation, OH valence vibration of Kaolinite and stretching vibration of some Metal-Oxygen bond. SEM micrographs of the samples exhibit microstructureformed by inter-aggregates particles with porous cavities. TGA/DSCconfirm the existence of quartz (570˚C to 870˚C), carbonates (600˚C - 760˚C), kaolinite (569˚C - 988˚C), illite (566˚C - 966˚C), MgO (410˚C - 720˚C) and smectite (650˚C - 900˚C). The overall characterization indicates that, these clayey soils exhibit good properties for ceramic application.

关键词： Clay Soils Characterization Mineralogy Physicochemical Properties Ceramic Application

Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.Lynch Alan G.Palestine Nathan C.Grove Karen L.Christopher richard S.Davidson Michael J.Taravella Naresh Mandava Jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To investigate sex-based differences in the occurrence of intra-operative and post-operative complications and associated visual outcomes following cataract ***:This was a retrospective study of patients who had phacoemulsification cataract surgery at the University of Colorado School of *** collected included the patient’s health history,ocular comorbidities,operative and post-operative complications,and the post-operative best corrected visual acuity(BCVA).The data were analyzed using univariate and multivariable logistic regression with generalized estimating equations to account for the correlation of some patients having two eyes included in the ***:A total of 11977 eyes from 7253 patients were included in the *** comorbidities differed by sex,with males having significantly higher percentages of traumatic cataracts(males 0.7%vs females 0.1%),prior ocular surgery(6.7%vs 5.5%),and mature cataracts(2.8%vs 1.9%).Conversely,females had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,males had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustment for *** had a significantly increased risk of post-operative retinal detachment,but in multivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)laser capsulotomy for posterior capsule opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was slightly worse for males pre-operatively;but post-operatively,both sexes exhibited similar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative comorbidities and surgical characteristics that contribute to higher rates of some complications for ***,observed surgical complicatio

关键词： cataract surgery sex-based disparity phacoemulsification outcomes

糙毛苎麻，来自中国西南的一个新变种（英文）

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广西植物 2024年第09期 1617-1624页

作者：赵颖 richard I.MILNE 李志鹏 Amos KIPKOECH 吴增源中国科学院昆明植物研究所中国西南野生生物种质资源库云南大学生命科学学院英国爱丁堡大学生物科学学院/分子植物科学研究所中国科学院东亚植物多样性与生物地理学重点实验室中国科学院大学

糙毛苎麻(Boehmeria nivea *** Zeng Y. Wu&Y. Zhao)是一个苎麻新变种，原产于中国西南地区。该文主要基于形态学和分子系统学证据对其进行了描述。该变种的主要特征包括叶片背面绿色、托叶部分合生以及茎和叶柄上浓密的糙毛。基于rbcL... 详细信息

糙毛苎麻(Boehmeria nivea *** Zeng Y. Wu&Y. Zhao)是一个苎麻新变种，原产于中国西南地区。该文主要基于形态学和分子系统学证据对其进行了描述。该变种的主要特征包括叶片背面绿色、托叶部分合生以及茎和叶柄上浓密的糙毛。基于rbcL、nrDNA和rbcL+nrDNA 3个数据集构建的系统发育关系结果均表明strigosa糙毛苎麻的所有个体形成一个单系分支。根据IUCN的评估标准，糙毛苎麻被评估为“近危”(NT)。该新变种的发现对苎麻的分类至关重要，并且为苎麻资源的开发和利用提供了科学依据。

关键词：苎麻形态分子系统学新变种中国西南云南