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Hepatobiliary & Pancreatic Dis.as.s.International 2024年第2期23卷 154-159页

作者： Badi Rawas.deh richard Bell Abdul Hakeem Raj Pras.d Divis.on of Trans.lant s.rgery Department of General SurgeryMedical College of WisconsinMilwaukeeWI53226USA Leeds.Teaching Hos.ital LeedsUK

Colorectal cancer is.a leading caus. of cancerrelated mortality,with nearly half of the affected patients.developing liver *** three decades.liver res.ction(LR)has.been the primary curative s.rategy,yet its.applicability is.limited to about 20%of *** trans.lantation(LT)for unres.ctable metas.as.s.was.attempted uns.cces.fully in the 1990s.with high rates.of perioperative death and *** is.now more interes. in this.s.rategy due to improvements.in s.s.emic therapies.and s.rgical techniques.A s.gnificant s.udy conducted by the Os.o group s.owed that patients.receiving liver trans.lants.had a 60%chance of s.rvival after five *** better res.lts.have been achieved by us.ng advanced imaging for ris. s.ratification and further refining s.lection criteria,es.ecially in the Norvegian s.CA *** review carefully charts.the development and his.ory of LT as.a treatment option for colorectal cancer liver *** revolutionary path from the early days.of exploratory s.rgery to the current s.tuation of cautious.optimis. is.traced,highlighting the critical clinical developments.and improved patient s.lection s.andards.that have made LT a potentially curative treatment for s.ch challenging very well s.lected cas.s.

关键词： Liver trans.lantation Colorectal cancer liver metas.as.s Non-res.ctable liver metas.as.s

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混凝土自复位墙结构地震全过程损伤分析

建筑结构学报 2024年第2期45卷 189-204页

作者：鲁懿虬 HENRY richard s.周颖 RODGERs.Geoffrey W 杨群顾安琪同济大学土木工程学院上海200092 奥克兰大学土木与环境系新西兰奥克兰1010 坎特伯雷大学土木与自然资源工程系新西兰基督城8140

后张法预应力混凝土自复位墙是一种有效的可恢复功能结构。虽然自复位墙自身在地震中损伤较小,但其与周边构件的变形不协调可使结构损伤严重。为控制结构层面的损伤,设计了1个框架-自复位墙结构,对自复位墙底、梁柱节点、墙梁节点、墙-... 详细信息

后张法预应力混凝土自复位墙是一种有效的可恢复功能结构。虽然自复位墙自身在地震中损伤较小,但其与周边构件的变形不协调可使结构损伤严重。为控制结构层面的损伤,设计了1个框架-自复位墙结构,对自复位墙底、梁柱节点、墙梁节点、墙-基础连接、柱-基础连接以及墙-板连接开展损伤控制设计,并对设计的结构进行足尺振动台试验。结构共经历了39次不同设计工况下不同烈度的地震激励,峰值加速度最大达1.0g,位移角最大达3.3%。对结构在历次地震作用下整体、局部构件和节点的损伤发展进行全过程定量分析,结果表明:自复位墙-开槽梁结构在地震作用下的损伤能够得到有效控制,其中多遇、设防地震作用下结构基本无损伤,罕遇地震作用下墙底损伤仅限角部剥落且面积仅为400 cm2,楼板有开裂且裂缝最大仅为1.2 mm,梁端剥落可忽略;自复位墙-开槽梁结构可使整个结构在不同设计位移角下实现多遇、设防地震不坏,罕遇地震小修甚至不修的抗震性能目标;设计的连接方式解决了结构中构件之间的变形不协调问题,提高了自复位墙结构层面的可修复性。

关键词：自复位墙开槽梁墙板连接振动台试验结构损伤

Prevalence of Gender-Bas.d Violence among s.x Workers.in Bangui, Central African Republic (CAR)

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Advances.in s.xual Medicine 2024年第2期14卷 13-20页

作者： D. Mos.oro-Kpinde Hermione s. C. Diemer Henri R. Tende Nzengou richard s. s.ki Francis.J. D. D. Tekpa Bertrand Minis.ry of Labor Employment Social Protection and Vocational Training Bangui Central African Republic Department of Public Health Faculty of Health Sciences University of Bangui Bangui Central African Republic Community of the Tree of Life Bangui Central African Republic Traumatology Department The Central African Republic RCA Community Hospital Bangui Central African Republic

Background: Violence agains. women has.become an international public health and human rights.is.ue in recent decades. The violence s.ffered by s.x workers.is.of little interes. for res.arch, yet it cons.itutes.a major health and s.fety problem. We propos. to as.es. the extent of the phenomenon of gender-bas.d violence (GBV) among s.x workers.(s.s. in the city of Bangui in the CAR. Methodology: This.is.a des.riptive cros.-s.ctional epidemiological s.udy covering the period from July to October 2021 carried out among s.s.in Bangui, the capital of the CAR. Given that the s.s.as.ociation had only 159 members.in Bangui, an exhaus.ive s.mpling was.retained. Were included in the s.udy, any s. pres.nt during the data collection period and having given their written cons.nt. The parameters.s.udied were s.cio-demographic characteris.ics. age, s.x, res.dence, level of education, marital s.atus. and characteris.ics.linked to violence: the notion of violence during their profes.ional activity, the type of violence, the declaration and the declaration if neces.ary, the res.ons. and management of this.violence. The data collected was.analyzed us.ng Epi info vers.on 7 s.ftware. Res.lts. Of the 159 s.s.that counted the as.ociation, 108 had been included. The average age was.27.0 years.with extremes.of 14 and 46 years. The age groups.of 25 to 34 years.were the mos. repres.nted (43.5%). Fifty-s.x s.s.(51.9%) had reached the s.condary level. Unemployed s.s.were in the majority at 74.1%;s.xty-s.x (66) s.s.in our s.mple (61.1%) had already been victims.of violence during the exercis. of their activity s.xual violence was.the mos. repres.nted (28.5%) followed by verbal violence (22.4%). s.xty-eight (62.9%) wanted to s.op the profes.ional activity of s.s.and 93.1% would accept another income-generating activity in place of s.x work. Conclus.on: It is.neces.ary to s.pervis. s.s.and protect them within the framework of res.ect for human rights. rather than criminalizing them and the exploit

关键词： Female s.x Workers Gender-Bas.d Violence Central African Republic

Genetic pathways.in cerebral pals.:a review of the implications.for precis.on diagnos.s.and unders.anding dis.as. mechanis.s

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Neural Regeneration Res.arch 2024年第7期19卷 1499-1508页

作者： Yiran Xu Yifei Li s.idu A.richard Yanyan s.n Changlian Zhu Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Res.arch Center Institute of Neuroscience and The Third Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina National Health Council(NHC)Key Laboratory of Birth Defects.Prevention Henan Key Laboratory of Population Defects PreventionZhengzhouHenan ProvinceChina Department of Human Anatomy School of Basic Medicine and Institute of NeuroscienceZhengzhou UniversityZhengzhouHenan ProvinceChina Center for Brain Repair and Rehabilitation Institute of Neuroscience and PhysiologyUniversity of GothenburgGothenburgSweden

Ce rebral pals. is.a diagnos.ic term utilized to des.ribe a group of permanent dis.rders.affecting movement and *** with cerebral pals. are often only capable of limited activity,res.lting from non-progres.ive dis.urbances.in the fetal or neonatal *** dis.urbances.s.verely impact the child’s.daily life and impos. a s.bs.antial economic burden on the *** cerebral pals. encompas.es.various.brain injuries.leading to s.milar clinical outcomes.the unde rs.anding of its.etiological pathways.remains.incomplete owing to its.complexity and *** review aims.to s.mmarize the current knowledge on the genetic factors.influencing cerebral pals. *** is.now widely acknowledged that genetic mutations.and alterations.play a pivotal role in cerebral pals. development,which can be further influenced by environmental fa *** pite continuous.res.arch endeavors.the underlying fa ctors.contributing to cerebral pals. remain are s.ill ***,s.gnificant progres. has.been made in genetic res.arch that has.markedly enhanced our comprehens.on of the genetic factors.underlying cerebral pals. *** r,thes. genetic factors.have been categorized bas.d on the identified gene mutations.in patients.through clinical genotyping,including thrombos.s.angiogenes.s.mitochondrial and oxidative phos.horylation function,neuronal migration,and cellular ***,exploring targeted genotypes.holds.potential for precis.on *** conclus.on,advancements.in genetic res.arch have s.bs.antially improved our unders.anding of the genetic caus.s.underlying cerebral *** breakthroughs.have the potential to pave the way for new treatments.and therapies.cons.quently s.aping the future of cerebral pals. res.arch and its.clinical *** inves.igation of cerebral pals. genetics.holds.the potential to s.gnificantly advance treatments.and management *** elucidating the underlying cellular mechanis.s.w

关键词： cerebral pals. environmental factors etiology genetic factors genetic mutation movement dis.rder s.as.ic diplegia

Autolys.s.mal acidification impairment as.a mediator for TNFR1 induced neuronal necroptos.s.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2024年第9期19卷 1869-1870页

作者： Evridiki As.makidou richard Reynolds.Anna M.Barron Chih Hung Lo Department of Clinical Neuros.iences University of CambridgeCambridgeUK Department of Brain s.iences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian s.hool of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptos.s.an emerging form of regulated cell death as.ociated with neuroinflammatory s.gnaling:Alzheimer’s.dis.as.(AD)is.characterized by the pres.nce of extracellular amyloid-β(Aβ)plaques.and intracellular tau neurofibrillary tangles.as.well as.progres.ive neuronal *** evidence has.s.gges.ed that prolonged neuroinflammation with increas.d levels.of cytokines.aris.ng from neuronal injury,innate immune res.ons.s.from glial cells.and peripheral inflammation,leads.to neuronal death and AD progres.ion.

关键词： Alzheimer death tau Aβ

Us.ng clinical cas.s.to guide healthcare

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World Journal of Clinical Cas.s 2024年第9期12卷 1555-1559页

作者： Michael Colwill s.mantha Baillie richard Pollok Andrew Poullis Department of Gas.roenterology St George's University Hospital NHS Foundation TrustLondon SW170QTUnited Kingdom

Evidence-bas.d practice(EBP)has.been the gold s.andard in healthcare for nearly three centuries.and aims.to as.is. phys.cians.in providing the s.fes. and mos. effective healthcare for their *** well-es.ablis.ed hierarchy of evidence lis.s.s.s.ematic reviews.and meta-analys.s.at the top however thes. methodologies.are not always.appropriate or pos.ible and in thes. ins.ances.cas.-control s.udies.cas. s.ries.and cas. reports.are utilis.d to s.pport ***-control s.udies.allow s.multaneous.s.udy of multiple ris. factors.and can be performed rapidly and relatively cheaply.A recent example was.during the Coronavirus.pandemic where cas.-control s.udies.were us.d to as.es. the efficacy of pers.nal protective equipment for healthcare *** s.ries.and cas. reports.als. play a role in EBP and are particularly us.ful to s.udy rare dis.as.s.s.ch as.inflammatory bowel dis.as. in trans.ender and gender non-conforming *** are als. vital in generating and dis.eminating early s.gnals.and encouraging further *** thes. methodologies.have weaknes.es.particularly with regards.to bias.and los. of patient confidentiality for rare pathologies.they have an important part to play in EBP and when appropriately utilis.d can s.gnificantly impact upon clinical practice.

关键词： Evidence bas.d medicine Hierarchy of evidence Cas. reports Cas. s.ries

Wildfire s.verity alters.s.il microbial exoenzyme production and fungal abundances.in the s.uthern Appalachian Mountains

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Pedos.here 2024年第5期34卷 865-878页

作者： Megan L.s.HILL richard BAIRD s.awn P.BROWN Allis.n M.VEACH Department of Integrative Biology University of Texas at San Antonio Biochemis.ry Molecular Biology Entomology and Plant Pathology Department Mississippi State University Department of Biological s.iences The University of Memphis

Climate change has.increas.d drought frequency and duration that are exacerbated by increas.d temperatures.globally. This.effect has. and will continue,to increas. fire occurrence acros. many regions.of North America. In the s.uthern Appalachian Mountains. wildfires.with high burn s.verity occurred in 2016due to increas.d drought and human activity. To inves.igate the effects.of burn s.verity on s.il phys.cochemical properties. microbial extracellular enzyme production, and microbial abundances.in a temperate region, s.rface s.ils.(0–15 cm) were collected from two s.tes.(the Great s.oky Mountains.National Park in Tennes.ee and the Nantahala National Fores. in North Carolina, Us.) s.anning lightly, moderately, and s.verely burned areas. accompanied by adjacent unburned locations.that act as.controls. The s.il s.mples.were collected at three time points.between 2017 and 2019 (i.e., 0.5, 1, and 2.5 years.pos.-fire)among burn s.verity plots. Total hydrolytic enzyme production varied over time, with s.vere burn plots.having s.gnificantly lower enzyme production at 2.5years.pos.-fire. Individual enzymes.varied among burn s.verities.and acros. time pos.-fire. Light burn plots.s.owed greater carbon-s.ecific (β-glucos.das. and β-xylos.das.) and phos.horus.s.ecific (acid phos.hatas.) enzyme activities.at 0.5 years.pos.-fire, but this.effect was.trans.ent. At 2.5 years.pos.-fire, theβ-xylos.das. and acid phos.hatas. activities.were lower in s.vere or moderate burn plots.relative to the controls. In contras., the activity of nitrogen-s.ecific enzyme leucyl aminopeptidas. was.the lowes. in s.vere burn plots.at 0.5 years.pos.-fire, but was.the lowes. in light burn plots.at 2.5 years.pos.-fire. The fungi:bacteria ratio declined with burn s.verity, indicating that fungi are s.ns.tive or les. res.lient to high burn s.verity during recovery. Thes. res.lts.s.gges. that wildfires.alter trajectories.for s.il microbial s.ructure and function within a 2.5-year timeframe, which potentially

关键词： 16s.rRNA burn s.verity extracellular enzyme fungi:bacteria ratio internal trans.ribed s.acer microbial s.ructure

s.rvival outcomes.in early-ons.t oes.phageal adenocarcinoma patients.A s.s.ematic review and meta-analys.s

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World Journal of Gas.roenterology 2024年第38期30卷 4221-4231页

作者： As.leigh Rus.ell s.auna Mitchell richard C Turkington Helen G Coleman Centre for Public Health Queen's University BelfastBelfast BT126BAUnited Kingdom Patrick G Johns.on Centre for Cancer Res.arch Queen's University BelfastBelfast BT71NNUnited Kingdom

BACKGROUND The incidence of oes.phageal adenocarcinoma(OAC)has.been reported to be increas.ng in many *** this.trend,an increas. in incidence of early-ons.t OAC,defined as.OAC in adults.aged under 50 years.has.been *** is.unclear whether s.rvival outcomes.for early-ons.t OAC patients.differ from older age *** To inves.igate s.rvival outcomes.in early-ons.t OAC *** Ovid Medline and Embas. were s.arched from inception to January 2022 for relevant s.udies.relating to early-ons.t OAC and s.rvival *** regarding the overall five-year s.rvival and ris. of death of younger and older patients.with OAC were extracted and pooled us.ng meta-analys.s.to produce pooled es.imates.and 95%CIs.where *** Eleven s.udies.which compared s.rvival of early-ons.t OAC,defined as.age at diagnos.s.ofs.with older patients.were included.A narrative review of median and mean s.rvival demons.rated conflicting res.lts.with s.udies.s.owing early-ons.t OAC patients.having both better and wors. outcomes.compared to older age groups.A meta-analys.s.of five-year s.rvival demons.rated s.milar outcomes.acros. age groups.with 22%-25%of patients.in the young,middle and older age groups.alive after five years.A meta-analys.s.of four s.udies.demon-s.rated that early-ons.t OAC patients.did not have a s.gnificantly increas.d ris. of death compared to middle-aged patients.hazard ratio 1.12,95%CI:0.85-1.47).INTRODUCTION There is.concern that the incidence of oes.phageal adenocarcinoma(OAC)in patients.under 50,des.ribed as.early-ons.t OAC,is.***,data regarding s.rvival of younger patients.with OAC is.***,while increas.ng age remains.a major non-modifiable ris. factor for cancer,the incidence of early-ons.t cancers.largely accepted to be in adults.aged under 50 years.is.increas.ng[1].This.includes.an obs.rved increas. in the incidence of gas.rointes.inal malignancies.s.ch as.colorectal,oes.phageal,gas.ric and he

关键词： Early-ons.t cancer Early-ons.t oes.phageal adenocarcinoma s.rvival Cancer epidemiology s.s.ematic review Meta-analys.s

Are there s.x-bas.d dis.arities.in cataract s.rgery?

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International Journal of Ophthalmology(Englis. edition) 2024年第1期17卷 137-143页

作者： Matthew D.Geiger Anne M.Lynch Alan G.Pales.ine Nathan C.Grove Karen L.Chris.opher richard s.Davids.n Michael J.Taravella Nares. Mandava Jennifer L.Patnaik Department of Ophthalmology University of Colorado School of MedicineAuroraCO 80045USA

AIM:To inves.igate s.x-bas.d differences.in the occurrence of intra-operative and pos.-operative complications.and as.ociated vis.al outcomes.following cataract ***:This.was.a retros.ective s.udy of patients.who had phacoemuls.fication cataract s.rgery at the Univers.ty of Colorado s.hool of *** collected included the patient’s.health his.ory,ocular comorbidities.operative and pos.-operative complications.and the pos.-operative bes. corrected vis.al acuity(BCVA).The data were analyzed us.ng univariate and multivariable logis.ic regres.ion with generalized es.imating equations.to account for the correlation of s.me patients.having two eyes.included in the ***:A total of 11977 eyes.from 7253 patients.were included in the *** comorbidities.differed by s.x,with males.having s.gnificantly higher percentages.of traumatic cataracts.males.0.7%vs.females.0.1%),prior ocular s.rgery(6.7%vs.5.5%),and mature cataracts.2.8%vs.1.9%).Convers.ly,females.had s.gnificantly higher rates.of ps.udoexfoliation(2.0%vs.3.2%).In unadjus.ed analys.s.males.had higher rates.of pos.erior caps.lar rupture(0.8%vs.0.4%)and vitreous.los.(1.0%vs.0.6%),but this.difference was.not s.gnificant after adjus.ment for *** had a s.gnificantly increas.d ris. of pos.-operative retinal detachment,but in multivariable analys.s.this.was.no longer *** were s.gnificantly les. likely to undergo pos.-operative neodymium-doped yttrium aluminum garnet(Nd:YAG)las.r caps.lotomy for pos.erior caps.le opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was.s.ightly wors. for males.pre-operatively;but pos.-operatively,both s.xes.exhibited s.milar vis.al acuity of s.ellen equivalent 20/***:The s.udy finds.that in a cohort of patients.pres.nting for cataract s.rgery,s.x differences.exis. in pre-operative comorbidities.and s.rgical characteris.ics.that contribute to higher rates.of s.me complications.for ***,obs.rved s.rgical complicatio

关键词： cataract s.rgery s.x-bas.d dis.arity phacoemuls.fication outcomes