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Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type Ⅱ as prognostic factors for colorectal cancer： results of a 10-year prospective study using tissue microarray analysis

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Chinese Medical Journal 2011年第4期124卷 483-490页

作者： ZHAO Dong-bing Ian Chandler CHEN Zheng-ming PAN Hong-chao sanjay Popat sHAO Yong-fu richard s houlston Department of Abdominal surgical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Cellular Pathology St George's Hospital LondonSW170QT UK section of Cancer Genetics Institute of Cancer Research SuttonSM2 5NG UK Clinical Trial service Unit Richard Doll Building Old Road CampusRoosevelt Drive Oxford OX3 7LF UK section of Cancer Genetics Institute of Cancer Research SuttonSM2 5NG UK Department of Abdominal surgical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Background The expression of genes encoding a number of pathogenetic pathways involved in colorectal cancer could potentially act as prognostic markers. Large prospective studies are required to establish their relevance to disease *** We investigated the relevance of 19 markers in 790 patients enrolled in a large randomised trial of 5-fluorouracil using immunohistochemistry and chromogenic in situ hybridisation. The relationship between overall 10-year survival and marker status was *** Minichromosome maintenance complex component 2 （MCM2） and cyclin A were significantly associated with overall survival. Elevated MCM2 expression was associated with a better prognosis （HR=0.63, 95%CI： 0.46-0.86）.Cyclin A expression above the median predicted an improved patient prognosis （HR=0.71, 95%CI： 0.53-0.95）. For mismatch repair deficiency and transforming growth factor β receptor type Ⅱ （TGFBRII） overexpression there was a borderline association with a poorer prognosis （HR=0.69, 95%C/： 0.46-1.04 and HR=2.11, 95%CI： 1.02-4.40,respectively）. No apparent associations were found for other *** This study identified cell proliferation and cyclin A expression as prognostic indicators of patient outcome in colorectal cancer.

关键词： colorectal cancer tissue microarray immunohistochemistry prognostic markers

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