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Efficacy of Detoxsan~? powder on diarrhea caused by gastrointestinal neuroendocrine tumors

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World Journal of Gastroenterology 2019年第17期25卷 2133-2143页

作者： Thomas Langbein Wilfried Dathe Anika Deuerling richard p.baum Theranostics Center for Molecular Radiotherapy and Molecular Imaging Zentralklinik Bad Berka Scientific Managment Heck Bio-Pharma GmbH

BACKGROUND patients with neuroendocrine tumors(NETs) of the gastrointestinal tract suffer frequently from chronic diarrhea. A well characterized medical advice containing zeolite(Detoxsan~? powder) was applied to patients suffered from therapyrefractory diarrhea either by its frequency or by watery stool, despite receiving standard pharmacotherapy according to the guidelines for carcinoid syndrome and comorbidities. Detoxsan~? powder acts as an adsorbent and might reduce significantly symptoms of diarrhea in patients suffering from *** To overcome the therapy-refractory diarrhea of patients with NETs by the zeolite containing medical advice Detoxsan~? *** A total of 20 patients(12 female and 8 male) suffering from diarrhea either by its frequency or from watery stool caused by NETs were included. In each patient,the diagnosis had been confirmed by histology and somatostatin receptors expression proven by positron emission tomography/computed tomography using Ga-68-labeled somatostatin analogs. All patients received standard-of-care pharmacotherapy and were additionally given Detoxsan~? powder as an extemporaneous drug containing 90% natural Cuban zeolite and 10% magnesium aspartate. Recommended daily dosage ranges between 3 g once to three times per day. Each day dose and bowel movements were documented by the patients themselves in a pre-defined table. Additionally to the bowel movements quantitative determinations of serotonin, urea, creatinine and single ions were performed within the serum of the patients by commercially available equipment used as a matter of routine in the *** All patients enrolled in this pilot study did not only suffer from NETs, but also from comorbidities and treatment-resistant diarrhea. There was insufficient control of diarrhea, most probably due to the secretion of hormones like serotonin produced by the slowly growing and highly differentiated NETs. All patients only took Detoxsan~? powder as an antidiarrhea

关键词： Neuroendocrine tumor Diarrhea Carcinoid syndrome Treatment Clinoptilolite Mordenite Zeolite

Molecular phylogeny of Solms-laubachia(Brassicaceae) s.l.,based on multiple nuclear and plastid DNA sequences,and its biogeographic implications

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Journal of Systematics and Evolution 2009年第5期47卷 402-415页

作者： David A.baum Ihsan A.AL-SHEHBAZ richard REE Department of Botany University of Wisconsin Missouri Botanical Garden PO Box 299St LouisMO 63166-0299USA 3. Department of BotanyThe Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA

The Hengduan Mountains region of south-west China is a noted biodiversity hotspot,but the geographic origins and historical assembly of its rich endemic flora,including the sky-island species of Solms-laubachia Muschl.(Brassicaceae),have been little *** molecular studies on the phylogeny of Solms-laubachia showed it to be paraphyletic,leading to considerable expansion not only of its taxonomic limits,but also its geographic range,with the inclusion of taxa from outside the Hengduan ***,these studies provided little resolution of interspecific relationships,preventing inferences about historical biogeography within the *** the present study,new sequence data from two nuclear genes(LEAFY and G3pdh) and two chloroplast intergenic spacers(petN-psbM and psbM-trnD) were combined with existing markers to increase phylogenetic *** villosum(Maxim.) Al-Shehbaz was found to be nested within Solms-laubachia *** general,phylogenetic relationships appear to be a good predictor of geography,with the Hengduan Mountain endemics embedded in a paraphyletic grade of species from the western Himalayas and central Asia,but they also imply morphological *** was detected between the nuclear and chloroplast gene trees,perhaps resulting from incomplete lineage sorting of ancestral *** crown age of Solms-laubachia *** estimated to be approximately 1.42-3.68 mya,using Bayesian relaxed molecular clock *** biogeographic analysis using a parametric dispersal-extinction-cladogenesis model inferred central Asia and the western Himalayas as most probable ancestral range of Solms-laubachia s.l.,and estimated higher rates of eastward expansion than westward during the diversification of descendant *** summary,our results suggest that Solms-laubachia *** during the pliocene in central Asia,and subsequently migrated eastward into the Hengduan Mountains,colonizing sky-island,alpine scr

关键词： biogeography Brassicaceae Hengduan Mountains phylogeny Solms-laubachia s.l.

Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor

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World Journal of Gastroenterology 2009年第46期15卷 5867-5870页

作者： Daniel Kaemmerer Vikas prasad Wolfgang Daffner Dieter Hrsch Günter Klppel Merten Hommann richard p.baum Department of General and Visceral Surgery Zentralklinik Bad Berka Department of Nuclear Medicine Center for PETZentralklinik Bad Berka Department of Internal Medicine Gastroen-terologyEndocrinology and OncologyZentralklinik Bad Berka Department of pathology University of Kiel

pancreatic endocrine tumors are rare but are among the most common neuroendocrine neoplasms of the *** diagnosis many of them are already advanced and diff icult to *** report on an initially inoperable malignant pancreatic endocrine tumor in a 33-year-old woman,who received neoadjuvant peptide receptor radionuclide therapy(pRRT)as firstline *** resulted in a signif icant downstaging of the tumor and allowed its subsequent complete surgical ***-up for eighteen months revealed a complete *** is the first report on neoadjuvant pRRT in a neuroendocrine neoplasm with subsequent successful complete resection.

关键词： Endocrine pancreatic carcinoma peptidereceptor radionuclide therapy Neodjuvant treatment pancreatic surgery Molecular imaging Receptor pan-creatic endocrine tumor Computed tomography

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Meteor Shower

当代外语研究 2001年第10期 4-9页

作者： richard baum 管抒野

Meteors are particles of space dust that enter the earth’s atmosphere and burnup, creating a streak of light in the night sky. Over 120 recognized meteor showersoccur during the year. Humans have recorded observations of meteor showers for atleast 3000 years. Within the last 50 years astronomers have begun to study meteorshowers with photography, video, radio, and radar equipment. Observations

关键词：地球轨道天文学家观测者粒子流流星雨 Meteor Shower 宇宙尘埃

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Is <sup>18</sup>F-FDG-pET/CT a Valid Non-Invasive predictor for Regression Grade after Neoadjuvant Treatment in patients with NSCLC Stage III?

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Journal of Cancer Therapy 2014年第6期5卷 531-541页

作者： Natalie Desiree Klass richard p. baum Michael Schmuecking Norbert presselt Klaus-Michael Mueller Thomas G. Wendt Reiner Bonnet Department of Nuclear Medicine Zentralklinik Bad Berka Bad Berka Germany Department of pneumology Zentralklinik Bad Berka Bad Berka Germany Department of Radiation Oncology University of Jena Jena Germany Department of Radiation-Oncology Inselspital Bern University Hospital and University of Bern Bern Switzerland Department of Thoracic Surgery Zentralklinik Bad Berka Bad Berka Germany Institute of pathology University of Münster Münster Germany

Introduction: CT alone cannot provide sufficient information referring to response after neoadjuvant therapy in a timely manner. To evaluate the role of 18F-FDG-pET after neoadjuvant chemoradiation as a valid, non-invasive predictor for early therapy response and its effect on survival as compared to histopathologic tumor response, data of 32 of 210 randomized patients with NSCLC stage IIIA/IIIB, who were treated in a?prospective randomized controlled multicenter trial (LUCAS- MD), were re-evaluated. Material and Methods: For 32 patients with NSCLC stage IIIA (44%) IIIB (56%) neoadjuvant treatment consisted of two to three cycles of chemotherapy (225 mg/m2 paclitaxel and carboplatin AUC 6 d1q22) and concomitant chemoradiation (50 mg/m2 paclitaxel and carboplatin AUC 2 d1, d8, d15;1.5 Gy b.i.d. up to 45 Gy). Documentation of involved lymph node stations as detected by 18F-FDG-pET/CT and lymph node sampling during surgery according to the IASLC lymph node mapping (2009). Evaluation of histological regression grade (RG) according to Junker et al. (2001) and correlation with?18F-FDG-pET/CT for primary tumor and each lymph node station. Calculation of disease free survival using Kaplan-Meier estimates and log rank tests. Results: Actuarial tumor specific survival for the 32 patients with concomitant chemoradiation plus?chemotherapy: complete vs. incomplete metabolic remission prior to surgery after 60 months:?40% vs. 24% (p?= 0.018). RG III/IIb (no/less than 10% of vital tumor cells) vs. RG IIa/I (more than 10% vital tumor cells) after 60 months: 46% vs. 15% (p?= 0.006). 18/32 (56%) patients had RG III/IIb, 8/32 (25%) patients had regression grade III. 1/8 pts. with RG III were in the 18F-FDG- pET/CT false positive, 10 pts. with RG IIb (i.e. all pts. with RG IIb) were in the 18F-FDG-pET/CT false negative. One patient with RG IIa was in the 18F-FDG-pET/CT false negative. Hence, the cut-off level in detecting vital tumor cells by 18F-FDG-pET/CT after neoadjuvant chemoradia

关键词： NSCLC 1818F-FDG-pET Neoadjuvant Treatment Non-Invasive predictor

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数据库计算机-向数据公用迈出的一步

计算机科学 1979年第5期 25-30页

作者： richard I.baum David K.Hsiao 张海门

数据库计算机在美国已很热门,在广泛应用数据库的基础上,发现光靠数据库管理系统(软件)已解决不了问题,还得考虑新型硬件,才能真正达到“数据公用”的目的,据说美国尤尼瓦克公司已接受了本文作者的设计,准备正式研制数据库计算机,为使... 详细信息

数据库计算机在美国已很热门,在广泛应用数据库的基础上,发现光靠数据库管理系统(软件)已解决不了问题,还得考虑新型硬件,才能真正达到“数据公用”的目的,据说美国尤尼瓦克公司已接受了本文作者的设计,准备正式研制数据库计算机,为使读者了解数据库系统今后可能的一个发展趋势,引起国内重视,因而译出这篇介绍性的文章.它综述了数据库计算机早期活动,讨论了现状,并试图对将来数据库计算机体系结构的研究提出一些指导意见.

关键词：数据库计算机名字硬件第五代计算机联想存储器按内容寻址存储器映象存储器系统数据库系统数据模型寻址机构询问语言环带结构器件技术数据完整