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Comparison of visual acuity outcomes between ranibizumab and bevacizumab treatment in neovascular age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 85-88页

作者： Ian J Constable Ian l McAllister Timothy Isaacs lions Eye Institute Centre for Ophthalmology and Visual ScienceUniversity of Western AustraliaPerthWestern AustraliaAustralia

AIM: To compare visual acuity (VA) outcomes between intravitreal injection of bevacizumab and ranibizumab in the treatment of neovascular age-related macular degeneration (AMD). METHODS: We conducted a consecutive, retrospective case series study in patients with newly diagnosed all type choroidal neovascularization (CNV) secondary to AMD who received an intravitreal injection of bevacizumab (1.25mg) or ranibizumab (0.3mg) at lions Eye Institute, Western Australia from Mar. 2006 to May 2008. All patients received injection at baseline with additional monthly injections given at the discretion of the treating physician. Main outcome measures were changes in VA. RESUlTS: There were 371 consecutive patients received injection at least in one eye with at least 6 months of follow up (median of 12.0 months). Bevacizumab treatment prevented 221 out of 278 (79.5%) patient from losing letters in VA compared with 79 out of 93 (84.9%) of ranibizumab treated patients (P=0.25). While 68 (24.5%) of bevacizumab treated patients gained 15 letters of VA compared with 24 (25.8%) of ranibizumab treated patients (P=0.79). 75.3% and 66.2% patients benefited from ranibizumab and bevacizumab respectively with final VA better than 6/60 (P=0.10). Multivariate analysis showed that pre-treatment VA was negatively associated with benefit outcome. Assignment of injection was not associated with VA outcome of benefit after adjusting the covariate (P=0.857). CONClUSION: There are no difference in treatment efficacy in terms of VA between bevacizumab and ranibizumab in routine clinical condition.

关键词： age-related macular degeneration anti-VEGF bevacizumab ranibizumab choroidal neovascularization

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Precision livestock Farming: Precision feeding technologies and sustainable livestock production

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International Journal of Agricultural and Biological Engineering 2012年第4期5卷 54-61页

作者： T M Banhazi l Babinszky V Halas M Tscharke National Centre for Engineering in Agriculture University of Southern QueenslandToowoombaQueensland4350 Australia Department of Feed and Food Biotechnology University of DebrecenH-4015 DebrecenHungary Department of Animal Nutrition Kaposvár UniversityH-7400 KaposvárHungary PlF Agritech Pty.ltd.Queensland 4350 Australia

In order to be able to produce safe,uniform,cheap,environmentally-and welfare-friendly food products and market these products in an increasingly complex international agricultural market,livestock producers must have access to timely production related *** the information related to feeding/nutritional issues is important,as feeding related costs are always significant part of variables costs for all types of livestock ***,automating the collection,analysis and use of production related information on livestock farms will be essential for improving livestock productivity in the ***-controlled livestock production systems with an information and communication technology(ICT)focus are required to ensure that information is collected in a cost effective and timely manner and readily acted upon on *** electronic and ICT related technologies introduced on farms as part of Precision livestock Farming(PlF)systems will facilitate livestock management methods that are more responsive to market *** PlF technologies encompass methods for electronically measuring the critical components of the production system that indicate the efficiency of resource use,interpreting the information captured and controlling processes to ensure optimum efficiency of both resource use and livestock *** envisaged real-time monitoring and control systems could dramatically improve production efficiency of livestock ***,further research and development is required,as some of the components of PlF systems are in different stages of *** addition,an overall strategy for the adoption and commercial exploitation of PlF systems needs to be developed in collaboration with private *** article outlines the potential role PlF can play in ensuring that the best possible management processes are implemented on farms to improve farm profitability,quality of products,welfare of livestock and

关键词： Precision livestock Farming(PlF) precision feeding control systems automation software-based technology sensors nutrition pig farm

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Antioxidant potential and physicochemical properties of protein hydrolysates from body parts of North Atlantic sea cucumber(Cucumaria frondosa)

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Food Production, Processing and Nutrition 2021年第1期3卷 48-69页

作者： Tharindu R.l.Senadheera Deepika Dave Fereidoon Shahidi Department of Biochemistry Memorial University of NewfoundlandSt.John’sNL A1B 3X9Canada Marine Bioprocessing Facility Centre of Aquaculture and Seafood DevelopmentFisheries and Marine InstituteMemorial University of NewfoundlandSt.John’sNL A1C 5R3Canada

Protein hydrolysates were prepared from North Atlantic sea cucumber(Cucumaria frondosa)body wall(BW),and processing by-product flower(Fl)and internal organs(IN).Sea cucumber proteins from these three tissues were hydrolysed with selected endopeptidases and *** enzymes used were Alcalase(A),and Corolase(C)as endopeptidases and Flavourzyme(F)with both endo-and exopeptidase *** were employed individually or in combination under controlled *** hydrolysates so prepared were subsequently analysed for their antioxidant potential and functionalities in food systems for the first *** treated with the combination of A and F exhibited the highest radical scavenging activity against DPPH and ABTS *** highest metal chelation activity was observed for samples hydrolysed with the combination of enzymes(C+F and A+F).All treatments inhibited beta-carotene bleaching in an oil-in-water emulsion and TBARS production in a meat model *** addition,sea cucumber protein hydrolysates were more than 75%soluble over a pH range of 2–*** proteins were also effective in enhancing water holding capacity in a meat model system compared to their untreated *** amino acids of sea cucumber protein hydrolysates had desirable profiles with glutamic acid as the predominant component in samples *** findings demonstrate the desirable functionalities of hydrolysates from North Atlantic sea cucumber and their potential for use as functional food ingredients.

关键词： Sea cucumber Protein hydrolysates Antioxidant activity Physicochemical properties

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Soil Organic C:N vs. Water-Extractable Organic C:N

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Open Journal of Soil Science 2012年第3期2卷 269-274页

作者： richard l. Haney Alan. J. Franzluebbers Virginia. l. Jin Mari-Vaughn. Johnson Elizabeth. B. Haney Mike. J. White Robert. D. Harmel Texas Agrilife Research Blackland Research & Extension Center Temple TX USDA-Agricultural Research Service (ARS) Grassland Soil & Water Research Laboratory Temple TX USA USDA-ARS Agroecosystem Management Research Unit Lincoln NE 4USDA-NRCS Resources Inventory and Assessment Division Temple TX USDA-ARS J. Phil Campbell Sr. Natural Resource Conservation Center Watkinsville GA USDA-NRCS Resources Inventory and Assessment Division Temple TX

Traditionally, soil-testing laboratories have used a variety of methods to determine soil organic matter, yet they lack a practical method to predict potential N mineralization/immobilization from soil organic matter. Soils with high micro-bial activity may experience N immobilization (or reduced net N mineralization), and this issue remains unresolved in how to predict these conditions of net mineralization or net immobilization. Prediction may become possible with the use of a more sensitive method to determine soil C:N ratios stemming from the water-extractable C and N pools that can be readily adapted by both commercial and university soil testing labs. Soil microbial activity is highly related to soil organic C and N, as well as to water-extractable organic C (WEOC) and water-extractable organic N (WEON). The relationship between soil respiration and WEOC and WEON is stronger than between respiration and soil organic C (SOC) and total organic N (TON). We explored the relationship between soil organic C:N and water-extractable organic C:N, as well as their relationship to soil microbial activity as measured by the flush of CO2 following rewetting of dried soil. In 50 different soils, the relationship between soil microbial activity and water-extractable organic C:N was much stronger than for soil organic C: N. We concluded that the water-extractable organic C:N was a more sensitive measurement of the soil substrate which drives soil microbial activity. We also suggest that a water-extractable organic C:N level > 20 be used as a practical threshold to separate those soils that may have immobilized N with high microbial activity.

关键词： Soil Microbial Activity C:N Ratios Soil Organic C N Mineralization N Immobilization Soil Testing

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Extremotolerant rock inhabiting black fungi from Italian monumental sites

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Fungal Diversity 2016年第1期76卷 75-96页

作者： D.Isola l.Zucconi S.Onofri G.Caneva G.S.de Hoog l.Selbmann DEB Universitàdegli Studi della TusciaLargo dell’UniversitàViterboItaly Department of Sciences UniversitàRoma TreViale Marconi 44600146 RomeItaly CBS-KNAW Fungal Biodiversity Centre Uppsalalaan 83584 CT UtrechtThe Netherlands

A wide sampling for isolating highly destructive and extremotolerant black fungi was performed from Italian monuments in selected historical sites which include the "Cortile della Pigna",Vatican Museum and the St Peter colonnade(Vatican City State),the monumental cemetery of Bonaria(Cagliari),and other monuments in the city of *** out of seventy-four strains isolated were identified basing on ITS Blastn *** on multilocus phylogeny and morphological data,one new genus and species lithophila guttulata,five new species Knufia marmoricola,***,***,*** and Exophiala bonariae,order Chaetothyriales and one new genus and species,Saxophila tyrrhenica,and two new species Vermiconia calcicola and Devriesia sardiniae,order Capnodiales,were *** considerations are put forward.

关键词： Extremotolerance Monuments Microcolonial fungi Multilocus phylogeny

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An improved protocol for the treatment of fulminant myocarditis

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Science China(life Sciences) 2019年第3期62卷 433-434页

作者： Matthew l.Edin Darryl C.Zeldin Division of Intramural Research National Institute of Environmental Health Sciences National Institutes of HealthResearch Triangle Park

Fulminant myocarditis is a rare form of severe myocarditis that is most commonly caused by viral *** myocarditis is often pathophysiologically indistinguishable from milder forms of acute myocarditis but is categorically defined based on clinical disease *** may initially present with mild symptoms,such as fever,shortness of breath or heart palpitations,but rapidly progress to severe respiratory distress,arrhythmias,and cardiogenic shock.

关键词： protocol the treatment myocarditis

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Research on Parallel Corpus Based Chinese-English lexicon Builder

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High Technology letters 2003年第4期9卷 61-66页

作者：刘晓月 Yang Muyun Zhao Tiejun lü Yajuan School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 P.R.China

Translation lexicons are fundamental to natural language processing tasks like machine translation and cross language information retrieval. This paper presents a lexicon builder that can auto extract (or assist lexicographer in compiling) the word translations from Chinese English parallel corpus. Key mechanisms in this builder system are further described, including co occurrence measure, indirection association resolution and multi word unit translation. Experiment results indicate the effectiveness of the authors’ method and the potentiality of the lexicon builder system.

关键词： lexicon builder Chinese English parallel corpus co occurrence

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Creation of an optic nerve sheath diameter ultrasound model for Neuro ICU education

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Military Medical Research 2021年第1期8卷 116-120页

作者： Heidi M.Felix Kristin A.Rosenbush Amy M.lannen Robert A.Pooley Jason l.Siegel Benjamin l.Brown Melissa l.Mc Mullan Christina I.Collins William D.Freeman J.Wayne and Delores Barr Weaver Simulation Center Mayo Clinic4500 San Pablo RoadJacksonvilleFL 32224USA Division of Medical Physics Mayo ClinicJacksonvilleFL 32224USA Department of Critical Care Medicine Mayo ClinicJacksonvilleFL 32224USA Department of Neurology Mayo ClinicJacksonvilleFL 32224USA Department of Neurologic Surgery Mayo ClinicJacksonvilleFL 32224USA Department of Radiology Mayo ClinicJacksonvilleFL 32224USA Department of Nursing Mayo ClinicJacksonvilleFL 32224USA

Background: Using ultrasound to measure optic nerve sheath diameter(ONSD) is an emerging bedside technique to noninvasively assess intracranial pressure(ICP) in patients with brain injury. This technique is unique among bedside ultrasonography and is often performed by providers who have no formal ultrasound training. We sought to create a low-cost, 3 D, reusable ONSD model to train neurology, neurosurgery, and critical care providers in measuring ***: We identified 253 articles, of which 15 were associated with models and 2 with simulation. One gelatin model was reported, upon which we based our initial design. We could not validate the visual findings of this model;however, after constructing multiple beta models, the design most representative of human eye anatomy was a globe made of ballistics gel and either a 3 mm, 5 mm, or 7 mm×50 mm 3 D-printed optic nerve inserted into a platform composed of ballistics gel, all of which sat inside a 3 D-printed skull. This model was used to teach ONSD measurements with ultrasound at a continuing medical education event prior to training on a live human ***: A simple 3 D ballistic ONSD model allows learners to practice proper hand placement and pressure, basic landmarks, and ONSD measurement prior to operating on a human eye. This model is replicable and sustainable given that the globe and platform are composed of ballistics gel.

关键词： Intracranial pressure Simulation Task trainer Ultrasound

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Transient convection-diffusion modelling of peak temperature in orthogonal cutting

Transient convection-diffusion modelling of peak temperature...

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23rd International Congress of Theoretical and Applied Mechanics

作者： Timothy J.Burns Steven P.Mates richard l.Rhorer Eric P.Whitenton Debasis Basak Information Technology laboratory NISTGaithersburgUSA Material Measurement laboratory NISTGaithersburgUSA Engineering laboratory NISTGaithersburgUSA

＜正＞Numerical finite-difference simulations of a two-dimensional transient fast convection-slow diffusion model of the temperature field in orthogonal cutting,due to Tlusty,have been shown to provide better predictions of the peak temperature during orthogonal cutting of AISI 1045 steel,than a commercial finite-element method

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A novel direct reduction method to synthesize ordered Fe-Pt alloy nanoparticles

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Journal of Materials Science & Technology 2019年第4期35卷 560-567页

作者： Q.Zheng Z.R.Zhang J.Du l.l.lin W.X.Xia J.Zhang B.R.Bian J.P.liu School of Materials and Chemical Engineering Ningbo University of Technology CAS Key laboratory of Magnetic Materials and Devices Ningbo Institute of Material Technology & EngineeringChinese Academy of Sciences Department of Physics University of Texas at Arlington

In this work, a direct green solid-phase reduction method for the fabrication of large yield of ordered phase Fe-Pt alloy nanoparticles was reported, in which inorganic salts were used as metal precursors and H_2-containing atmosphere was used as reducer. Utilizing this method, the composition and chemical ordered phase, such as l1_2-Fe_3 Pt, l1_2-FePt_3, and l1_0-FePt phases can be easily achieved by one step reaction. The synthesized nanoparticles have clean surface because no organic precursors, no organic solutions or organic surfactants/ligands were used. Their magnetic performance and the formation mechanism of Fe-Pt alloy nanoparticles were also investigated. This strategy can be applied to synthesize many other types of alloy nanoparticles with desired composition and necessary crystal structure, which can be used for a variety of practical applications, such as in magnetism and catalyst research fields.

关键词： Magnetic nanoparticles FePt Chemical synthesis

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