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Muscle, myeloid cells, and complement: a complex interaction

Cellular & Molecular Immunology 2018年第11期15卷 992-993页

作者： jessy j.Alexander richard j.quigg Department of Medicine SUNY at BuffaloBuffaloNY14086USA

The complement system is a critical arm of the immune system that plays an important role not only in maintaining health but also contributes to *** activation generates biologically active products C3a and C5a,which are important links between complement and cellular *** studies have revealed that C5a/C5aR signaling is critical in both humoral and inflammatory responses,resulting in functional renal insufficiency in immune complex-mediated glomerulonephritis.1 Consistent with these studies and considering the complexity of complement system interactions based on location and setting,a recent article by Zhang et al.2 has shed light on C3a/C3aR signaling as the link that regulates monocyte function and trafficking and facilitates skeletal muscle *** commentary highlights the important themes originating from the work described,which include the following:(1)complement C3 depletion reduced muscle regeneration,(2)C3a signaling through its G-coupled receptor C3aR facilitated muscle regeneration by regulating monocyte/macrophage infiltration through CCL5,and(3)C5a/C5aR signaling does not affect monocyte/macrophage infiltration in this particular setting.

关键词： complex interaction critical

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Double negative T cells,a potential biomarker for systemic lupus erythematosus

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Precision Clinical Medicine 2020年第1期3卷 34-43页

作者： jessy j.Alexander Alexander jacob Anthony Chang richard j.quigg james N.jarvis Department of Pathology University of ChicagoChicagoIL 60637USA Departments of Medicine PediatricsJacobs School of Medicine and Biomedical Sciences and GeneticsGenomics&Bioinformatics ProgramUniversity at BuffaloBuffaloNY 14203USA

Systemic lupus erythematosus(SLE)is an autoimmune disease that is a challenge to diagnose and *** is an urgent need for biomarkers to help define organ involvement,and more effective therapies.A unique population of T cells,the CD3^(+)CD4^(−)CD8^(−)(DNeg)cells,is significantly increased in lupus *** cases(53%)of pediatric SLE patients had elevated DNeg cells in their peripheral blood,which correlated with kidney function(R^(2)=0.54).Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by *** the first time,this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus *** lupus mice,the increase in DNeg cells tracked with worsening disease and correlated with kidney function(R^(2)=0.85).Our results show that DNeg cells per se can cause kidney dysfunction,increase in number with increase in disease pathology,and could serve as a potential biomarker.

关键词： CD3^(+)CD4^(−)CD8^(−)T cells glomerulonephritis inflammation lupus

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Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor

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Cellular & Molecular Immunology 2016年第5期13卷 651-657页

作者： jessy j. Alexander Lee D. Chaves Anthony Chang Shruti Dighe Alexander jacob richard j. quigg Division of Nephrology Department of Medicine University at Buffalo School of Medicine and Health Sciences Buffalo NY USA Department of Pathology The University of Chicago Chicago IL USA Correspondence: Dr Jessy J. Alexander Division of Nephrology State University of New York at Buffalo Clinical and Translational Research Center 875 Ellicott Street 8-022 Buffalo NY 14203 USA

Activation of complement generates C5a which leads to signaling through C5aR 1. This is tightly controlled, including by the plasma proteins factor H （FH） and carboxypeptidase N. Here we studied a chronic serum sickness （CSS） model of glomerulonephritis （GN） in which there is an active humoral immune response, formation of glomerular immune complexes （ICs）, and resulting glomerular inflammation. The antibody response, glomerular IC deposition, the degree of GN, and consequent renal functional insufficiency in CSS were all worse in FH-/- mice compared to wild-type FH＋/＋ animals. This was ameliorated in the former by giving a C5aR1 antagonist for the final 3 weeks of the 5-week protocol. In contrast, blocking CP-mediated inactivation of C5a increased these disease measures. Thus, complement regulation by both plasma FH and CP to limit the quantity of active C5a is important in conditions where the humoral immune response is directed to a continuously present foreign antigen. Signaling through C5aR1 enhances the humoral immune response as well as the inflammatory response to ICs that have formed in glomeruli. Both effects are relevant even after disease has begun. Thus, pharmacological targeting of C5a in IC-mediated GN has potential clinical relevance.

关键词： C5a carboxypeptidase N factor H glomerulonephritis

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双极深部脑刺激时可常规记录EKG、EEG和多导睡眠图

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世界核心医学期刊文摘(神经病学分册) 2006年第11期 53-53页

作者： Frysinger R.C quigg M Elias W.j 郭俊 Department of Neurosurgery University of Virginia School of Medicine Box 800212 Charlottesville VA 22908-0212 United States Dr.

As the population of patients treated with deep brain stimulation (DBS) grows and the patients age, more will require routine or emergent electrophysiologic tests. DBS artifact may render these uninterpretable, whereas stopping DBS may release symptoms that confound evaluation. The authors find that monopolar, but not bipolar, stimulation produces significant artifact during EKG, EEG, and polysomnography.

关键词：深部脑刺激双极 EKG EEG 常规

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