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成人急性髓细胞性白血病免疫表型与细胞遗传学及临床特征的关系

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癌症 2005年第6期24卷 667-671页

作者：王兴兵郑金娥谷俊侠姚军霞杨晶刘隽李小青贺艳丽喻竞明魏君刘仲萍黄士昂华中科技大学同济医学院附属协和医院干细胞研究与应用中心湖北武汉430022

背景与目的:新的WHO分类已迅速应用于白血病的诊断。依据多个系相关抗原的表达,多参数高分辨流式细胞术可准确地识别白血病细胞的系列来源和分化阶段,而且某些抗原表达与细胞遗传学改变和预后密切相关。本研究旨在探讨初治成人急性髓细... 详细信息

背景与目的:新的WHO分类已迅速应用于白血病的诊断。依据多个系相关抗原的表达,多参数高分辨流式细胞术可准确地识别白血病细胞的系列来源和分化阶段,而且某些抗原表达与细胞遗传学改变和预后密切相关。本研究旨在探讨初治成人急性髓细胞性白血病(acutemyeloidleukemia,AML)的免疫表型特征,并对其与FAB分类、细胞遗传学和临床表现的关系进行分析。方法:采用多参数高分辨流式细胞术对96例成人AML患者骨髓进行免疫表型分析,染色体G显带技术对其中的73例进行核型分析。结果:AML患者中,某些免疫表型特征与FAB分类具有相关性,包括M3中缺乏表达HLA鄄DR、CD34和CD56,但CD2的表达增加;M2中CD19、M5中CD14和CD56的表达增加,而M0中未见MPO的表达。本组AML核型异常率为54.8%,其中CD22、CD56和TdT的表达与核型异常有显著性相关。10例t(8;21)改变仅见于M2中,并高表达CD15、CD19、CD34和CD56,但未见CD2和CD7表达。7例伴t(15;17)的M3患者中未见淋系抗原的表达。此外,CD4和TdT抗原的表达与患者年龄、CD7和CD14的表达与外周血白细胞计数、CD4、CD14和CD56的表达与血小板计数等均有显著性正相关。结论:AML患者免疫表型与细胞遗传学的相关性提示AML抗原的异常表达可能与基因的异常改变密切相关。

关键词：白血病髓细胞性急性免疫表型流式细胞术细胞遗传学

苜蓿花叶病毒和白三叶草花叶病毒复合侵染对本氏烟4种抗病相关酶活性的影响

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甘肃农业大学学报 2023年第5期58卷 122-129,140页

作者：王冬梁巧兰魏列新程守丰陈应娥同发宇田龙张国印甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室甘肃兰州730070

【目的】探明苜蓿花叶病毒(alfalfa mosaic virus,AMV)和白三叶草花叶病毒(white clover mosaic virus,WCMV)(3∶1)复合侵染后对本氏烟(Nicotiana benthamiana)的致病机理。【方法】试验以单独摩擦接种AMV、WCMV和PBS缓冲液(pH 7.0)的本氏烟为对照,分别采用生物化学法测定了AMV+WCMV(3∶1)复合接种的本氏烟在第2、4、6、8、10天时叶片中4种抗病相关酶的活性。【结果】当AMV+WCMV(3∶1)复合接种的本氏烟叶片中过氧化物酶(peroxidase,POD)、多酚氧化酶(polyphenol oxidase,PPO)、苯丙氨酸解氨酶(phenylalanine ammonialyase,PAL)和过氧化氢酶(catalase,CAT)活性达到最大值时,与单独接种AMV、WCMV和PBS缓冲液对照相比显著提高(P<0.01),且4种酶应激反应速度不同。【结论】AMV+WCMV(3∶1)复合侵染可加重病毒病害的发生,并显著提高寄主中与抗病性相关的POD、PAL、PPO、CAT4种酶活性。

关键词：苜蓿花叶病毒白三叶草花叶病毒复合侵染本氏烟抗病相关酶

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The Palestinian Terrestrial Vertebrate Fauna Preserved at the Biology exhibitions of the Universities of the Gaza Strip

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Research in ecology 2020年第4期2卷 9-21页

作者： Abdel Fattah N Abd Rabou Nour J Musallam eman J Musallam Kamal e elkahlout Kamal J elnabris Tarek A el-Bashiti Ismail I Abdel Aziz Reham M Ishneiwra eqbal S Radwan Hana S Saada Ashraf A Shafei Nedal A Fayyad Saleh N Mwafy Huda e Abu Amra Ramy A Abu Alajeen Mohammed F Abu Owda Randa N Alfarra Haifaa A Hassouna Reem A Hassouna Mohammed R Al-Agha Mohammed A Abd Rabou Department of Biology and Biotechnology Islamic University of GazaGaza StripPalestine Department of english Islamic University of GazaGaza StripPalestine Department of Biology Al-Azhar UniversityGaza StripPalestine Department of Biology Al-Aqsa UniversityGaza StripPalestine Department of Geography Al-Aqsa UniversityGaza StripPalestine Department of Curricula and Teaching Methods Islamic University of GazaGaza StripPalestine Department of Curricula and Teaching Methods Ministry of EducationGaza StripPalestine Department of Pharmaceutical Sciences University of PalestineGaza StripPalestine Department of environment and earth Sciences Islamic University of GazaGaza StripPalestine Department of Information Technology University College of Applied SciencesGaza StripPalestine

The Gaza Strip(365 km^(2))of Palestine(27,000 km^(2))is home to a wealth of terrestrial vertebrate *** of these faunistic species find their ways to preservation at the local ***,the current study comes to document the Palestinian terrestrial vertebrate fauna acquired by the biology exhibitions(Bes)of Al-Azhar University,Islamic University of Gaza and Al-Aqsa University that are located at the Gaza City of the Gaza *** amphibians,reptiles,birds and mammals preserved at Bes of the universities in question were surveyed and scientifically classified during a three-month period extending from January to March,*** study showed that all Bes of local universities are underdeveloped,lacking attention and suffer from specimen scarcity and good *** Be at Al-Azhar University is the best in the arrangement and preservation of bird specimens.A total number of 200 specimens belonging to 54 terrestrial vertebrate fauna species,39 families and 17 orders was recorded at *** constituted 40.7%of the total species recorded,followed by birds(38.9%),mammals(14.8%)and amphibians(5.6%).The Islamic University of Gaza was considered the best in terms of the number of preserved species(39.8%),followed by Al-Azhar University(36.3%)and Al-Aqsa University(23.9%).The Common Toad(Bufo viridis)was the most preserved among the amphibian species *** was the biggest reptilian order,comprising 20 species(8 lizards and 12 snakes),with the Syrian Black Snake(Coluber jugularis asianus)was the *** Palestine Viper(Vipera palaestinae)is endemic to Palestine and most venomous and dangerous to human *** Great white Pelican(Pelecanus onocrotalus)was the largest Palestinian bird preserved at Be of Al-Azhar *** egyptian Mongoose(Herpestes ichneumon)and the Common Badger(Meles meles)were the biggest mammalian specimens preserved,while the Palestine Mole-rat(Spalax leucodon ehrenbergi)was the only Palestine endemic spe

关键词： Terrestrial vertebrate fauna Preservation Biology exhibitions Gaza universities Gaza Strip Palestine

用DNA差异显示技术分离、测序和鉴定猪的两个新分子标记及其与性状的关联分析(英文)

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农业生物技术学报 2005年第5期13卷 51-55页

作者：刘永刚熊远邓昌炎雷明刚左波李家连蒋思文李凤娥郑嵘华中农业大学猪遗传育种农业部重点实验室武汉430070 华中农业大学猪遗传育种农业部重点实验室

为了寻找更多的和性状关联的猪候选基因或分子标记,用DNA差异显示技术扫描140头大白×梅山F2猪的DNA,发现了2个与猪的性状具有显著关联的分子标记,并对这2个分子标记进行测序和鉴定。标记1与最后肋骨处估测背膘厚(P<0.01)、倒数三四肋... 详细信息

为了寻找更多的和性状关联的猪候选基因或分子标记,用DNA差异显示技术扫描140头大白×梅山F2猪的DNA,发现了2个与猪的性状具有显著关联的分子标记,并对这2个分子标记进行测序和鉴定。标记1与最后肋骨处估测背膘厚(PenBank进行Blast比较,这2个标记与已知的猪基因或基因组序列没有明显的同源性,提交到GenBank,登陆号分别为CN605659和AY626262。研究所用的方法为揭示新的猪候选基因或分子标记提供了一条新的途径。

关键词：猪 DNA差异显示分子标记关联分析

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儿童营养鱼糜制品的研制

农产品加工（下） 2008年第1期 29-32页

作者：林素娥王清林卞智英瞿宜昌李丁俊林向阳福州大学生物科学与工程学院福建福州350108 福建海壹食品饮料有限公司福建福清350301

中国儿童的每日膳食中,普遍缺乏蛋白质和矿物质,需要在日常膳食外进行补充。在调查我国儿童目前营养状况的基础上,以儿童喜爱、美味可口和营养丰富的鱼糜制品为原料,通过添加猪肉和儿童易吸收的食品营养强化剂,研制出了无腥味、高品质... 详细信息

中国儿童的每日膳食中,普遍缺乏蛋白质和矿物质,需要在日常膳食外进行补充。在调查我国儿童目前营养状况的基础上,以儿童喜爱、美味可口和营养丰富的鱼糜制品为原料,通过添加猪肉和儿童易吸收的食品营养强化剂,研制出了无腥味、高品质、高营养性的复合鱼糜猪肉制品。该产品具有弹性好、脂肪含量低和营养丰富等特性。通过正交试验得到儿童营养鱼糜制品的最优配方为:鱼糜200g,猪瘦肉糜30g,淀粉20g,蛋清22g。通过改善鱼糜制品的加工工艺,克服了传统鱼糜制品在加热过程中发生的香味容易消失、腥味重、风味差等缺点,大大提高了产品品质。该产品是促进儿童健康成长的理想食品。

关键词：营养儿童食品鱼糜制品

Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas e.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CeRN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research Center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York University Abu Dhabi Dipartimento di Fisica enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt extreMe Matter Institute eMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & electrical engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this white Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

老年高血压患者的海马萎缩、全脑容积改变及白质损伤情况

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 29-29页

作者： Wiseman R.M. Saxby B.K. Burton e.J. 胡慧敏

Objective: To determine the potential role of whole brain atrophy, hippocampa l atrophy, or both, and small vessel disease/white matter lesions as mechanisms underlying the cognitive impairment associated with hypertension. Methods: Using MRI scanning the authors determined hippocampal volumes, whole brain volumes, a nd location and severity of white matter lesions, using Scheltens scale, in 103 hypertensive (166 ± 8/88 ± 7 mm Hg, 54 female) and 51 normotensive (132 ± 12/ 74 ± 7 mm Hg, 21 female) subjects age ≥ 70 years. Results: Compared to normote nsive subjects, older hypertensive subjects had significantly smaller whole brai n volumes (887 ± 109 vs 930 ± 97 cm3, p = 0.02) and nonsignificantly reduced h ippocampal volumes (5.39 ± 1.60 vs 5.67 ± 1.80 cm 3, p = 0.33). Hypertensive s ubjects had an increased burden of periventricular lesions: bands (p = 0.03), fr ontal caps (p = 0.08), occipital caps (p = 0.07), and total periventricular hype rintensities (p = 0.02). They also had higher scores in subcortical areas: front al (p = 0.04), temporal (p = 0.03), and deep white matter areas (p = 0.05). A co rrelation was found between whole brain volumes and systolic blood pressure (r = - 0.19, p = 0.02). No correlation was seen between whole brain volumes and whi te matter lesion burden. Conclusions: Moderate hypertension in non-impaired ol der subjects is associated with smaller whole brain volume and an increased burd en of subcortical and periventricular white matter lesions.

关键词：老年高血压海马萎缩血压正常者正常血压海马体积血管疾病认知功能损伤潜在作用脑容量有室

血管周围脂肪组织的趋化性产物在动脉粥样硬化发病中起作用

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中国动脉硬化杂志 2006年第2期14卷 155-155页

作者： Henrichot e Juge-Aubry Ce Pernin A Pache JC Velebit V Dayer JM 曹冬黎

肥胖与增加心血管疾病的危险有联系。虽然知道白色脂肪组织(white adipose tissue,WAT)产生大量炎症和致动脉粥样硬化的细胞因子和趋化物,但在动脉粥样硬化中脂肪源性趋化信号对慢性炎症的影响尚不清楚。组织学检查发现,血管周围WAT紧... 详细信息

肥胖与增加心血管疾病的危险有联系。虽然知道白色脂肪组织(white adipose tissue,WAT)产生大量炎症和致动脉粥样硬化的细胞因子和趋化物,但在动脉粥样硬化中脂肪源性趋化信号对慢性炎症的影响尚不清楚。组织学检查发现,血管周围WAT紧靠血管壁,尤其是那些有发生动脉粥样硬化趋势的部位。啮齿类动物在高脂饮食下血管周围WAT显著增加。[第一段]

关键词：致动脉粥样硬化白色脂肪组织血管周围趋化性发病产物慢性炎症心血管疾病组织学检查啮齿类动物

不同浓度亚硒酸钠对猪骨骼肌卫星细胞增殖和硒蛋白基因表达的影响

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广东畜牧兽医科技 2022年第4期47卷 9-14页

作者：何逸懿申露露李莉洪兴李大江肖明飞唐青松徐娥贵州大学动物科学学院动物营养与饲料研究所贵州贵阳550025

为研究不同浓度亚硒酸钠对猪骨骼肌卫星细胞增殖分化以及硒蛋白W(Selenoprotein W,SelW)和硒结合蛋白1(Selenium-binding protein 1,SBP1)表达的影响。分别在0(对照组)、0.02(0.02%组)、0.1(0.1%组)、0.5(0.5%组)、2.5μg/mL(2.5%组)亚硒酸钠浓度的培养基条件下培养骨骼肌卫星细胞,在第1、2、3、4天观察细胞增殖分化情况,分别在第1、3、5、7天收集处理后的细胞。提取上述收集细胞的mRNA,检测SelW和SBP1基因表达。结果表明:1)从第1天到第4天,0.02%组、0.1%组、0.5%组细胞增殖与对照组相似,其中以0.1%组与对照组最接近。然而,2.5%组在第3天后降低了细胞数量,细胞出现大量死亡。2)不同浓度亚硒酸钠对SelW的表达在第3天影响最大,随着亚硒酸钠浓度增加呈现先增加后降低的趋势。第3天数据表明,与对照组相比,0.02%组、0.1%组、0.5%组和2.5%组均显著增加SelW的mRNA表达量,且0.1%组和0.5%的表达量显著高于0.02%组和2.5%组(PelW和SBP1的mRNA表达,2.5%浓度亚硒酸钠抑制SelW和SBP1的mRNA表达。

关键词：亚硒酸钠硒蛋白细胞增殖 SelW SBP1