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Progesterone modulates m TOR in the hippocampus of mice after traumatic brain injury

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Neural Regeneration Research 2018年第3期13卷 434-439页

作者： richard Justin Garling Lora Talley watts Shane Sprague Murat Digicaylioglu Department of Neurosurgery Wayne State University Detroit MI USA School of Medicine The University of Texas Health Science Center at San Antonio San Antonio TX USA Department of Neurosurgery The University of Texas Health Science Center at San Antonio San Antonio TX USA

Spinal cord injury results in the loss of motor and sensory pathways and spontaneous regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium alginate have good biocompatibility, biodegradability, and are suitable to assist the recovery of damaged tissues, such as skin, bone and nerve. Chitosan scaffolds, sodium alginate scaffolds and chitosan-sodium alginate scaffolds were separately transplanted into rats with spinal cord hemisection. Basso-Beattie-Bresnahan locomotor rating scale scores and electrophysiological results showed that chitosan scaffolds promoted recovery of locomotor capacity and nerve transduction of the experimental *** days after surgery, chitosan scaffolds retained the original shape of the spinal cord. Compared with sodium alginate scaffolds- and chitosan-sodium alginate scaffolds-transplanted rats, more neurofilament-H-immunoreactive cells （regenerating nerve fibers） and less glial fibrillary acidic protein-immunoreactive cells （astrocytic scar tissue） were observed at the injury site of experimental rats in chitosan scaffold-transplanted rats. Due to the fast degradation rate of sodium alginate, sodium alginate scaffolds and composite material scaffolds did not have a supporting and bridging effect on the damaged tissue. Above all, compared with sodium alginate and composite material scaffolds, chitosan had better biocompatibility, could promote the regeneration of nerve fibers and prevent the formation of scar tissue,and as such, is more suitable to help the repair of spinal cord injury.

关键词： nerve regeneration spinal cord injury chitosan sodium alginate functional recovery scaffold neurofilament-H glial fibrillary acidic protein scar tissue locomotor capacity neural regeneration

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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High Performance Electrically Small Huygens Rectennas Enable wirelessly Powered Internet of Things Sensing Applications:A Review

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Engineering 2022年第4期8卷 42-59页

作者： wei Lin richard w.Ziolkowski Global Big Data Technologies Centre School of Electrical and Data EngineeringUniversity of Technology SydneyUltimoNSW 2007Australia

Far-field wireless power transfer(wPT)is a major breakthrough technology that will enable the many anticipated ubiquitous Internet of Things(IoT)applications associated with fifth generation(5G),sixth generation(6G),and beyond wireless ***,which are the combination of rectifying circuits and antennas,are the most critical components in far-field wPT ***,compact application devices require even smaller integrated rectennas that simultaneously have large electromagnetic wave capture capabilities,high alternating current(AC)-to-direct current(DC)(AC-to-DC)conversion efficiencies,and facilitate a multifunctional wireless *** paper reviews various rectenna miniaturization techniques such as meandered planar inverted-F antenna(PIFA)rectennas;miniaturized monopole-and dipole-based rectennas;fractal loop and patch rectennas;dielectric-loaded rectennas;and electrically small near-field resonant parasitic *** performance characteristics are summarized and then compared with our previously developed electrically small Huygens rectennas that are proven to be more suitable for IoT *** have been tailored,for example,to achieve batteryfree IoT sensors as is demonstrated in this ***-free,wirelessly powered devices are smaller and lighter in weight in comparison to battery-powered ***,they are environmentally friendly and,hence,have a significant societal benefit.A series of high-performance electrically small Huygens rectennas are presented including Huygens linearly-polarized(HLP)and circularly-polarized(HCP)rectennas;wirelessly powered IoT sensors based on these designs;and a dual-functional HLP rectenna and antenna ***,two linear uniform HLP rectenna array systems are considered for significantly larger wireless power *** arrays illustrate how they can be integrated advantageously with DC or radio frequency(RF)power-combining schemes for practical IoT applications.

关键词： Antenna Array Cardioid pattern Electrically small antenna Huygens dipole antenna Internet of Things(IoT) Rectenna Rectifier circuit wireless power transfer

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

A remembrance of Professor TP FENG

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生理学报 2007年第6期59卷 713-715页

作者： richard w.Tsien Department of Molecular and Cellular Physiology Stanford University

It is both an honor and pleasure to be given this opportunity to remember Professor TP FENG and his many *** made many important scientific discoveries,labored mightily to establish firmly Physiology and Neuroscience in China,and was a major force in setting a high standard for scientific *** is safe to say that the past and future of Neuroscience in China would be very different had Professor FENG not provided leadership,by dint of organization,persuasion and strong personal example.

关键词：神经系统科学中国冯德培生理学院士科研教学

On ethics,the pursuit of knowledge,truth and status in the hallowed halls of academe

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Integrative Zoology 2013年第3期8卷 223-231页

作者： John S.BUCKERIDGE Rob watts Earth&Oceanic Systems Group RMIT UniversityMelbourneVictoriaAustralia

Advancement in academe is largely on the basis of research output;that is,refereed journal *** paper first explores pressures on academics,especially emerging researchers,when English is not a first *** assess why,when faculty members rush to improve their station that they may elect to circumvent ethical protocols to accelerate their promotion and *** resulting unethical behavior includes plagiarism and forms of duplication such as *** is then given to the wider implications of both plagiarism and the theft of intellectual property,and the role these have played in the development of individuals,the university and society.

关键词： ethics plagiarism promotion publication social evolution