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Cellular & Molecular Immunology 2013年第6期10卷 497-505页

作者： Xi Chen ti Wen Jun Wei Zhenzhou Wu Puyue Wang Zhangyong Hong Liqing Zhao Bin Wang richard Flavell Shumei Gao Min Wang Zhinan Yin Key Laboratory of Industrial Fermentation Microbiology (tianjin University of Science and Technology) Ministry of Education College of Biotechnology Tianjin University of Science and Technology Tianjin China State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin China Department of Medical Oncology The First Hospital of China Medical University Shenyang China Key Laboratory of Medical Molecular Virology of MOE and MOH Fudan University Shanghai Medical College Shanghai China Department of Immunobiology Yale School of Medicine New Haven CT USA tianjin University of Traditional Chinese Medicine Tianjin China

Asthmatic inflammation is mediated by a type 2 helper T cell （Th2） cytokine response, and blocking Th2 cytokine production is proven to have a potent therapeutic effect against asthmatic inflammation. Using IL-4-green fluorescent protein （GFP） reporter mice, we demonstrated that Bavachinin, a single compound isolated from a Chinese herb, significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin （OVA）-sensitized animal asthma model. Furthermore, we demonstrated that this chemical selectively affects the level of GATA-3, most likely by affecting the stability of GATA-3 mRNA. Our results demonstrate, for the first time, the potential therapeutic value of this single compound derived from Chinese herbs.

关键词： asthma bavachinin IL-4

A study of process-induced grain structures during steady state and non-steady state electron-beam welding of a titanium alloy

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Journal of Materials Science & Technology 2022年第18期113卷 117-127页

作者： Yu Lu richard Turner Jeffery Brooks Hector Basoalto School of Metallurgy and Materials University of BirminghamBirminghamB152TTUnited Kingdom Department of Materials Science and Engineering The University of SheffieldMappin StreetSheffieldS13JDUnited Kingdom

A detailed microstructural characterisation of the emerging weld-line grain structure,for bead-upon-plate welds in ti-6Al-4V(ti64)of differing plate thickness,was *** microstructure studied was formed during both steady state and non-steady state sections within the weld path,with the non-steady state portion being taken from the end of the plate as the weld bead and heat source overhang the edge of the *** allows for the effects of welding process conditions on the microstructural evolution to be *** weld pool geometry and 3D tomography of the weld-induced defects have been *** characterisation of microstructure and texture for different welding parameters and for steady and non-steady states have been used to identify physical parameters for the microstructure predictions that are difficult to obtain *** different states significantly affect the weld crown shape and formation,weld toe,weld bead depth and ***,the heat affected zone(HAZ)re-mains *** the microstructural evolution,both the steady and non-steady states have similar microstructure and *** defects were observed in the steady state section of welds,but sub-surface spherical pores have been observed in the non-steady state section of a *** element modelling to simulate the thermal-metallurgical-mechanical fields within the steady and non-steady state sections of the welds was considered,and the cooling rates predicted within steady state and non-steady sections were interrogated to improve the theoretical understanding of the microstructure and defect formation differences in these ti64 EB weld regions.

关键词： Electron-beam fusion welding Processing Microstructure ti-6Al-4V

Design of New Thiadiazole Derivatives with Improved Antidiabetic Activity

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Computational Chemistry 2023年第3期11卷 67-80页

作者： Chiépi Nadège Dominique Dou Georges Stéphane Dembele Mamadou Guy-richard Kone Nanou tiéba Tuo Fandia Konate Adama Niare Panaghiotis Karamanis Nahossé Ziao Laboratoire de Thermodynamique et de Physico-Chimie du Milieu Université NANGUI ABROGOUA Abidjan C&ocircte-d’Ivoire Groupe Ivoirien de Recherches en Modélisation des Maladies (GIR2M) Université NANGUI ABROGOUA Abidjan C&ocircte-d’Ivoire E2S UPPA CNRS IPREM Université de Pau et des Pays de l’Adour Pau France Laboratoire de Physique Fondamentale et Appliquée UFR SFA Université NANGUI ABROGOUA Abidjan C&ocircte-d’Ivoire

Diabetes is a serious, long-term (or chronic) disease that occurs when a person’s blood sugar levels are high because their body cannot produce enough insulin, or does not produce enough insulin or that it cannot effectively use the insulin it produces. According to the literature, this disease has several causes, but certain types of diabetes such as type 2 diabetes are most closely linked to a metabolic disorder due to abdominal obesity. Thus, the number of individuals with type 2 diabetes is increasing. It is with this in mind that we work to improve human health. The aim of this study is to design new derivatives of 1,3,4-thiadiazole with improved antidiabetic activity by the mathematical model of multiple linear regression (MLR) established previously. The analysis of the effect on the substituents influencing the antidiabetic activity, fourteen (14) new molecules coded CDTH were generated and presenting values of the potential of inhibitory concentration higher than that of the base compound (pIC50 = 2.526). But thirteen (13) of these new compounds belong to the domain of applicability of the MLR model established previously. In addition, the thermodynamic quantities of formation formed at 298K have been calculated. Lipinski’s rule and pharmacokinetic properties proved that five (5) (TH4, TH9, TH10, TH13 and TH14) new molecules can be used as diabetes medicine.

关键词： Design Antidiabetic Activity 1 3 4-Thiadiazole Lipinski’s Rule

Recent progress in MgB_(2)superconducting joint technology

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Journal of Magnesium and Alloys 2023年第7期11卷 2217-2229页

作者： Hao Liang Dipak Patel Mahboobeh Shahbazi Andrzej Morawski Daniel Gajda Matt Rindfleisch richard Taylor Yusuke Yamauchi Md Shahriar A.Hossain School of Mechanical and Mining Engineering The University of QueenslandSt LuciaQueensland 4072Australia QUT Centre for Materials Science and School of Chemistry and Physics Queensland University of TechnologyBrisbaneQueensland 4001Australia Institute of High Pressure Physics Polish Academy of Sciences(PAS)Sokolowska 29/37Warsaw 01-142Poland Institute of Low Temperature and Structure Research Polish Academy of Sciences(PAS)Okólna 2Wrocław 50-422Poland Hyper Tech Research Inc.539 Industrial Mile RdColumbusOhio 43228USA Applied Superconductivity Laboratory Queensland University of TechnologyBrisbaneQueensland 4001Australia Australian Institute for Bioengineering and Nanotechnology(AIBN) The University of QueenslandSt LuciaQueensland 4072Australia Department of Materials Process Engineering Graduate School of EngineeringNagoya UniversityFuro-choChikusa-kuNagoya 464-8603Japan The Commonwealth Scientific and Industrial Research Organisation(CSIRO) LindfieldNew South Wales 2070Australia

Magnesium diboride(MgB_(2))magnets have the potential to be the next-generation liquid-helium-free magnet for magnetic resonance imaging(MRI)application due to their relatively high superconducting transition temperature,high current density and low raw material cost compared with current commercial niobium-titanium(Nb-ti)magnets.A typical superconducting magnet includes several *** produce an ultra-stable magnetic field for imaging in MRI,a superconducting electromagnet operating in a persistent mode is *** coils of the electromagnet in MRI are short-circuited to operate in the persistent mode by connecting coils with superconducting ***-sistent joints have been demonstrated for in-situ and ex-situ wires of both mono-and multi-filamentary structures,made predominantly by PIT techniques similar to those used in wire *** realise further engagement of MgB_(2)in MRI applications,enhancing the performance of MgB_(2)superconducting joints is *** literature review summarises research and development on MgB_(2)superconducting joining technology.

关键词： MgB_(2) Superconducting joints Persistent-mode magnets MRI application Field-decay measurement

A Numerical Investigation into the Bending of Metallic Laminate Sheet

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World Journal of Engineering and Technology 2019年第2期7卷 314-324页

作者： richard P. Turner School of Metallurgy & Materials University of Birmingham Birmingham United Kingdom

A finite element model to simulate the bending of tri-layer laminate metallic sheet was proposed, and the model?was?developed in the commercial finite element (FE) solver deform. The model was simulated under adiabatic conditions (thus assuming zero heat transfer), with room temperature material properties and an ambient atmosphere assumed throughout. The models used copper as the core layer, whilst the upper and lower face layers were alternated between an aluminium alloy Al 2017, a titanium alloy ti-6Al-4V, and a stainless steel 316L. Thus, room temperature mechanical properties for ti-6Al-4V, copper, 316L stainless steel and 2017 Al alloy were entered into the model. FE predictions suggest that the material used in the face layers are of significant design importance, with variation in the peak strain in the face layers of around one-third, whilst significant variation in these layers for peak Von Mises stress, with ti-6Al-4V and Al 2017 alloys was significantly closer to their ultimate tensile strength (UTS) values than 316L. However in the core copper layer the stress and strain predictions were largely unaffected. In models that mixed Al 2017 and 316L upper and lower face layers, significant differences in peak strains in the face layers were predicted, with the 316L layer suffering greater strains when paired with the Al 2017 alloy than paired with itself. A sensible locating of the materials in upper and lower face layers is predicted to give optimised stress and strain fields.

关键词： Stress Strain Layer Simulation Cockroft-Latham

Flexible ti-Ni-N Thin Films Prepared by Magnetron Sputtering

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材料科学与工程（中英文A版） 2014年第1期4卷 27-33页

作者： Jindrich Musil richard Jilek Radomir Cerstvy Department of Physics and New Technologies for Information Society (NtiS) European Centre of Excellence Faculty of AppliedSciences University of West Bohemia CZ-306 14 Plzeh Czech Republic

A Study of the Deformation Derivatives for a ti-6Al-4V Inertia Friction Weld

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Advances in Aerospace Science and Technology 2021年第2期6卷 114-121页

作者： richard P. Turner Nils Warnken Jeffery W. Brooks School of Metallurgy & Materials University of Birmingham Birmingham UK

The velocity–versus-time rundown curves from two experimental ti-6Al-4V inertia friction welds were analysed and differentiated several times, to produce rotational acceleration, jerk, jounce (or snap), crackle and pop versus-times curves for each weld. titanium alloys and their mechanical properties are known to be highly sensitive to strain rate as the material is deformed, though nothing has ever been considered in terms of the higher-order time-derivatives of position. These curves have been studied and analysed further, for a more complete understanding of the derivative trends. Rotational acceleration and jerk traces both display behavior patterns across the two welds as the part rotates under action from the flywheel. The rotational snap also displays a pattern in this derivative during the final approximately 0.5 s of welding, as the energy dissipates. Evidence of a distinct oscillatory pattern in the rotational crackle and pop terms was noted for one weld when differentiating over a larger time-base, though could not be replicated in the 2nd weld. The higher derivative curves allow distinction of different process regimes, indicating that inertial energy mostly influences the time-base of dynamically steady-state phase. Qualitative differences between initial energies are evident in higher derivatives.

关键词： Rotation Acceleration Jerk Snap Crackle Pop

Microstructural Modeling of Thermally-Driven β Grain Growth, Lamellae &Martensite in ti-6Al-4V

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Modeling and Numerical Simulation of Material Science 2020年第3期10卷 55-73页

作者： Matteo Villa Jeffery W. Brooks richard P. Turner Mark Ward School of Metallurgy & Materials University of Birmingham Birmingham UK

The microstructural kinetics of β grain growth in the β field of a ti-6Al-4V alloy was studied by a series of controlled heat treatments at constant temperature rates. Heating rates of 5°C/s, 50°C/s and 500°C/s were considered, stopping at different peak temperatures. The thickness evolution of martensitic needles and lamellar α laths, formed on cooling, was also investigated, by soaking the material above its β-transus temperature and cooling down at 5°C/s, 50°C/s, 100°C/s and 300°C/s till ambient temperature. Quantitative microstructural analyses were used to measure the particle dimensions. The β grain growth kinetics was reasonably well described by a modified Avrami equation. The thickness of α lamellae was a function of the cooling rate and the β grain dimension in which they nucleated. The martensite needle thickness was shown to be a function of the cooling rate to which the material was subjected.

关键词： titanium Welding Rapid Heating Phase Alpha Beta

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PWM与模拟调光解决方案

今日电子 2015年第2期 63-67页

作者： richard YangLv Jian ti公司

随着天花板灯的调光控制要求越来越严格,单个传统模拟调光或PWM调光无法满足当前市场要求。但PWM与模拟调光的整合模式却是一个很好的选择。然而,由于寄生效应对MOS与输出二极管的结点电容器的影响,更深、更宽的调光仍然是一个挑战。还... 详细信息

随着天花板灯的调光控制要求越来越严格,单个传统模拟调光或PWM调光无法满足当前市场要求。但PWM与模拟调光的整合模式却是一个很好的选择。然而,由于寄生效应对MOS与输出二极管的结点电容器的影响,更深、更宽的调光仍然是一个挑战。还有一项挑战是满足LED输出电流与调光信号之间的良好线性规范要求。在本文中,我们将介绍基于U C C28810/11器件的模拟调光与PWM调光整合解决方案,以满足该规范要求。

关键词：调光 PWM 寄生效应光信号电感器输出电压整合模式功率因数校正正向电压占空比

Coexistence of Polaronic States and Superconductivity in Iron-Pnictide Compound Ba_2ti_2Fe_2As_4O

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Chinese Physics Letters 2018年第5期35卷 119-122页

作者： Li-Yuan Rong Xun Shi Pierre richard Yun-Lei Sun Guang-Han Cao Xiang-Zhi Zhang Jun-Zhang Ma Ming Shi Yao-Bo Huang tian Qian Hong Ding Ren-Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201204 School of Physics University of Chinese Academy of Sciences Beijing 100190 Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of Sciences Beijing 100190 Collaborative Innovation Center of Quantum Matter Beijing 100084 Department of Physics Zhejiang University Hangzhou 310027 Paul Scherrer Institut Swiss Light Source Villigen PSI CH-5232 Switzerland

The electronic structure of iron-pnictide compound superconductor Ba_2ti_2Fe_2As_4O, which has metallic intermediate ti_2O layers, is studied using angle-resolved photoemission spectroscopy. The ti-related bands show a‘peak-dip-hump＇ line shape with two branches of dispersion associated with the polaronic states at temperatures below around 120 K. This change in the spectra occurs along with the resistivity anomaly that was not clearly understood in a previous study. Moreover, an energy gap induced by the superconducting proximity effect opens in the polaronic bands at temperatures below T_c（~21 K）. Our study provides the spectroscopic evidence that superconductivity coexists with polarons in the same bands near the Fermi level, which provides a suitable platform to study interactions between charge, lattice and spin freedoms in a correlated system.

关键词： ti As Coexistence of Polaronic States and Superconductivity in Iron-Pnictide Compound Ba2ti2Fe2As4O Fe Ba