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In Vivo Improvements in Facial Appearance and in Vitro Changes in Gene Expression Using a Topical Formulation Designed to Repair Environmentally Induced DNA Damage

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Journal of Cosmetics, Dermatological Sciences and Applications 2024年第2期14卷 141-173页

作者： Amaryllis Aganahi richard parker Yohei Tanaka RATIONALE Kyneton Australia Clinica Tanaka Plastic Reconstructive Surgery and Anti-aging Center Matsumoto Japan

Background: While sunscreen has been accepted as a mainline defence against photodamage from ultraviolet, visible light and near-infrared radiation, there appears to be a lack of research into photorepair. The concept of protecting the skin during the day and repairing cellular damage at night is intuitive, yet specific strategies revolving around combinations of proven reparative active ingredients remain unelucidated. Purpose: To investigate the efficacy of a solar repair Formulation following ultraviolet and environmental exposure in order to improve overall skin health and appearance through three hypotheses: The Formulation increases expression of DNA repair mechanisms markers;The Formulation enhances overall skin appearance through reducing signs of inflammation, elevating hydration, reinforcing skin firmness and amplifying radiance;In-Vivo efficacy test results are aligned with measured gene expression changes. Methods: The Formulation (#6NIC1.V1.1-1) was tested for: In-vitro LDH cytotoxicity activity, In-vitro qPCR gene expression with and without ultraviolet exposure on a reconstructed 3-dimensional skin model, and In-Vivo efficacy study on a panel of 22 participants objectively and subjectively. Results: Skin radiance, firmness, hydration, redness, and inflammation are significantly improved after In-Vivo skin exposure to the Formulation and environmental challenges such as ultraviolet radiation. These outcomes were confirmed by in-vitro genetic testing on a reconstructed human skin model. Conclusion: The studies allowed us to identify and group results in four main skin functions that were significantly enhanced following the application of the Formulation: firmness, hydration, radiance and soothing.

关键词： Photoprotection Photorepair DNA Repair Anti-Photoaging Gene Expression Antioxidant Rejuvenation

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In Vivo Improvements in Facial Appearance and in Vitro Changes in Gene Expression Using a Topical Formulation Designed to Repair Environmentally Induced DNA Damage

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Journal of Cosmetics, Dermatological Sciences and Applications（化妆品、皮肤病及应用期刊） 2024年第2期 141页

作者： Amaryllis Aganahi richard parker Yohei Tanaka

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CRITICAL THINKING / 7th ed.

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2004年

作者： BROOKE NOEL MOORE richard parker.

Includes index.

ISBN: (数字)0072818816

ISBN: (纸本)0072818816

Includes index.

关键词： Critical thinking.

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The role of adipose tissue in fatty liver diseases

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Liver Research 2018年第1期2卷 35-42页

作者： richard parker Liver Unit St James's University HospitalLeedsUK

Fatty liver disease is almost always a consequence of obesity or alcohol *** both cases significant changes to adipose tissue(AT)occur,which are remarkably similar despite their different *** and hypoxic adipocytes develop an inflammatory phenotype and become necrotic,secreting inflammatory cytokines into circulation,principally but not limited to tumor necrosis factor(TNF)α.The secretion of adipokines is altered in obesity and alcohol *** acids,instead of being stored in adipocytes are delivered to the *** multiple pathways of adipose-liver crosstalk contribute to the development and progression of liver disease:TNFαinduces hepatocyte death and modulates hepatic immune *** acids promote hepatic steatosis and are pro-inflammatory,whilst adipokines mediate and exacerbate liver injury,for example leptin enhances fibrotic responses to *** nonalcoholic fatty liver disease(NAFLD)reducing adipose inflammation through weight loss or thiazolidinediones(TZDs)both improve liver *** data that suggest that this might also be of benefit in alcoholic liver disease(ALD)but human studies are lacking at present.

关键词： Fatty liver disease Adipose tissue(AT) Leptin Adiponectin Tumor necrosis factor(TNF)α

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Up-Regulated Expression of SOD2 and HPRT1 Following Topical Photoprotection and Photorepair Skincare Formulations in A 3-Dimensional Reconstructed Human Skin Model

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第4期13卷 322-332页

作者： Yohei Tanaka richard parker Amaryllis Aganahi Clinica Tanaka Plastic Reconstructive Surgery and Anti-Aging Center Matsumoto Nagano Japan RATIONALE Kyneton Victoria Australia

Photodamage continues to threaten human skin health despite worldwide sun awareness campaigns and the widespread use of sunscreens. To date, extensive research is lacking into the effects of sun avoidance and solar specific skincare regimens on gene expression changes and DNA repair activity. We have previously reported that photoprotection and photorepair formulations which minimize the harmful effects of ultraviolet, visible light and near-infrared radiation can provide photoprotection, anti-photoaging benefits and rejuvenating effects optically, clinically and genetically. To investigate gene expression changes, specifically antioxidant and DNA repair effects following the use of topical photoprotection and photorepair formulations (The Essential Six, RATIONALE, Victoria, Australia), we used epidermal keratinocytes and dermal fibroblasts derived from a 3-dimensional reconstructed human skin model, and assessed upregulation of SOD2 and HPRT1. Gene expression was assessed via the Genemarkers Standard Skin Panel and quantitative real-time PCR exploration. Tissues were inoculated with solar specific topical formulations, then collected after 24 hours following application of photoprotection formulations and 16 hours following photorepair formulations. The quantitative real-time PCR revealed that, in comparison to the control, the genes encoding SOD2 and HPRT1 have been significantly up-regulated following usage of the photoprotection formulations, 1.86, and 1.41, respectively. SOD2 and HPRT1 were up-regulated following use of the photorepair formulations, 2.15, and 1.28, respectively. We were able to substantiate that the photo protection and photorepair formulations upregulated genes involved in antioxidant and DNA repair mechanisms in a 3-dimensional reconstructed human skin model, suggesting a promising anti-photoaging skin regimen. .

关键词： Antioxidant Anti-Photoageing DNA Repair Gene Expression Photoprotection Photorepair

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Photoprotective Ability of Colored Iron Oxides in Tinted Sunscreens against Ultraviolet, Visible Light and Near-Infrared Radiation

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Optics and Photonics Journal 2023年第8期13卷 199-208页

作者： Yohei Tanaka richard parker Amaryllis Aganahi Clinica Tanaka Plastic Reconstructive Surgery and Anti-Aging Center Matsumoto Japan RATIONALE Kyneton Victoria Australia

Solar-induced skin damage continues to pose a problem to human health worldwide, despite the widespread recommendation and use of sunscreens. We have previously reported that solar visible light and near-infrared also contribute to skin damage and photoageing. Most commonly recommended sunscreens are only effective throughout the UV spectrum, offering no protection from visible light and near-infrared. To evaluate the enhanced solar-spectrum blocking ability of iron oxides, a double-beam spectrophotometer was used to optically measure the transmission spectra. The spectrophotometer deploys a unique, single monochromatic design to detect wavelength penetration in the range of 240 to 2600 nm. The sample without iron oxide (control) blocked over 80% of ultraviolet-C and ultraviolet-B but did not block ultraviolet-A, visible light, or near-infrared wavelengths. The samples with yellow, and red iron oxide blocked over 90% ultraviolet, but did not block visible light and near-infrared effectively. The sample with black iron oxide blocked visible light, and near-infrared effectively compared with other samples with yellow, blue, and red iron oxide. The sample with red and black iron oxides, and the sample with yellow, blue, red, and black iron oxides blocked ultraviolet through to near-infrared. It can be concluded that dark colored iron oxide combinations are effective at blocking from ultraviolet through to visible light and near-infrared radiation. The results of this study may also suggest that biological colour of human skin and subcutaneous tissues are conserved for comprehensive photoprotection.

关键词： Anti-Photoageing Photoimmunosuppression Photoprotection Sunscreen Ultraviolet Visible Light Near-Infrared

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Novel Low Viscosity Zinc Oxide, Iron Oxides and Erioglaucine Sunscreen Potential to Protect from Ultraviolet, Visible Light and Near-Infrared Radiation

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Optics and Photonics Journal 2023年第9期13卷 217-226页

作者： Yohei Tanaka richard parker Amaryllis Aganahi Ailen Pedroso Clinica Tanaka Plastic Reconstructive Surgery and Anti-Aging Center Matsumoto Japan RATIONALE Kyneton Australia

Despite the widespread recommendation and use of sunscreens and ultraviolet blocking materials, solar-induced skin damage and photoageing continues to pose a problem to human health worldwide. We have previously reported that solar visible light and near-infrared also contribute to skin damage and photo ageing. Most commonly recommended sunscreens are only effective throughout the UV spectrum, offering no protection from visible light and near-infrared. A possible solution could be to augment sunscreens with metal oxides which block visible light and near-infrared radiation. To evaluate the enhanced solar-spectrum blocking ability of novel low viscosity sunscreen containing zinc and iron oxides, a double-beam spectrophotometer was used to optically measure the transmission spectra. The spectrophotometer deploys a unique, single monochromatic design to detect wavelength penetration in the range of 240 to 2600 nm. The Sunscreen base without zinc oxide and iron oxides (control) blocked over 80% of ultraviolet-C and ultraviolet-B but did not block ultraviolet-A, visible light, or near-infrared. The novel low viscosity zinc oxide sample blocked almost over 90% ultraviolet, but did not block visible light and near-infrared sufficiently. However, the samples with the novel low viscosity zinc oxide, iron oxides and erioglaucine blocked almost over 90% of ultraviolet, visible light and near-infrared. It can be concluded that this novel combination of low viscosity zinc oxide, iron oxides and erioglaucine is effective at blocking ultraviolet, visible light and near-infrared radiation. The results of this study imply that sunscreens that provide comprehensive photoprotection from ultraviolet through to near-infrared should be adopted to prevent skin photodamage.

关键词： Anti-Photoageing Photoimmunosuppression Photoprotection Sunscreen Ultraviolet Visible Light Near-Infrared

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A Non-Invasive Skin Treatment Combining LED with Pharmacologic and Ultrasonic Technologies for Facial Rejuvenation

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第4期13卷 333-344页

作者： Keely Marsh Bianca Coppa Katie Matten richard parker Yohei Tanaka RATIONALE Kyneton Victoria Australia Clinica Tanaka Plastic Reconstructive Surgery and Anti-Aging Center Matsumoto Nagano Japan

Background: Non-invasive facial treatments have the ability to rejuvenate the facial profile when specific pharmacologic agents and modalities are prescribed and used in combination taking into consideration each patient’s unique skin type and condition. RATIONALE Epinova is a non-invasive skin treatment that combines the correct concentrations and combinations of topicals and modalities to elicit facial rejuvenation with no down-time or side effects. Purpose: This paper focuses on facial rejuvenation improvements combining the RATIONALE Essential Six skincare system (RATIONALE, Victoria, Australia) to protect and repair the skin with the RATIONALE Epinova facial treatment every 4-6 weeks—which uses non-invasive technologies and professional strength active ingredients to deliver visible changes to skin tone and texture. Methods: Subjects underwent a RATIONALE consultation, including taking a skin history and skin imaging, followed by a data analysis and diagnosis of skin condition and prescription of a customized RATIONALE treatement (Epinova), including appropriate pharmacologic agents and treatment with personalized photo/sono therapeutic devices. Results: Subjects reported increased skin hydration, tactile improvements, skin firmness and visible radiance following the RATIONALE Epinova treatment. Further investigations will be initiated to explore the potential for longer term improvements, including connenctive tissue deposition, reduction of erythema etc. Treatments should be performed every 4-6 weeks for patients under 40 and every 3-4 weeks for patients over 40, to support cell differentiation, migration and desquamation to achieve non-invasive facial rejuvenation. Conclusion: This study demonstrated that the synergy of pharmacologic, LED light therapy and ultrasonic technologies when prescribed and administered by a trained skin therapist, can lead to a visible improvement in the signs of facial ageing and photodamage, restoring the appearance of healthy, r

关键词： LED Non-Invasive Skin Treatment Pharmacologic Agents Rejuvenation Ul-trasonic Technology

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Up-Regulated Expression of SOD2 and HPRT1 Following Topical Photoprotection and Photorepair Skincare Formulations in A 3-Dimensional Reconstructed Human Skin Model

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Journal of Cosmetics, Dermatological Sciences and Applications（化妆品、皮肤病及应用期刊） 2023年第4期

作者： Yohei Tanaka richard parker Amaryllis Aganahi

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Photoprotective Ability of Colored Iron Oxides in Tinted Sunscreens against Ultraviolet,Visible Light and Near-Infrared Radiation

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Optics and Photonics Journal（光学与光子学期刊） 2023年第8期

作者： Yohei Tanaka richard parker Amaryllis Aganahi

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