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Associations of lifestyle and diet with the risk of nasopharyngeal carcinoma in Singapore:a case–control study

Chinese Journal of Cancer 2017年第2期36卷 63-70页

作者： Sook Kwin Yong Tam Cam Ha Ming Chert richard Yeo Valerie Gaborieau james D.McKay Joseph Wee Division of Clinical Trials and Epidemiological Sciences National Cancer Centre Singapore11 Hospital DriveSingapore 169610Singapore Medical Education Research&Evaluation Department(MERE)Duke-NUS Medical School8 College RoadSingapore 169857Singapore Division of Radiation Oncology National Cancer Centre Singapore11 Hospital DriveSinga-pore 169610Singapore Genetic Cancer Susceptibility Group International Agency for Research on CancerWorld Health Organization150 Cours Albert Thomas69372 Lyon Cedex 08France

Background: Nasopharyngeal carcinoma(NPC) is a commonly diagnosed cancer in Southeast Asia. Many studies have examined the risk factors for NPC, yet the roles of some risk factors remain inconclusive. The purpose of this study was to examine associations between modifiable lifestyle factors and the risk of NPC in the Singaporean ***: We conducted a case–control study in Singapore with 300 patients and 310 controls who were recruited between 2008 and 2012. Each control was selected and individually matched to each patient based on sex, ethnicity, and age(±5 years). A total of 290 pairs of cases and controls were matched successfully. We examined lifestyle factors such as tobacco smoking, alcohol drinking, various salted and preserved food consumption, and weaning ***: After adjusting for covariates, multivariate analysis showed that those participants who were current smokers and had ever smoked tobacco had a higher risk of NPC than participants who had never smoked, with odds ratios(ORs) of 4.50(95% confidence interval [CI] 2.58–7.86; P < 0.001) and 2.52(95% CI 1.54–4.12; P < 0.001), respectively. Those who consumed salted vegetables at least once a week also showed a significantly increased risk of NPC than those who never or rarely consumed salted vegetables, with an OR of 4.18(95% CI 1.69–10.38; P = 0.002).Conclusion: Smoking(currently and ever-smoked) and consuming salted vegetables once a week or more were lifestyle risk factors for NPC, and changes of these factors for the better may reduce the risk of NPC.

关键词： Nasopharyngeal carcinoma Diet Smoking Alcohol drinking Case–control study Preserved food

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MicroRNA sequences modulating inflammation and lipid accumulation in macrophage “foam” cells: Implications for atherosclerosis

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World Journal of Cardiology 2020年第7期12卷 303-333页

作者： richard james Lightbody Janice Marie Walsh Taylor Yvonne Dempsie Annette Graham Department of Biological and Biomedical Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgow G40BAUnited Kingdom

Accumulation of macrophage"foam"cells,laden with cholesterol and cholesteryl ester,within the intima of large arteries,is a hallmark of early"fatty streak"lesions which can progress to complex,multicellular atheromatous plaques,involving lipoproteins from the bloodstream and cells of the innate and adaptive immune *** accumulation triggers induction of genes encoding proteins mediating the atheroprotective cholesterol efflux *** the arterial intima,however,this mechanism is overwhelmed,leading to distinct changes in macrophage phenotype and inflammatory *** the last decade marked gains have been made in understanding of the epigenetic landscape which influence macrophage function,and in particular the importance of small non-coding micro-RNA(miRNA)sequences in this *** review identifies some of the miRNA sequences which play a key role in regulating"foam"cell formation and atherogenesis,highlighting sequences involved in cholesterol accumulation,those influencing inflammation in sterol-loaded cells,and novel sequences and pathways which may offer new strategies to influence macrophage function within atherosclerotic lesions.

关键词： Coronary heart disease Atherosclerosis Macrophage“foam”cell Cholesterol Inflammation MicroRNA

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Relating environmental variables with aquatic community structure in an agricultural/urban coldwater stream

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Ecological Processes 2021年第1期10卷 481-499页

作者： Daniel T.L.Myers richard R.Rediske james N.McNair Aaron D.Parker E.Wendy Ogilvie Annis Water Resources Institute Grand Valley State University740 W Shoreline DriveMuskegonMI 49401USA. Michigan Department of Environment Great Lakesand Energy525 W Allegan StreetLansingMI 48909USA. Grand Valley Metropolitan Council 678 Front Avenue NWSuite 200Grand RapidsMI 49504USA.

Background:Urban areas are often built along large rivers and surrounded by agricultural *** may lead to small tributary streams that have agricultural headwaters and urbanized lower *** study objectives assessed are as follows:(1)landscape,geomorphic,and water quality variables that best explained variation in aquatic communities and their integrity in a stream system following this agricultural-to-urban land use gradient;(2)ways this land use gradient caused aquatic communities to differ from what would be expected for an idealized natural stream or other longitudinal gradients;and(3)whether the impacts of this land use gradient on aquatic communities would grow larger in a downstream direction through the agricultural and urban *** study area was an impaired coldwater stream in Michigan,***:Many factors structured the biological communities along the agricultural-to-urban land use *** woody debris had the strongest relationship with EPT(Ephemeroptera,Plecoptera,and Trichoptera)abundance and richness and were most common in the lower,urbanized *** streambed substrate had the strongest relationship with Diptera taxa and surface air breather macroinvertebrates and was dominant in agricultural *** community assemblage was influenced largely by stream flow and temperature regimes,while poor fish community integrity in lower urban reaches could be impacted by geomorphology and episodic urban pollution *** macroinvertebrates were most abundant in deforested,first-order agricultural headwaters,while EPT macroinvertebrate richness was the highest downstream of agricultural areas within the urban zone that had extensive forest ***:Environmental variables and aquatic communities would often not conform with what we would expect from an idealized natural *** richness improved downstream of agricultural *** shows promise for the recovery of aquatic systems using we

关键词： Land use Habitat Stream Fish Macroinvertebrate Gradient

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A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia

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Asian Journal of Andrology 2020年第2期22卷 222-226页

作者： Scott J Morin Brent M Hanson Caroline R Juneau Shelby A Neal Jessica N Landis richard T Scott Jr james M Hotaling Reproductive Medicine Associates of New Jersey 140 Allen RoadBasking RidgeNJ 07920USA Division of Reproductive Endocrinology and Infertility Department of Obstetrics and GynecologySidney Kimmel Medical College at Thomas Jefferson University833 Chestnut StreetPhiladelphiaPA 19107USA Foundation for Embryonic Competence 140 Allen RoadBasking RidgeNJ 07920USA Division of Urology Department of SurgeryUniversity of Utah School of Medicine30 N 1900 ESalt Lake CityUT 84132USA Department of Obstetrics and Gynecology University of Utah School of Medicine30 N 1900 ESalt Lake CityUT 84132USA.An abbreviated version of this manuscript was published and presented as an abstract at the American Society for Reproductive Medicine(ASRM)2017 Scientific Congress.

This is a retrospective cohort study comparing blastocyst transfer outcomes following intracytoplasmic sperm injection utilizing epididymal versus testicular sperm for men with obstructive *** cases at a single center between 2012 and 2016 were *** approach was selected at the surgeon’s discretion and included microepididymal sperm aspiration or testicular sperm *** culture was exclusively utilized prior to *** primary outcome was live birth *** outcomes included fertilization rate,blastulation rate,euploidy rate,and implantation rate.A mixed effects model was ***-six microepididymal sperm aspiration cases and 93 testicular sperm extraction cases were *** live birth rate was equivalent(48.6%vs 50.5%,P=0.77).However,on mixed effects model,epididymal sperm resulted in a greater likelihood of fertilization(adjusted OR:1.37,95%CI:1.05–1.81,P=0.02)and produced a higher blastulation rate(adjusted OR:1.41,95%CI:1.1–1.85,P=0.01).As a result,the epididymal sperm group had more supernumerary blastocysts available(4.3 vs 3,P<0.05).The euploidy rate was no *** rates were no different through the first transfer ***,intracytoplasmic sperm injection following microepididymal sperm aspiration resulted in a greater number of usable blastocysts per ***,the true benefit of epididymal sperm may only be demonstrated via a comparison of cumulative pregnancy rates after multiple transfers from one cohort.

关键词： azoospermia intracytoplasmic sperm injection male infertility testicular sperm extraction

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Porphyria cutanea tarda as a complication of therapy for chronic hepatitis C

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World Journal of Gastroenterology 2008年第38期14卷 5913-5915页

作者： james Azim Heather McCurdy richard H Moseley Division of Gastroenterology Department of Internal Medicine Department of Veterans Affairs Medical Center and University of Michigan School of Medicine Ann ArborMichigan United States

There is a strong association between porphyria cutanea tarda (PCT) and chronic viral hepatitis C. Therapy for chronic viral hepatitis C may improve PCT. However, there are only a few reports of the de novo development of PCT during therapy for chronic viral hepatitis C. We describe the development of PCT in a 56-year-old patient with chronic viral hepatitis C after 12 wk of peginterferon/ribavirin therapy. In addition, the patient was homozygous for the H63D hereditary hemochromatosis gene (HFE ) mutation. The association of PCT with chronic viral hepatitis C and the possible role of hepatic iron overload and ribavirin-induced hemolytic anemia in the development of PCT during therapy for chronic viral hepatitis C are discussed.

关键词： Porphyria Hepatitis C virus Ribavirin Pegylated interferon Hemochromatosis

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An enhanced functional ability questionnaire(faVIQ) to measure the impact of rehabilitation services on the visually impaired

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 77-85页

作者： james Stuart Wolffsohn Jonathan Jackson Olivia Anne Hunt Charles Cottriall Jennifer Lindsay richard Gilmour Anne Sinclair Robert Harper Aston University Life and Health SciencesOphthalmic Research Group Australian College of Optometry Royal Victoria Hospital Oxford Eye Hospital Royal Victoria Hospital Belfast Altnagelvin Area Hospital Low Vision Clinic Fife Low Vision Centre for the Blind Manchester Royal Eye Hospital and Manchester Academic and Health Science Centre Central Manchester University Hospitals NHS Foundation Trust

AIM: To develop a short,enhanced functional ability Quality of Vision(faVIQ) instrument based on previous questionnaires employing comprehensive modern statistical techniques to ensure the use of an appropriate response scale,items and scoring of the visual related difficulties experienced by patients with visual impairment. · METHODS: Items in current quality-of-life questionnaires for the visually impaired were refined by a multi-professional group and visually impaired focus groups. The resulting 76 items were completed by 293 visually impaired patients with stable vision on two occasions separated by a month. The faVIQ scores of 75 patients with no ocular pathology were compared to 75 age and gender matched patients with visual impairment. ·RESULTS: Rasch analysis reduced the faVIQ items to 27. Correlation to standard visual metrics was moderate(r =0.32-0.46) and to the NEI-VFQ was 0.48. The faVIQ was able to clearly discriminate between age and gender matched populations with no ocular pathology and visual impairment with an index of 0.983 and 95% sensitivity and 95% specificity using a cut off of 29.·CONCLUSION: The faVIQ allows sensitive assessment of quality-of-life in the visually impaired and should support studies which evaluate the effectiveness of low vision rehabilitation services.

关键词： quality of life visual impairment low vision functional ability sensitivity specificity

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Inexpensive Geophysical Instruments Supporting Groundwater Exploration in Developing Nations

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Journal of Water Resource and Protection 2011年第10期3卷 768-780页

作者： james A. Clark richard Page 不详

Geophysical methods are often used to aid in exploration for safe and abundant groundwater. In particular resistivity and seismic refraction methods are helpful in determining depth to bedrock and zones of saturation in the subsurface. However the expense of these instruments ($5000 to $20,000) has resulted in their limited use in developing countries. This paper describes how to construct these devices for less than $250 each. The instruments are small, light and robust and are as useful for groundwater exploration as the commercial models for shallow aquifers (less than 35 m deep) where wells can be hand dug, augured or drilled with small portable drill rigs. Data interpretation can be accomplished quickly in the field with free software implemented on a laptop computer. A suite of geophysical instruments and software can therefore be assembled for less than $850. This paper gives the design for these instruments and essential information needed to use them. It is hoped that these inexpensive geophysical instruments can be widely distributed among drillers and aid workers in developing countries, improving the success rate of water wells.

关键词： Groundwater Geophysics Inexpensive Developing World Resistivity Seismic Refraction Groundwater Exploration

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The wings of the dove

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作者： Henry james edited by J. Donald Crowley and richard A. Hocks.

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Maturity-associated considerations for training load,injury risk,and physical performance in youth soccer:One size does not fit all

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Journal of Sport and Health Science 2021年第4期10卷 403-412页

作者： Chris Towlson Jamie Salter Jack D.Ade Kevin Enright Liam D.Harper richard M.Page james J.Malone Department of Sport Health and Exercise ScienceUniversity of HullHull HU67RXUK School of Sport York St John UniversityYork YO317EXUK Liverpool FC Academy Liverpool Football ClubLiverpool L337EDUK Research Institute for Sport and Exercise Sciences L3Liverpool John Moores UniversityLiverpool L33AUK Human and Health Sciences University of HuddersfieldHuddersfield HD13DHUK Department of Sport and Physical Activity Edge Hill UniversityOrmskirk L394QPUK School of Health Sciences Liverpool Hope UniversityLiverpool L169JDUK

Biological maturation can be defined as the timing and tempo of progress to achieving a mature *** estimation of age of peak height velocity(PHV)or percentage of final estimated adult stature attainment(%EASA)is typically used to inform the training process in young *** youth soccer,maturity-related changes in anthropometric and physical fitness characteristics are diverse among individuals,particularly around *** this time,players are also at an increased risk of sustaining an overuse or growth-related *** a result,the implementation of training interventions can be *** purpose of this review was to(1)highlight and discuss many of the methods that can be used to estimate maturation in the applied setting and(2)discuss the implications of manipulating training load around PHV on physical development and injury *** have provided key stakeholders with a practical online tool for estimating player maturation status(Supplementary Maturity Estimation Tools).Whilst estimating maturity using predictive equations is useful in guiding the training process,practitioners should be aware of its *** increase the accuracy and usefulness of data,it is also vital that sports scientists implement reliable testing protocols at predetermined time-points.

关键词： Growth Injury Maturation Soccer Training

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Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis

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World Journal of Gastroenterology 2013年第39期19卷 6656-6664页

作者： james D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay richard B Gearry Rebecca L Roberts Department of Medicine University of OtagoChristchurch 8011New Zealand Department of Gastroenterology Christchurch HospitalChristchurch 8011New Zealand Department of Biochemistry University of OtagoDunedin 9054New Zealand Department of Pathology University of OtagoChristchurch 8011New Zealand Department of Surgical Sciences Dunedin School of MedicineDunedin 9054New Zealand

AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)***:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,*** were analysed for single site and haplotype association with IBD risk and ***-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with *** published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified *** genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel *** New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,***:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni ***-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall ***,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients

关键词： Crohn’s disease Ulcerative colitis Migration inhibitory factor rs755622 rs5844572 Genetic association study

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