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Etiology and management of urethral calculi:A systematic review of contemporary series

Asian journal of Urology 2024年第1期11卷 10-18页

作者： Andrew Morton Arsalan Tariq Nigel Dunglison Rachel Esler Matthew j.roberts Faculty of Medicine The University of QueenslandBrisbaneQueenslandAustralia Department of Urology Ipswich HospitalQueenslandAustralia Department of Urology Royal Brisbane and Women's HospitalQueenslandAustralia The University of Queensland Centre for Clinical Research HerstonAustralia

Objective:To conduct a systematic literature review on urethral calculi in a contemporary cohort describing etiology,investigation,and management ***:A systematic search of MEDLINE and Cochrane Central Register of Controlled Trials(CENTRAL)databases was ***,including case reports and case series on urethral calculi published between january 2000 and December 2019,were ***-text manuscripts were reviewed for clinical parameters including symptomatology,etiology,medical history,investigations,treatment,and *** were collated and analyzed with univariate ***:Seventy-four publications met inclusion criteria,reporting on 95 *** symptoms(41.1%),pain(40.0%),and acute urinary retention(32.6%)were common presenting *** calculi were most often initially investigated using plain X-ray(63.2%),with almost all radio-opaque(98.3%).Urethral calculi were frequently associated with coexistent bladder or upper urinary tract calculi(16.8%)and underlying urethral pathology(53.7%)including diverticulum(33.7%)or stricture(13.7%).Urethral calculi were most commonly managed with external urethrolithotomy(31.6%),retrograde manipulation(22.1%),and endoscopic in situ lithotripsy(17.9%).Conclusion:This unique systematic review of urethral calculi provided a summary of clinical features and treatment trends with a suggested treatment *** in contemporary urological practice should be according to calculus size,shape,anatomical location,and presence of urethral pathology.

关键词： Urinary calculi Urethra Urethral calculi Management algorithm

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DNA序列分析与计算机的应用

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中国生物工程杂志 1981年第3期 24-29页

作者： Thomas R.Gingcras richard j.roberts 阮可三中国科学院生物物理所二室

研究核酸结构和功能相互关系的各种规律,这是科学工作者的基本目标。对分子生物学家来说,这意味着去弄清核酸序列中所包含的信息。这就是说要去分析和介绍这些序列的真正含义。由于大部分DNA分子实在太长,长期以来严重地妨害了我们对DN... 详细信息

研究核酸结构和功能相互关系的各种规律,这是科学工作者的基本目标。对分子生物学家来说,这意味着去弄清核酸序列中所包含的信息。这就是说要去分析和介绍这些序列的真正含义。由于大部分DNA分子实在太长,长期以来严重地妨害了我们对DNA分子进一步研究的种种努力。幸而,人们发现了限制性内切酶,这种酶可以把DNA大分

关键词：序列分析领域全序列长序列序列数据计算机 DNA

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The risk of prostate cancer on incidental finding of an avid prostate uptake on 2-deoxy-2-[^(18)F]fluoro-D-glucose positron emission tomography/computed tomography for non-prostate cancer-related pathology:A single centre retrospective study

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Asian journal of Urology 2024年第1期11卷 33-41页

作者： Anthony Franklin Troy Gianduzzo Boon Kua David Wong Louise McEwan james Walters Rachel Esler Matthew j.roberts Geoff Coughlina john W.Yaxley Department of Urology The Wesley HospitalBrisbaneQLDAustralia Wesley Medical Research BrisbaneQLDAustralia School of Medicine The University of QueenslandBrisbaneQLDAustralia Department of Radiology Wesley Medical ImagingBrisbaneQLDAustralia Department of Urology Royal Brisbane and Women's HospitalBrisbaneQLDAustralia

Objective:To review the risk of prostate cancer(PCa)in men with incidentally reported increased intraprostatic uptake at 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)ordered at Department of Urology,The Wesley Hospital,Brisbane,QLD,Australia for non-PCa related ***:Retrospective analysis of consecutive men between August 2014 and August 2019 presenting to a single institution for 18F-FDG PET/CT for non-prostate related conditions was *** were classified as benign,indeterminate,or malignant depending of the results of prostate-specific antigen(PSA),PSA velocity,biopsy histopathology,and three-Tesla(3 T)multiparametric MRI(mpMRI)Prostate Imaging Reporting and Data System score,or gallium-68-prostate-specific membrane antigen(68Ga-PSMA)PET/CT ***:Three percent(273/9122)of men demonstrated 18F-FDG avidity within the ***-five percent(231/273)were further investigated,including with PSA tests(227/231,98.3%),3 T mpMRI(68/231,29.4%),68Ga-PSMA PET/CT(33/231,14.3%),and prostate biopsy(57/231,24.7%).Results were considered benign in 130/231(56.3%),indeterminate in 31/231(13.4%),and malignant in 70/231(30.3%).PCa was identified in 51/57(89.5%)of the men who proceeded to biopsy,including 26/27(96.3%)men with Prostate Imaging Reporting and Data System scores 4-5 mpMRI and six men with a positive 68Ga-PSMA PET/*** most common Gleason score on biopsy was greater than or equal to 4+5(14/51,27.5%).68Ga-PSMA PET/CT was concordant with the 18F-FDG findings in 26/33(78.8%).All 13 men with a positive concordant 18F-FDG,3 T mpMRI,and 68Ga-PSMA PET/CT had PCa on *** was no statistically significant difference in the 18F-FDG maximum standardized uptake value between the benign or malignant groups(5.7 vs.6.1;p=0.580).Conclusion:In this study,after an incidental finding of an avid intraprostatic lesion on 18F-FDG PET/CT,70 of the 231 cases(30.3%;0.8%of the entire cohort)had results c

关键词： Prostatecancer Positionemission tomography Multiparametric magneticresonance imaging Prostatebiopsy

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Surgical management of the diabetic foot:The current evidence

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World journal of Orthopedics 2024年第5期15卷 404-417页

作者： richard Henry Randall roberts Gareth Rhys Davies-jones james Brock Vaishnav Satheesh Greg Aj.robertson Department of Trauma and Orthopaedics Wrexham Maelor HospitalWrexham LL137TDUnited Kingdom Department of Trauma and Orthopaedics The Robert Jones and Agnes Hunt Orthopaedic HospitalOswestry SY107AGUnited Kingdom

The prevalence of diabetes mellitus and its associated complications,particularly diabetic foot pathologies,poses significant healthcare challenges and economic burdens *** review synthesises current evidence on the surgical management of the diabetic foot,focusing on the interplay between neuropathy,ischemia,and infection that commonly culminates in ulcers,infections,and,in severe cases,*** escalating incidence of diabetes mellitus underscores the urgency for effective management strategies,as diabetic foot complications are a leading cause of hospital admissions among diabetic patients,significantly impacting morbidity and mortality *** review explores the pathophysiological mechanisms underlying diabetic foot complications and further examines diabetic foot ulcers,infections,and skeletal pathologies such as Charcot arthropathy,emphasising the critical role of early diagnosis,comprehensive management strategies,and interdisciplinary care in mitigating adverse *** addressing surgical interventions,this review evaluates conservative surgeries,amputations,and reconstructive procedures,highlighting the importance of tailored approaches based on individual patient profiles and the specific characteristics of foot *** integration of advanced diagnostic tools,novel surgical techniques,and postoperative care,including offloading and infection control,are discussed in the context of optimising healing and preserving limb function.

关键词： Diabetes Diabetic foot Charcot Osteomyelitis Amputation Diabetic foot attack Conservative surgery

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The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges

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BioDesign Research 2020年第1期2020卷 1-8页

作者： Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry jacoby Mary Lidstrom jerry Melillo Ron Milo Keith Paustian john Reilly richard j.roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang Department of Biomedical Engineering and Program in Bioinformatics College of EngineeringBoston UniversityBoston MA 02215USA The NOVIM Group Kohn HallUC Santa BarbaraCA 93106USA Climate Institute WashingtonDCUSA Department of Energy WashingtonDCUSA Center for Health Law Ethics&Human Rights at the Boston University School of Public HealthSchool of MedicineBoston UniversityUSA Department of Bioengineering University of CaliforniaBerkeley CAUSA Department of Genetics Harvard Medical SchoolCambridge MAUSA School for the Future of Innovation in Society Arizona State UniversityBarrett&O’Connor Washington Center1800 I StreetNWWashingtonDC 20006USA Sloan School of Management MITCambridge MAUSA Department of Chemical Engineering University of WashingtonSeattle WashingtonUSA The Ecosystems Center of the Marine Biological Laboratory in Woods Hole MAUSA Department of Plant and Environmental Sciences Weizmann Institute of ScienceRehovotIsrael Department of Soil and Crop Sciences Colorado State UniversityFort Collins CO 80523USA MIT joint Program on the Science and Policy of Global Change MITCambridge MAUSA New England Biolabs Beverly MAUSA Department of Biology and Program in Bioinformatics Boston UniversityBoston MA 02215USA Department of Earth Atmospheric and Planetary SciencesMITCambridge MAUSA Soil and Crop Sciences Section School of Integrated Plant SciencesCornell UniversityIthaca NYUSA Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TNUSA Biosciences Division Oak Ridge National LaboratoryOak RidgeTNUSA

The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory *** and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric *** participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,june Medford,jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala jones Prather,Kent Redford,David Resnik,john Reilly,richard ***,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and *** include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed.

关键词： Synthetic roberts enable

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Multi-Time-Scale Variational Mode Decomposition-Based Robust Fault Diagnosis of Railway Point Machines Under Multiple Noises

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Chinese journal of Electronics 2024年第3期33卷 814-822页

作者： junqi LIU Tao WEN Guo XIE Yuan CAO Clive roberts Shaanxi Key Laboratory of Complex System Control and Intelligent Information Processing Xi'an University of Technology The School of Electronic and Information Engineering Beijing Jiaotong University Birmingham Centre for Railway Research and Education University of Birmingham

The fault diagnosis of railway point machines(RPMs) has attracted the attention of engineers and *** have studies considered diverse noises along the *** fulfill this aspect,a multi-time-scale variational mode decomposition(MTSVMD) is proposed in this paper to realize the accurate and robust fault diagnosis of RPMs under multiple *** decomposes condition monitoring signals after coarse-grained processing in varying *** this manner,the information contained in the signal components at multiple time scales can construct a more abundant feature space than at a single *** the experimental validation,a random position,random type,random number,and random length(4R) noise-adding algorithm helps to verify the robustness of the *** adequate experimental results demoristrate the superiority of the proposed MTSVMD-based fault diagnosis.

关键词： Fault diagnosis Condition monitoring Noise Signal processing algorithms Aerospace electronics Rail transportation Robustness

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Determining minimum sample size for the conditioned Latin hypercube sampling algorithm

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Pedosphere 2024年第3期34卷 530-539页

作者： Daniel D.SAURETTE Asim BISWAS richard j.HECK Adam W.GILLESPIE Aaron A.BERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In digital soil mapping(DSM),a fundamental assumption is that the spatial variability of the target variable can be explained by the predictors or environmental *** to adequately sample the predictors have been well documented,with the conditioned Latin hypercube sampling(cLHS)algorithm receiving the most attention in the DSM *** advances in sampling design,a critical gap remains in determining the number of samples required for DSM *** propose a simple workflow and function coded in R language to determine the minimum sample size for the cLHS algorithm based on histograms of the predictor variables using the Freedman-Diaconis rule for determining optimal bin *** preprocessing was included to correct for multimodal and non-normally distributed data,as these can affect sample size determination from the *** on a user-selected quantile range(QR)for the sample plan,the densities of the histogram bins at the upper and lower bounds of the QR were used as a scaling factor to determine minimum sample *** technique was applied to a field-scale set of environmental covariates for a well-sampled agricultural study site near Guelph,Ontario,Canada,and tested across a range of *** results showed increasing minimum sample size with an increase in the QR *** sample size increased from 44 to 83 when the QR increased from 50% to 95% and then increased exponentially to 194 for the 99%*** technique provides an estimate of minimum sample size that can be used as an input to the cLHS algorithm.

关键词： bin width digital soil mapping normal distribution quantile range sampling design

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Exertional calf pain at kilometer five - Finding the cause

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Sports Medicine and Health Science 2024年第1期6卷 89-93页

作者： Samuel A.Renier Angela M.Voight Emilee j.Trost William O.roberts St.john's Hospital Family Medicine Residency Department of Family Medicine and Community HealthUniversity of Minnesota Medical SchoolMinneapolisMNUSA Summit Orthopedics Woodbury Clinic2090 Woodwinds Dr.WoodburyMN55125USA Minnesota Distance Elite 4007Forest RdMinneapolisMN55416USA Department of Family Medicine and Community Health University of Minnesota Medical School516 Delaware St.SE6-240 Phillips-Wangensteen BuildingMinneapolisMN55455USA

A 23-year-old professional distance runner with several years of exertional calf pain was diagnosed with a unique mixed type III and functional popliteal artery entrapment syndrome(PAES).Surgical reduction of the obstructing tissue allowed her to return to professional *** case highlights the importance of including PAES in the differential for chronic intermittent lower extremity claudication and outlines the work-up required to diagnose this vascular obstruction in younger athletes.

关键词： Claudication Lower leg pain Vascular imaging PAES FPAES Popliteal entrapment

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Design,Development and Testing of the jTech Bolt for Use in Static,Quasi-Static and Dynamic Domains

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journal of Civil Engineering and Architecture 2024年第6期18卷 282-295页

作者： Trent roberts jennmar Australia Pty Ltd. 40-44 Anzac Avenue Smeaton Grange NSW 2567Australia

Designing a rock reinforcement element requires knowledge of:geomechanical behaviour,interaction of the reinforcement element with rock mass and the element’s mechanistic response in static and dynamic *** this knowledge the jTech bolt was developed and subjected to a thorough program to test,gather data and validate the bolt performance in varying *** conducting FE(finite element)modeling,the simulation reviews the jTech bolt design evaluating the effects of threadbar geometric variation,threadbar and nut engagement results under high stress,coating friction response and effects of thread tolerance extremes on the failure *** results determine safety factors,tolerances and quality management *** manufactured,in-situ system testing,laboratory and underground short encapsulation testing,resin mixing testing,double shear testing and dynamic testing at varying velocity and mass,determine the system’s capacity and effectiveness in static,quasi-static and dynamic mining *** this paper,the process and results are described.

关键词： Rock reinforcement geomechanical behavior static quasi-static dynamic domains

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Hepatic vein reconstruction during hepatectomy:A feasible and underused technique

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 421-427页

作者： Manish Ahuja Kunal joshi Chris Coldham Paulo Muiesan Bobby Dasari Manuel Abradelo Ravi Marudanayagam Darius Mirza john Isaac David Bartlett Nikolaos A Chatzizacharias Robert P Sutcliffe Keith j.roberts Department of HPB and Liver Transplant Surgery University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Immunology and Immunotherapy University of BirminghamBirminghamUK

Complete surgical resection(R0)of liver tumors,primary or metastatic,remains the main objective in management of primary and metastatic liver tumors[1].Tumors invading to the proximity of the hepatic venous outflow pose a peculiar challenge to achieve R0 resections,because this location may render a tumor *** median survival of patients with liver tumor without surgery is less than 12 months[2].Even with surgery,post-hepatectomy liver failure and subsequently increased mortality are the main problems associated with complex resection[3].Moreover,when the vein is affected,vein resection and subsequent reconstruction are *** resection is a standard practice in liver resection and transplantation[4],for example,hepatic vein reconstruction during a living-donor liver transplant,porto-mesenteric axis reconstruction during resection of advanced pancreatic cancer and caval reconstruction during resection of retroperitoneal ***,novel techniques like total hepatic vascular exclusion(HVE)[5],veno-venous bypass[6]and ex vivo hepatic resection[7,8]have facilitated curative resections of tumors close to one or more major hepatic veins.

关键词： hepatectomy surgery mortality

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