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Pharmacological effects of aqueous-ethanolic extract of Hibiscus rosasinensis on volume and acidity of stimulated gastric secretion

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Asian Pacific journal of Tropical Medicine 2011年第11期4卷 883-888页

作者： Rajesh j Mandade SA Sreenivas DM Sakarkar Avijit Choudhury Pharmacology Department S.N.Institute of PharmacyPusadIndia Guru Nanak Institute of Pharmacy IbrahimpattnamHyderabad.(A.P.) India S.N.Institute of Pharmacy PusadIndia Pharmacology Department Shree Dhanvantary college pharmacyKimIndia

Objective:To explore the effects of extract of Hibiscus rosasinensis(***) on the volume,free and total acidity of gastric secretion induced by ***:Animals were kept on fasting for 48 *** the pylorus of each animal was *** were randomly divided into 5 groups and treated by carbachol at 600μg/*** animals in groupⅡ-Ⅴwere treated by *** extract at 250 and 500 mg/kg body weight,cimetidine at 2.5 mg/ kg and verapamil at 10 mg/kg body weight intraperitoneally,*** volume,free and total acidity of gastric secretion were observed and ***:It was found that the extract significantly reduced the volume,free and total acidity of gastric secretion(P<0.01). These reductions were comparable to cimetidine and *** the reduction in the volume and free acidity were more significant in cimetidine and verapamil treated group indicating that cimetidine and verapamil were more ***:The extract of *** can reduced the volume,free and total acidity of gastric secretion,and can be used effectively in the treatment of peptic ulcer.

关键词： Verapamil Cimetidine Carbachol Hibiscus rosasinensis Rats

Manipulating extrinsic and intrinsic obstacles to axonal regeneration after spinal cord injury

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Neural Regeneration Research 2016年第2期11卷 224-225页

作者： Eugene Mironets Di Wu Veronica j.Tom Department of Neurobiology and Anatomy Drexel University College of Medicine

Spinal cord injury（SCI）is a traumatic event that can lead to permanent motor and sensory *** the initial trauma,axons of surviving neurons rapidly *** there may be a small degree of abortive sprouting,virtually all attempts at robust regrowth across the lesion site ultimately ***,neurons below the level of the injury are permanently disconnected from their normal input,resulting in persistent loss of function.

关键词： Rheb Manipulating extrinsic and intrinsic obstacles to axonal regeneration after spinal cord injury

Preface: Metamorphism and Orogenic Belts——Response from Micro-to Macro-Scale

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journal of Earth Science 2019年第6期30卷 1075-1083页

作者： Xu-Ping Li Hans-Peter Schertl jürgen Reinhardt Shandong Key Laboratory of Depositional Mineralization and Sedimentary Minerals Shandong University of Science and TechnologyQingdao 266590China Ruhr-University Bochum Institute of GeologyMineralogy and GeophysicsD-44780 BochumGermany College of Earth Science and Engineering Shandong University of Science and TechnologyQingdao 266590China Department of Earth Sciences University of the Western CapeBellville 7535South Africa

The geological toolbox for the analysis of orogenic processes has seen substantial additions over the recent *** advances have been made in the ability to simulate geological conditions and processes by computer modeling,we have a much improved knowledge of geochemical processes(trace elements and isotopes in particular),and,last but not least,the range and versatility of micro-analytical methods and instrumentation available to us has been expanded *** latter aspect has had a particular impact on metamorphic petrology as the conventional tools to determine pressure-temperaturetime paths via rock and mineral analysis combined with isotope geochronology have generally gained in precision and accuracy through a much improved *** has moved from whole-grain analysis to spot analyses on zoned single grains while analyzing trace elements and isotopes at the same *** is therefore possible to recognize complex multi-stage orogenic events in single samples or single *** profiles in minerals provide us with time-scales of metamorphic and magmatic *** and trace elements as well as isotope profiles of mineral grains give us insight into changing ambient conditions during mineral *** special issue focuses on pressure-temperature conditions and geochronology of metamorphic rocks,isotope studies of magmatic rocks,partial melting and metasomatic processes,all with a view at tectonic implications and *** of the evidence has been gained from small-scale observation and *** field work and detailed microscopic examination remain indispensable,though,as demonstrated clearly by the"expansion"of the P-T space as applicable to crustal metamorphic processes towards extreme pressures and *** a consequence,much interest has thus focused on UHP and UHT rocks and the orogenic processes that generate *** is petrological evidence for subduction to,and subsequent exhumation fr

关键词： orogeny metasomatism UHP metamorphism UHT metamorphism geochemistry geochronology

Managing reservoir sedimentation by venting turbidity currents:A review

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International journal of Sediment Research 2016年第3期31卷 195-204页

作者： Sabine Chamoun Giovanni De Cesare Anton j.Schleiss Laboratory of Hydraulic Constructions(LCH) Swiss Federal Institute of Technology Lausanne(EPFL)

Reservoir sedimentation is an issue that dam operators are increasingly facing as dams are *** only does it reduce a reservoir's capacity but it also affects its outlet structures such as bottom outlets and powerhouse *** may also impoverish downstream *** these reasons,several strategies for sediment management are being investigated and applied *** these methods,venting of turbidity currents reaching the dam can be very beneficial and *** measure helps in preserving a certain continuity of sediment transport in rivers obstructed by ***,several practical but also theoretical challenges hamper this technique,rendering its use less common and its aspects relatively *** present paper aims to gather the actual state-of-the-art concerning turbidity currents venting and to present an outlook for future development and research in this field.

关键词： Reservoir management Sedimentation Turbidity current Venting efficiency Bottom outlet

How Do Sugars Regulate Plant Growth and Development？ New Insight into the Role of Treha Iose-6-Phosphate

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Molecular Plant 2013年第2期6卷 261-274页

作者： Liam E. O'Hara Matthew j. Paul Astrid Wingler Genetics Evolution and Environment University College London Gower Street London WCl E 6BT UK Plant Science Rothamsted Research Harpenden Hertfordshire AL5 2JQ UK

Plant growth and development are tightly controlled in response to environmental conditions that influence the availability of photosynthetic carbon in the form of sucrose. Trehalose-6-phosphate （T6P）, the precursor of trehalose in the biosynthetic pathway, is an important signaling metabolite that is involved in the regulation of plant growth and development in response to carbon availability. In addition to the plant＇s own pathway for trehalose synthesis, formation of T6P or trehalose by pathogens can result in the reprogramming of plant metabolism and development. Developmental processes that are regulated by T6P range from embryo development to leaf senescence. Some of these processes are regulated in interaction with phytohormones, such as auxin. A key interacting factor of T6P signaling in response to the environment is the protein kinase sucrose non-fermenting related kinase-1 （SnRK1）, whose catalytic activity is inhibited by T6R SnRK1 is most likely involved in the adjustment of metabolism and growth in response to starvation. The transcription factor bZlP11 has recently been identified as a new player in the T6P/SnRK1 regulatory pathway. By inhibiting SnRK1, T6P promotes biosynthetic reactions. This regulation has important consequences for crop production, for example, in the developing wheat grain and during the growth of potato tubers.

关键词： bZlP11 carbon availability plant development starvation sucrose non-fermenting related kinase-1 (SnRK1) trehalose trehalose-6-phosphate.

Targeting cell death signaling in colorectal cancer:Current strategies and future perspectives

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World journal of Gastroenterology 2014年第8期20卷 1923-1934页

作者： Bruno Christian Koehler Dirk jger Henning Schulze-Bergkamen National Center for Tumor Diseases University Hospitals Heidelberg69120 HeidelbergGermany

The evasion from controlled cell death induction has been considered as one of the hallmarks of cancer cells. Defects in cell death signaling are a fundamental phenomenon in colorectal cancer. Nearly any non-invasive cancer treatment finally aims to induce cell death. However, apoptosis resistance is the major cause for insufficient therapeutic success and disease relapse in gastrointestinal oncology. Various compounds have been developed and evaluated with the aim to meet with this obstacle by triggering cell death in cancer cells. The aim of this review is to illustrate current approaches and future directions in targeting cell death signaling in colorectal cancer. The complex signaling network of apoptosis will be demonstrated and the “druggability” of targets will be identified. In detail, proteins regulating mitochondrial cell death in colorectal cancer, such as Bcl-2 and survivin, will be discussed with respect to potential therapeutic exploitation. Death receptor signaling and targeting in colorectal cancer will be outlined. Encouraging clinical trials including cell death based targeted therapies for colorectal cancer are under way and will be demonstrated. Our conceptual understanding of cell death in cancer is rapidly emerging and new types of controlled cellular death have been identified. To meet this progress in cell death research, the implication of autophagy and necroptosis for colorectal carcinogenesis and therapeutic approaches will also be depicted. The main focus of this topic highlight will be on the revelation of the complex cell death concepts in colorectal cancer and the bridging from basic research to clinical use.

关键词： Colorectal cancer Apoptosis Necroptosis Autophagy Clinical trial Bcl-2 proteins BH-3 mimetics Inflammatory bowel disease

Overview of SPH-ALE applications for hydraulic turbines in ANDRITZ Hydro

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journal of Hydrodynamics 2018年第1期30卷 114-121页

作者： M.Rentschler j.C.Marongiu M.Neuhauser E.Parkinson R&D Department ANDRITZ Hydro

Over the past 13 years, ANDRITZ Hydro has developed an in-house tool based on the SPH-ALE method for applications in flow simulations in hydraulic turbines. The initial motivation is related to the challenging simulation of free surface flows in Pelton turbines, where highly dynamic water jets interact with rotating buckets, creating thin water jets traveling inside the housing and possibly causing disturbances on the runner. The present paper proposes an overview of industrial applications allowed by the developed tool, including design evaluation of Pelton runners and casings, transient operation of Pelton units and free surface flows in hydraulic structures.

关键词： Pelton turbine two-phase folw smoothed particle hydrodynamics(SPH) arbitrary Lagrange-Euler(ALE)

Impact of time delay and cooperation strategy on the stability of a predator-prey model with Holling type III functional response

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International journal of Biomathematics 2023年第3期16卷 165-193页

作者： I.Benamara A.El Abdllaouit j.Mikramt Laboratory of Mathematics Computer Science&Applications-Security of Information Department of Mathematics Faculty of Sciences Mohammed V University in RabatMorocco

In this paper,we propose and analyze a delayed predator-prey model with Holling type III functional response taking into account cooperation behavior in *** time delay is introduced in the attack rate to represent the time necessary to trigger the *** analytical result is followed by an ecological *** investigate the effect of hunting cooperation on both the number and the level of positive steady *** observe that the level of the positive equilibrium decreases when increasing the hunting cooperation ***,we study the impact of the delay as well as the cooperation in hunting on the dynamics of the *** prove that the presence of delay in the attack rate induces stability switches around the coexisting equilibrium when predators *** addition,we consider the discrete delay as a bifurcation parameter and prove that the model undergoes a Hopf-bifurcation at the coexisting equilibrium when the delay crosses some critical *** simulations are presented to confirm our analytical findings.

关键词： Predator-prey system Holling type III discrete delay cooperative hunting Hopf-bifurcation switch of stability

TRANSCRIPTION AND TRANSLATION OF ALFALFA LEGHEMOGLOBIN GENES DURING ROOT NODULE DEVELOPMENT

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Science China Chemistry 1990年第9期33卷 1078-1083页

作者：荆玉祥 ALAN S.PAAU WINSTON j.BRILL Institute of Botany Chinese Academy of Sciences Beijing 100044 PRC Department of Bacteriology and Center for Studies of Nitrogen Fixation University of Wisconsin Madison WI 53562 USA Agracetus8520 University GreenMiddletonWI 53562USA

LegHb mRNAs isolated from 2 to 10-week old alfalfa nodules are actively translated in vitro to give a full component of legHb products suggesting that legHb genes, once expressed, are not regulated at the transcription level during the lifetime of a nodule. In vitro translation studies with legHb mRNAs from 10-week old nodules indicate that translation of mRNAs is partially inhibited by addition of alfalfa legHb components themselves and is not promoted by addition of myoglobin and hemoglobin as compared with those of alfalfa legHb mRNAs isolated from 4-week old nodules. This intimates that the regulation of alfalfa legHb synthesis in old nodules at the translation level is weakened.

关键词： leghemoglobin root nodules transeription translation Medicago sativa L. Vernal