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Uncovering genetic and metabolite markers associated with resistance against anthracnose fruit rot in northern highbush blueberry

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Horticulture Research 2023年第10期10卷 25-36页

作者： MacKenzie jacobs Samantha thompson Adrian E.Platts Melanie j.A.Body Alexys Kelsey Amanda Saad Patrick Abeli Scott j.Teresi Anthony Schilmiller Randolph Beaudry Mitchell j.Feldmann Steven j.Knapp Guo-qing Song Timothy Miles Patrick P.Edger Department of Biochemistry and Molecular Biology Michigan State UniversityEast LansingMI 48824USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA Molecular Plant Science Program Michigan State UniversityEast LansingMI 48824USA Department of Plant Soil and Microbial SciencesMichigan State UniversityEast LansingMI 48824USA Department of Horticulture and Natural Resources Kansas State UniversityOlatheKS 66061USA Genetics and Genome Sciences Program Michigan State UniversityEast LansingMI 48824USA Mass Spectrometry&Metabolomics Core Michigan State UniversityEast LansingMI 48824USA Department of Plant Sciences University of CaliforniaDavisCA 95616USA

Anthracnose fruit rot(AFR),caused by the fungal pathogen Colletotrichum fioriniae,is among the most destructive and widespread fruit disease of blueberry,impacting both yield and overall fruit *** cultivars have highly variable resistance against *** date,this pathogen is largely controlled by applying various fungicides;thus,a more cost-effective and environmentally conscious solution for AFR is *** we report three quantitative trait loci associated with AFR resistance in northern highbush blueberry(Vaccinium corymbosum).Candidate genes within these genomic regions are associated with the biosynthesis of flavonoids(***)and resistance against ***,we examined gene expression changes in fruits following inoculation with Colletotrichum in a resistant cultivar,which revealed an enrichment of significantly differentially expressed genes associated with certain specialized metabolic pathways(*** biosynthesis)and pathogen *** non-targeted metabolite profiling,we identified a flavonol glycoside with properties consistent with a quercetin rhamnoside as a compound exhibiting significant abundance differences among the most resistant and susceptible individuals from the genetic mapping *** analysis revealed that this compound exhibits significant abundance differences among the most resistant and susceptible individuals when analyzed as two ***,individuals within each group displayed considerable overlapping variation in this compound,suggesting that its abundance may only be partially associated with resistance against *** findings should serve as a powerful resource that will enable breeding programs to more easily develop new cultivars with superior resistance to AFR and as the basis of future research studies.

关键词： applying resistance specialized

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帕米尔北缘木什背斜第四纪滑脱褶皱作用与北翼逆断裂的生长

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地震地质 2011年第2期33卷 289-307页

作者：肖伟鹏陈杰李涛李文巧 thompson j 中国地震局地质研究所地震动力学国家重点实验室北京100029 中国矿业大学(北京)地球科学与测绘工程学院北京100083 Department of Earth Science University of CaliforniaSanta Barbara CA 93106 USA

发育在帕米尔弧形推覆构造带最前缘的木什活动背斜是一南缓北陡的第四纪滑脱褶皱,背斜的最小地壳缩短量为0.7km,构造隆升幅度可达1.5km。木什背斜北翼逆断层由一系列坡向北的反向断层陡坎组成,不同断坎间垂直位移分布呈现此消彼长的特征... 详细信息

发育在帕米尔弧形推覆构造带最前缘的木什活动背斜是一南缓北陡的第四纪滑脱褶皱,背斜的最小地壳缩短量为0.7km,构造隆升幅度可达1.5km。木什背斜北翼逆断层由一系列坡向北的反向断层陡坎组成,不同断坎间垂直位移分布呈现此消彼长的特征,不论是整个北翼逆断层西段还是单条断坎,其垂直位移均呈东高西低的不对称分布,位移梯度东高西低,这可能反映了背斜西段晚第四纪褶皱作用的东强西弱。该断层可能是背斜生长过程中为了调节褶皱逐渐紧闭时不断减小的核部空间形成的浅部、无根的前翼次级剪切逆冲断层,本身不会产生中强地震。该断层晚第四纪平均水平缩短速率为0.8mm/a,仅吸收了该区现今GPS地壳缩短速率的1/5。木什背斜和背斜北翼逆断层的生长均遵从根据全球断层数据获得的断层长度>100m的标度律。木什背斜北翼逆断层西段陡坎的幂律回归标度指数n=1.37(R2=0.88),其断层最大位移(Dmax)与断层长度(L)的比值(k)远小于木什背斜的约4.3%,但比全球地震地表破裂带的k值(10-4～10-5)要大1～2个数量级,这表明木什背斜北翼断裂陡坎可能是数个中强震的派生产物,但尚处于断层发育的早期。

关键词：帕米尔木什背斜褶皱相关逆断层断层陡坎断层位移-长度标度律

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Flexible, diamond-based microelectrodes fabricated using the diamond growth side for neural sensing

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Microsystems & Nanoengineering 2020年第1期6卷 742-753页

作者： Bin Fan Cory A.Rusinek Cort H.thompson Monica Setien Yue Guo Robert Rechenberg Yan Gong Arthur j.Weber Michael F.Becker Erin Purcell Wen Li Department of Electrical and Computer Engineering Michigan State UniversityEast LansingMIUSA Fraunhofer USA Center for Coatings and Diamond Technologies East LansingMIUSA Department of Biomedical Engineering Michigan State UniversityEast LansingMIUSA Department of Physiology Michigan State UniversityEast LansingMIUSA

Diamond possesses many favorable properties for biochemical sensors,including biocompatibility,chemical inertness,resistance to biofouling,an extremely wide potential window,and low double-layer *** hardness of diamond,however,has hindered its applications in neural implants due to the mechanical property mismatch between diamond and soft nervous ***,we present a flexible,diamond-based microelectrode probe consisting of multichannel boron-doped polycrystalline diamond(BDD)microelectrodes on a soft Parylene C *** developed and optimized a wafer-scale fabrication approach that allows the use of the growth side of the BDD thin film as the sensing *** to the nucleation surface,the BDD growth side exhibited a rougher morphology,a higher sp^(3) content,a wider water potential window,and a lower background *** dopamine(DA)sensing capability of the BDD growth surface electrodes was validated in a 1.0 mM DA solution,which shows better sensitivity and stability than the BDD nucleation surface *** results of these comparative studies suggest that using the BDD growth surface for making implantable microelectrodes has significant advantages in terms of the sensitivity,selectivity,and stability of a neural ***,we validated the functionality of the BDD growth side electrodes for neural recordings both in vitro and in *** biocompatibility of the microcrystalline diamond film was also assessed in vitro using rat cortical neuron cultures.

关键词： neural film diamond

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The impact of storage conditions upon gentamicin coated antimicrobial implants

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journal of Pharmaceutical Analysis 2016年第6期6卷 374-381页

作者： Nicholas D. Mullins Benjamin j. Deadman Humphrey A. Moynihan Florence O. McCarthy Simon E. Lawrence jonathan thompson Anita R. Maguirea Department of Chemistry Analytical and Biological Chemistry Research Facility Synthesis and Solid State Pharmaceutical Centre University CollegeCork Ireland DePuy Synthes (Ireland) Loughbeg Ringaskiddy Co. Cork Ireland School of Pharmacy Analytical and Biological Chemistry Research Facility Synthesis and Solid State Pharmaceutical Centre University College CorkIreland

A systematic approach was developed to investigate the stability of gentamicin sulfate(GS) and GS/poly(lacticco-glycolic acid)(PLGA) coatings on hydroxyapatite *** influence of environmental factors(light,humidity,oxidation and heat) upon degradation of the drug in the coatings was investigated using liquid chromatography with evaporative light scattering detection and mass *** coated rods were found to be stable across the range of environments assessed,with only an oxidizing atmosphere resulting in significant changes to the gentamicin *** contrast,rods coated with GS/PLGA were more sensitive to storage conditions with compositional changes being detected after storage at 60 °C,75% relative humidity or exposure to *** effect of γ-irradiation on the coated rods was also investigated and found to have no significant ***,liquid chromatography–mass spectrometry analysis revealed that known gentamines C_1,C_1 aand C_2were the major degradants *** degradation of gentamicin coatings did not produce any unexpected degradants or impurities.

关键词： Gentamicin Coatings Storage stability testing LC–ELSD

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Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience

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World journal of Hepatology 2017年第1期9卷 48-56页

作者： Grace C Lovett Tin Nguyen David M Iser jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally j Bell Paul V Desmond Alexander j thompson Department of Gastroenterology St Vincent’s Hospital Melbourne Faculty of Medicine University of Melbourne

AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care *** We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over *** Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%C

关键词： Tenofovir 肝炎 B 病毒澳大利亚真实 Virological 抑制长期的肝炎 B

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在旱化土壤条件下来自不同生境的20种植物幼苗根系的形态反应的比较(英文)

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Acta Botanica Sinica 2000年第6期42卷 628-635页

作者：刘志民 K.thompson R.E.SPENCER R.j.READER 中国科学院兰州寒区旱区环境与工程研究所兰州730000 DepartmentofBotany UniversityofGuelph

在浇水和未浇水的塑料管中栽培了 2 0个植物种 ,测量了其幼苗的根深、根重和茎重。这些种的原始生境含水状况差异较大 ,是从沼泽到沙漠的系列。植物种原始生境的水分状况用Ellenberg水分序数定量。幼苗首先在湿沙中生长 2 1d ,然后进入... 详细信息

在浇水和未浇水的塑料管中栽培了 2 0个植物种 ,测量了其幼苗的根深、根重和茎重。这些种的原始生境含水状况差异较大 ,是从沼泽到沙漠的系列。植物种原始生境的水分状况用Ellenberg水分序数定量。幼苗首先在湿沙中生长 2 1d ,然后进入为期也是 2 1d的处理阶段 (浇水和不浇水 )。浇水植株的根深与Ellenberg水分序数无关。在旱化的沙层中 ,源于干旱生境的植物的根深趋向于增加 ,来自湿润生境的则减少。根深塑性 (即未浇水的根深 /浇水的根深 )与Ellenberg水分序数显著相关 (R2 =0 .5 6 ) ,茎 /根比值塑性也与Ellenberg水分序数相关 ,但不如根深塑性的关系明显。根深塑性表现最为明显的植物种具有在未浇水沙层中维持茎生长的最大能力。有迹象表明 ,在浇水处理时 ,来自很干旱生境的植物生长减弱。研究结果表明 :幼苗利用深层水分的能力是植物对干旱生境的主要适应。

关键词：干旱 Ellenberg序数根生长幼苗根深塑性

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STUDY OF THE NUCLEATION MECHANISM OF α-Al GRAINS AFTER ADDITION OF Al-Ti-B MASTER ALLOYS

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Acta Metallurgica Sinica(English Letters) 1998年第3期11卷 157-162页

作者： X.F.Liu X.F.Bian X.G.Qi M.thompson j.jMa

Nucleation sites of α-Al grains after addition of an Al-Ti-B master alloy into pure aluminium have been investigated using EPMA. The results show that either TiAl3 or boride particales can nucleate α-Al grains. But the number of TiAl3 nucleants is reduced with the holding time prolonged and the boride-nuclei are increasing gradually. Based on these results, a new refining method, adding molten Al-Ti-B into commercially pure aluminium, which has a quicker and better refining efficiency is presented.

关键词： Al-Ti-B master alloy grain refinement nucleation mechanism,α-Al nucleant

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Reimagining large river management using the Resist–Accept–Direct(RAD) framework in the Upper Mississippi River

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Ecological Processes 2023年第4期12卷 3-22页

作者： Nicole K.Ward Abigail j.Lynch Erik A.Beever joshua Booker Kristen L.Bouska Holly Embke jeffrey N.Houser john F.Kocik joshua Kocik David j.Lawrence Mary Grace Lemon Doug Limpinsel Madeline R.Magee Bryan M.Maitland Owen Mc Kenna Andrew Meier john M.Morton jeffrey D.Muehlbauer Robert Newman Devon C.Oliver Heidi M.Rantala Greg G.Sass Aaron Shultz Laura M.thompson jennifer L.Wilkening National Park Service Climate Change Response Program Habitat Conservation Division NOAA Wisconsin Department of Natural Resources Aquatic Sciences Center Center for Limnology U.S. Geological Survey Northern Prairie Wildlife Research Center and Midwest Climate Adaptation Science Center U.S. Army Corps of Engineers Alaska Wildlife Alliance U.S. Geological Survey Alaska Cooperative Fish and Wildlife Research Unit University of Alaska Fairbanks University of North Dakota Great Lakes Indian Fish and Wildlife Commission (GLIFWC) Minnesota Department of Natural Resources U.S. Geological Survey National Climate Adaptation Science Center and School of Natural Resources University of Tennessee U.S. Geological Survey National Climate Adaptation Science Center U.S. Geological Survey Northern Rocky Mountain Science Center Department of Ecology Montana State University U.S. Fish and Wildlife Service National Wildlife Refuge System U.S. Geological Survey Upper Midwest Environmental Sciences Center U.S. Geological Survey Midwest Climate Adaptation Science Center NOAA NEFSC Orono University of Nebraska-Lincoln

Background Large-river decision-makers are charged with maintaining diverse ecosystem services through unprecedented social-ecological transformations as climate change and other global stressors intensify. The interconnected, dendritic habitats of rivers, which often demarcate jurisdictional boundaries, generate complex management challenges. Here, we explore how the Resist–Accept–Direct(RAD) framework may enhance large-river management by promoting coordinated and deliberate responses to social-ecological trajectories of change. The RAD framework identifies the full decision space of potential management approaches, wherein managers may resist change to maintain historical conditions, accept change toward different conditions, or direct change to a specified future with novel conditions. In the Upper Mississippi River System, managers are facing social-ecological transformations from more frequent and extreme high-water events. We illustrate how RAD-informed basin-, reach-, and site-scale decisions could:(1) provide cross-spatial scale framing;(2) open the entire decision space of potential management approaches; and(3) enhance coordinated inter-jurisdictional management in response to the trajectory of the Upper Mississippi River *** The RAD framework helps identify plausible long-term trajectories in different reaches(or subbasins) of the river and how the associated social-ecological transformations could be managed by altering site-scale conditions. Strategic reach-scale objectives may reprioritize how, where, and when site conditions could be altered to contribute to the basin goal, given the basin's plausible trajectories of change(e.g., by coordinating action across sites to alter habitat connectivity, diversity, and redundancy in the river mosaic).Conclusions When faced with long-term systemic transformations(e.g., > 50 years), the RAD framework helps explicitly consider whether or when the basin vision or goals may no longer be achievable,

关键词： Ecosystem Management Transformation Social-ecological system Anthropocene Climate change Basin planning Cross-scale interactions

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西南天山前缘乌拉根背斜南翼逆断层的发现及其地质意义

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地震地质 2011年第2期33卷 277-288页

作者：李涛陈杰肖伟鹏 Burbank D W thompson j 杨晓东中国地震局地质研究所地震动力学国家重点实验室北京100029 中国矿业大学(北京)地球科学与测绘工程学院北京100083 Department of Earth Science University of California Santa Barbara CA 93106 USA

塔里木盆地新疆喀什以西部分是西南天山和帕米尔两大对冲构造系统的会聚带,关于两者变形前缘和分界的确切位置存在不同认识。在乌恰县以南的玛依卡克盆地南缘,清晰可见属于帕米尔构造带、向N或NNE逆冲的帕米尔前缘逆冲推覆体(PFT)。最... 详细信息

塔里木盆地新疆喀什以西部分是西南天山和帕米尔两大对冲构造系统的会聚带,关于两者变形前缘和分界的确切位置存在不同认识。在乌恰县以南的玛依卡克盆地南缘,清晰可见属于帕米尔构造带、向N或NNE逆冲的帕米尔前缘逆冲推覆体(PFT)。最近野外调查在盆地北部发现了西南天山前缘的最新变形带:向南逆冲的乌拉根背斜南翼断层。断层总体近EW走向,在克孜勒苏河南岸和别尔托阔依河两岸河流阶地上形成了长约12km、坡向南的逆断坎,近地表断层产状为6°∠15°。由于乌拉根背斜及其南翼断层的活动,断层上盘阶地面上形成了多条弯滑断层,并发生了明显的反向掀斜。高阶地形成以来(区域对比表明,该阶地与木什背斜北翼T2大致为同一期阶地,其光释光年龄约为16ka),西南天山南缘吸收的总缩短量约71.4km,平均缩短速率约4.5mm/a。

关键词：天山帕米尔塔里木盆地乌拉根背斜南翼断层弯滑断层阶地变形

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利用变形河流阶地限定帕米尔北缘木什背斜的缩短、隆升和侧向扩展

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地震地质 2011年第2期33卷 308-322页

作者：李涛陈杰肖伟鹏 Burbank D W 黄明达 thompson j 中国地震局地质研究所地震动力学国家重点实验室北京100029 中国矿业大学(北京)地球科学与测绘工程学院北京100083 Department of Earth Science University of California Santa Barbara CA 93106 USA

位于帕米尔前缘逆冲推覆体(Pamir Front Thrust,PFT)东端的木什滑脱背斜,是帕米尔弧形推覆构造带最前缘和最新的变形带。对地形横剖面、纵剖面和水系发育特征的分析表明,木什背斜总体上具有由西向东扩展生长的特征。在背斜核部及北翼发... 详细信息

位于帕米尔前缘逆冲推覆体(Pamir Front Thrust,PFT)东端的木什滑脱背斜,是帕米尔弧形推覆构造带最前缘和最新的变形带。对地形横剖面、纵剖面和水系发育特征的分析表明,木什背斜总体上具有由西向东扩展生长的特征。在背斜核部及北翼发育数级开阔平坦的沿轴向展布的河流阶地,阶地可划分为4期。利用阶地堆积细颗粒石英光释光测年获得阶地面T2a、T3和T4的形成年龄分别为(15.8±2.40)ka、(55.1±10.3)ka、(131.4±23.9)ka。伴随背斜的生长扩展,河流阶地面发生了横向和纵向掀斜,并形成断层陡坎和褶皱陡坎。木什背斜晚第四纪的缩短和隆升主要是通过褶皱翼旋转机制进行的,估算其最小缩短速率为(1.6±0.3)mm/a,最小隆升速率为(1.9±0.3)mm/a。与此同时,沿轴向背斜发生了向东的侧向迁移和旋转。根据背斜垂直隆升与侧向扩展之间的关系,估算背斜在131～16ka期间向东的侧向迁移扩展速率较快,为(14.6±3.6)mm/a;自16ka至今,侧向迁移扩展速率迅速减小至(1.7±0.3)mm/a,背斜向东的迁移扩展可能已基本停止,而以侧向旋转为主。

关键词：帕米尔木什背斜晚第四纪河流阶地褶皱生长侧向扩展

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