检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

偏头痛与月经过多和子宫内膜异位症相关

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 56-57页

作者： Tietjen G. E. conway A. Utley C. 周永(译) Medical College of Ohio Department of Neurology 3120 Glendale Avenue Toledo OH 43614 United States 不详

Objective. -To evaluate the frequency of menorrhagia and endometriosis in female migraineurs compared to age-matched women without headache. Background. -Migraine predominantly affects women of childbearing age and is often associated with the menstrual period, yet there is a paucity of data regarding the relationship of migraine and menstrual disorders. Methods. -Women diagnosed with migraine, using International headache Society criteria and an age-and sex-matched control group, were administered a semistructured questionnaire regarding migraine and migraine-related disability, menstrual history, other bleeding history, vascular event history, and vascular risk factors. Results. -Fifty female migraineurs between the ages of 22 and 50 years and 52 age-matched women (mean age 37 years) were enrolled in the study. Similar proportions of women in each group reported using hormone contraceptives (30%vs. 33%, P= .77) and hormone replacement therapy (12%vs. 8%, P= .69). The proportions presently menstruating (64 %vs. 80%, P= .20) and status after hysterectomy were similar (24%vs. 14%, P= .84). Menorrhagia (defined as at least three consecutive heavy periods), both current and prior, was more commonly reported in migraineurs (63%vs. 37%, P=.009), with higher likelihood of staining clothes by menses (35%vs. 8%, P= .003), and significant impact of menses on activities of daily living (on a 10-point Likert scale) with work/school participation (P= .02), family activities (P hich may be associated with menorrhagia, was also more commonly diagnosed in the migraineurs (30%vs. 4%, P= .001). The migraineurs more frequently described bruising (40%vs. 10%, P he migraine group (28%vs. 12%, P= .036), and si

关键词：子宫内膜异位症偏头痛患者月经过多日常生活活动能力 Logistic回归血管危险因素结构式问卷调查非甾体类抗炎药

在线全文

学校读者我要写书评

暂无评论

木材采运技术

木材采运技术

与半乳糖激酶基因高度同源的新型葡萄糖激酶的克隆表达和特性研究

1981年

作者：（美）康韦（S.conway）贾铭钰李光大等译

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

与半乳糖激酶基因高度同源的新型葡萄糖激酶的克隆表达和特性研究

conway的数学在conway之后的发展

第十一届中国酶工程学术研讨会

作者：李倩刘方方 Louis Patrick conway Josef Voglmeir Glycomics and Glycan Bioengineering Research Center 南京农业大学

半乳糖(Galactose)是一种六碳单糖,它常以D-半乳糖苷的形式存在于动物的脑组织和神经组织中。半乳糖基修饰了一系列具有生物活性的聚糖,如黏蛋白、红细胞系列的糖鞘脂等,要将半乳糖基转移到糖链上,首先需要通过半乳糖激酶对半乳糖进行... 详细信息

半乳糖(Galactose)是一种六碳单糖,它常以D-半乳糖苷的形式存在于动物的脑组织和神经组织中。半乳糖基修饰了一系列具有生物活性的聚糖,如黏蛋白、红细胞系列的糖鞘脂等,要将半乳糖基转移到糖链上,首先需要通过半乳糖激酶对半乳糖进行磷酸化。半乳糖激酶(GalK)能够将半乳糖磷酸化生成半乳糖-1-磷酸,在过去的研究中,GalK由于其在糖代谢中的重要作用而引起了重大的研究关注,除了体内的生物学功能外,GalK还具有广泛的底物范围,可用于体外制备多种特殊的糖-1-磷酸或者衍生物。本研究以细菌属Shewanellawoodyi源半乳糖激酶-Sw3773、Sw2155和Sw0678作为研究对象,以包括单糖、单糖衍生物或二糖在内的47种糖为底物检测酶的底物特异性,结果显示(附图1-3)三种激酶都对半乳糖没有活性,反而都能作用于葡萄糖。然而目前报道过的半乳糖激酶都对半乳糖有活性,且相比其他底物,活性最高。为了确定激酶催化产物的磷酸化位置,我们通过核磁共振波谱法(NMR)对产物进行结构分析。将纯化后样品的NMR谱图分别与商业化葡萄糖-1-磷酸和葡萄糖-6-磷酸标准品的谱图进行对比(附图4),发现纯化产物为葡萄糖-6-磷酸。我们己知,半乳糖激酶对底物的C-1位进行磷酸化,而葡萄糖激酶对底物的C-6位上进行磷酸化,因此我们猜测三种***源拟半乳糖激酶实际上为葡萄糖激酶。对三种激酶的氨基酸序列进行分析,发现序列中一处具有高度保守性的甘氨酸,在Sw3773和Sw2155中被丝氨酸取代,在Sw0678中被谷氨酰胺取代(附图5中甘氨酸被红色方框标记,丝氨酸和谷氨酸被蓝色方框标记)。hoffmeister等[1]曾经报道过,大肠杆菌半乳糖激酶中单个酪氨酸(Tyr371)的突变,导致该酶的底物特异性发生很大变化,使其对D-半乳糖醛酸、D-塔洛糖、L-阿卓糖,甚至L-葡萄糖都有活性。因此,初步猜测可能是由于该甘氨酸的突变,导致***源半乳糖激酶的功能发生了改变。以葡萄糖为底物,利用已经建立的生物酶标仪检测法,对三种新型葡萄糖激酶的生化特性进行探究,结果表明:三种激酶的最适反应ph都为7.5;Sw3773的最适反应温度为37℃,其他两个酶都为42℃;三种葡萄糖激酶的活性都依赖于金属离子,Mg对三种酶的促进作用最强;Sw3773、Sw2155和Sw0678对底物葡萄糖的Km值分别为1.9 mM、0.9 mM和3.9 mM;Vmax分别为5.9μM/min、15.2μM/min和6.6μM/min;在对葡萄糖激酶的磷酸供体依赖性进行测定时,发现ATP是四种被测核苷三磷酸中唯一的磷酸基供体,CTP、UTP和GTP都不能被GalK利用。三种激酶对ATP的高度专一性可用于核苷三磷酸的分离或鉴定,温和的反应条件也有利于今后进一步的实验与应用。

关键词：葡萄糖激酶基因克隆基因表达底物特异性

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

数学译林 2023年第2期42卷 97-110,124页

作者： Alex Ryba Philip Ehrlich richard Kenyon Jeffrey Lagarias James Propp Louis h.Kauffman 范颖玭(译) 楼璐娅(译) 周啸(译) 刘文奡(校) 纽约市立大学皇后学院不详耶鲁大学密歇根大学 Lowell麻萨诸塞大学

数学家们总是排着队去听Joh.conway(康韦)的演讲,钻研他的著作.他们希望享受漂亮的数学,相信自己会得到宝贵的启发.John欢迎这种关注,并将做出更优雅的数学当成自己的责任.他的数学真正宝贵的地方在于其丰富的洞察.他在其工作过的所有... 详细信息

数学家们总是排着队去听Joh.conway(康韦)的演讲,钻研他的著作.他们希望享受漂亮的数学,相信自己会得到宝贵的启发.John欢迎这种关注,并将做出更优雅的数学当成自己的责任.他的数学真正宝贵的地方在于其丰富的洞察.他在其工作过的所有领域都留下了供我们探索的康庄大道.John通过多种方式带给我们启发与挑战.他的生命游戏被成千上万的人研究,而他的河流(river)方法则提供了研究经典对象二次型的新方法.

关键词：生命游戏二次型数学启发

内脏恶性肿瘤在眼周皮脂腺癌患者中的发生率及临床特征

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 27-28页

作者： conway R.M. von Moller A. Ballhausen W. 陈立军 Department of Oph thalmology Eye Hospital University of Erlangen-Nürnberg Erlangen Germany

Purpose: To report the frequency and clinical features of internal visceral ma lignancy in an unselected series of patients with sebaceous gland carcinoma (SGC ).Methods: A non-comparative retrospective case series of consecutive patients with a histologically proven diagnosis of periocular sebaceous cell carcinoma tr eated at the University Eye hospital, University of Erlangen-Nürnberg between 1981 and 2000. Results: Twenty three patients were identified, each with one tum or. Men and women were almost equally affected with a mean age at diagnosis of 6 2 years (range 37-83 years). The majority of tumors were located in the upper l id, but five tumors were situated in the lower lid or caruncle. In 22 of the 23 patients the diagnosis at referral was either incorrect or not suspected. In all cases, the SGC was treated by surgical excision. In the systems review, 11 of t he 23 patients (48%) had evidence of previous systemic malignancy, the most com mon being colorectal cancer followed by liver and bronchial carcinoma. Forty-fi ve percent of patients with SGC and internal visceral malignancy eventually died as a result of their tumors. Conclusion: Periocular SGC remains an underdiagnos ed entity for which a high level of clinical suspicion is critical for early rec ognition. Almost half the patients additionally had an internal visceral maligna ncy. Internal visceral malignancy in unselected patients with SGC may be more co mmon and have a more guarded prognosis than has been appreciated.

关键词：皮脂腺癌眼周下睑泪阜上睑单发肿瘤病理组织学检查支气管肺癌眼科医院结肠癌

射频消融治疗神经内分泌源性肝转移癌:Middle-sex地区的治疗经验

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 4-5页

作者： Gillams A. Cassoni A. conway G. Lees W. 刘丽娜 Department of Medical Imaging Middlesex Hospital Mortimer Street London W1T 3AA United Kingdom

Background: Current treatment options for neuroendocrine liver metastases are not widely applicable or not that effective. Image- guided thermal ablation offers the possibility of a minimally invasive, albeit palliative, treatment that decreases tumor volume, preserves most of the normal liver, and can be repeated several times. We report our experience with image- guided thermal ablation in 25 patients with unresectable liver metastases. Methods: Since 1990 we have treated 189 tumors at 66 treatment sessions in 25 patients (12 female, 13 male; median age, 56 years; age range, 26- 78 years). Thirty treatments were performed with a solid- state laser, and 36 treatments were performed with radiofrequency ablation. All but one treatment was performed percutaneously under image guidance. Sixteen patients had metastases from carcinoid primaries, three from gastrinoma, two from insulinoma, and four from miscellaneous causes. Fourteen of 25 had symptoms from hormone secretion. Results: Imaging follow- up was available in 19 patients at a median of 21 months (range, 4- 75 months). There was a complete response in six patients, a partial response in seven, and stable disease in one; hence, tumor load was controlled in 14 of 19 patients (74% ). Relief of hormone- related symptoms was achieved in nine of 14 patients (69% ). The median survival period from the diagnosis of liver metastases was 53 months. One patient with end- stage cardiac disease died after a carcinoid crisis. There were eight (12% ) complications: five local and three distant, four major and four minor. Conclusions: As a minimally invasive, readily repeatable procedure that can be used to ablate small tumors, preferably before patients become severely symptomatic, radiofrequency ablation can provide effective control of liver tumor volume in most patients over many years.

关键词：肝转移癌 Middle-sex 射频消融肝癌转移癌灶类癌瘤胰岛素瘤胃泌素瘤存活期固态激光器

在线全文

学校读者我要写书评

暂无评论

超大规模集成电路系统导论

超大规模集成电路系统导论

作者： C.·米德(C. Mead) L.·加威(L. conway)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

粮食战争

hurler综合征时供体混合嵌合状态和低水平艾杜糖醛酸苷酶可能对神经发育起保护作用

作者： (英)戈登·康韦(Gordon conway) (英)凯蒂·威尔逊(Katy Wilson)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（儿科学分册） 2005年第12期1卷 35-36页

作者： conway J. Dyack S. Crooks B.N.A. Fernandez C.V. 郭战宏 IWK health Centre 5850 University Avenue Halifax NS B3K 6R8 CanadaDr.

hurler syndrome is a lysosomal storage disease resulting in fatal cardiac or neurologic sequelae unless alpha-iduronid-ase production is reconstituted with hematopoietic stem cell transplantation. We report on a 4- ye... 详细信息

关键词：混合嵌合状态 hurler综合征艾杜糖醛酸神经发育神经系统后遗症溶酶体造血干细胞移植发育曲线