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Bidirectional regulation of angiogenesis by phytoestrogens through estrogen receptor-mediated signaling networks

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Chinese Journal of Natural Medicines 2016年第4期14卷 241-254页

作者： LIU hai-Xin WANG Yu LU Qing YANG Ming-Zhu FAN Guan-Wei KARAS richard h GAO Xiu-Mei ZhU Yan Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Research and Development Center of Traditional Chinese Medicine Tianjin International Joint Academy of Biotechnology & Medicine Molecular Cardiology Research Institute Tufts Medical Center

Sex hormone estrogen is one of the most active intrinsic angiogenesis regulators; its therapeutic use has been limited due to its carcinogenic potential. Plant-derived phytoestrogens are attractive alternatives, but reports on their angiogenic activities often lack in-depth analysis and sometimes are controversial. herein, we report a data-mining study with the existing literature, using IPA system to classify and characterize phytoestrogens based on their angiogenic properties and pharmacological consequences. We found that pro-angiogenic phytoestrogens functioned predominantly as cardiovascular protectors whereas anti-angiogenic phytoestrogens played a role in cancer prevention and therapy. This bidirectional regulation were shown to be target-selective and, for the most part, estrogen-receptor-dependent. The transactivation properties of ERa and ERβ by phytoestrogens were examined in the context of angiogenesis-related gene transcription. ERa and ERβ were shown to signal in opposite ways when complexed with the phytoestrogen for bidirectional regulation of angiogenesis. With ERa, phytoestrogen activated or inhibited transcription of some angiogenesis-related genes, resulting in the promotion of angiogenesis, whereas, with ERβ, phytoestrogen regulated transcription of angiogenesis-related genes, resulting in inhibition of angiogenesis. Therefore, the selectivity of phytoestrogen to ERa and ERβ may be critical in the balance of pro- or anti-angiogenesis process.

关键词： Phytoestrogen Selective estrogen receptor modifies (SERMs) ERa ERβ Bidirectional regulation of angiogenesis IPA

Development of a CO_2 Tolerant Fischer-Tropsch Catalyst:from Laboratory to Commercial-Sca1e Demonstration in Alaska

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Journal of Natural Gas Chemistry 2004年第1期13卷 1-9页

作者： Joep J h M Font Freide Tim D Gamlin J richard hensman Barry Nay Christopher Sharp BP Exploration Operating Company Chertsey RoadSunbury on ThamesMiddlesexTWl6 7LNEnglandDavy Process Technology Lid 20 Eastbourne TerraceLondon W2 6LEEnglandDavy Process Technology Lid 20 Eastbourne TerraceLondon W2 6LEEnglandBP Chemicals LtdChertsey RoadSunbury on ThamesMiddlesexTW16 7LLEnglandBP Chemicals LtdChertsey RoadSunbury on ThamesMiddlesexTW16 7LLEngland

This article describes the development of BP's Fischer-Tropsch catalyst, used for the conversion of carbon monoxide and hydrogen into liquid hydrocarbons. It covers the 18 year period from the early eighties, when laboratory scale preparations and micro-reactors were heavily used, right through to the present day with the commercial scale manufacture and proving of the finished catalyst in BP's new ＄86 million gas to liquids demonstration facility in Nikiski, Alaska. Extensive performance testing and scale-up experiments have been successfully carried out, all proof that a laboratory preparation can indeed be translated into a commercial manufacturing process. In addition, the resulting catalyst does not only meet the process design targets, but also exhibits enhanced stability and is tolerant to carbon dioxide. Above all, a commercial scale, fixed bed Fischer-Tropsch catalyst is now available and ready for licensing. Manufacturing procedures and quality control have all been successfully detailed and transferred to the commercial manufacturer.

关键词： carbon dioxide Fisher-Tropsch development syngas commercial catalyst

Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion

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World Journal of Gastroenterology 2017年第48期23卷 8443-8451页

作者： Yuri L Boteon richard Laing hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky h Bhogal The Liver Unit University Hospitals of BirminghamMindelsohn Way The Centre for Liver Research Institute for Biomedical ResearchUniversity of Birmingham

Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI.

关键词： Autophagy Liver transplant Ischaemiareperfusion injury Normothermic machine liver perfusion

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资深专家谈图片编辑

出版经济 2005年第11期 24-25页

作者： richard ellis 孙雨新

在美国的中小城市,一些中小报刊对版面图片的要求一般不是很重高,图片编辑的工作重心以处理商业图片为主要内容,商业图片的要求比较多,大多用在广告上面,读者所能看到的图片大多是以广告的形式体现在报刊中.

关键词：图片编辑专家中小城市报刊商业广告版面读者

Excessive participation in on-line internet action games by two American teenagers: Case report, description of extent of overuse, and adverse consequences

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Open Journal of Pediatrics 2013年第3期3卷 201-203页

作者： richard h. Schwartz Inova Children’s hospital Falls Church USA

In the past 15 years, there have been more than 40 articles in the medical literature about excessive participation in on-line internet action games by adolescents and young adults. The following case reports provide detailed information on two boys, ages 16 and 20 years respectively, who are compulsive and enthusiastic internet gamers, to the exclusion of family communication, school activities, academic performance, participation in sports and dating. They have not mastered any of the usual goals of adolescent development.

关键词： Internet Game Addiction Excessive Internet Gaming

Investigation of the hydrogen adsorbed density inside the pores of MOF-5 from path integral grand canonical Monte Carlo at supercritical and subcritical temperature

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Science Bulletin 2016年第8期61卷 594-600页

作者： David Durette Pierre Benard Renju Zacharia richard Chahine hydrogen Research Institute Universite du Quebec a Trois-RivibresTrois-Rivieres G9A 5H7Canada Gas Processing Center College of EngineeringQatar UniversityDohaQatar

We examine the high density limit of the adsorption isotherms of hydrogen on MOF-5. The isotherms are calculated using quantum GCMC simulations over the pressure range： 0-150 atm （1 atm = 1.01325 ~ 105 Pa） in the subcritical and supercritical state at 30, 50, 77, 113, 196 and 296 K. The fluid phase density in the pores for each temper- ature is calculated and shown to reach values higher than normal liquid density. The fluid phase density obtained at 30 K is observed to correspond to a highly compressed liquid. The radial distribution function of the adsorbed phase at 30 and 50 K are calculated. The adsorption isotherms are compared with available experimental data at 30, 50, 77 and 298 K.

关键词： hydrogen adsorption isotherms MOF-5 Metal-organic frameworks Path integralgrand canonical Monte Carlo Radial distributionfunction . hydrogen storage hydrogen energyapplications

Co-crystals of non-steroidal anti-inflammatory drugs(NSAIDs):Insight toward formation,methods,and drug enhancement

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Particuology 2021年第5期19卷 227-241页

作者： Andre L.C.S.Nascimento richard P.Fernandes Maxime D.Charpentier Joop h.ter horst Flavio J.Caires Marius Chorilli Sao Paulo State University(UNESP) School of Pharmaceutical Sciences14800-903 AraraquaraSao PauloBrazil São Paulo State University(UNESP) Institute of Chemistry14800-060 AraraquaraSao PauloBrazil EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation University of StrathclydeGlasgowUK Sao Paulo State University(UNESP) School of Sciences17033-260 BauruSao PauloBrazil

Pharmaceutical co-crystals have been explored by many researchers as a strategy to optimize physicochemical properties of solid-state *** improvements of solubility,bioavailability,and the reduced tendency for phase transformation occurrence,are factors that highlight benefits of pharmaceutical co-crystals among other solid *** to the Biopharmaceutical Classification System(BCS),non-steroidal anti-inflammatory drugs(NSAIDs)are class Ⅱ drugs,which have low aqueous solubility and therefore co-crystallization has the potential to optimize NSAID product *** this review,we highlight the recent progress made on NSAIDs co-crystals,their co-formers,synthesis,methods and use,while we underline some promising results on in vitro and in vivo co-crystal properties.A celecoxib-tramadol co-crystal reaches phase Ⅲ clinical trials,showing greater analgesic activity than both individual *** aqueous solubility of the co-crystal formed between l-proline and diclofenac is very high in comparison with the pure *** co-crystals with urea and thiourea have an increase of drug release of almost 60%.Co-crystal design brings a new perspective in drug development since the co-former used can also be a biologically active component allowing to combine different anti-inflammatory drugs,which have an incredible spectrum of application due to the analgesic,anti-pyretic and anti-inflammatory properties.

关键词： Pharmaceutical co-crystals NSAIDs Supramolecular synthons Co-crystal discovery Bioavailability

Mental health status in veterans residing in rural versus non-rural areas: results from the veterans’ health study

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Military Medical Research 2021年第1期8卷 79-89页

作者： Joseph J.Boscarino Charles R.Figley richard E.Adams Thomas G.Urosevich h.Lester Kirchner Joseph A.Boscarino Clinical Psychology Department William James CollegeNewtonMA 02459USA School of Social Work Tulane UniversityNew OrleansLA 70112USA Department of Sociology Kent State UniversityKentOH 44242USA Ophthalmology Service Geisinger ClinicMount PoconoPA 18344USA Department of Population health Sciences Geisinger Clinic100 N.Academy Avenue44-00DanvillePA 17822USA

Background: The majority of Veterans Affair(VA) hospitals are in urban areas. We examined whether veterans residing in rural areas have lower mental health service use and poorer mental health ***: Veterans with at least 1 warzone deployment in central and northeastern Pennsylvania were randomly selected for an interview. Mental health status, including posttraumatic stress disorder(PTSD), major depression, alcohol abuse and mental health global severity, were assessed using structured interviews. Psychiatric service use was based on self-reported utilization in the past 12 months. Results were compared between veterans residing in rural and non-rural areas. Data were also analyzed using multivariate logistic regression to minimize the influence by confounding ***: A total of 1730 subjects(55% of the eligible veterans) responded to the survey and 1692 of them had complete geocode information. Those that did not have this information(n=38), were excluded from some analyses. Veterans residing in rural areas were older, more often of the white race, married, and experienced fewer stressful events. In comparison to those residing in non-rural areas, veterans residing in rural areas had lower global mental health severity scores;they also had fewer mental health visits. In multivariate logistic regression, rural residence was associated with lower service use, but not with PTSD, major depression, alcohol abuse, and global mental health severity score after adjusting confounding factors(e.g., age, gender, marital status and education).Conclusions: Rural residence is associated with lower mental health service use, but not with poor mental health in veterans with former warzone deployment, suggesting rural residence is possibly protective.

关键词： Veterans Rural Risk factors PTSD Alcohol abuse Depression Service use Census data

3-D Structural Geology 2nd ed. 2006

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