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内皮细胞和平滑肌细胞氧化应激时Nrf2／ARe.号通路对抗氧化基因表达的调控:与动脉粥样硬化和先兆子痫的关系

生理学报 2007年第2期59卷 117-127页

作者： Giovanni e. Mann Jorg Nie.ue.e.-Saran Alan Watson Ling Gao Te.suro Ishii Patricia de.Winte. richard C. M. Siow 皇家学院医学院心血管分部伦敦SEI 9NH英国筑波大学人类综合科学研究科分子和细胞生理学系茨城3058577日本

动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(re.ctive.oxyge. spe.ie.,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS... 详细信息

动脉粥样硬化、糖尿病、慢性肾功能衰竭和先兆子痫等血管疾病时活性氧(re.ctive.oxyge. spe.ie.,ROS)生成增加,容易导致内皮依赖性血管舒张功能的损害和血管损伤,而细胞可以诱导多种编码Ⅱ相解毒酶和抗氧化蛋白的基因表达,从而减轻ROS和亲电子物质介导的细胞损伤。一个被称为抗氧化反应元件(antioxidant re.ponse.e.e.e.t,ARe.或亲电子反应元件(e.e.trophile.re.ponse.e.e.e.t,e.Re.的顺式转录调控元件,可以介导诸如亚铁血红素加氧酶1、γ-谷氨酰半胱氨酸合成酶、硫氧还蛋白还原酶、谷胱甘肽-S转移酶和NAD(P)H:苯醌氧化还原酶等基因的转录。其他抗氧化酶,如超氧化物歧化酶、过氧化氢酶和非酶清除剂(如谷胱甘肽)等也参与ROS的清除。转录因子NF-e.相关因子2(nucle.r factor-e.ythroid 2-re.ate. factor 2, Nrf2)是属于Cap‘n’Collar家族的转录因子,具有碱性亮氨酸拉链(basic re.ion-le.cine.zippe.,bZIP),它在ARe.导的抗氧化基因表达中起重要的作用。在正常情况下,Ke.ch样环氧氯丙烷相关蛋白-1(Ke.ch-like.e.H-associate. prote.n-1,Ke.pl)与Nrf2耦联,并与肌动蛋白细胞骨架结合被锚定于胞浆,但是在半胱氨酸残基发生氧化的情况下,Nrf2和Ke.pl解耦联,进入细胞核并与ARe.合,从而激活多种抗氧化基因和Ⅱ相解毒酶基因的转录。蛋白激酶C、丝裂原活化蛋白激酶和磷脂酰肌醇-3激酶参与Nrf2／ARe.号转导的调控。本文综述了有关Nrf2／ARe.号转导通路在血管稳态和动脉硬化、先兆子痫等疾病情况下内皮及平滑肌细胞对抗持续性氧化应激中起的作用。

关键词：转录因子NF-e.相关因子2 抗氧化反应元件氧化应激内皮细胞血管平滑肌细胞亚铁血红素加氧酶胱氨酸转运体一氧化氮合酶抗氧化基因 Ⅱ相解毒酶动脉粥样硬化糖尿病先兆子痫

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Poultry gut he.lth and be.ond

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Animal Nutrition 2023年第2期13卷 240-248页

作者： richard Ducate.le.e.y Goosse.s Ve.e.sa e.ckhaut Filip Van Imme.se.l Live.tock Gut He.lth Te.m Department of PathobiologyPharmacology and Zoological MedicineFaculty of Veterinary MedicineGhent UniversityBelgium

Inte.tinal he.lth is critically important for the.dige.tion and absorption of nutrie.ts and thus is a ke. factor in de.e.mining *** he.lth issue. are.ve.y common in high pe.forming poultry line. due.to the.high fe.d intake.which puts pre.sure.on the.physiology of the.dige.tive.*** nutrie.ts which are.not dige.te. and absorbe. in the.small inte.tine.may trigge. dysbiosis,i.e.a shift in the.microbiota composition in the.inte.tinal *** as we.l as othe. stre.sors e.icit an inflammatory re.ponse.and loss of inte.rity of the.tight junctions be.we.n the.e.ithe.ial ce.ls,le.ding to gut *** this pape.,ke. factors de.e.mining inte.tinal he.lth and the.most important nutritional tools which are.available.to support inte.tinal he.lth are.re.ie.e..

关键词： Poultry Inte.tinal he.lth Inflammation Gut le.kage Microbiota Fe.d additive

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Se.me.tal arte.ial me.iolysis, re.arative.phase. An analysis and case.re.ort showing conve.sion to fibromuscular dysplasia with re.al infarction

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World Journal of Cardiovascular Dise.se. 2014年第2期4卷 50-60页

作者： richard e. Slavin Julian de. Ce.ro Gonzale. Jose.Manue. Machin Ange. Roble. Rita Maria Re.ojo Marie.Luisa Die. De.artme.t of Inte.nal Me.icine La Paz University Hospital Madrid Spain De.artme.t of Inte.nal Me.icine University Hospital Guadalajara Spain De.artme.t of Pathology Legacy Emanuel Hospital Portland Oregon USA De.artme.t of Pathology University Hospital Guadalajara Spain Family Practice.Physician Guadalajara Health Center Cervantes Branch Guadalajara Spain Inte.ve.tional Radiologist University Hospital Guadalajara Spain

Se.me.tal arte.ial me.iolysis (SAM), an uncommon arte.iopathy putative.y cause. by nore.ine.hrine.re.e.se. by alpha-1 adre.e.gic agonists or some.Be.a-2 agonists capable.of re.e.sing nore.ine.hrine.from the.pe.iphe.al sympathe.ic ne.vous syste. pote.tially can pre.e.t ische.ic and organ injury symptoms cause. by se.ue.ae.cre.te. in its re.arative.phase.in lie. of catastrophic he.orrhage. announce. in its injurious phase. The.case.docume.ts this pre.e.tation—the.patie.t pre.e.ting re.al infarcts and ische.ic le.ions causing abdominal angina, hype.te.sion and a ne.hre.tomy e.e.t de.e.oping 10 ye.rs afte. prolonge. ritodrine.tre.tme.t for pre.ature.labor. This age.t may have.dire.tly cause. SAM or se.sitize. the.patie.t to agonists causing SAM e.counte.e. at a latte. date. A varie.y of le.ions de.ive. from injurious phase.arte.ial injurie. characte.ize.re.arative.phase.SAM. All we.e.e.counte.e. in a hilar branch of the.re.e.te. re.al arte.y. The.e.include. side.by-side.se.ue.a ane.rysms grossly forming a large.fusiform ane.rysm, granulation tissue.filling adve.titial me.ial te.r space. in which a disse.ting he.atomas de.e.ope., me.ial muscle.loss ce.te.e. to the.oute. me.ia re.aire. with fibrous tissue. arte.ial ste.osis cre.te. by re.arative.intimal plaque., and arte.ial thrombo-e.bolism. The.e.le.ions we.e.mirrore. in accompanying radiologic studie.. The.accompanying re.al ve.n e.hibite. change. consiste.t with re.air of the.spastic ve.ous angiopathy that ofte. accompanie. abdominal SAM. This angiopathy, putative.y induce. by e.dothe.in-1, sugge.te. that this age.t playe. a role.in the.ge.e.is of the.arte.ial le.ions. Angiographic re.olution of non-tre.te. se.ue.ae.occurre. in 5 months e.the. spontane.usly or due.to tre.tme.t with bose.te.. Conclusions: The.histologic and angiographic change. de.onstrate.that the.clinical onse. of re.arative.SAM may be.significantly de.aye. to produce.ische.ic le.ions, re.al infarction and in this case.re.ort, me.ial fibromuscular dy

关键词： Se.me.tal Arte.ial Me.iolysis Fibromuscular Dysplasia Ritodrine Re.al Infarcts Disse.ting He.atoma Inte.tinal Angina e.dothe.in-1 Bose.te.

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创意产业经济学艺术的商业之道

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2004年

作者：（美）理查德·e.凯夫斯（richard e.Cave.）孙绯等译

本书研究了包括视觉艺术、表演艺术、电影、声像制品和图书出版业在内的艺术创作产业的组织形式，同时还阐释了为什么购买权合同形式在艺术创作领域如此广为流行、为什么成功的制片人也会创作出像《天堂之门》这样的败笔等。

ISBN: (纸本)7501166641

关键词：艺术产业经济研究

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e.fe.t of adult le.de. participation on physical activity in childre.

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Ope. Journal of Pre.e.tive.Me.icine 2012年第4期2卷 429-435页

作者： Tanis J. Hastmann Karla e. Foste. richard R. Rose.kranz Sara K. Rose.kranz David A. Dze.altowski Cincinnati Childre.’s Hospital Me.ical Ce.te. Cincinnati USA De.artme.t of Human Nutrition Kansas State University Manhattan USA De.artme.t of Kine.iology Kansas State University Manhattan USA De.artme.t of Physical e.ucation Exercise Science & Wellness University of North Dakota Grand Forks USA

Background: Participation in physically active.game. is one.way to incre.se.e.e.gy e.pe.dture.in childre.. Howe.e., it is unknown whe.he. adult le.de. participation (LP) in game. can impact childre.’s physical activity (PA) le.e.s. The.purpose.of this study was to e.amine.the.influe.ce.of LP compare. to no LP on PA le.e.s among childre. participating in organize. active.game.. Me.hods: Childre. (n = 14) in grade. 4-6 (Male.= 42.8%, White.= 50%, Ove.we.ght/ Obe.e.= 42.8%) participate. in four active.game. across two conse.utive.days. e.ch day, childre. participate. in two 16-minute.game. and re.e.ve. ve.bal e.courage.e.t from an adult le.de.. e.ch game.was divide. into four-minute.inte.vals alte.nating be.we.n LP or no LP. LP was counte.-balance. across two days. e.ch child wore.an Actigraph GT1M acce.e.ome.e.. Time.spe.t in mode.ate.to-vigorous PA (MVPA), vigorous PA (VPA), and se.e.tary be.avior (SB) was de.e.mine. by Fre.dson’s Me. pre.iction. Data we.e.analyze. using a condition (LP or no LP) by game.re.e.te.-me.sure. ANCOVA. Re.ults: Childre. participate. in MVPA 52.3% of game.time.across all game.. The.e.we.e.no diffe.e.ce. in MVPA, VPA, and SB by ge.de., we.ght status, or e.hnicity. LP and no LP conditions we.e.not diffe.e.t for MVPA, VPA, or SB. Conclusions: The.e.re.ults show no e.fe.t of LP on PA in childre. during active.game.. It may be.that LP could not incre.se.PA be.ause.the.childre. we.e.alre.dy e.hibiting high le.e.s of MVPA.

关键词： Acce.e.ome.e. Obe.ity e.e.cise e.ide.ce.Base. Re.e.rch

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e.e.cise. for we.the. and climate./ 5th ed.

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2004年

作者： carbone Gre.ory J.

来源：畅想之星图书光盘版（南... 评论

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AC Impe.ance.Be.aviour of Black Diamond Films

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Journal of Mate.ials Scie.ce.& Te.hnology 2005年第6期21卷 879-882页

作者： Olivie. GAUDIN richard B.JACKMAN e.e.tronic and e.e.trical e.gine.ring University College London Torrington Place London WC1E 7JE UK

The.first me.sure.e.t of impe.ance.on fre.-standing diamond films from 0.1 Hz to 10 MHz up to 300℃ we.e.re.orte.. A wide.range.of che.ical vapour de.osition （CVD） mate.ials we.e.inve.tigate., but he.e.we.conce.trate.on ‘black＇ diamond grown by microwave.plasma e.hance. CVD （MWPe.VD）. The.Cole.Cole.（Z′ via Z″） plots are.we.l fitte. to a RC paralle. circuit mode. and the.e.uivale.t re.istance.and capacitance.for the.diamond films have.be.n e.timate. using the.Zvie. curve.fitting. The.re.ults show only one.single.se.icircle.re.ponse.at e.ch te.pe.ature.me.sure.. It was found that the.re.istance.de.re.se. from 62 MΩ at room te.pe.ature.to 4 kΩ at 300℃, with an activation e.e.gy around 0.51 e.. The.e.uivale.t capacitance.is maintaine. at the.le.e. of 100 pF up to 300℃ sugge.ting that the.diamond grain boundarie. are.dominating the.conduction. At 400℃, the.impe.ance.at low fre.ue.cie. shows a line.r tail, which can be.e.plaine. that the.AC polarization of diamond/Au inte.face.occurs.

关键词： Black diamond Impe.ance.spe.troscopy Activation e.e.gy

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Photoprote.tive.e.fe.t of the.Hydroalcoholic e.tract from Re. and Black Pe.uvian Varie.ie. of <i>Phase.lus vulgaris</i>L.

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Journal of Bioscie.ce. and Me.icine. 2020年第11期8卷 46-59页

作者： L. Papuico-Sánche. M. Santa-Cruz-e.mitanio Juana e. Cháve.-Flore. richard A. Solórzano-Acosta Facultad de.Farmacia y Bioquímica Universidad Norbert Wiener Lima Perú De.artame.to de.Fitote.nia Universidad Nacional Agraria La Molina Lima Perú

Introduction: Ultraviole. radiation can be.harmful to the.skin and can cre.te.se.ious proble.s whe. a prote.tive.substance.or e.uipme.t is not use. re.ularly, for this re.son the.pre.e.t study se. out to e.aluate.the.photoprote.tive.e.fe.t of the.hydroalcoholic e.tracts of the.inte.ume.t of the.re. and black varie.ie. of pop be.ns (e.>Phase.lus vulgarise.>). Mate.ials and Me.hod: The.e.tracts we.e.obtaine. by mace.ating the.te.ume.t of the.two varie.ie. of pop be.ns, black and re., in an e.hanol/wate. (80:20) solution. The.thin-laye. chromatographic me.hod was use. to obse.ve.anti-tyrosinase.activity, using the.0.05% kojic acid standard as a positive.control. The.photoprote.tive.e.fe.t was e.aluate. in fe.ale.mice.of se.e.-we.k-old, Mus e.>musculus e.>Balb/c, with shave. back and e.pose. to UV-C radiation for 30 minute. once.a day for thirty days to induce.photo-damage.in the.skin. The.tre.tme.ts consiste. in the.application of e.tracts at 2% and 5% W/V in ge. on the.shave. are.. Only the.ge. formulation, sunscre.n or no tre.tme.t at all was use. for the.control group. Acute.photodamage.was quantifie. using the.Draize.scale. me.suring the.de.re. of e.ythe.a and e.e.a;and the.de.re. of photoaging using the.Glogau scale.at 7 days and 30 days. Re.ults: It was found that the.e.hanolic e.tracts of the.inte.ume.t of both varie.ie. of e.>Phase.lus vulgarise.>, re. and black, are.practically non-toxic in mice.by oral and de.mal route. at a limit dose.of 5000 mg/kg. The.anti-tyrosinase.e.fe.t at a qualitative.le.e., e.aluate. by thin laye. chromatography, showe. the.black varie.y we.e.more.active.than the.re. one.and both can be.compare. to the.activity of the.kojic acid. The.two e.tracts of the.two varie.ie. showe. photoprote.tive.e.fe.t, howe.e. the.e.tracts in 5% ge. to a gre.te. de.re.. Conclusions: It was conclude. that the.hydroalcoholic e.tract of the.pop black be.ns te.ume.t at 5% in ge. has

关键词： Anti-Tyrosinase.e.fe.t Photoprote.tive.e.fe.t Phase.lus vulgaris

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Adapting the.Succe.sful S-DARS Busine.s for Fixe. and Mobile.Marke.s in China

Adapting the Successful S-DARS Business for Fixed and Mobile...

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2004中国卫星应用大会

作者： richard（Dick）e.Butle. Chairman AsiaSpace.Ltd（WorldSpace.Asia）

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A 1.78 Ga large.igne.us province.in the.North China craton:The.Xiong'e. Volcanic Province.and the.North China dyke.swarm

A 1.78 Ga large igneous province in the North China craton:T...

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中国科学院地质与地球物理研究所2008学术年会

作者： richard e.e.nst e.nst Ge.scie.ce. 43 Margrave Ave OttawaOntario K1T 3Y2Canada and Department of Earth ScienceCarleton UniversityOttawaOntarioCanada K1S 5B6

The.1.78 Ga Xiong’e. Volcanic Province.XVP) and coe.al North China giant mafic Dyke.Swarm(NCDS) are.the.most important magmatic e.e.ts occurring afte. the.amalgamation of the.North China craton(NCC).The.XVP consists of 3-7 km of e.trusive.volcanics and some.fe.de. dyke./sills locate. along the.southe.n margin of the.NCC and e.te.ding ove. an are.>0.06 M km .Compositions vary from basalt to rhyolite.but are.pre.ominantly inte.me.iate.in te.ns of silica *** are.also minor se.ime.tary inte.calations and pyroclastic *** se.ime.tary inte.laye.s indicate.an e.vironme.t changing from contine.tal-facie. to oce.nic-facie. *** XVP is characte.ize. by fractional crystallization from an e. I type.mantle.source.and both contine.tal arc(Ande.n-type. and rift e.vironme.ts have.be.n *** NCDS is wide.pre.d in the.ce.tral NCC with an outcrop are.>0.1 M km,and are.e.pose. at variable.de.ths up to 20 km(de.pe.t in the.north).Dyke.compositions vary from basalt to ande.ite.and dacite.but are.dominantly mafic,and comprise.two se.ie. of *** studie. re.e.le. that the.NCDS re.orde. assimilation and fractional crystallization of an e. I type.magma source.with a minor DM contribution in the.younge. *** syn-collisional and infra-contine.tal anoroge.ic e.vironme.ts have.be.n *** and pe.roge.ic corre.ations sugge.t a coge.e.ic re.ationship be.we.n the.NCDS and XVP,and conside.e. toge.he.,the. de.ine.a Large.Igne.us Province.LIP) of>0.1 M km in are. and>0.1 M km in volume.which is also notable.for its continuous compositional range.from mafic to fe.sic(with no gap at inte.me.iate.compositions).The.pe.rology is e.plaine. by a common magma source.that unde.goe. a silica-poor and iron-e.riche. fractionation tre.d at de.th followe. by a silica-rich and iron-poor fractionation tre.d in shallow-le.e. magma conduits(dyke.) and surface.lavas.A mantle.plume.is favore. as the.cause.of this～1.78 Ga North China LIP.

关键词： Pale.prote.ozoic North China craton Xiong’e. Volcanic Province North China dyke.swarm Large.igne.us province.LIP) Plume

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