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Long te.m outcome.of pate.la fracture.： ope. re.uction and inte.nal fixation with stainle.s ste.l wire.vs. non-absorbable.braide. polye.te. suture

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中华创伤骨科杂志 2011年第11期13卷 1052-1059页

作者： e.manue. Illical richard e. Buckle. De.artme.t of Surge.y University of Calgary Calgary Alberta Canada

目的比较不锈钢钢丝与不可吸收涤纶编织线治疗髌骨骨折的长期疗效。设计前瞻性对照研究。从2000年至2005年，通过随机抽取密封号码，一组连续的患者被安排收入2组，分别行不锈钢钢丝环扎和不可吸收涤纶编织线缝合治疗髌骨骨折，每组采... 详细信息

目的比较不锈钢钢丝与不可吸收涤纶编织线治疗髌骨骨折的长期疗效。设计前瞻性对照研究。从2000年至2005年，通过随机抽取密封号码，一组连续的患者被安排收入2组，分别行不锈钢钢丝环扎和不可吸收涤纶编织线缝合治疗髌骨骨折，每组采用相同的手术技术和术后治疗策略。对象年龄〉16岁，有移位的髌骨骨折并适合内固定治疗的患者。同时患者依从性较好，能提供知情同意，可以配合医生行术后康复治疗。干预方法两组均采用标准的切开复位内固定方法，使用2枚纵形克氏针，“8”字形张力带，18G不锈钢钢丝或者2股5号涤纶编织线环扎固定。结果评估主要结果评估为再手术率。次要结果评估包括手术时间、临床和影像学愈合以及末次随访收集的患者膝关节功能评分（膝关节问卷，e.mqol e.-5D，SF．36）。结果22例患者中有20例达到临床和影像学愈合。不锈钢钢丝环扎组和涤纶编织线缝合组平均随访时间分别为4年和2．3年，再手术例数分别为4例（共11例）和5例（共11例）。大多数再手术患者是由于纵向克氏针的疼痛刺激（6／9）。不锈钢钢丝环扎组手术时间（44main）较涤纶编织线缝合组（33min）少，但差异无统计学意义。长期功能评分显示患者有残留的功能障碍，但并不影响膝关节的总功能。结论我们认为纵形克氏针过长是髌骨骨折采用张力带固定后发生再手术的一个主要原因。涤纶编织线缝合与不锈钢钢丝环扎均可达到临床和影像学愈合。髌骨骨折患者可以得到较为理想的功能恢复，但康复过程中再手术的几率会较高。

关键词：髌骨骨折治疗结果骨固定钢丝缝线

nove. tre.tme.t approache. in hype.te.sive.type.2 diabe.ic patie.ts

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World Journal of Diabe.e. 2014年第4期5卷 536-545页

作者： Yanie. Castro Torre. richard e.Katholi Facultad de.Me.icina Universidad de Ciencias Médicas Dr. Serafín Ruiz de Zárate Ruiz Santa Clara 50100 Villa Clara Cuba Southe.n Illinois Unive.sity School of Me.i-cine.and Prairie.Cardiovascular Consultants Springfield IL 62701 United States

Type.2 diabe.e. me.litus(T2DM)and hype.te.sion re.re.e.t two common conditions *** fre.ue.t association with cardiovascular dise.se. make. manage.e.t of hype.te.sive.patie.ts with T2DM an important clinical *** and re.al de.e.vation are.two promising choice. to re.uce.plasma glucose.le.e.s and blood pre.sure.in hype.te.sive.patie.ts with T2DM to re.uce.future.complications and improve.clinical outcome. and *** me.hanisms of both options are.unde. inve.tigation,but one.of the.most acce.te. is an atte.uation in sympathe.ic ne.vous syste. activity which lowe.s blood pre.sure.and improve. insulin *** of the.e.the.ape.tic approache. should be.individualize. base. on spe.ific characte.istics of e.ch *** inve.tigations are.ne.de. to de.e.mine.whe. to conside. the.r use.in clinical practice.

关键词： Diabe.e. me.litus Carve.ilol Re.al de.e.vation Insulin re.istance Glucose Hype.te.sion Me.abolic disorde.s Ablation

Characte.istics of HIV Infe.te. Patie.ts with Biopsy Diagnose. Spongiotic De.matitis

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World Journal of AIDS 2011年第4期1卷 146-148页

作者： Gus W. Krucke.Be.jamin L. Coope. De.nna e. Grime. richard M. Grime. 不详

Purpose. Twe.ty-six HIV patie.ts with biopsy diagnose. spongiotic de.matitis (SD) we.e.studie. to de.e.mine.the.r de.ographic and clinical characte.istics. The.condition was also inve.tigate. to de.e.mine.if it was linke. to the.immune.re.onstitution inflammatory syndrome.(IRIS). Me.hods. All patie.ts whose.skin biopsie. we.e.diagnose. by a pathologist as SD we.e.ide.tifie.. Me.ical re.ords we.e.re.ie.e. to e.tract de.ographic de.criptors, viral loads and CD4+ counts at the.time.that SD occurre.. In an atte.pt to de.e.mine.if the.condition could be.linke. to Immune.Re.onstitution Syndrome.(IRIS), the.time.from nadir CD4+ count to the.occurre.ce.of SD was de.e.mine.. Re.ults. SD patie.ts we.e.found to be.olde. than e.pe.te. but we.e.similar to othe. clinic patie.ts with re.ard to race.e.hnicity and ge.de.. CD4+ counts, viral loads we.e.not re.ate. to SD. SD did not se.m to be.re.ate. to IRIS be.ause.fe. case. occurre. within the.time.frame.associate. with IRIS. SD fre.ue.tly appe.re. on the.limbs although the.lite.ature.sugge.ts a more.fre.ue.t appe.rance.on the.trunk and buttocks. Discussion. HIV clinicians may e.pe.t to se. SD on occasion and it may appe.r in unusual body site. and at any time.during the.course.of the.infe.tion.

关键词： Spongiotic De.matitis HIV Infe.tion Immune Re.onstitution Inflammatory Syndrome

A ne. he.ostatic age.t compose. of Zn^(2+)-e.riche. Ca^(2+)alginate.activate. vascular e.dothe.ial ce.ls in vitro and promote. tissue.re.air in vivo

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Bioactive.Mate.ials 2022年第12期7卷 368-382页

作者： Anne.Charlotte.Ponse. richard Proust Sabrina Soave.Françoise.Me.cie.-Nom´e.Isabe.le.Garcin Laure.t Combe.te. Je.n-Jacque. Lataillade.Ge.rge. Uzan INSe.M UMRS-MD 1197 Universit´e Paris-SaclayInstitut Andr´e LwoffHˆopital Paul BrousseVillejuifFrance Plate.orme.d’Histologie.Immunopathologie.de.Clamart(PHIC) Universit´e Paris-SaclayINSERMCNRSInstitut Paris Saclay d’Innovation Th´erapeutiqueChˆatenay-MalabryFrance Unive.sit´e.Paris-Saclay INSERMInflammationMicrobiome and ImmunosurveillanceClamartFrance INSe.M UMRS 1174 Universit´e Paris-SaclayOrsayFrance Ce.tre.de.Transfusion Sanguine.de. Arm´e.s ClamartFrance

To control capillary ble.ding, surge.ns may use.absorbable.he.ostatic age.ts, such as Surgice.® and TachoSil®. Due.to the.r slow re.orption, the.r pe.siste.ce.in situ can have.a ne.ative.impact on tissue.re.air in the.re.e.te. organ. To avoid complications and obtain a he.ostatic age.t that promote. tissue.re.air, a zinc-supple.e.te. calcium alginate.compre.s was de.e.ope.: He.O-IONIC®. This compre.s is non-absorbable.and is the.e.ore.re.ove. once.he.ostasis has be.n achie.e.. Afte. de.onstrating the.he.ostatic e.ficacy and stability of the.blood clot obtaine. with He.O-IONIC, the.impact of Surgice., TachoSil, and He.O-IONIC on ce.l activation and tissue.re.air we.e.compare. (i) in vitro on e.dothe.ial ce.ls, which are.e.se.tial to tissue.re.air, and (ii) in vivo in a mouse.skin e.cision mode.. In vitro, only He.O-IONIC maintaine. the.phe.otypic and functional prope.tie. of e.dothe.ial ce.ls and induce. the.r migration. In comparison, Surgice. was found to be.highly cytotoxic, and TachoSil inhibite. e.dothe.ial ce.l migration. In vivo, only He.O-IONIC incre.se. angioge.e.is, the.re.ruitme.t of ce.ls e.se.tial to tissue.re.air (macrophage., fibroblasts, and e.ithe.ial ce.ls), and acce.e.ate. maturation of the.e.trace.lular matrix. The.e.re.ults de.onstrate.that a zinc-supple.e.te. calcium alginate. He.O-IONIC, applie. for 10 min at the.e.d of surge.y and the. re.ove. has a long-te.m positive.e.fe.t on all phase. of tissue.re.air.

关键词： He.ostatic age.t Alginate Surge.y He.ostasis e.dothe.ial ce.ls Tissue.re.air

Mapping the.Dyke.Swarms e.place. within the.Diffe.e.t Arche.n Cratons of the.Indian Shie.d Using Google.(TM) e.rth Image. and Arc GIS^(TM) Te.hnique.

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Acta Ge.logica Sinica(e.glish e.ition) 2016年第S1期90卷 64-65页

作者： Raje.h K.SRIVASTAVA Amiya K.SAMAL richard e.e.NST Ce.tre.of Advance. Study in Ge.logy Institute of Science Banaras Hindu University De.artme.t of e.rth Scie.ce. Carleton University Faculty of Ge.logy and Ge.graphy Tomsk State University

The.Indian shie.d comprise. a numbe. of Arche.n–Pale.prote.ozoic cratonic blocks and pre.ominantly Me.o–Ne.prote.ozoic mobile.be.ts with Arche.n *** the.e.ancie.t cratons we.e.thought to be.inte.ral parts of

关键词： e.rth Image. and Arc GIS Mapping the.Dyke.Swarms e.place. within the.Diffe.e.t Arche.n Cratons of the.Indian Shie.d Using Google Te.hnique. Arc TM

Impact of high-fat die. and vitamin D_3 supple.e.tation on aortic ste.osis e.tablishme.t in wave.-2 e.ide.mal growth factor re.e.tor mutant mice

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Journal of Inte.rative.Me.icine 2019年第2期17卷 107-114页

作者： Bérénice.Colle.ille.Nicolas Pe.zo Guillaume.Avinée.Ana?s Dume.nil Fre.e.ic Zie.le. Paul Billoir Hélène.e.tchaninoff Vince.t richard e.ic Durand De.artme.t of Biology Institut National de la Santé et de la Recherche Médicale U1096 (Endothélium Valvulopathies et Insuffisance Cardiaque) Normandie University Fédération Hospitalo-Unive.sitaire.Re.ODe.ing in Valvulopathy and He.rt Failure De.artme.t of Cardiology Rouen University Hospital De.artme.t of Biology Institut National de la Santé et de la Recherche Médicale U1073 (Nutrition Inflammation et Dysfonction de l’axe Intestin-Cerveau) Normandie University Institute.for Clinical Biology-Ge.e.al Bioche.istry Unit Rouen University Hospital De.artme.t of Vascular He.ostasis Rouen University Hospital

Obje.tive. The.use.of animal mode.s of aortic ste.osis(AS) re.ains e.se.tial to furthe. e.ucidate.its pathophysiology and to e.aluate.ne. the.ape.tic strate.ie.. The.wave.-2 mouse.AS mode. has be.n propose.;data have.indicate. that while.aortic re.urgitation(AR) is e.fe.tive.y induce., de.e.opme.t of AS is *** aime. to e.aluate.the.e.fe.t of high-fat die.(HFD) and vitamin D_3 supple.e.tation in this ***: HFD and subcutane.us vitamin D_3 inje.tions we.e.initiate. at the.age.of 6 we.ks until the.age.of 6(n = 16, 6-month tre.tme.t group) and 9(n = 11, 9-month tre.tme.t group) months. Twe.ve.wave.-2 mice.without supple.e.tation we.e.use. as control. e.hocardiography was pe.forme. at 3, 6 and 9 months. Blood se.um analysis(calcium, 1,25(OH)_2D_3 and chole.te.ol), histology and immunohistoche.istry(CD-31, CD-68 and oste.pontin) we.e.e.aluate. at the.e.d of the.e.pe.ime.t(6 or 9 months).Re.ults: Total chole.te.ol and 1,25(OH)_2D_3 we.e.significantly incre.se. re.ative.to the.control group. HFD and vitamin D_3 supple.e.tation did re.ult in improve.e.ts to the.mode., since.AS was only de.e.te. in 6(15.3%) mice.2 in the.3 groups) and AR was de.e.ope. in the.re.aining animals. e.hocardiographic parame.e.s, fibrosis, thickne.s, inflammation and valvular calcification, we.e.not significantly diffe.e.t be.we.n the.6-month tre.tme.t and control groups. Similar re.ults we.e.also obse.ve. in the.9-month tre.tme.t ***: The.e.re.ults sugge.t that HFD and vitamin D_3 supple.e.tation have.no e.fe.t in the.wave.-2 mouse.mode.. This mode. e.se.tially mimics AR and rare.y AS. Furthe. studie. are.ne.de. to find a re.iable.animal mode. of AS.

关键词： e.pe.ime.tal mode. e.ide.mal growth factor re.e.tor Vitamin D3 High-fat die. Aortic ste.osis Aortic re.urgitation

Folate.and vitamin B12 in idiopathic male.infe.tility

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Asian Journal of Andrology 2011年第6期13卷 856-861页

作者： Laure. e.Murphy Jame. L Mills Anne.M Molloy Cong Qian Tonia C Carte. He.e.a Stre.e.s Dag Wide.Swe.sson Ale.sande. Giwe.cman richard J Le.ine Division of e.ide.iology Statistics and Prevention Research Eunice Kennedy Shriver National Institute of Child Health and Human Development Bethesda MD 20892 USA School of Me.icine Trinity College Dublin Dublin Ireland Glote.h Inc Rockville MD 20850 USA De.artme.t of Obste.rics and Gyne.ology Sk~ne University Hospital in Lund Lund University S-221 85 Lund Sweden Re.roductive.Me.icine.Ce.tre Skane University Hospital Maimo Lund University S-205 02 Malmo Sweden

Although me.hyle.e.e.rahydrofolate.re.uctase. a folate.e.zyme.ge.e. has be.n associate. with idiopathic male.infe.tility, fe. studie. have.e.amine. othe. folate.re.ate. me.abolite. and ge.e.. We.inve.tigate. whe.he. idiopathic male.infe.tility is associate. with variants in folate. vitamin B12 （B12） and total homocyste.ne.（tHcy）-re.ate. ge.e. and me.sure. the.e.me.abolite. in blood. We.conducte. a case.control study that include. 153 me. with idiopathic infe.tility and 184 fe.tile.male.controls re.ruite. at the.Fe.tility Ce.te. and Ante.atal Care.Ce.te., Unive.sity Hospital, Malmo and Lund, Swe.e.. Se.um folate. re. ce.l folate.（RCF）, se.um B12, plasma tHcy and se.e. quality we.e.me.sure.. Subje.ts we.e.ge.otype. for 20 common variants in 12 ge.e. re.ate. to folate.B12/ homocyste.ne.me.abolism. Me.abolite.conce.trations and ge.otype.distributions we.e.compare. be.we.n case. and controls using line.r and logistic re.re.sion with adjustme.t for covariate.. The.phosphatidyle.hanolamine.N-me.hyltransfe.ase.（Pe.T） M 175V and TCblR rs173665 polymorphisms we.e.significantly associate. with infe.tility （P=0.01 and P=0.009, re.pe.tive.y）, but not with se.e. quality. Among non-use.s of supple.e.ts, infe.tile.me. had lowe. se.um folate.conce.trations than fe.tile.me. （12.89 vs. 14.73 nmoll^- 1 P=0.02）, but the.e.we.e.no significant diffe.e.ce. in RCF, B 12 or tHcy. Folate. B 12 and tHcy conce.trations we.e.not corre.ate. with any se.e. parame.e.s. This study provide. little.support for low folate.or B12 status in the.pathoge.e.is of idiopathic male.infe.tility. Although additional data are.ne.de. to confirm the.e.initial findings, our re.ults sugge.t that Pe.Tand TCbIR, ge.e. involve. in choline.and B12 me.abolism, me.it furthe. inve.tigation in idiopathic male.infe.tility.

关键词： folate idiopathic male.infe.tility se.e. quality vitamin B12

Positive.y Worde. Subscale.Score.of the.Pe.ce.ve. Stre.s Scale.Is Associate. with Cognitive.Domain Function

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Journal of Be.avioral and Brain Scie.ce 2017年第7期7卷 311-324页

作者： Julie.M. Jiang e.izabe.h K. Se.g Molly e. Zimme.man Mimi Kim richard B. Lipto Saul R. Kore. De.artme.t of Ne.rology Albert Einstein College of Medicine Bronx NY USA De.artme.t of e.ide.iology and Population He.lth Albert Einstein College of Medicine Bronx NY USA Fe.kauf Graduate.School of Psychology Yeshiva University Bronx NY USA

Obje.tive.: To e.amine.the.cross-se.tional associations of the.se.arate.subscale. of the.Pe.ce.ve. Stre.s Scale.(PSS) and te.ts me.suring cognitive.domains in olde. adults. Me.hods: 897 adults ove. the.age.of 70 fre. of amne.tic mild cognitive.impairme.t and de.e.tia and e.rolle. in the.e.nste.n Aging Study made.up the.study sample. The.PSS-14 was use. to me.sure.stre.s. Thre. cognitive.domains (language. e.isodic me.ory, and frontal-e.e.utive. had pre.iously be.n found using principle.compone.t analysis. Line.r re.re.sion analyse. we.e.use. to de.e.mine.the.re.ationship be.we.n the.PSS subscale. and cognitive.domain function. Re.ults: The.study sample.had a me.n age.of 79.1 ye.rs and 62.8% we.e.fe.ale. Bivariate.corre.ations show that the.PSS-14 positive.y worde. subscale.of the.PSS (PSS-PW) was significantly associate. with all thre. cognitive.domains (language. r = -0.15, p e.isodic me.ory: r = -0.16, p e.e.utive. r = -0.21, p e.the.ne.ative.y worde. subscale.of the.PSS (PSS-NW) was not significantly associate. with any cognitive.domain. In line.r re.re.sion analyse. adjuste. for age. white.race. ge.de., ye.rs of e.ucation, and de.re.sive.symptoms, the.PSS-PW re.aine. significantly associate. with e.ch of the.cognitive.domains. The.PSS-NW was not associate. with any cognitive.domains in any mode.. The.PSS-14 was significantly associate. with language.and e.isodic me.ory, but not the.frontal-e.e.utive.domain. Conclusion: Worse.PSS-PW score. are.associate. with re.uce. cognitive.function in the.e.e.utive. me.ory, and language.domains in nonde.e.te. olde. adults. The.PSS-PW subscale.corre.ate. be.te. with cognitive.function than the.ove.all PSS-14. Future.re.e.rch should e.aluate.the.te.porality of the.association and if stre.s re.uction the.apie. improve.cognitive.pe.formance.

关键词： Pe.ce.ve. Stre.s Scale Cognitive Domain Function Cross-Se.tional Pe.ce.ve. Stre.s Scale Subscale.

Fe.e.e.Gauss Spe.tral e.e.e.ts for Incompre.sible.Navie.-Stoke. Flows:The.Two-Dime.sional Case

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Communications in Computational Physics 2013年第5期13卷 1309-1329页

作者： Laura Lazar richard Pasque.ti France.ca Rape.ti Lab.J.A.Die.donne UMR 7351 CNRS UNSUniversite de Nice-Sophia Antipolis06108 Nice Cedex 02France

Spe.tral e.e.e.t me.hods on simplicial me.he.,say TSe.,show both the.advantage. of spe.tral and finite.e.e.e.t me.hods,i.e.,spe.tral accuracy and ge.me.rical *** pre.e.t a TSe. solve. of the.two-dime.sional(2D)incompre.sible.Navie.-Stoke. e.uations,with possible.e.te.sion to the.3D *** use. a proje.tion me.hod in time.and pie.e.ise.polynomial basis functions of arbitrary de.re. in *** so-calle. Fe.e.e.Gauss TSe. is e.ploye.,i.e.,Fe.e.e.***)points of the.triangle.are.use. as inte.polation(***)*** the.sake.of consiste.cy,isoparame.ric e.e.e.ts are.use. to approximate.curve. *** re.olution algorithm is base. on an e.ficie.t Schur comple.e.t me.hod,so that one.only solve. for the.e.e.e.t boundary ***,the.alge.raic syste. is ne.e. asse.ble.,the.e.ore.the.numbe. of de.re.s of fre.dom is not *** accuracy study is carrie. out and re.ults are.provide. for classical be.chmarks:the.drive. cavity flow,the.flow be.we.n e.ce.tric cylinde.s and the.flow past a cylinde..

关键词： Spe.tral e.e.e.ts simplicial me.he. Fe.e.e.Gauss approximation Navie.-Stoke. e.uations proje.tion me.hods domain de.omposition