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Male contraception:prospects for the new millennium

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Asian journal of Andrology 2000年第1期2卷 3-12页

作者： W.M.hair F.C.W.Wu Department of Medicine University of Manchester Manchester MI3 9WL UKDepartment of Medicine University of Manchester Manchester MI3 9WL UK

Effective regulation of human fertility has global consequences in terms of resource depletion, pollution and pover-ty. Current family planning services predominantly target a female clientele with few significant developments in malefertility regulation for over a century. The last two decades have witnessed a gathering interest, initially from the scien-tific community, and laterally from industry, in the development of safe, reliable, reversible methods of contraceptionfor men. This review summarises the methods of male fertility regulation which are currently available and critically ex-amines the published data on novel developments in male hormonal contraception which offer the potential of improvedcontraceptive choice for all in new millennium. (Asian j Androl 2000; 2: 3 - 12)

关键词： contraception male contraceptive agents male contraceptive devices gonadotropins testosterone androgen

Study on the Photoreaction Between Alkyl Amine and Selenium Dispersion in Heptane

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Chinese Science Bulletin 1994年第9期39卷 744-747页

作者：陈次平 R.P.Veregin j.R.Harbour M.L.hair Institute of Photographic Chemistry Academia Sinica Beijing 100101 PRC Xerox Research Centre of Canada 2660 Speakman DriveMississaugaOntario L5K 2L1Canada

1 Introduction There has been a considerable amount of researches on the photoinduced chargeexchange of photoactive pigments dispersed in water. However, very littleattention has been paid to those dispersed in solvents with low dielectric *** pigment electrophotography (PAPE) is based upon a photoinduced chargeexchange of pigments in solvents with low dielectric constants. In PAPE systems

关键词： charge transfer spin trapping selenium amine.

Platelet-Rich Plasma for Androgenetic Alopecia:What the Dermatologist Needs to Know

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International journal of Dermatology and Venereology 2024年第3期7卷 174-175页

作者： Shivali Devjani ogechi Ezemma Kristen j.Kelley Maryanne Makredes Senna Department of Dermatology Lahey Hospital&Medical CenterBurlingtonMA 01803USA Harvard Medical School BostonMA 02115USA.

Platelet-rich plasma(PRP)has been used as a regenerative therapy for more than 30 years in wound healing,ortho-pedics,dentistry and cosmetics,and aesthetic *** is an autologous preparation of platelets in concentrated plasma at 2 to 7 times the normal concentration of whole blood.1 The popularity of PRP stems from its success rate,autologous nature,and absence of major adverse *** recent years,PRP has been successfully used as a treat-ment option for hair loss.

关键词： Platelet healing wound

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脂胺在硒-庚烷分散体系中光反应的研究

科学通报 1994年第2期39卷 139-141页

作者：陈次平 R.P.Veregin j.R.Harbour M.L.hair 中国科学院感光化学研究所北京100101 Xerox Research Centre of Canada OntarioCanada

人们对半导体颜料在水的分散体系中的光诱导的电荷转移过程已进行了大量的研究.但对其在低介电常数的溶剂中的研究还不多.光活性颜料电照相体系(Photo activepigment electrophotography,PAPE)正是基于颜料在低介电常数的溶剂中的电荷转... 详细信息

人们对半导体颜料在水的分散体系中的光诱导的电荷转移过程已进行了大量的研究.但对其在低介电常数的溶剂中的研究还不多.光活性颜料电照相体系(Photo activepigment electrophotography,PAPE)正是基于颜料在低介电常数的溶剂中的电荷转移.在PAPE体系中,某些添加物如醇、胶等捕获空穴或空穴产物将对体系中电荷交换起稳定作用.虽然人们一直认为在这些体系中产生的自由基是关键的中间体,但这种假设还需要实验证明.

关键词：脂胺庚烷光化学反应分散体系硒

Soil Contamination due to E-Waste Disposal and Recycling Activities: A Review with Special Focus on China

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Pedosphere 2012年第4期22卷 470-488页

作者： G. ECHEVARRIA T. STERCKEMAN M. o. SIMoNNoT j. L. MoREL INPL(ENSAIA)/INRA Laboratoire Sols et Environnement 2 Avenue de la For et de Haye BP 172 54505 Vandoeuvre-lès-Nancy Cedex (France) Laboratoire Réactions et Génie des Procédés (LRGP) Université de Lorraine-CNRS (UPR 3349) 1 Rue Grandville BP20451 54001 Nancy Cedex (France)

Considering that even contaminated soils are a potential resource for agricultural production, it is essential to develop a set of cropping systems to allow a safe and sustainable agriculture on contaminated lands while avoiding any transfer of toxic trace elements to the food chain. In this review, three main strategies, i.e., phytoexclusion, phytostabilization, and phytoextraction, are proposed to establish cropping systems for production of edible and non-edible plants, and for extraction of elements for industrial use. For safe production of food crops, the selection of low-accumulating plants/cultivars and the application of soil amendments are of vital importance. Phytostabilization using non-food energy and fiber plants can provide additional renewable energy sources and economic benefit with minimum cost of agricultural measures. Phytoextracting trace elements （e.g., As, Cd, Ni, and Zn） using hyperaccumulator species is more suitable for slightly and moderately polluted sites, and phytomining of Ni from serpentine soils has shown a great potential to extract Ni-containing bio-ores of economic interests. We conclude that appropriate combinations of soil types, plant species/cultivars, and agronomic practices can restrict trace metal transfer to the food chain and/or extract energy and metals of industrial use and allow safe agricultural activities.

关键词： agronomic practices food safety hyperaccumulator phytoremediation trace element

Experience of Patients Undergoing Mini-Arthroscopy Compared to MRI in the Earliest Phases of Arthritis

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International journal of Clinical Medicine 2013年第12期4卷 1-5页

作者： Maria j. H. de hair Marleen G. H. van de Sande Mario Maas Danielle M. Gerlag Paul P. Tak Department of Clinical Immunology and Rheumatology Aca-demic Medical Center University of Amsterdam Amsterdam The Netherlands Department of Radiology Academic Medical Center University of Amsterdam Amsterdam The Netherlands

objective: To evaluate the expectations and experience of patients undergoing mini-arthroscopy compared to contrast enhanced MRI for research purposes. Methods: Seventeen patients with early, active arthritis (Group A) and 21 autoantibody-positive individuals without any evidence of arthritis upon physical examination (Group B) were included. All subjects underwent both contrast enhanced MRI and synovial biopsy sampling by mini-arthroscopy of the same joint within one week. At inclusion and after both procedures, subjects filled in questionnaires with items about expectations and experience with regard to the procedures. Results: Before procedures, subjects in group B had a higher fear of and reluctance to undergo mini-arthroscopy compared to MRI (p ore procedures, 42% of the subjects preferred MRI, 11% of the subjects preferred mini-arthroscopy and 47% had no preference for either procedure. After both procedures, subjects preferences changed to 39% for MRI, 32% for mini-arthroscopy and 29% for no preference for one or the other procedure. When comparing Group A with Group B, there were no significant differences in preference before and after the procedures. Conclusion: Synovial biopsy sampling by mini-arthroscopy for analysis of synovial inflammation is a well-experienced procedure when compared to contrast enhanced MRI. These results support the use of mini-arthroscopy in a research setting from a patient perspective.

关键词： Arthritis Rheumatoid Synovium Arthroscopy MRI

灰鼠畸变产物耳声发射改变和外毛细胞缺失程度的相关分析

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中华耳鼻咽喉头颈外科杂志 2009年第2期44卷 145-149页

作者：于栋祯丁大连殷善开 richard j Salvi 上海交通大学附属第六人民医院耳鼻咽喉科上海交通大学(医学院)耳鼻咽喉科研究所 200233 纽约州立大学布法罗分校听力和耳聋中心

目的探讨灰鼠畸变产物耳声发射（DPoAE）幅值的降低与外毛细胞缺失率之间的关系。方法联合应用顺铂和利尿酸钠，建立灰鼠耳蜗毛细胞损伤模型。12只灰鼠在静脉注射利尿酸钠（40mg／kg）同时，腹腔注射顺铂（0．2mg/kg），分别于用药前和... 详细信息

目的探讨灰鼠畸变产物耳声发射（DPoAE）幅值的降低与外毛细胞缺失率之间的关系。方法联合应用顺铂和利尿酸钠，建立灰鼠耳蜗毛细胞损伤模型。12只灰鼠在静脉注射利尿酸钠（40mg／kg）同时，腹腔注射顺铂（0．2mg/kg），分别于用药前和用药后的1周、2周及3周在清醒状态下检测动物DPoAE，并在施行最后1次DPoAE检测后处死动物。常规制备灰鼠耳蜗基底膜铺片并进行全耳蜗毛细胞计数。计算用药前和处死前DPoAE幅值的改变程度，通过Person相关分析对DPoAE幅值的降低与外毛细胞缺失程度之间的相关性进行分析。结果顺铂和利尿酸钠引起灰鼠耳蜗外毛细胞缺失的特点是病变始发于基底膜的底回并逐渐向顶回发展，外毛细胞的缺损程度沿着基底膜从底回向顶回逐渐减轻，而不同频率DPoAE幅值降低的程度亦遵循从高频向低频发展的规律，各频率DPoAE在注射顺铂和利尿酸钠后的幅值改变与基底膜上相应部位的外毛细胞缺损程度存在一定的对应关系（r=0．796，P〈0．05）。外毛细胞每损失1％，可引起约0．24dB的DPoAE幅值降低。结论在灰鼠耳蜗损伤模型中，从DPoAE幅值的变化可以大致评估耳蜗外毛细胞的缺失程度。

关键词：毛细胞外耳声发射自发性顺铂依他尼酸毛丝鼠属

硫酸链霉素对体外培养大鼠前庭毛细胞的损害作用

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中华耳鼻咽喉头颈外科杂志 2009年第1期44卷 53-56页

目的探讨硫酸链霉素对离体培养条件下大鼠前庭毛细胞的损害特征。方法取出生后3—4d的大鼠球囊斑和椭圆囊斑进行离体前庭器官培养，经培养过夜后再用不同浓度的硫酸链霉素培养液继续培养24h。应用荧光标记的鬼笔环肽对前庭毛细胞的静纤... 详细信息

目的探讨硫酸链霉素对离体培养条件下大鼠前庭毛细胞的损害特征。方法取出生后3—4d的大鼠球囊斑和椭圆囊斑进行离体前庭器官培养，经培养过夜后再用不同浓度的硫酸链霉素培养液继续培养24h。应用荧光标记的鬼笔环肽对前庭毛细胞的静纤毛和表皮板进行染色，同时应用Topro-3DNA探针显示细胞核的形态，在激光共聚焦显微镜下计数和摄像。结果在离体培养条件下，对照组前庭毛细胞生长良好，随着培养液中硫酸链霉素浓度的增加，毛细胞的密度逐渐降低。培养24h后，0．25mmol／L硫酸链霉素可造成大约10％的前庭毛细胞缺损，1mmol／L硫酸链霉素损害的毛细胞数量在50％左右，3mmol／L硫酸链霉素破坏的毛细胞数量超过75％。细胞核染色显示硫酸链霉素引起的前庭毛细胞损害伴随着细胞核浓缩或破碎现象。存活毛细胞的数量随着硫酸链霉素浓度的增加而减少，但前庭的支持细胞未发生明显病变。结论在体外培养条件下，硫酸链霉素可引起剂量依赖性的大鼠前庭毛细胞缺失，其损伤机制可能与凋亡有关。

关键词：毛细胞前庭器官培养技术链霉素细胞凋亡

卡铂损伤南美栗鼠耳蜗内毛细胞及对听觉复合动作电位的影响

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中华耳鼻咽喉头颈外科杂志 2020年第5期55卷 506-513页

作者：袁芳丁大连王坚曹轶倓 Salvi richard j 亓卫东复旦大学附属华山医院耳鼻咽喉头颈外科上海200040 Center for Hearing and Deafness Department of Communicative Disorders and SciencesState University of New York at Buffalo.BuffaloNY 14214USA 上海交通大学附属第六人民医院耳鼻咽喉头颈外科上海交通大学耳鼻咽喉科研究所200233 School of Human Communication Disorders Dalhousie UniversityHalifaxNS 250101Canada

目的通过卡铂耳蜗损伤模型,观察成年南美栗鼠耳蜗听神经复合动作电位(compound action potential,CAP)及其基底膜内、外毛细胞密度,探讨内毛细胞损害程度与CAP振幅、阈值改变的关系。方法18只成年南美栗鼠经耳科学检查后按随机数字表法... 详细信息

目的通过卡铂耳蜗损伤模型,观察成年南美栗鼠耳蜗听神经复合动作电位(compound action potential,CAP)及其基底膜内、外毛细胞密度,探讨内毛细胞损害程度与CAP振幅、阈值改变的关系。方法18只成年南美栗鼠经耳科学检查后按随机数字表法分为3组(每组6只):A组为对照组,B组和C组分别接受1次和2次卡铂注射(76 mg/kg,腹腔注射,2次注射间隔1周)。B组和C组动物在卡铂注射后30 d、A组在相应时间行终点功能测试。经下鼓室径路将记录电极安放到麻醉后南美栗鼠的圆窗龛,记录短声(click)及0.5、1、2、4、8、16 kHz短纯音刺激下的CAP。测试结束后处死动物。耳蜗基底膜铺片经琥珀酸脱氢酶组织化学染色标记毛细胞,在光学显微镜下对全耳蜗基底膜铺片连续高清拍摄,统计毛细胞数量及基底膜长度,计算10%基底膜长度内耳蜗内、外毛细胞的数量作为毛细胞密度。采用GraphPad 6软件进行统计学处理。结果A组成年南美栗鼠click及0.5、1、2、4、8、16 kHz短纯音声刺激CAP阈值分别为(7.1±2.6)、(25.4±5.0)、(24.6±5.4)、(10.4±5.0)、(0.4±1.4)、(4.2±6.3)和(17.1±14.1)dB SPL(±s,n=12)。A组单个耳蜗毛细胞总数为(8936±643)个(±s,n=7),全耳蜗基底膜长度为(17.73±1.01)mm(n=12)。与A组相比,B组动物CAP阈值未见明显变化,但CAP饱和振幅降低了40%并伴有约40%的内毛细胞缺失。C组动物CAP明显升高并损失了近90%的内毛细胞。结论成年南美栗鼠短纯音CAP阈值在2、4、8 kHz最低,在低频或高频时阈值略有升高。卡铂造成的部分内毛细胞损伤与CAP振幅改变有良好的对应关系,但在内毛细胞损失40%时并不改变CAP的阈值,当内毛细胞缺失超过80%时,CAP阈值的升高不可避免。

关键词：毛细胞,听觉基底膜卡铂复合动作电位南美栗鼠