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Dynamics of Potable Well Water Quality in Key Mining Chiefdoms in Kono District, Eastern Sierra Leone

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Open Journal of Applied Sciences 2024年第7期14卷 1927-1943页

作者： richard Tamba Simbo Alhaji Brima Gogra Yahaya Kudus Kawa Juana Paul Moiwo Department of Science and Mathematics College of Arts and Sciences William V.S. Tubman University Harper Liberia Port Loko University College Campus Ernest Bai Koroma University of Science and Technology Port Loko Sierra Leone Department of Chemistry School of Basic Sciences Njala University Bo Sierra Leone Department of Agricultural Engineering School of Technology Njala University Bo Sierra Leone

Groundwater is increasingly being used due to its universal availability and generally good quality. However, the risk of contamination of groundwater due to various human activities such as mining is equally increasing across the globe. In this study, the physical parameters of potable well waters in the key mining areas in Nimikoro and Tankoro Chiefdoms in Kono District were analyzed for compliance with drinking water quality standard. To do this, both unpurged and purged well water samples were collected once every month for a period of one year. Some of the well water properties like temperature, Total Dissolved Solids (TDS) and Electrical Conductivity (EC) were measured on site and others determined in the laboratory. The data collected from the laboratory analyses were statistically analyzed in MS Excel, SPSS and ArcGIS environments for quality trends in time-space fabric. The results showed that well water quality in the study area generally fell short of drinking water quality standards of Sierra Leone and WHO. There were high temperature and turbidity during the dry season and then high TDS and EC during the rainy season. Temperature and turbidity also significantly influenced well water quality in the study area, much more than TDS and EC. The implications for drinking water of lower quality than the standard could be huge for the local population and therefore needs the attention of stakeholders in the study area and decision makers in the country.

关键词： Temperature Total Dissolved Solids Turbidity Electrical Conductivity Water Quality

Analysis of the Characteristics of Materials Obtained by Recycling Scrap Metal in Guinea

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材料科学与工程（中英文A版） 2024年第1期14卷 1-10页

作者： Alpha Issa Diallo Jean Ahmed Kourouma Adama Moussa Sakho Alexandre Lucien richard Mechanical Laboratory Higher Institute of Technology of MamouMamou 063Republic of Guinea Materials Laboratory of Gamal Abdel Nasser University ConakryMamou1147Republic of Guinea Department of Laboratory Technology Higher Institute of Technology of MamouMamou 063Republic of Guinea

The aim of this study was to determine the quality of rebar produced from recycled scrap metal collected throughout the country,and imported rebar sold in the Republic of *** do this,the samples were subjected to various mechanical tests involving traction,bending and microscopic *** the Lambanyi and Casse Sonfonia samples,all the tensile strength values for diameters 12,14 and 16 were above 550 ***,the iron samples from Baillobaye and the 10 mm diameters of the samples from Casse Sonfonio and Lambanyi have less appreciable *** limits of elasticity were *** various values found vary more or less from the conventional yield strength of the NF A35-016 reference supplied by CBITEC,which is 500 *** analysis gives us an insight into the internal structure of the iron samples *** study may provide the company and the vendors with an alternative for their improvements.

关键词： Steel in construction recycled scrap strength test traction bending.

Mesh representation matters:investigating the influence of different mesh features on perceptual and spatial fidelity of deep 3D morphable models

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虚拟现实与智能硬件（中英文） 2024年第5期6卷 383-395页

作者： Robert KOSK richard SOUTHERN Lihua YOU Shaojun BIAN Willem KOKKE Greg MAGUIRE Centre for Digital Entertainment National Centre for Computer AnimationBournemouth UniversityPoole BH125BBUK Humain Ltd. Belfast BT12LAUK School of Creative and Digital Industries Buckinghamshire New UniversityHigh Wycombe HP112JZUK Belfast School of Art Ulster UniversityBelfast BT151EDUK

Background Deep 3D morphable models(deep 3DMMs)play an essential role in computer *** are used in facial synthesis,compression,reconstruction and animation,avatar creation,virtual try-on,facial recognition systems and medical *** applications require high spatial and perceptual quality of synthesised *** their significance,these models have not been compared with different mesh representations and evaluated jointly with point-wise distance and perceptual *** We compare the influence of different mesh representation features to various deep 3DMMs on spatial and perceptual fidelity of the reconstructed *** paper proves the hypothesis that building deep 3DMMs from meshes represented with global representations leads to lower spatial reconstruction error measured with L_(1) and L_(2) norm metrics and underperforms on perceptual *** contrast,using differential mesh representations which describe differential surface properties yields lower perceptual FMPD and DAME and higher spatial fidelity *** influence of mesh feature normalisation and standardisation is also compared and analysed from perceptual and spatial fidelity *** The results presented in this paper provide guidance in selecting mesh representations to build deep 3DMMs accordingly to spatial and perceptual quality objectives and propose combinations of mesh representations and deep 3DMMs which improve either perceptual or spatial fidelity of existing methods.

关键词： Shape modelling Deep 3D morphable models Representation learning Feature engineering Perceptual metrics

Social and Environmental Impacts of Maryland Oil Palm Plantations on Forests,Biodiversity,and Community Livelihoods in Liberia

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Journal of Agricultural Science and Technology(A) 2024年第2期14卷 83-92页

作者： richard N.Sam Sampson Williams Nornor N.Bee Dioh Flahn Community Rights and Corporate Governance Program Sustainable Development Institute(SDI)DuarzonRobert Field HighwayMargibi10 Liberia

Liberia holds 44.5% of the remaining portion of the Upper Guinean Rainforest in West Africa,which is home to critically endangered forest elephants and western *** forests are of vital importance for the livelihoods of millions of West Africans and provide key ecosystem services of local and global importance for food systems transformation and ***’s efforts toward land reform through legislation and policies recognise communities’rights to own and manage their customary lands and *** include the National Forestry Reform Law of 2006,the Community Rights Law Concerning Forest Lands of 2009,and the Land Rights Act of 2018,and *** May 2022,a program team from the Sustainable Development Institute(SDI)-Friends of the Earth Liberia researched the social and environmental impacts of Maryland Oil Palm Plantations(MOPPs)in ***-three(23)key informant interviews(KIIs)and 10 focus group discussions(FGDs)were conducted in seven communities in and around the *** included farmers,contract workers,MOPP staff,local authorities,women and youth leaders,the Environmental Protection Agency(EPA)Inspector,the Civil Society Head,and the Gender Coordinator of Maryland *** team cross-checked information with formal documents as much as possible and took photographs and global positioning system(GPS)locations of areas of deforestation,pollution,and *** team also used observation to monitor environmental pollution,such as affluent into water bodies and planting oil palm in *** team used narrative analysis and geospatial landscape analysis to analyze the *** research finds that land conflict and deforestation have several negative impacts on *** has not respected land tenure rights or followed Free Prior and Informed Consent(FPIC)standards,including resettlement without reparation and destruction of farms and old towns without(sufficient)compensation or *** MOPP land acquisiti

关键词： Biodiversity climate change community rights deforestation ecosystem services food security human rights land rights forest rights livelihood

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细胞壁降解酶在球刺盘孢侵染过程中的作用

植物保护 2024年第3期50卷 88-98,110页

作者：金梦军杨成德李统华 OSEI richard 蔡锋锋马婷甘肃省农作物病虫害生物防治工程实验室甘肃农业大学植物保护学院兰州730070

为明确球刺盘孢Colletotrichum coccodes产生的细胞壁降解酶(CWDEs)在其侵染马铃薯过程中的作用,本文对球刺盘孢离体和活体条件下产生的CWDEs种类及活性进行检测,并通过RT-qPCR测定了球刺盘孢侵染过程中多聚半乳糖醛酸酶(PG)基因的表达... 详细信息

为明确球刺盘孢Colletotrichum coccodes产生的细胞壁降解酶(CWDEs)在其侵染马铃薯过程中的作用,本文对球刺盘孢离体和活体条件下产生的CWDEs种类及活性进行检测,并通过RT-qPCR测定了球刺盘孢侵染过程中多聚半乳糖醛酸酶(PG)基因的表达情况。通过定性测定发现,球刺盘孢能够产生果胶酶、纤维素酶和蛋白酶;定量测定发现,球刺盘孢可产生羧甲基纤维素酶(Cx)、β-葡萄糖苷酶(β-Glu)、PG和聚甲基半乳糖醛酸酶(PMG)。在活体条件下,球刺盘孢可在马铃薯茎秆内产生PG、PMG和多聚半乳糖醛酸反式消除酶(PGTE),且酶活分别于接种后48、72 h和144 h达到最大值,分别为26.50、77.61 U/mL和0.16 U/mg。分别将羧甲基纤维素钠和果胶诱导后的酶液接种至马铃薯茎秆可引起植物组织浸腐,与球刺盘孢引起的典型症状相似。除此之外,球刺盘孢的4个PGs基因均在其侵染后24 h和48 h显著共上调表达。综上所述,该研究结果表明,果胶酶在球刺盘孢致病过程中发挥重要作用。

关键词：球刺盘孢马铃薯细胞壁降解酶多聚半乳糖醛酸酶

Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere Vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

Compound heterozygous mutation of AFG3L2 causes autosomal recessive spinocerebellar ataxia through mitochondrial impairment and MICU1 mediated Caoverload

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Science China Life Sciences 2024年

作者： Hongyu Li Qingwen Ma Yan Xue Linlin Cai Liwen Bao Lei Hong Yitao Zeng Shuzhen Huang richard H.Finnell Fanyi Zeng Shanghai Institute of Medical Genetics Shanghai Children's Hospital Shanghai Jiao Tong University School of Medicine Department of Histo-Embryology Genetics and Developmental Biology Shanghai Jiao Tong University School of Medicine NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology Shanghai Key Laboratory of Embryo and Reproduction Engineering Center for Precision Environmental Health Baylor College of Medicine School of Pharmacy Macau University of Science and Technology

Autosomal recessive spinocerebellar ataxias（SCARs） are one of the most common neurodegenerative diseases characterized by progressive ataxia. Although SCARs are known to be caused by mutations in multiple genes, there are still many cases that go undiagnosed or are misdiagnosed. In this study, we presented a SCAR patient, and identified a probable novel pathogenic mutation（c.1A>G, p.M1V） in the AFG3L2 start codon. The proband's genotype included heterozygous mutations of the compound AFG3L2(p.[M1V]; [R632X]（c.[1A>G];[1894.C>T]）), which were inherited from the father（c.1A>G, p.M1V） and mother（c.1894C>T, p.R632X）. Functional studies performed on hiPSCs（human induced pluripotent stem cells） generated from the patients and HEK293T cells showed that the mutations impair mitochondrial function and the unbalanced expression of AFG3L2 mRNA and protein levels. Furthermore, this novel mutation resulted in the degradation of the protein and the reduction of the stability of the AFG3L2 protein, and MCU（mitochondrial calcium uniporter） complex mediated Ca2+overload.

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文化、道德、行为等与会计行业相关的事项

新理财（公司理财） 2024年第1期 76-78页

作者： richard Crump 不详

当我们作出正确决策时,要从各个角度去考虑,并非所有事情都像合规处理一样有明确的界限。道德分析,金融道德学副教授、Tezos基金会首席财务官和瑞银集团首席运营官埃尔科·菲奥莱(Ecelco Fiole)认为,金融从业人员面临的一个问题是,他们... 详细信息

当我们作出正确决策时,要从各个角度去考虑,并非所有事情都像合规处理一样有明确的界限。道德分析,金融道德学副教授、Tezos基金会首席财务官和瑞银集团首席运营官埃尔科·菲奥莱(Ecelco Fiole)认为,金融从业人员面临的一个问题是,他们接受的道德决策培训非常有限,面对道德困境时,只能运用个人的道德观念来进行评判,不能客观、公平地分析与判断。

关键词：金融从业人员会计行业道德决策道德分析道德困境道德观念首席运营官正确决策

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感恩记录

疯狂英语（初中天地） 2024年第1期 21-24页

作者： richard Edwards 不详

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享... 详细信息

在这纷繁复杂的生活中,我们可能会碰上各种烦心事,但别忘了,有时候正是在这些微妙的瞬间里蕴藏着无尽的感激之情。或许,我们可以像文中的小马克一样,拥有一本属于自己的感恩记录。一起踏上感恩之旅吧,用心感知那些被时间淡忘的温暖,享受生命的美好,发现感恩的力量。

关键词：感恩享受生命用心记录