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Multimodal nonlinear microscopy: A powerful label-free method for supporting standard diagnostics on biological tissues

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 1-16页

作者： riccardo cicchi Francesco Saverio Pavone National Institute of Optics National Research Council(INO-CNR)Largo E.Fermi6 50125 FlorenceItaly European Laboratory for Nonlinear Spectroscopy(LENS)University of Florence Sesto FiorentinoItaly Department of Physics University of Florence Sesto FiorentinoItaly International Center of Computational Neurophotonics(ICON)Florence Italy

The large use of nonlinear laser scanning microscopy in the past decade paved the way forpot ential clinical application of this imaging *** nonlinear microscopy techniquesoffer promising label-free solutions to improve diagnostic performances on *** particular,the combination of multiple nonlinear imaging techniques in the same microscope allows inte-grating_morphological with functional information in a morpho-functional *** provides a high-resolution label-free alternative to both histological and immunohis-tochemicai examination of tissues and is becoming increasingly popular among the ***,several technical improvements,including automatic scanning andimage analysis,are required before the technique represents a standard diagnostic *** thisreview paper,we highlight the capabilit ies of multimodal nonlinear microscopy for tissue inaging,by providing various examples on colon,arterial and skin *** comparison between images acquired using multimodal nonlinear microscopy and histology shows a good agreement bet ween the two *** results demonstrate that multimodal nonlinear microscopy is apowerful label-free alternative to standard histopathological methods and has the potential tofind a stable place in the clinical setting in the near future.

关键词： Non-linear microscopy tissue imaging.

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Multimodal nonlinear imaging of atherosclerotic plaques differentiation of triglyceride and cholesterol deposits

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Journal of Innovative Optical Health Sciences 2014年第5期7卷 114-123页

作者： Christian Matthäus riccardo cicchi Tobias Meyer Annika Lattermann Michael Schmitt Bernd F.M.Romeike Christoph Krafft Benjamin Dietzek Bernhard R.Brehm Francesco S.Pavone Jürgen Popp Leibniz Institute of Photonic Technology(IPHT-Jena)Albert Einstein Straβe 9 0T145 JerlaGermany Institute of Physical Chemistry and Abbe Center of PhotonicsFriedrich Schiller University Jena Helmholtzweg 407743 JenaGermany National Institute of Optics National Research Council(INO-CNR)Largo E.Fermi 6-50125FlorenceItaly European Laboratory for Non-Linear Spectroscopy(LENS)University of Florence Via Nello Carrara 1-50019 Sesto Fiorentino(Firenze)Italy Clinic for Internal Medicine Jena University Hospital Friedrich-Schiller-UniversityErlanger Allee 10107747 JenaGermany Institute of Pathology Department of Neuropathology Jena University Hospital-Friedrich-Schiller-University Erlanger Allee 1010140 JenaGermany Catholic Clinic-Koblenz Intermal Medicine&Cardiology Rudolf Virchow Str.956073 KoblenzGermany

Cardiovascular diseases in general and atherothrombosis as the most common of its individualdisease entities is the leading cause of death in the developed ***,visualizationand characterization of inner arterial plaque composition is of vital diagnostic interest,especilly for the early recognition of vulnerable *** clinical techniques provide valuablemorphological information but cannot deliver information about the chemicai composition ofindividual ***,spectroscopic imaging techniques have recently drawn consider-able *** on the spectroscopic properties of the individual plaque components,as forinstance diferent types of lipids,the composition of atherosclerotic plaques can be analyzedqualitatively as well as ***,we compare the feasibility of multimodal nonlinearimaging combining,two-photon fluorescence(TPF),coherent anti-Stokes Raman scatering(CARS)and second-hamonic generation(SHG)microscopy to contrast composition and mor-phology of lipid deposits against the surrounding matrix of connective tissue with diffractionlimited spatial *** this contribution,the spatial distribution of major constituents of the arterial wall and atherosclerotic plaques like elastin,collagen,triglycerides and cholesterol can be simultaneously visualized by a combination of nonlinear imaging methods,providing a powerful label-free complement to standard histopathological methods with great potential forin vivo application.

关键词： Nonlinear microscopy Raman spectroscopy atherosclerosis.

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