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On the effects of urban-like intersections on ventilation and pollutant dispersion

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Building Simulation 2022年第3期15卷 419-433页

作者： Xin Guo riccardo buccolieri Zhi Gao Mingjie Zhang Tong Lyu Liyan Rui Jialei Shen School of Architecture and Urban Planning Nanjing University22 Hankou RoadNanjing 210093Jiangsu ProvinceChina Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali Laboratory of MicrometeorologyUniversity of SalentoS.P.6 Lecce-Monteroni73100LecceItaly Department of Green Building and Low-Carbon Development Shanghai Research Institute of Building Sciences568 Shenfu RoadShanghai201108China Department of Mechanical and Aerospace Engineering Syracuse UniversitySyracuseNY13210USA

Focusing on the effect of street morphology on the ventilation efficiency,this paper presents 3D computational fluid dynamics(CFD)simulations of airflow and pollutant dispersion within urban-like three-way intersections,four-way intersections and *** steady-state Reynolds-averaged Navier-Stokes(RANS)k-εturbulence model is adopted and eight directions of the approaching wind are *** ventilation efficiency is evaluated using the ventilation indices purging flow rate(PFR)and the net escape velocity(NEV).Results show the sensitivity of the ventilation efficiency to the type of intersection,to the wind direction and to the number of ***,the ventilation efficiency of the investigated three-way intersections is found to be better than that of the other intersections,especially when the angle between the streets is large,while that of roundabouts is also considerable,even with a similar average wind velocity,among the cases evaluated in this ***,the influence of the wind direction for the three-way and four-way intersections is greater than that on *** on the ventilation efficiency at urban intersections are not common in the literature and this work may help urban planners to better design such hub nodes of urban traffic,where traffic-related pollutants are not easily dispersed,thus avoiding harm to the health of pedestrians and surrounding residents.

关键词： urban-like intersections ventilation efficiency CFD simulations traffic-related pollutants

Investigation of typical residential block typologies and their impact on pedestrianlevel microclimate in summers in Nanjing, China

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Frontiers of Architectural Research 2022年第2期11卷 278-296页

作者： Mingjie Zhang Wei You Qin Qin Dandan Peng Youpei Hu Zhi Gao riccardo buccolieri School of Architecture and Urban Planning Nanjing UniversityNanjing 210093China Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali Laboratory of MicrometeorologyUniversity of Salento73100LecceItaly

The morphology of urban residential blocks in China,which is strictly affected by regulations,can potentially improve or deteriorate *** paper first proposes a framework for identifying typical residential block typologies using Nanjing as an example.A thorough investigation,consisting of 114 samples,was conducted,and 18 typical residential block typologies were ***,3D non-isothermal numerical simulations were performed on the hottest days of summer using the *** effect of morphological indices on the microclimate at the pedestrian level was explored using statistical methods and a novel graphic method named *** results revealed a strong correlation between the urban heat island intensity(UHII),mean radiation temperature,and universal thermal climate index(UTCI)and floor area ratio(FAR),as well as between wind velocity(U)and building coverage ratio(BCR).A significant increase in FAR(by approximately 1.0)can result in a low UTCI that was driven by MRT and shading ***-floor blocks,with FAR between 1.8 and 2.1,had a better overall thermal environment(except for lower U)than that of 11-floor *** considering a similar BCR,blocks with slab-type buildings tended to have a U that was higher by approximately 30%.

关键词： Chinese residential blocks Morphological indices Urban heat island Outdoor thermal comfort Microclimate simulation ENVI-met

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Improving Scalability of Cloud Monitoring Through PCA-Based Clustering of Virtual Machines

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Journal of Computer Science & Technology 2014年第1期29卷 38-52页

作者： Claudia Canali riccardo Lancellotti IEEE Department of Information Engineering University of Modena and Reggio Emilia ACM

Cloud computing has recently emerged as a leading paradigm to allow customers to run their applications in virtualized large-scale data centers. Existing solutions for monitoring and management of these infrastructures consider virtual machines （VMs） as independent entities with their own characteristics. However, these approaches suffer from scalability issues due to the increasing number of VMs in modern cloud data centers. We claim that scalability issues can bc addressed by leveraging the similarity among VMs behavior in terms of resource usage patterns. In this paper we propose an automated methodology to cluster VMs starting from the usage of multiple resources, assuming no knowledge of the services executed on them. The innovative contribution of the proposed methodology is the use of the statistical technique known as principal component analysis （PCA） to automatically select the most relevant information to cluster similar VMs. We apply the methodology to two case studies, a virtualized testbed and a real enterprise data center. In both case studies, the automatic data selection based on PCA allows us to achieve high performance, with a percentage of correctly clustered VMs between 80% and 100% even for short time series （1 day） of monitored data. Furthermore, we estimate the potential reduction in the amount of collected data to demonstrate how our proposal may address the scalability issues related to monitoring and management in cloud computing data centers.

关键词： cloud computing resource monitoring principal component analysis k-means clustering

Comparing leaf area index estimates in a Mediterranean forest using field measurements, Landsat 8, and Sentinel-2 data

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Ecological Processes 2023年第1期12卷 402-414页

作者： Alessandro Sebastiani riccardo Salvati Fausto Manes Research Centre for Forestry and Wood(FL) Council for Agricultural Research and Economics(CREA)Via Valle Della Quistione 2700166 RomeItaly Research Institute On Terrestrial Ecosystems(IRET) National Research Council of Italy(CNR)Strada Provinciale 35d900015 Monterotondo(RM)Italy Presidential Estate of Castelporziano Via Pontina 69000128 RomeItaly Department of Environmental Biology Sapienza University of RomeP.Le Aldo Moro500185 RomeItaly

Background Leaf area index(LAI)is a key indicator for the assessment of the canopy’s processes such as net primary production and *** this reason,the LAI is often used as a key input parameter in ecosystem services’modeling,which is emerging as a critical tool for steering upcoming urban reforestation ***,LAI field measures are extremely time-consuming and require remarkable economic and human *** this context,spectral indices computed using high-resolution multispectral satellite imagery like Sentinel-2 and Landsat 8,may represent a feasible and economic solution for estimating the LAI at the city ***,as far as we know,only a few studies have assessed the potential of Sentinel-2 and Landsat 8 data doing so in Mediterranean forest *** fill such a gap,we assessed the performance of 10 spectral indices derived from Sentinel-2 and Landsat 8 data in estimating the LAI,using field measurements collected with the LI-COR LAI 2200c as a *** hypothesized that Sentinel-2 data,owing to their finer spatial and spectral resolution,perform better in estimating vegetation’s structural parameters compared to Landsat *** We found that Landsat 8-derived models have,on average,a slightly better performance,with the best model(the one based on NDVI)showing an R^(2) of 0.55 and NRMSE of 14.74%,compared to R^(2) of 0.52 and NRMSE of 15.15%showed by the best Sentinel-2 model,which is based on the *** models were affected by spectrum saturation for high LAI values(e.g.,above 5).Conclusion In Mediterranean ecosystems,Sentinel-2 and Landsat 8 data produce moderately accurate LAI estimates during the peak of the growing ***,the uncertainty introduced using satellite-derived LAI in ecosystem services’assessments should be systematically accounted for.

关键词： Mediterranean forest Leaf area index Field measurement Multispectral satellite imagery Sentinel-2 Landsat 8 Spectral vegetation index Global change

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New opportunities for light-based tumor treatment with an“iron fist”

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Light(Science & Applications) 2022年第4期11卷 457-459页

作者： riccardo Marin Erving Ximendes Daniel Jaque Nanomaterials for Bioimaging Group(NanoBIG) Departamento de Ffsica de MaterialesFacultad de CienciasUniversidad Aut6noma de MadridMadrid 28030Spain

The efficacy of photodynamic treatments of tumors can be significantly improved by using a new generation of nanoparticles that take advantage of the unique properties of the tumor microenvironment.

关键词： protective light treatment

CFD Study of Ejector Flow Behavior in a Blast Furnace Gas Galvanizing Plant

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Journal of Thermal Science 2015年第1期24卷 58-66页

作者： Giorgio Besagni riccardo Mereu Fabio Inzoli Politecnico di Milano Department of EnergyVia Lambruschini 4 Milan 20156 Italy

In recent years, there has been a growing interest toward Blast Furnace Gas （BFG） as a low-grade energy source for industrial furnaces. This paper considers the revamping of a galvanic plant furnace converted to BFG from natural gas. In the design of the new system, the ejector on the exhaust line is a critical component. This paper studies the flow behavior of the ejector using a Computational Fluid Dynamics （CFD） analysis. The CFD model is based on a 3D representation of the ejector, using air and exhaust gases as working fluids. This paper is divided in three parts. In the first part, the galvanic plant used as case study is presented and discussed, in the second part the CFD approach is outlined, and in the third part the CFD approach is validated using experimental data and the numerical results are presented and discussed. Different Reynolds-Averaged Navier-Stokes （RANS） turbulence models （k-to SST and k-e Realizable） are evaluated in terms of convergence capability and accuracy in predicting the pressure drop along the ejector. Suggestions for future optimization of the system are also provided.

关键词： CFD Ejector Blast Furnace Gas Galvanic plant RANS Turbulence models

Effect of acoustic field on C02 desorption in a fluidized bed of fine activated carbon

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Particuology 2015年第6期13卷 8-15页

作者： Federica Raganati Paola Ammendola riccardo Chirone Department of Chemical Engineering Materials and Industrial Production University of Naples Federico II P. le V. Tecchio 80 80125 Napoli Italy Istituto di Ricerche sulla Combustione CNR P. le K Tecchio 80 80125 Napoli Italy

Adsorption using solid sorbents has the potential to complement or replace current absorption technol- ogy, because of its low energy requirements. Among the commercially available adsorbent materials, attention is focused on activated carbons because they are easily regenerable by reason of their low heat of adsorption. These sorbents are generally available in the form of fine powders. Sound-assisted fluidization can process large amounts of fine powders, promoting and enhancing CO2 capture on fine sorbents, because it maximizes gas-solid contact. Temperature swing adsorption （TSA）, consisting of inducing sor- bent regeneration and CO2 recovery by appropriate temperature increase and gas purge, is one of the most promising techniques. This study investigates the CO2 desorption process by TSA in a sound-assisted flu- idized bed of fine activated carbon. Desorption tests were performed under ordinary and sound-assisted fluidization conditions to assess the capability of sound to promote and enhance the desorption efficiency in terms of CO2 recovery, CO2 purity, and desorption time. The results show that the application of sound results in higher desorption rates, CO2 recovery and purity. Regular and stable desorption profiles can be obtained under sound-assisted fluidization conditions. This stability makes it possible to successfully realize a cyclic adsorption/desorption process.

关键词： Temperature swing adsorption Sound-assisted fluidization CO2 capture Activated carbons Fine powders

Defective autophagy and Alzheimer’s disease: is calcium the key?

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Neural Regeneration Research 2019年第12期14卷 2081-2082页

作者： riccardo Filadi Paola Pizzo Department of Biomedical Sciences University of Padua and Neuroscience Institute-Italian National Research Council (CNR)

Presenilins and autophagy: Presenilin 1 (PS1) and presenilin 2 (PS2) are homologous, multi-pass transmembrane proteins endowed with pleiotropic functions, ranging from the regulation of membrane trafficking to cell differentiation. Their catalytic activity within the γ-secretase complex, an aspartyl-protease responsible for the intramembrane cleavage of several different type I transmembrane proteins, has been intensively studied in the context of Alzheimer’s disease (AD). Indeed, tens of autosomal dominant mutations in the PSEN1 and PSEN2 genes (encoding PS1 and PS2, respectively) have been associated with the rare familial forms of AD (FAD).

关键词： Alzheimer is cell tens has PS1 PS2