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The Importance of the Multidisciplinary Approach to Surgical Treatment of Extremity Soft-Tissue Sarcomas

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Journal of Cancer Therapy 2020年第12期11卷 772-784页

作者： Eurico Cleto Ribeiro de campos Marcos Gonçalves Adriano Júnior Diego Sanches Marcus Rivabem Winheski Robson Menezes Leal ricardo Poroski Guataçara Salles Júnior Renan Martins Franciele Soares Pott Department of Melanoma and Soft Tissue Sarcoma from Prevent Senior Sao Paulo Group Sao Paulo Brasil Oncology Surgical Department of Evangélico Mackenzie University Hospital Curitiba Paraná Plastic Surgery of Sao Vicente Hospital Curitiba Paraná Ponta Grossa State University Paraná Brasil Paraná Military State Hospital Curitiba Paraná Brazil

Soft tissue sarcomas (STS) are rare neoplasm with frequencies around 1% of all neoplasms. Although it consists of a high heterogeneous group of tumors, surgery is the mean treatment. The STS surgery is still challenging and complex procedure is usually required: this is because STS requires different types of resection and reconstruction due to various tissue-commitments (nerve, arteries, skin and muscle). So, a multidisciplinary team must be prepared for STS approach to obtain the maximum local control and a limited extremity functional impairment. We, here, showing our experience, wish to introduce some technical contrivances in STS surgery, with special reference to tissue reconstruction. This may illustrate the necessity of a multidisciplinary team approach in this surgery.

关键词： Limb-Sparing Surgery Musculoskeletal Oncology Sarcoma Soft-Tissue Sarcoma

Litopenaeus vannamei immunestimulated with Macrocystis pyrifera extract:improving the immune response against Vibrio campbellii

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Journal of Coastal Life Medicine 2014年第8期 617-624页

作者： Liliana Noemi Sánchez campos Fernando Díaz Herrera Ana Denisse Re Araujo ricardo Alberto Gonzalez Sánchez Marcial Leonardo Lizárraga Partida Manuel de Jesús Acosta Ruiz Alexei Fedorovish Licea Navarro Molecular Immunology Laboratory Marine Biotechnology DepartmentCenter for Scientific Research and Higher Education of Ensenada(CICESE)3918 Ensenada Tijuana Road Ensenada Baja CaliforniaMexico Ecophysiology of Aquatic Organisms Laboratory Marine Biotechnology DepartmentCenter of Scientific Research and High Education of Ensenada Baja California3918 Ensenada Tijuana Road Ensenada Baja CaliforniaMexico Molecular Ecology Laboratory Marine Biotechnology DepartmentCenter of Scientific Research and High Education of Ensenada Baja California3918 Ensenada Tijuana Road Ensenada Baja CaliforniaMexico Functional Nutrition Laboratory Marine Biotechnology DepartmentCenter of Scientific Research and High Education of Ensenada Baja California3918 Ensenada Tijuana Road Ensenada Baja CaliforniaMexico

Objective:To examine the immune responses of Litopenaeus vannamei after different treatments with a hot water extract of Macrocystis pyrifera(***)and a subsequent challenge with Vibrio campbellii(***).Methods:A total of 184 adult white shrimp that were infected with ***(1×10^(6) CFU/shrimp)were immunostimulate by the hot-water extract from *** via either injection(10μg)or immersion(350 mg/L),the experimental controls were injected with either saline solution or ***(1×10^(6) CFU/shrimp).The bacterial DNA depuration rate,antimicrobial activity and total hemocyte count were evaluated in hemolymph samples at 2,6,12,24,48 and 72 h ***:Injected shrimp(10μg *** extract)demonstrated the best clearance of bacterial infection,with 82%survival at 72 h post-infection(cellular response).Hemolymph from the immersed organisms had the best antimicrobial activity against Escherichia coli growth;specifically,the most efficient antimicrobial activity was observed at 24 h *** types of immunostimulated shrimp had similar total hemocyte counts at 24 h post-infection(1.63-1.59 million/mL);however,after 72 h,injected shrimp had higher total hemocyte counts than immersed animals(2.59 v.s.0.56 million/mL).Conclusions:The injection of the *** hot-water extract facilitated a more efficient response to *** infection due to the stimulation of the hemocytes of the *** other words,the cellular immune response was more efficient to eliminate bacterial infection than the humoral response in shrimp.

关键词： Immune stimulation Hot-water extract Clearance rate Antimicrobial activity Seaweed Vibrio campbellii Litopenaeus vannamei Macrocystis pyrifera PCR

Evaluation of Adverse Events Following Immunization against Rotavirus Regardless of Recommended Age Restriction

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Journal of Biosciences and Medicines 2017年第8期5卷 78-82页

作者： Jesus Reyna-Figueroa Irina Jeanette Bercholc-Urinowsky Gabriela Cardoso-Yah ricardo Platón Vazquez-Alvarado Dalila Ramos-López Freya Helena campos-Romero Cory Handelsman Ana Elena Limón-Rojas Central South Hospital Mexican Oil Company Petróleos Mexicanos México City Mexico Robert Wood Johnson University Hospital New Jersey USA

Introduction: Mild and moderate Adverse Events Following Immunization (AEFI) against Rotavirus has not received much attention when the vaccine is administered regardless of recommended age restriction. Objectives: To describe the behavior of mild and moderate AEFI in immunized subjects against Rotavirus, in who age restriction period had not been considered. Methods: A case-control study in which we included immunized patients with monovalent oral vaccine against rotavirus and divided them into two groups: 1) Infants who received RV1 vaccine without considering the recommended period, and 2) Infants who were vaccinated with the recommended schedule. Results: From the total doses, 143/1894 (7.5%) were administered outside the restriction period. The most frequent AEFIs with the first dose were purpura, polypnea, and rhinorrhea;For the second dose: purpura, bloody stools, irritability and rhinorrhea. Conclusions: This study shows the benefits from vaccination regardless of age restriction are more beneficial compared to the possible risks of AEFI.

关键词： Rotavirus Vaccination Age Restriction Adverse Reaction

Prognostic performance of an index based on lactic dehydrogenase and transaminases for patients with liver steatosis and COVID-19

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World Journal of Gastroenterology 2022年第37期28卷 5444-5456页

作者： ricardo Ulises Macías-Rodríguez Alberto Adrián Solís-Ortega Victoria J Ornelas-Arroyo Astrid Ruiz-Margáin Maria Sarai González-Huezo Nestor A Urdiales-Morán Berenice M Román-Calleja Juan M Mayorquín-Aguilar JoséA González-Regueiro Alejandro campos-Murguía Israel Vicente Toledo-Coronado Mónica Chapa-Ibargüengoitia Bernardo Valencia-Peña Carlos Fernando Martínez-Cabrera Nayelli C Flores-García Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Department of Gastroenterology Centro Médico ISSEMYMToluca 52140Mexico Department of Radiology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

BACKGROUND Metabolic associated fatty liver disease(MAFLD)is associated with complications and mortality in patients with coronavirus disease 2019(COVID-19).However,there are no prognostic scores aimed to evaluate the risk of severe disease specifically in patients with MAFLD,despite its high *** dehydrogenase,aspartate aminotransferase and alanine aminotransferase have been used as markers of liver ***,we propose an index based on lactate dehydrogenase,aspartate aminotransferase and alanine aminotransferase for the prediction of complications and mortality in patients with MAFLD and *** To evaluate the prognostic performance of an index based on lactate dehydrogenase and transaminases(aspartate aminotransferase/alanine aminotransferase)in patients with COVID-19 and MAFLD[liver fibrosis and nutrition(LNF)-COVID-19 index].METHODS In this retrospective cohort study,two cohorts from two different tertiary centers were *** first was the derivation cohort to obtain the score cutoffs,and the second was the validation *** included hospitalized patients with severe COVID-19 and *** steatosis was evaluated by computed tomography *** under the receiver operating characteristic(ROC)curve analysis and survival analysis were *** In the derivation cohort,44.6%had MAFLD;ROC curve analysis yielded a LFN-COVID-19 index>1.67 as the best cutoff,with a sensitivity of 78%,specificity of 63%,negative predictive value of 91%and an area under the ROC curve of *** the multivariate analysis,the LFN-COVID-19 index>1.67 was independently associated with the development of acute kidney injury(odds ratio:1.8,95%confidence interval:1.3-2.5,P<0.001),orotracheal intubation(odds ratio:1.9,95%confidence interval:1.4-2.4,P<0.001),and death(odds ratio:2.86,95%confidence interval:1.6-4.5,P<0.001)in both *** LFN-COVID-19 index has a good performance to predict prognosis in patients with MAFLD and COVID-19,which

关键词： COVID-19 Metabolic associated fatty liver disease Lactate dehydrogenase Transaminases Prognosis Nonalcoholic fatty liver disease

Role of Genetic Ancestry in Oropharyngeal Squamous-Cell Carcinoma: A Cross-Sectional Study in Brazil

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Journal of Biosciences and Medicines 2023年第1期11卷 150-161页

作者： Chrystiano De campos Ferreira ricardo Ribeiro Gama Ana Carolina De Carvalho Iara Santana Raiany S. Carvalho Debora S. De A. e Silva Lais M. De Jesus Rui M. Reis Rozany Dufloth Department of Head and Neck Surgery Barretos Cancer Hospital S&atilde o Paulo Brazil Department of Medicine Federal University of Rond&ocirc nia Rond&ocirc nia Brazil Molecular Oncology Research Center Barretos Cancer Hospital S&atilde o Paulo Brazil Department of Pathology Barretos Cancer Hospital S&atilde o Paulo Brazil Life and Health Sciences Research Institute (ICVS) Medical School University of Minho Braga Portugal Institute of Anatomical Pathology Rede D’Or S&atilde o Luiz Hospitals Network S&atilde o Paulo Brazil

Background: HPV infection represents an important etiologic factor for Oropharyngeal Squamous Cell Carcinoma (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Human Papillomavirus (HPV). The aim of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients. Methods: We conducted a cross-sectional study on patients with OPSCC admitted to the Barretos Cancer Hospital, Brazil from 2014 to 2019. Of these, DNA extraction was performed on 40 patients and genetic ancestry was assessed using a specific panel of 46 informative ancestry markers. Results: We observed a predominance of European ancestry (63%), followed by African (18%), Amerindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group. We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Amerindian (p = 0.836) ancestry. Conclusions: We found a predominance of European ancestry, both in the HPV-positive and HPV-negative groups. In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.

关键词： Oropharyngeal Neoplasms Genetic Ancestry HPV Head and Neck Neoplasms P16

Sorafenib after Arterial Chemoembolization in Child-Pugh A and B Cirrhotic Patients with Intermediate Hepatocellular Carcinoma: A Retrospective Analysis

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Journal of Cancer Therapy 2015年第3期6卷 286-292页

作者： Fernando Gomes Romeiro Luciana Yumi Odani Sigahi Matheus Alvarez Fabio da Silva Yamashiro Fábio Cardoso de Carvalho Leonardo Pelafsky Talles Bazeia Lima Letícia de campos Franzoni José ricardo de Arruda Miranda Giovanni Faria Silva Gastroenterology Division Department of Internal Medicine Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Department of Physics and Biophysics Instituto de Biociências de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Gastroenterology Division Department of Surgery and Orthopedics Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of mortality among cirrhotic patients, and current guidelines recommend single-treatment modalities according to patient and liver disease classifications. New studies have shown promising results from combining locoregional and systemic treatments, but most of them were limited to Child-Pugh A patients due to toxicity concerns. Aim: The objective of this study was to analyze survival rates of Child-Pugh A and B patients with intermediate HCC tumors treated with transarterial chemoembolization (TACE) followed by full-dose sorafenib usage. Material and methods: a retrospective analysis of 37 cirrhotic patients (Child-Pugh A and B rates = 23/14) treated with TACE and TACE followed by sorafenib usage (17 and 20 patients, respectively). Results: The mean survival was 379 days in the combined treatment group and 151 days in the single-treatment group (p = 0.007). There were no differences in survival according to the Child-Pugh classification. Conclusions: sorafenib after TACE can be an option for selected cirrhotic patients with intermediate HCC tumors if this combined approach is cautiously performed on an individualized schedule. Our results suggest that the Child-Pugh classification should not be a limitation to this combined treatment.

关键词： Hepatocellular Carcinoma Cirrhosis Arterial Chemoembolization Sorafenib

Prognosis of Patients with Acute Coronary Syndromes and Bleeding—The Importance of Routine Use of a Bleeding Risk Score

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World Journal of Cardiovascular Diseases 2015年第12期5卷 327-334页

作者： Alexandre de Matos Soeiro ricardo Cesar campos Devezae Silva Aline Siqueira Bossa Cindel Nogueira Zullino Tatiana de Carvalho Andreucci Torres Leal Maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares Oliveira Jr. Emergency Unit-Heart Institute University of Sao Paulo Medical School Sao Paulo Brazil

Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without in-hospital major and/or minor bleedings. Methods: This was a pro-spective data bank analysis study with 546 patients (39 with bleeding (group I) and 507 without bleeding (group II)) with acute coronary syndromes included between May 2010 and May 2013. Besides, Mehran bleeding risk score was calculated to all patients. The primary endpoint was all causes of in-hospital death and combined events. Comparison between groups was made by Anova and Q-square. Multivariate analysis was determined by logistic regression and was considered significant when p p = 0.005) and combined events (35.9% vs 11.4%, p < 0.001). The same results were observed in multivariate and long-term analysis. Con-clusions: Almost half of patients with acute coronary syndromes had higher risk of bleeding, and that with major or minor bleedings had greater deaths and combined events.

关键词： Unstable Angina Bleeding Acute Myocardial Infarction

The Cumulative Effects of Sewage Sludge Compost on Raphanus sativus L: Growth and Soil Properties

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Green and Sustainable Chemistry 2016年第1期6卷 1-10页

作者： Vanessa N. Lima ricardo V. Trótski O. Silva Patrícia Nunes Paulo H. da Silva Kyriale Morant Rosileide F. S. Andrade Aline E. Nascimento Galba M. campos-Takaki Arminda Saconi Messias Development of Environmental Processes Catholic University of Pernambuco Recife PE Brazil Chemical Engineering Course Catholic University of Pernambuco Recife PE Brazil Nucleus of Research in Environmental Sciences and Biotechnology Catholic University of Pernambuco Recife PE Brazil

The main goal of this research study was to establish the physicochemical characteristics of sewage sludge, and the nutrients needed to enhance the properties of soil with a view to exploiting were potential for agriculture. The example used was the cultivation of radish (Raphanus sativus). The findings are intended as a contribution towards making agriculture sustainable. This study was carried out to assess the response of radish (Raphanus sativus L.) to doses of sewage sludge applied in medium texture soils, and the socioeconomic contributions that such cultivation of radish would make. Levels of 0.25 and 75 ton/ha of sewage sludge plus the equivalent dose of 25 ton/ha of sewage sludge vermin compost by California Red were used after making a randomized experimental design with three replicates. 30 days after sowing radish seeds, the following data were collected: the number of leaves per plant (NLP);plant height (PH in cm);root diameter (RD) and tubercle production (TP ton/ha). In addition, the pH, EC-electric conductivity (EC), and soil organic matter (SOM) were determined. Statistical analysis showed that 25 and 50 tons/ha gave the best results for the parameters assessed. The estimated increase in family mean income from selling radish crops fertilized with sewage sludge is around 17%.

关键词： Sewage Sludge Productivity Soil Solid Waste Raphanus sativus L.

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新与旧的对话

建筑实践 2015年第8期 10-17页

作者：李莹 José campos

项目名称:Arquip e lago-Contemporary Arts Centre建筑设计:Menos e Mais Arquitectos,Joao Mendes Ribeiro Arquitecto项目地点:Ribeira Grande,Portugal主持建筑师:Francisco Vieira de campos,Cristina Guedes(Menos e Mais Arquitectos),Joao Mandes Ribeiro(Joao Mendes Ribeiro Arquitecto)团队:Ines Mesquita,Cristina Maximino,Joao Pontes,Lu i s campos,Ana Leite Fernandes,Mariana Sendas,Pedro Costa,Ines Ferreira,Joao Fernandes,ricardo Cardoso,o scar Ribas,

关键词：建筑师亚速尔当代艺术里贝罗