检索结果-南通市图书馆

Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni

World Journal of Gastroenterology 2008年第38期14卷 5842-5850页

作者： Sheilla Andrade Oliveira Bruno Solano Freitas Souza Carla Adriana Guimares-Ferreira Elton Sá Barreto Siane Campos Souza Luiz Antonio Rodrigues Freitas ricardo ribeiro-dos-santos Milena Botelho Pereira Soares Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Centro de Pesquisas Aggeu Magalhes Fundao Oswaldo Cruz Recife Av Moraes Rego s/n Cidade Universitária Recife 50670-420 PE Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas Salvador 40295-001 BA Brazil Centro de Pesquisas Gonalo Moniz Fundao Oswaldo Cruz Rua Waldemar Falco 121 Brotas 40295-001 Salvador BA Brazil Hospital So Rafael Av So Rafael 2152 So Marcos Salvador 41256-900 BA Brazil

AIM： To investigate the potential of bone marrow mononuclear cells （BM-MCs） in the regeneration of hepatic lesions induced by Schistosoma mansoni （***） chronic infection. METHODS： Female mice chronically infected with *** were treated with BM-MCs obtained from male green fluorescent protein （GFP） transgenic mice by intravenous or intralobular injections. Control mice received injections of saline in similar conditions, Enzyme-linked immunosorbent assay （ELISA） assay for transforming growth factor-beta （TGF-β）, polymerase chain reaction （PCR） for GFP DNA, immunofluorescence and morphometric studies were performed. RESULTS： Transplanted GFP^＋ cells migrated to granuloma areas and reduced the percentage of liver fibrosis. The presence of donor-derived cells was confirmed by Fluorescence in situ hybridization （FISH） analysis for detection of cells bearing Y chromosome and by PCR analysis for detection of GFP DNA. The levels of TGF-β, a cytokine associated with fibrosis deposition, in liver fragments of mice submitted to therapy were reduced. The number of oval cells in liver sections of ***-infected mice increased 3-4 fold after transplantation. A partial recovery in albumin expression, which is decreased upon infection with ***, was found in livers of infected mice after cellular therapy. CONCLUSION： In conclusion, transplanted BMCs migrate to and reduce the damage of chronic fibrotic liver lesions caused by ***.

关键词： Schistosoma mansoni Liver injury Fibrosis Bone marrow cells Transplantation Albumin Oval cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia

引用

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2531-2540页

作者： Jose Sebastiao dos santos Vitor de Moura Arrais William Jose Rosseto Ferreira ricardo ribeiro Correa Filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez Jose Celso Ardengh Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making investigation and treatment *** To investigate the management of patients with visceral PCM admitted with *** All patients diagnosed with PCM treated in a public,tertiary teaching hospital between 1982 and 2020 were retrospectively *** also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical,laboratory,and imaging findings,resources used for etiological diagnosis,treatment results,and *** analyses were performed using the linear mixed-effects model(random and fixed effects),which was adjusted using the PROC MIXED procedure of the SAS®9.0 software,and Fisher’s exact *** Of 1645 patients diagnosed with PCM,40(2.4%)had *** these,20(50.0%)lived in the rural area and 29(72.5%)were men,with a mean age of 27.1 years(3-65 years).Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients(40.0%),and a mass in the head of the pancreas was observed in 8(20.0%).The etiological diagnosis was made by tissue collection during surgery in 4 cases(10.0%)and by endoscopic methods in 3 cases(7.5%).Twenty-seven patients(67.5%)received drug treatment alone(Group 1),whereas 13(32.5%)underwent endoscopic and/or surgical procedures in combination with drug treatment(Group 2).EHC was significantly reduced in both groups(40.7% in Group 1,with a mean time of 3 months;and 38.4% in Group 2,with a mean time of 7.5 months),with no statistically significant difference between *** recurrence rates,associated mainly with treatment nonadherence,were similar in both groups:37% in Group 1 and 15.4% in Group *** mortality rate was 18.5% in Group 1 and 23% in Group 2,with survival estimates of 71.3% and 72.5%,respectively,with

关键词： Cholestasis Jaundice Obstructive Blastomycosis Paracoccidioides Diagnosis Treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

引用

World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser ricardo ribeiro dos santos luiz Guilherme Costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM： To evaluate the safety and feasibility of bone marrow cell （BMC） transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS： Ten patients （eight males） with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS： The median age of the patients was 52 years （range 24-70 years）. All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 （2.19 ± 0.9） and 4 mo （2.10 ± 1.0） after cell transplantation that baseline levels （238 ± 1.2）. Albumin levels 4 mo after BMC infusion （3.73 ± 0.5） were higher than baseline levels （3.47 ± 0.5）. International normalized ratio （INR） decreased from 1.48 （SD = 0.23） to 1.43 （SD = 0.23） one month after cell transplantation. CONCLUSION： BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词： Bone marrow Cell transplantation Liverfailure Stem cell Cirrhosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Direct Electrochemical Determination of Glyphosate Herbicide Using a Screen-Printed Carbon Electrode Modified with Carbon Black and Niobium Nanoparticles

引用

Journal of Analysis and Testing 2023年第4期7卷 425-434页

作者： Julia Oliveira Fernandes Cassiano Augusto Rolim Bernardino Juliana dos santos Fernandes Claudio Fernando Mahler Bernardo Ferreira Braz Luiz Henrique Carpenter dos santos Rodrigo JoséCorrêa ricardo Erthal Santelli Braulio Soares Archanjo Emerson Schwingel ribeiro Fernando Henrique Cincotto Departament of Analytical Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Departament of Civil Engineering COPPEFederal University of Rio de JaneiroRio de Janeiro 21941-598Brazil National Institute of Science&Technology of Bioanalytics(INCTBio) CampinasSão Paulo 13083-862Brazil Departament of Inorganic Chemistry Institute of ChemistryFederal University of Rio de JaneiroRio de Janeiro 21941-909Brazil Unesp National Institute of Alternative Technologies for DetectionToxicological Assessment and Removal of Micropollutants and Radioactives(INCT-DATREM)AraraquaraSão Paulo 14800-060Brazil National Institute of Metrology Quality and TechnologyInmetroAv.Nossa Senhora das Graças50XerémDuque de Caxias 25250-020Brazil

Glyphosate is a herbicide that has been widely used worldwide and is used in agricultural areas to control weeds and unwanted *** sensors developed from different nanomaterials have high efficiency,excellent cost-benefit,and fast analysis time for detecting traces of environmental *** study aimed to produce an electrochemical sensor with disposable screen-printed electrodes based on carbon black modified with niobium nanoparticles to determine glyphosate in aqueous *** morphology,structure and electrochemical performance of the sensor were characterized by scanning electron microscopy,energy-dispersive X-ray spectroscopy,X-ray diffraction and cyclic *** pulse voltammetry in BR buffer solution at pH 5.0 allowed the generation of a method to quantify glyphosate concentration in a linear range of 5.90-172.30μmol/L(1.00-29.13μg/mL),with a limit of detection calculated at 3.07μmol/L(0.52μg/mL).The method efficiently quantified glyphosate in real water samples and showed no interference from K^(+),Na^(+),Ca^(2+),Mg^(2+)ions or thiamethoxam,imidacloprid and carbendazim pesticides.

关键词： Glyphosate Electrochemical sensor Carbon black Niobium nanoparticles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nutrition and exercise can attenuate inflammatory and psychobiological changes in hypoxia?

引用

Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 86-90页

作者： Aline Venticinque Caris Wanessa Ysis Valdir de Aquino Lemos ricardo Bottura Ronaldo Vagner Thomatieli dos santos Department of Psychobiology Federal University of Sao Paulo(UNIFESP)SantosBrazil Department of Bioscience Federal University of Sao Paulo(UNIFESP)SantosBrazil

Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa B pathway in macrophages and Th2 response from lymphocytes. These changes may result in transient immunosuppression and happen at the same time to worsening of cognition and other psychobiological aspects. Furthermore, exercise and nutrition, especially glutamine supplementation may provide important role, not pharmacological partially reversing the effects of hypoxia. In fact, recent studies show that moderate exercise can improve cognition in people exposed to hypoxia while the exercise associated with glutamine supplementation can reverse the increase in inflammatory markers and the Th1/Th2 balance. This review aims to bring the light of the discussion about nonpharmacological ways to prevent the effects of hypoxia on the connection between the immune system and the central nervous system.

关键词： Physical exercise High altitude Inflammation Cognition Glutamine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distinguishing the Regional Atmospheric Controls on Precipitation Isotopic Variability in the Central-Southeast Portion of Brazil

引用

Advances in Atmospheric Sciences 2022年第10期39卷 1693-1708,I0018-I0020页

作者： Vinícius dos santos Peter MARSHALL FLEMING Luís HENRIQUE MANCINI Stela DALVA santos COTA Graziele Beatriz de LIMA Rafaela RODRIGUES GOMES Roberto Eduardo KIRCHHEIM ricardo SANCHÉZ-MURILLO Didier GASTMANS São Paulo State University(UNESP) Environmental Studies Center.Av.24ABased1515-Bela Vista13.506-900Rio Claro(SP)Brazil Center for the Development of the Nuclear Technology(CDTN-CNEN) Av.Presidente Antônio Carlos6.627Campus da UFMG-Pampulha31270-90Belo Horizonte(MG)Brazil Universidade de Brasília-UnB Instituto de GeociênciasLaboratório de Isótopos Estáveis.Campus"Darcy Ribeiro"Asa Norte70.910-900Brasília(DF)Brasil Hydrology and Territorial Management Directory(DHT) The Geological Survey of Brazil(CPRM-SGB)São Paulo(SP)Brazil University of Texas at Arlington Earth and Environmental Sciences Department500 Yates StreetArlingtonTexas76019USA Stable Isotopes Research Group and Water Resources Management Laboratory Universidad NacionalHerediaCosta Rica

Precipitation isotope ratios(O and H)record the history of water phase transitions and fractionation processes during moisture transport and rainfall ***,we evaluated the isotopic composition of precipitation over the central-southeastern region of Brazil at different *** isotopic compositions were associated with classical effects(rainfall amount,seasonality,and continentality),demonstrating the importance of vapor recirculation processes and different regional atmospheric systems(South American Convergence Zone-SACZ and Cold Fronts-CF).While moisture recycling and regional atmospheric processes may also be observed on a daily timescale,classical effects such as the amount effect were not strongly correlated(δ^(18)O-precipitation rate r≤-0.37).Daily variability revealed specific climatic features,such asδ^(18)O depleted values(~-6‰to-8‰)during the wet season were associated with strong convective activity and large moisture *** isotopic analysis revealed the role of different moisture sources and transport *** ratios combined with d-excess explain how atmospheric recirculation processes interact with convective activity during rainfall formation *** findings provide a new understanding of rainfall sampling timescales and highlight the importance of water isotopes to decipher key hydrometeorological processes in a complex spatial and temporal context in central-southeastern Brazil.

关键词： precipitation stable water isotopes d-excess moisture source and transport southern Atlantic Ocean and Amazon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Introducing System Identification Strategy into Model Predictive Control

引用

Journal of Systems Science & Complexity 2020年第5期33卷 1402-1421页

作者： WANG Jianhong ricardo A.Ramirez-Mendoza JORGE de J Lozoya santos School of Electronic Engineering and Automation Jiangri University of Science and TechnologyGanzhou343000China School of Engineering and Sciences Tecnologico de MonterreyMonterreyAve.Eugenio Garza Sada 2501MonterreyN.L.64849Merico

As system identification theory and model predictive control are belonged to two different research fields separately,so one gap exists between these two *** alleviate this gap between them,one new idea proposed in this paper is to introduce system identification theory into model predictive *** the most important element in model predictive control is the prediction of the output value for a nonlinear system,then the problem of deriving the prediction of the output value can be achieved by system identification *** specifically,a Bayesian approach is applied for the nonparametric estimation by modeling the prediction as realizations of zero mean random *** comparing this kind of prediction corresponding to this Bayesian approach and the former direct weight optimization identification for nonlinear system,the authors see that if the unknown weights are chosen appropriately,these two approaches are equivalent to each *** on the obtained prediction of the output value,the authors substitute this prediction of the output value into one cost function of model predictive control,and then a quadratic programming problem with inequality constraints is *** to solve this quadratic programming problem,a detailed process about how to derive its dual form is *** the dual problem has a simple constraint set,it is amenable to the use of the common Gauss-Seidel algorithm,whose convergence can be shown ***,one simulation example confirms the proposed theoretical results.

关键词： Equivalence model predictive control nonparametric estimation system identification

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intelligent fault detection and location scheme for modular multi‐level converter multi‐terminal high‐voltage direct current

引用

High Voltage 2021年第1期6卷 125-137页

作者： Qingqing Yang Jianwei Li ricardo santos Kaijia Huang Petar Igic Coventry University CoventryUK Department of Engineering Science University of OxfordOxfordUK Centre of Engineering Federal University of ABCSanto AndreBrazil DTU Energy Technical University of DenmarkKongens LyngbyDenmark

In order to overcome the drawbacks of the conventional protection methods in high‐voltage direct current transmission lines, a deep learning approach is proposed that directly learn the fault conditions based on unsupervised feature extraction to the detection and location decision by leveraging the hidden layer activations of recurrent neural network. The deep‐recurrent neural network boosting with the gated recurrent unit compared with the long short‐term memory unit is used by analysing both the signal presented in time domain and frequency domain. The proposed method is tested based on a modular multilevel converter based four‐terminal high‐voltage direct current system. Various faults under different conditions were simulated against fault resistance, external faults and small disturbance immunity with the validity, and the simulation verified a high accuracy, robustness and fast results because of the utilization of characteristic feature extraction.

关键词： fault overcome high

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biological and chemical attributes of soils under forest species in Northeast Brazil

引用

Journal of Forestry Research 2020年第5期31卷 1959-1973页

作者： Olmar Baller Weber Maria Catia Barroso da Silva Cristiane Figueira da Silva Joao Alencar de Sousa Carlos Alberto Kenji Taniguch Deborah dos santos Garruti ricardo Espindola Romero Embrapa Tropical Agroindustry Rua Dra.Sara Mesquita2270PiciFortalezaCeara60511-110Brazil Centro de Ciencias e Tecnologia Universidade Estadual do CearaAv.Dr.Silas Munguba1700Campus do ItaperiFortaleza 60740-000Brazil Universidade Federal Rural do Rio de Janeiro BR 465Km 7SeropedicaRio De Janeiro 23890-000Brazil Depto Ciencia do Solo Universidade Federal do CearaCampus do PiciFortaleza 60021-970Brazil

Timber forests contribute to the sustainable development of the biomes in tropical *** aim of this study was to evaluate the biological and chemical properties of the soil as a consequence of the cover with native and non-native species in the Acarau basin,a transition area from the coast to the Brazilian semi-arid *** planted with four native species(Anadenanthera colubrina,Astronium fraxinifolium,Handroanthus impetiginosus,Colubrina glandulosa)and three exotic species(Acacia mangium,Casuarina equisetifolia,Eucalyptus urophylla)plus a non-forested agricultural area were evaluated for organic carbon contents,and microbial and chemical soil *** levels of soil organic carbon were highest in *** and *** *** basal soil respiration was observed but the microbial biomass was particularly low in the non-forested *** the ***,***,and *** plantations,elevated soil metabolic quotients were *** *** and *** plantations had the highest levels of easily extracted-glomalin related soil *** species affect concentrations of essential nutrients and the biological quality of the soil in different *** can also improve the biological and chemical properties of the soil in the coastal plains of tropical regions.

关键词： Soil quality Brazilian timber species Eucalyptus Acacia Casuarina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gender inequalities in physical activity among adolescents from 64 Global South countries

引用

Journal of Sport and Health Science 2022年第4期11卷 509-520页

作者： Luiza Isnardi Cardoso ricardo Andrea Wendt Caroline dos santos Costa Gregore Iven Mielke Javier Brazo-Sayavera Asaduzzaman Khan Tracy L Kolbe-Alexander Inacio Crochemore-Silva Federal University of Pelotas PelotasRS 96010-040Brazil University of Sao Paulo Sao PauloSP 01153-000Brazil School of Public Health The University of QueenslandHerstonQLD 4006Australia University of the Republic MontevideoMontevideo 11200Uruguay

Purpose:The aims of this study were to(a)describe gender inequalities in physical activity(PA)among adolescents from Global South countries,and(b)investigate the relationship between gender inequalities in PA and contextual factors,such as geographic region,human development index,gender inequality index,and unemployment ***:We analyzed cross-sectional data from the Global School-Based Student Health Survey conducted in Global South countries between 2010 and 2020 among 13-to 17-year-old ***-context variables were retrieved from secondary data sources(World Health Organization,World Bank,and Human Development Reports).PA was assessed by a self-administered questionnaire querying the number of days in the past week in which participants were physically active for a total of at least 60 *** absolute gender inequalities were evaluated by the differences in the prevalence between boys and girls,95%confidence intervals(95%CIs)were estimated using the bootstrap *** inequalities were obtained through Poisson ***-analyses with random effects were used to calculate pooled estimates of absolute and relative ***:Based on 64 Global South countries/surveys,the prevalence of PA was 6.7 percentage points(p.p.)higher in boys than in girls,ranging from 0.5 *** Afghanistan to 15.6 *** Laos(I^(2)=85.1%).The pooled ratio for all countries showed that boys presented a PA prevalence 1.58 times higher than girls(95%CI:1.47-1.70)on *** highest absolute and relative inequalities were observed in high income *** with higher Human Development Index rankings and lower Gender Inequality Index rankings also presented greater gender ***:Given that girls are overall less active than boys across the globe,the findings of this study reinforce that macro-and micro-level changes should be actively sought if we aim to increase population levels of PA in adolescents and promote equity i

关键词： Adolescents Gender differences Physical activity Social inequalities Students

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：