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Prevalence of Human Leukocyte Antigen HLA-B*5701 in HIV-1 Infected Individuals in Brazil

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Open Journal of Genetics 2014年第1期4卷 56-62页

作者： Claudinéia de Araújo Cristina Valetta de carvalho Miriam Estela de Souza Freire Amanda Yamaguti Ivens Cuiabano Scaff Fernando José de Souza Flávia Galindo Silvestre Silva ricardo Sobhie Diaz Ismael Dale Cotrim Guerreiro da Silva department of Gynecology Molecular Gynecology Laboratory Federal University of S&atildeo Paulo S&atildeo Paulo Brazil State department of Health of Mato Grosso Cuiabá Brazil Unirondon University Cuiabá Brazil Infectious Diseases Division Federal University of Mato Grosso Cuiabá Brazil Imunogenetics Laboratory General University Hospital Cuiabá Brazil

This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in Brazil. A total of 517 consecutive individuals were followed in this study from February 2009 through July 2011. The presence of HLA-B*5701 was determined by Nested-PCR with HLA-B*57 and HLA-B*5701 sequence-specific primers (PCR-SSP). The expression of HLA-B*57 was negative in the 385 (74.5%) and positive in the 103 (19.9%) of infected individuals. Among these, the expression of HLA-B5701 was positive in the 29 (5.6%) of individuals. No demographic or ethnic differences were found between HLA-B*57/HLA-B*5701 HIV-1 negative patients, with a prevalence of Caucasians (57.1%) individuals. During the period of study, 68 patients were submited to an abacavir contain- ing regimen. The HLA-B*5701 allele was observed in 7 (10.3%) patients, with a significant incidence of Hypersensitivity reactions at 4 of them (p < 0.001). Conclusions: Although Brazilian population consists of a mixture of individuals of Caucasian, African and Native American genetic background, prevalence of HLA-B*5701 in this population is similar to the one found in pure Caucasians.

关键词： Immunogenetics Human Immunodeficiency Virus HLA-B*5701 Antigen Human Abacavir

Bone Marrow Transplant Long-Term Survivors’ Satisfaction with Quality of Life: Comparison with a Control Group

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Open Journal of Medical Psychology 2014年第5期3卷 337-347页

作者： Maribel Pelaez Doro José Zanis Neto denise carvalho Julita Maria Pelaez Vaneuza Funke ricardo Pasquini International Society for Quality of Life Research (ISOQOL) Milwaukee USA

Purpose: To evaluate the global quality of life (QoL) of survivors with 10-year or more post-transplant, and to identify risk factors that interfere with well-being. Methods: This is a prospective analytic transversal study with 214 survivors of Bone Marrow Transplant (BMT) and 264 healthy people identified among blood donors, treated as the control group, of both sexes, 18 years or older. The protocol includes a demographic-socioeconomic questionnaire, World Health Organization Quality of Life (WHOQOL) and the Karnofsky Performance Status Scale. Results: 53.7% of the survivor group members are satisfied with their QoL. A similar result can be found in the control group (54.2%). Chronological maturity, anxiety, sexual difficulty, and being a provider are factors that interfere negatively in the QoL of male survivors. In female survivors, the risk factors are anxiety, low educational level, not having a stable partner, being a provider, and not being Caucasian. Conclusions: Survivors are as satisfied with their QoL as the control group. QoL is understood as a perceptive process composed of objective (functional and relational capacity) and subjective phenomenon (perceptive composition).

关键词： Quality of Life Bone Marrow Transplantation Long-Term Survivors Control Group Resilience

Macrolide-Clarithromycin Task-Force for the Treatment and Prophylaxis of Covid-19 as a Single Agent

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Pharmacology & Pharmacy 2020年第6期11卷 85-104页

作者： Eduardo Mansilla ricardo Rangel Martínez Gustavo Horacio Marín Idiberto Zotarelli Filho Elsa Rivas Jaime Rivas Katherine Athayde Teixeira de carvalho Mohammad Reza Dayer Alí Samadikuchaksaraei Internal Medicine School of Medical Sciences UNLP La Plata Argentina ExomePharma Ciudad de México DF México Pharmacology School of Medical Sciences UNLP La Plata Argentina Faceres Medical School Sao José do Rio Preto Sao Paulo Brazil Intensive Care Units-Hospital de la Amistad Perú Corea II Santa Rosa and Salvador University Hospital Piura Perú Intensive Care Unit Hospital de la Amistad Perú Corea II Santa Rosa Piura Perú Pequeno Príncipe Faculty & Pelé Pequeno Príncipe Institute Curitiba Paraná Brazil department of Biology Faculty of Science Shahid Chamran University of Ahvaz Ahvaz Iran department of Tissue Engineering & Regenerative Medicine Iran University of Medical Sciences Tehran Iran

SARS-CoV-2 is a novel RNA coronavirus responsible of a deadly pandemic: the clinical illness COVID-19. With only one authorized drug for emergency use in critically ill patients: Remdesivir, there is not any other approved drug or vaccine yet with proven potential to overcome this infection. We exposed here many scientific evidences to support our novel idea that a macrolide, basically Clarithromycin, could be effective as a single agent for treatment and prophylaxis of COVID-19. Clarithromycin could change the history of this pandemic. It could reduce the costs of treatment and the potential adverse effects when combining more than one drug such as with Hydroxychloroquine. Clarithromycin treatment and prophylaxis as a single agent could be much more simple, safe and cheaper as giving Chloroquine or Hydroxychloroquine alone or in combination with Azithromycin as well as other therapeutic options.

关键词： COVID-19 Macrolides Clarithromycin Single Agent Therapy Prophylaxis

Neurorestorative Effects of Constraint-Induced Movement Therapy after Stroke: An Integrative Review

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Neuroscience & Medicine 2013年第4期4卷 253-262页

作者： Marina Lucas Pedro Ribeiro Mauricio Cagy Silmar Teixeira Fernanda Chaves Diana carvalho Caroline Peressutti Sérgio Machado Juliana bittencourt Bruna Velasques Roberto Piedade Brain Mapping and Sensory Motor Integration Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ) Rio de Janeiro Brazil Brain Mapping and Sensory Motor Integration Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ) Rio de Janeiro Brazil Physiotherapy Laboratory Veiga de Almeida University (UVA) Rio de Janeiro Brazil Physiotherapy Department Piquet Carneiro Policlinic State University of Rio de Janeiro (UERJ) Rio de Janeiro Brazil Brain Mapping and Sensory Motor Integration Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ) Rio de Janeiro Brazil School of Physical Education Bioscience Department Federal University of Rio de Janeiro (EEFD/UFRJ) Rio de Janeiro Brazil Institute of Applied Neuroscience (INA) Rio de Janeiro Brazil Brain Mapping and Sensory Motor Integration Institute of Psychiatry of Federal University of Rio de Janeiro (IPUB/UFRJ) Rio de Janeiro Brazil Institute of Applied Neuroscience (INA) Rio de Janeiro Brazil Division of Epidemiology and Biostatistic Institute of Health Community Federal Fluminense University (UFF) Rio de Janeiro Brazil Laboratory of Panic and Respiration Federal University of Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Physical Activity Neuroscience Laboratory Salgado de Oliveira University Rio de Janeiro Brazil

Stroke has been considered as one of the main causes of death and of motor and cognitive sequels. Especially, many patients with upper limb hemiparesis improved their motor action and showed meaningful cortical changes after treatment with constraint-induced movement therapy. Therefore, this review aims to verify the literature about neuroimaging and behavioral evidences in the cortical reorganization through the use of the constraint-induced movement therapy. So, we conducted the literature research in indexed journals from many databases like Pubmed, Medline, Cochrane Database, Lilacs and Scielo. We concluded that the behavioral and neuroimaging studies using traditional and modified constraint-induced movement therapy promote cortical reorganization.

关键词： Stroke Constraint-Induced-Movement-Therapy Neuroplasticity Cerebral Reorganization

Sorafenib after Arterial Chemoembolization in Child-Pugh A and B Cirrhotic Patients with Intermediate Hepatocellular Carcinoma: A Retrospective Analysis

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Journal of Cancer Therapy 2015年第3期6卷 286-292页

作者： Fernando Gomes Romeiro Luciana Yumi Odani Sigahi Matheus Alvarez Fabio da Silva Yamashiro Fábio Cardoso de carvalho Leonardo Pelafsky Talles Bazeia Lima Letícia de Campos Franzoni José ricardo de Arruda Miranda Giovanni Faria Silva Gastroenterology Division Department of Internal Medicine Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil department of Physics and Biophysics Instituto de Biociências de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Gastroenterology Division Department of Surgery and Orthopedics Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of mortality among cirrhotic patients, and current guidelines recommend single-treatment modalities according to patient and liver disease classifications. New studies have shown promising results from combining locoregional and systemic treatments, but most of them were limited to Child-Pugh A patients due to toxicity concerns. Aim: The objective of this study was to analyze survival rates of Child-Pugh A and B patients with intermediate HCC tumors treated with transarterial chemoembolization (TACE) followed by full-dose sorafenib usage. Material and methods: a retrospective analysis of 37 cirrhotic patients (Child-Pugh A and B rates = 23/14) treated with TACE and TACE followed by sorafenib usage (17 and 20 patients, respectively). Results: The mean survival was 379 days in the combined treatment group and 151 days in the single-treatment group (p = 0.007). There were no differences in survival according to the Child-Pugh classification. Conclusions: sorafenib after TACE can be an option for selected cirrhotic patients with intermediate HCC tumors if this combined approach is cautiously performed on an individualized schedule. Our results suggest that the Child-Pugh classification should not be a limitation to this combined treatment.

关键词： Hepatocellular Carcinoma Cirrhosis Arterial Chemoembolization Sorafenib

Fermentative and Bromatological Characteristics of Piata Palisadegrass Ensiled with Energetic Brans

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American Journal of Plant Sciences 2014年第7期5卷 942-954页

作者： Rozana Castro Perim Kátia Aparecida de Pinho Costa Patrícia Soares Epifanio Wender Ferreira de Souza ricardo Francischini Daniel Augusto Alves Teixeira Walkíria Guimar?es carvalho Divino Rosa dos Santos Jr. Goiano Federal Institute Rio VerdeBrazil Federal University of Bahia SalvadorBrazil University of Rio Verde Rio VerdeBrazil

The objectives of this study were to evaluate the fermentative and bromatological characteristics of Piata palisadegrass that was ensiled with energetic brans and to assess the costs of different additive levels. This experiment was conducted at the Goiano Federal Institute on the Rio Verde campus in Goiás State, Brazil. The experimental design was entirely random with four replications in a 4 × 5 factorial scheme that included four energetic brans (millet, maize, sorghum and wheat) and five levels (0%, 8%, 16%, 24% and 32%). The energetic brans can be considered as a good source of additives for Piata palisadegrass ensiling, which improves the qualitative and nutritional fermentative characteristics of the silage. The maize and wheat brans were the most efficient for improving the fermentative characteristics of the silage. However, millet bran was the most efficient for improving the bromatological characteristics. In addition, the wheat bran had the greatest influence on the final production cost and the sorghum and millet brans were the most economically feasible. Overall, the addition of 24% bran is recommended due to its beneficial impact on silage quality and the average final production cost of the silage.

关键词： Organic Acids Brachiaria brizantha Ensiling Nutritive Value

Prognosis of Patients with Acute Coronary Syndromes and Bleeding—The Importance of Routine Use of a Bleeding Risk Score

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World Journal of Cardiovascular Diseases 2015年第12期5卷 327-334页

作者： Alexandre de Matos Soeiro ricardo Cesar Campos devezae Silva Aline Siqueira Bossa Cindel Nogueira Zullino Tatiana de carvalho Andreucci Torres Leal Maria Carolina Feres de Almeida Soeiro Carlos V. Serrano Jr. Múcio Tavares Oliveira Jr. Emergency Unit-Heart Institute University of Sao Paulo Medical School Sao Paulo Brazil

Introduction: Recent studies showed relation between mortality and bleeding in acute coronary syndromes. Objective: The objective is to analyze the prognosis of patients with acute coronary syndromes with or without in-hospital major and/or minor bleedings. Methods: This was a pro-spective data bank analysis study with 546 patients (39 with bleeding (group I) and 507 without bleeding (group II)) with acute coronary syndromes included between May 2010 and May 2013. Besides, Mehran bleeding risk score was calculated to all patients. The primary endpoint was all causes of in-hospital death and combined events. Comparison between groups was made by Anova and Q-square. Multivariate analysis was determined by logistic regression and was considered significant when p p = 0.005) and combined events (35.9% vs 11.4%, p deaths and combined events.

关键词： Unstable Angina Bleeding Acute Myocardial Infarction

Experience of more than 3000 cycles of Brazilian women using the contraceptive vaginal ring (nuvaring<sup>®</sup>)

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Open Journal of Obstetrics and Gynecology 2014年第1期4卷 10-15页

作者： denise Leite Maia Monteiro ricardo Vasconcelos Bruno Zuleide A. F. Cabral Célia Regina da Silva Danielle bittencourt Sodré Barmpas Nádia Cristina Pinheiro Rodrigues Gynecology and Obstetrics department Universidade do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Gynecology and Obstetrics department Universidade Federal de Mato Grosso (UFMT) Cuiabá Brazil Obstetrics department Maternidade Escola Universidade Federal do Rio de Janeiro (ME-UFRJ) Rio de Janeiro Brazil Ongoing MSc at UERJ Rio de Janeiro Brazil Public Health Researcher of Instituto Oswaldo Cruz (FIOCRUZ)/Universidade do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Reproduction department Institutode Ginecologia Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil

Objective: To evaluate the profile of the Brazilianvaginal ring user, reasons for choosing it, satisfaction, menstrual pattern, tolerability, efficacy, side effects and reasons for discontinuation. Methods: We reviewed the files of 148 users who attended the Hospital de Jacarepaguáand private clinics, between 2005 and 2011, in a total of 3107 cycles. Kaplan-Meier survival curves and regression models were used in statistical analysis. Results: The profile was: single, nulligravida, 30 years (mean) and with university education. The previous contraception used was mostly the oral hormonal contraception (75.7%). Women chose the ring for: practicality (32.4%), forgetting the pill (32.4%) and irregular vaginal bleeding (13.5%). The satisfaction degree was 80.5% (119). There were good cycle control and no pregnancies. Thirty-eight patients discontinued the use (25.7%). The main reasons were wish for pregnancy (6%), spotting (3.4%) and increased vaginal discharge (2.7%). At the end of the first year, use of the greatest reduction of continuity probability was observed (19.3%). Women with side effects were 68% less likely to be satisfied with the method than those without (p-value Conclusion: Nuvaring®is an excellent contraceptiveoption due to its sefficacy, cycle control, tolerability, practicality and safety.

关键词： Vaginal Ring Hormonal Contraception Efficacy Tolerability

<i>Oryza</i>Wild Species: An Alternative for Rice Breeding under Abiotic Stress Conditions

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American Journal of Plant Sciences 2018年第6期9卷 1093-1104页

作者： Viní cius Jardel Szareski Ivan ricardo carvalho Tiago Corazza da Rosa Simone Morgan dellagostin Alan Junior de Pelegrin Mauricio Horbach Barbosa Osmarino Pires dos Santos Dionei Schmidt Muraro Velci Queiró z de Souza Tiago Pedó Tiago Zanatta Aumonde Camila Pegoraro Federal University of Pelotas Pelotas Brazil Federal University of Santa Maria Santa Maria Brazil Federal University of Pampa Bag&eacute Brazil

Rice (Oryza sativa L.) presents a strategic role in social and economic levels. The aim of this study was to elucidate the presence of genetic variability for the genus Oryza, and the possibility of using genotypes with wild characteristics in rice breeding programs. The Oryza genus shows great genetic variability through wild genotypes available in the most varied environments around the world. The negative effects imposed by abiotic stresses such as flood, salinity, low temperatures, water deficiency and high temperatures may be minimized by the efficient identification of a genetic variability source from the Oryza genus. Among the main wild species presented by the Oryza genus, Oryza glumaepatula stands out being an active source of germplasm. The occurrence and preservation of genetic variability of Oryza genus is indispensable to obtain new rice genotypes, to guarantee food security for the human population, as well as to develop genotypes that adapt to climatic changes and natural adversities.

关键词： Oryza sativa Beeding Germplasm Source Genetic Variability