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Allogeneic stem cell transplantation-A curative treatment for paroxysmal nocturnal hemoglobinuria with PIGT mutation:A case report

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World Journal of Clinical Cases 2022年第17期10卷 5702-5707页

作者： Laurence Schenone Anne-Béatrice Notarantonio Véronique Latger-Cannard Veronique Fremeaux-Bacchi Marcelo de carvalho-bittencourt Marie-Thérèse Rubio Marc Muller Maud D'Aveni department of Hematology CHRU de NancyNancy F-54000France Genetic Laboratory CHRU de NancyNancy F-54000France IMoPA CNRS 7365University of LorraineNancy F-54000France Hematology Laboratory Cytometry PlatformCHRU de NancyNancy F-54000France Immunology Laboratory Hôpital Européen George PompidouParis 75015France Immunology Laboratory CHRU de NancyNancy F-54000France

BACKGROUND Patients with paroxysmal nocturnal hemoglobinuria(PNH)have a clonal population of blood cells deficient in glycosylphosphatidylinositol-anchored(GPIanchored)proteins,most of the time resulting from a mutation in the X-linked gene *** report a patient with PNH resulting from a rare biallelic PIGT mutation on chromosome *** SUMMARY A 47-year-old man was referred to our hospital for febrile *** patient reported a history of recurrent urticaria and arthralgia and he presented during 3 mo recurrent acute dermo-hypodermitis and aseptic *** on clinical cases published with PIGT-PNH,with clinically typical PNH and autoinflammatory symptoms,we treated our patients with repeated infusions of eculizumab to decrease autoinflammatory symptoms and then we performed an allogeneic stem cell transplantation(allo-SCT)with a mismatched unrelated *** patient experienced no acute Graft vs Host disease(GvHD)and a moderate chronic GvHD and is now considered cured at 24 mo after *** This case report suggests that allo-SCT should be considered to cure PIGT-PNH patients.

关键词： Paroxysmal nocturnal hemoglobinuria Allogeneic stem cell transplantation PIGT mutation Recurrent meningitidis Autoinflammatory symptoms Case report

Evaluation of total protein,peroxidase,and nutrients measured by pXRF for the determination of tissue rejuvenation/reinvigoration of Eucalyptus microcorys

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林业研究:英文版 2023年第5期34卷 1563-1576页

作者： Júlio Cézar Tannure Faria Caius Ribeiro-Kumara William Macedo delarmelina Filipe Aiura Namorato Dione Richer Momolli Anderson Cleiton José Enéas ricardo Konzen Dulcinéia de carvalho Gilvano Ebling Brondani department of Forestry and Wood Sciences Federal University of Espírito SantoJerônimo MonteiroEspírito SantoBrazil department of Forest Sciences University of HelsinkiHelsinkiFinland Federal Institute of Education Science and Technology of Espírito SantoIbatibaEspírito SantoBrazil department of Soil Science Federal University of LavrasLavrasMinas GeraisBrazil department of Forest Engineering Federal University of Santa MariaSanta MariaRio Grande Do SulBrazil department of Forestry Sciences Federal University of LavrasLavrasMinas GeraisBrazil department Interdisciplinary Federal University of Rio Grande Do SulImbéRio Grande Do SulBrazil

Ontogenetic aging of tissues and the gradual decrease of adventitious rooting are known challenges for the clonal propagation of woody species,hampering clonal forestry *** study examined possible signatures of tissue rejuvenation/reinvigoration in different propagated materials of Eucalyptus microcorys by analyzing the total protein profile,peroxidase activity,macro-and micronutrient contents,and adventitious rooting of mini *** analyses were performed on *** shoots which were successfully obtained by seminal and grafting propagation,micropropagation with epicormic shoots,and indirect *** four mature trees used in the propagation,tissues from the one with the best propagation results were investigated for signs of tissue rejuvenation and/or *** individuals from each technique were randomly selected and transferred to a semi-hydroponic"channel"*** four weeks in the seedbed,the total protein,peroxidase activity,nutrient content and rooting of the mini cuttings were ***-PAGE enabled the differentiation of leaf samples obtained by grafting from the other propagation techniques,as revealed by two distinct *** obtained by micropropagation with epicormic shoots showed the highest peroxidase activity,while those obtained by seminal propagation and from the selected mature tree showed the lowest peroxidase activity.A portable X-ray fluorescence spectroscope(pXRF)identified adequate nutrient content in most of the nutrients tested in materials obtained by seminal and grafting propagation,and by indirect *** analysis of adventitious rooting showed that the highest rooting percentage was observed in mini cuttings from seminal propagation(75%)followed by indirect organogenesis(35%).Based on principal component analysis,it was concluded that rooting of mini cuttings from both seminal propagation and indirect organogenesis was associated with phosphorous,sulphur,and potassium

关键词： Adventitious rooting Juvenility Reinvigoration Rejuvenation Ontogenetic age

Perspective on the use of synthetic biology in rudimentary food fermentations

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Systems Microbiology and Biomanufacturing 2023年第1期3卷 150-165页

作者： Alexander da Silva Vale Gilberto Vinícius de Melo Pereira Leonardo Martins Santana Dão Pedro de carvalho Neto Brigitte Sthepani Orozco Colonia Vanete Thomaz Soccol Bruna Leal Maske Carlos ricardo Soccol department of Bioprocess Engineering and Biotechnology Federal University of Paraná(UFPR)CuritibaPRBrazil department of Genetics University of São Paulo(USP)Ribeirão PretoSPBrazil Federal Institute of Education Science and Technology of Paraná(IFPR)LondrinaPRBrazil

Rudimentary food fermentation can be defined as a spontaneous process of conversion of food components through enzy-matic action.A great variety of fermented foods are produced using spontaneous approaches;however,cocoa and coffee represent the most important agricultural commodities on international *** a manner to increase the efficiency of these processes,starter cultures have been developed and applied under field *** selection process begins with the recovery of microbial strains from spontaneous fermentation through phenotypic and metabolic ***,mutation-based breeding is used to develop and improve well-adapted starter *** advances in synthetic biology,especially in the last decade,the development of robust cellular fabrications with high fermentative capacity has become easier-largely due to the development of genomic approaches,such as next-generation sequencing techniques,CRISPR-Cas system and bioinformatics *** review brings prospects on the use of synthetic biology to design new robust strains for use in cocoa and coffee fermentations,but which can be extended to other rudimentary *** addition,metabolic traits and target genes(e.g.,UvrA,RecA,GPD1,and GPP2)are proposed as a starting point for the improvement of cocoa and coffee ***,the regulatory and safety requirements for these food crops are *** review aims to stimulate research on the process of fermentation and the associated synthetic biology tools to produce fermented food efficiently and sustainably.

关键词： Coffee fermentation Cocoa fermentation Starter cultures CRISPR-Cas Synthetic promoters

Relationship between clinical remission of perianal fistulas in Crohn’s disease and serum adalimumab concentrations:A multicenter cross-sectional study

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World Journal of Gastroenterology 2022年第9期28卷 961-972页

作者： Laura Sirmai Anne-Laure Pelletier Nathalie Gault Camille Zallot Guillaume Bouguen Dominique Bouchard Pascale Roland Nicaise Marine Peyneau Sandrine Sironneau Marcelo de carvalho bittencourt Antoine Petitcollin Pedro Fernandez Xavier Roblin Laurent Siproudhis Laurent Abramowitz Division of Hepato-Gastroenterology and Digestive Oncology Bichat Claude Bernard University HospitalParis 75018France Division of Hepato-Gastroenterology Hospital Croix Saint SimonParis 75020France Division of Epidemiology Biostatistics and Clinical ResearchUniversity Hospital Center BichatParis 75018France National Institute of Health and Medical Research CIC-EC1425 University Hospital Center BichatParis 75018France Division of Gastroenterology Nancy Regional and University Hospital CenterNancy 54035France Imphy CIC 1414 Group and Division of Gastroenterology and Hepatology University Hospital of RennesPontchaillouRennes 35033France Division of Proctology Hospital BagatelleTalence 33400France Division of Immunology University Hospital Center BichatParis 75018France Inflammation Microbiome and ImmunosurveillanceFaculty of PharmacyUniversitéParis-SaclayChâtenay-Malabry 92290France Division of Radiology Bagatelle Hospital CenterTalence 33400France Division of Immunology Nancy Regional and University Hospital CenterNancy 54000France University of Lorraine CNRS UMR 7365IMoPANancy 54000France Antoine Petitcol department of Clinical and Biological Pharmacology and Pharmacovigilance Pharmacoepidemiology and Drug Information CenterRennes University HospitalRennes 35700France Division of Radiology University Hospital Center BichatParis 75018France Orangerie Center Le Perreux-sur-Marne 94170France Division of Gastroenterology CHU Saint EtienneSaint-Priest-en-Jarez 42270France Division of Gastroenterology and Hepatology and Proctology University Hospital Center BichatParis 75018France Ramsay GDS Clinique Blomet Paris 75018France

BACKGROUND Crohn’s disease(CD)is complicated by perianal fistulas in approximately 20%of *** permanent fistula closure remains a challenge for *** association between serum anti-tumor necrosis factor-αconcentrations and clinical outcomes in patients with CD has been demonstrated;however,little information is available on serum adalimumab(ADA)concentrations and remission of perianal fistulas in such *** To study the relationship between serum ADA concentrations and clinical remission of CDassociated perianal *** This cross-sectional study of patients with CD-associated perianal fistulas treated with ADA was performed at four French hospitals between december 2013 and March *** the time of each serum ADA concentration measurement,we collected information about the patients and their *** primary study endpoint was clinical remission of fistulas defined as the absence of drainage(in accordance with Present’s criteria),with a PDAI≤4,absence of a seton and assessment of the overall evaluation as favorable by the proctologist at the relevant *** also assessed fistula healing[defined as being in clinical and radiological(magnetic resonance imaging,MRI)remission]and adverse *** The study cohort comprised 34 patients who underwent 56 evaluations(patients had between one and four evaluations).Fifteen patients had clinical remissions(44%),four of whom had healed fistulas on *** ADA concentrations were significantly higher at evaluations in which clinical remission was identified than at evaluations in which it was not[14(10-16)vs 10(2-15)μg/mL,P=0.01].Serum ADA concentrations were comparable at the times of evaluation of patients with and without healed fistulas[11(7-14)vs 10(4-16)μg/mL,P=0.69].The adverse event rate did not differ between different serum ADA *** We found a significant association between high serum ADA concentrations and clinical remission of CD-associated

关键词： Crohn’s disease Clinical pharmacology Peri-anal disorders Adalimumab

An exotic Cretaceous kimberlite linked to metasomatized lithospheric mantle beneath the southwestern margin of the S?o Francisco Craton,Brazil

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Geoscience Frontiers 2022年第1期13卷 182-203页

作者： Luísa D.V.carvalho Tiago Jalowitzki ricardo Scholz Guilherme O.Gonçalves Marcelo Peres Rocha Rogério Silvestre Pereira Cristiano Lana Marco Paulo de Castro Gláucia Queiroga Reinhardt A.Fuck Universidade Federal de Ouro Preto(UFOP) Escola de MinasDepartamento de GeologiaCampus Morro do Cruzeiro35400-000 Ouro PretoMGBrazil Universidade de Brasília(UnB) Instituto de GeociênciasCampus Universitário Darcy Ribeiro70910-900 BrasíliaDFBrazil Independent Geologist Consultant

We present major and trace element compositions of mineral concentrates comprising garnet xenocrysts,ilmenite,phlogopite,spinel,zircon,and uncommon minerals(titanite,calzirtite,anatase,baddeleyite and pyrochlore)of a newly discovered Late Cretaceous kimberlite(U-Pb zircon age 90.0±1.3 Ma;2σ)named Osvaldo Franca 1,located in the Alto Paranaíba Igneous Province(APIP),southeastern *** grains are lherzolitic(Lherz-1,Lherz-2 and Lherz-3),harzburgitic(Harz-3)and wehrlitic(Wehr-2).The pyrope xenocrysts cover a wide mantle column in the subcratonic lithosphere(66–143 km;20–43 kbar)at relatively low temperatures(811–875°C).The shallowest part of this mantle is represented by Lherz-1 pyropes(20–32 kbar),which have low-Cr(Cr_(2)O_(3)=1.74–6.89 wt.%)and fractionated middle to heavy rare earth elements(MREE-HREE)*** deepest samples are represented by Lherz-2,Lherz-3,Harz-3,and Wehr-2 pyropes(36–43 kbar).They contain high-Cr contents(Cr_(2)O_(3)=7.36–11.19 wt.%)and are characterized by sinusoidal(Lherz-2 and Wehr-2)and spoon-like(Lherz-3 and Harz-3)REE *** to their REE and trace elements,pyrope xenocrysts have enriched nature(e.g.,Ce and Yb ***_(2)O_(3)),indicating that the cratonic lithosphere has been affected by a silicate melt with subalkaline/tholeiite composition due to their low Zr,Ti and Y *** minerals with typical kimberlitic signatures,such as ilmenite and zircon,the exotic compositions of phlogopite and ulvöspinel suggest an enriched component in the magma *** formation of rare mineral phases with strong enrichment of light-REE(LREE)and high field strength elements(HFSE)is attributed to the late-stage kimberlitic *** propose a tectonic model where a thermal anomaly,represented by the low-velocity seismic anomaly observed in P-wave seismic tomography images,supplied heat to activate the alkaline magmatism from a metasomatized cratonic mantle source during the late-stages of Gondwana fragmentation and conse

关键词： Osvaldo França 1 kimberlite Alto Paranaíba Igneous Province Metasomatized cratonic lithosphere Zircon U-Pb geochronology

Urethane Modified Hydrophobic Compact Wood Pulp Paper for Oil Spill Cleanup: A Preliminary Study

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Journal of Renewable Materials 2020年第10期8卷 1257-1268页

作者： Gustavo de Souza ricardo K.Kramer Antonio J.F.carvalho department of Materials Engineering Sao Carlos School of Engineering(EESC)University of São Paulo(USP)São PauloBrazil

Oil spills and oil/water wastewater are among the great concerns regarding oil *** technologies face many limitations and in some cases are responsible for causing secondary pollution,therefore there is as seek for environmental friendly ***,from which celluloses are highlighted,are being employed for oil/water separation or oil absorbents ***,these membranes are obtained by freeze drying of CNF(cellulose nano-fibrils)suspensions followed by chemical modification for hydrophobization,which involves expensive process as chemical vapor deposition and expensive reactants as sylanes,turning these processes hardly ***,we produced a natural porous structure paper from eucalyptus pulp fibers modified by a dipping and heating process in a blocked diisocyanate *** the surface treatment,contact angle with water reached 144°and water absorption reduced seven times,keeping the good oil *** chemical modification process is simple to be performed and use a very low quantity of reactant estimated to be less than 0.1 wt%based on *** good mechanical properties of the material allows its use in non usual conditions which can be of great importance depending on the environmental conditions.

关键词： Cellulose oil removal hydrophobization water repellency blocked isocyanates

Current role and future perspectives of artificial intelligence in echocardiography

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World Journal of Cardiology 2023年第6期15卷 284-292页

作者： Rafael Vidal-Perez Julia Grapsa Alberto Bouzas-Mosquera ricardo Fontes-carvalho Jose Manuel Vazquez-Rodriguez Servicio de Cardiología Unidad de Imagen y Función CardíacaComplexo Hospitalario Universitario A Coruña Centro de Investigación Biomédica en Red-Instituto de Salud Carlos ⅢA Coruña 15006Spain department of Cardiology Guys and St Thomas NHS TrustLondon SE17EHUnited Kingdom Cardiology department Centro Hospitalar de Vila Nova de Gaia/EspinhoVilanova de Gaia 4434-502Portugal Cardiovascular R&D Centre-UnIC@RISE Department of Surgery and PhysiologyFaculty of Medicine of the University of PortoPorto 4200-319Portugal Servicio de Cardiología Complexo Hospitalario Universitario A CoruñaA Coruña 15006Spain

Echocardiography is an essential tool in diagnostic cardiology and is fundamental to clinical *** intelligence(AI)can help health care providers serving as a valuable diagnostic tool for physicians in the field of echocardiography specially on the automation of measurements and interpretation of *** addition,it can help expand the capabilities of research and discover alternative pathways in medical management specially on *** this review article,we describe the current role and future perspectives of AI in echocardiography.

关键词： Echocardiography Artificial intelligence Machine learning deep learning Prognosis

An Overview of SWIPT Circuits and Systems

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ZTE Communications 2022年第2期20卷 13-18页

作者： ricardo TORRES Diogo MATOS Felisberto PEREIRA ricardo CORREIA Nuno Borges carvalho department of Electronics telecommunications and informationUniversity of AveiroAveiro 3810Portugal Institute of Telecommunications Aveiro 3800Portugal CISeD-Research Center in Digital Services Polytechnic of ViseuViseu 3500Portugal Sinuta SA. Estarreja 3860Portugal AlmaScience Colab Madan ParqueCaparica 2829-516Portugal

From a circuit implementation perspective,this paper presents a brief overview of simultaneous wireless information and power transmission(SWIPT).By using zero-power batteryless wireless sensors,SWIPT mixes wireless power transmission with wireless communications to allow the truly practical implementation of the Internet of Things as well as many other *** this paper,technical backgrounds,problem formation,state-of-the-art solutions,circuit implementation examples,and system integrations of SWIPT are presented.

关键词： simultaneous wireless information and power transmission(SWIPT)systems backscatter communication low power commu⁃nication

Encephalic hemodynamic phases in subarachnoid hemorrhage:how to improve the protective effect in patient prognoses

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Neural Regeneration Research 2015年第5期10卷 748-752页

作者： Marcelo de Lima Oliveira Daniel Silva de Azevedo Milena Krajnyk de Azevedo ricardo de carvalho Nogueira Manoel Jacobsen Teixeira Edson Bor-Seng-Shu Division of Neurological Surgery Hospital das ClinicasSchool of MedicineUniversity of Sao Paulo

Subarachnoid hemorrhage is frequently associated with poor prognoses. Three different hemo- dynamic phases were identified during subarachnoid hemorrhage： oligemia, hyperemia, and vasospasm. Each phase is associated with brain metabolic changes. In this review, we correlated the hemodynamic phases with brain metabolism and potential treatment options in the hopes of improving patient prognoses.

关键词： hemodynamic phases cerebral subarachnoid hemorrhage metabolic crises