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The Role of CD4+ and CD8+ T-Cells during Angiostrongylus vasorum Infection in Dogs

Open Journal of Animal Sciences 2014年第5期4卷 285-290页

作者： Thales Augusto Barcante Lis Ribeiro do Valle Antonelli Kenneth Gollob Thiago Pasqua Narciso Silvio Divino de Oliveira Junior Vitor Marcio Ribeiro ricardo toshio fujiwara Ana Paula Peconick Debora Negrao-Correa Walter dos Santos Lima Joziana Muniz de Paiva Barcante Laboratorio de Biologia Parasitaria(BIOPAR) Departamento de Medicina VeterinariaSetor PreventivaUniversidade Federal de Lavras(UFLA)LavrasBrazil Instituto de Ciencias Biologicas Universidade Federal de Minas GeraisBelo HorizonteBrazil Programa de Pos-graduacao em Ciencias Veterinarias Departamento de Medicina VeterinariaUniversidade Federal de Lavras(UFLA)LavrasBrazil

A determinant factor in the pathology of canine angiostrongylosis seems to be related to the location of the parasite in the definitive host. Their presence inside the arteries and its branches, promoting mechanical and metabolic action on the wall of the vessels, may alter its homeostasis. Bronchoalveolar lavage (BAL) is a procedure that retrieves cells and other elements from de lungs for evaluation, and helps in the diagnosis of many pulmonary diseases. The aim of this study was to evaluate CD4+/CD8+ lymphocyte profile during the infection by Angiostrongylus vasorum, using cells retrieved using BAL. The identification of subpopulations of T lymphocytes by evaluating the co-expression of CD4 and CD8 receptor proteins has shown that despite the increase in both populations, there was a predominance of CD4+ T-cells, instead of CD8+ T-cells. These increases of CD4+ T-cells associated with the increase of the ratio between CD4+/CD8+ suggest polarization of a Th2 response. However, the immune cells, signaling factors, and cytokines that mediate such immunity and how and where they act within the body remain largely undefined during angiostrongylosis.

关键词： Citometria Angiostrongyliasis Brochoalveolar Lavage

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Quality of ulcer healing in gastrointestinal tract:Its pathophysiology and clinical relevance

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World Journal of Gastroenterology 2012年第35期18卷 4811-4822页

作者： Tetsuo Arakawa toshio Watanabe Tetsuya Tanigawa Kazunari Tominaga Yasuhiro fujiwara Kenichi Morimoto Department of Gastroenterology Osaka City University Graduate School of Medicine

In this paper, we review the concept of quality of ulcer healing （QOUH） in the gastrointestinal tract and its role in the ulcer recurrence. In the past, peptic ulcer disease （PUD） has been a chronic disease with a cycle of repeated healing/remission and recurrence. The main etiological factor of PUD is Helicobacter pylori （H. pylorl~, which is also the cause of ulcer recur- rence. However, H. pylori-negative ulcers are pres- ent in 12%-20% of patients; they also recur and are on occasion intractable. QOUH focuses on the fact that mucosal and submucosal structures within ulcer scars are incompletely regenerated. Within the scars of healed ulcers, regenerated tissue is immature and with distorted architecture, suggesting poor QOUH. The abnormalities in mucosal regeneration can be the basis for ulcer recurrence. Our studies have shown that persistence of macrophages in the regenerated area plays a key role in ulcer recurrence. Our studies in a rat model of ulcer recurrence have indicated that proinflammatory cytokines trigger activation of macro- phages, which in turn produce increased amounts of cytokines and chemokines, which attract neutrophils to the regenerated area. Neutrophils release proteolytic enzymes that destroy the tissue, resulting in ulcer re- currence. Another important factor in poor QOUH can be deficiency of endogenous prostaglandins and a defi- ciency and/or an imbalance of endogenous growth fac- tors. Topically active mucosal protective and antiulcer drugs promote high QOUH and reduce inflammatory cell infiltration in the ulcer scar. In addition to PUD, the concept of QOUH is likely applicable to inflammatory bowel diseases including Crohn＇s disease and ulcer- ative colitis.

关键词： Quality of ulcer healing Peptic ulcer dis-ease Recurrence Prostaglandin Cytokines Growthfactors

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Sensorineural hearing dysfunction after discharge from critical care in adults:A retrospective observational study

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Journal of Otology 2021年第3期16卷 144-149页

作者： Takashi fujiwara Mizuki Sato Shin-ichi Sato toshio Fukuoka Department of Public Health Research Kurashiki Clinical Research InstituteMiwa 1-1-1Kurashiki CityOkayama Prefecture710-8602Japan Department of Otolaryngology Head and Neck Surgery Kurashiki Central HospitalMiwa 1-1-1Kurashiki CityOkayama Prefecture710-8602Japan Department of Critical Care and Emergency Medicine Kurashiki Central HospitalMiwa 1-1-1Kurashiki CityOkayama Prefecture710-8602Japan Emergency and Critical Care Center Kurashiki Central HospitalMiwa 1-1-1Kurashiki CityOkayama Prefecture710-8602Japan

Background Patients undergoing intensive care are exposed to risk factors for hearing *** study assessed the worse changes in pure tone average(PTA)thresholds after intensive care and identified the factors associated with worse hearing *** We conducted a single-centre retrospective study,and included adult patients admitted to the intensive care unit(ICU)of Kurashiki Central Hospital between January 2014 and September 2019,who had regular pure tone audiometry performed before and after ICU *** between changes in PTA threshold and patient characteristics,were *** included ears were classified as those with worse hearing(>10 dB increase in the PTA threshold)and those without worse hearing,and the baseline characteristics were *** During the study period,125 ears of 71 patients(male:female ratio,35:36;mean age,72.5±12.3 years)met the eligibility ***,sex,and the use of furosemide were not correlated with changes in PTA *** analysis showed that ears with worse hearing were associated with a lower serum platelet count than ears without worse hearing(153±85×10^(9)/L vs.206±85×10^(9)/L,respectively;P=0.010),and the rate of planned ICU admission(elective surgery)was higher in the worse hearing group(57.1% vs.28.8%,respectively;p=0.011).Conclusions Age,sex,and the use of furosemide did not have adversely affect hearing *** serum platelet count and planned admission appear to be risk factors for worse hearing.

关键词： Hearing loss Critical care Intensive care Adverse effects Observational study

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Comparison of cerebral activation between motor execution and motor imagery of self-feeding activity

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Neural Regeneration Research 2021年第4期16卷 770-774页

作者： Moemi Matsuo Naoki Iso Kengo fujiwara Takefumi Moriuchi Daiki Matsuda Wataru Mitsunaga Akira Nakashima toshio Higashi Unit of Medical Science Nagasaki University Graduate School of Biomedical SciencesNagasakiJapan Center for Child Mental Health Care and Education Nagasaki UniversityNagasakiJapan Department of Rehabilitation Faculty of Health SciencesTokyo Kasei UniversitySaitamaJapan Zeshinkai General Incorporated Association Nagasaki Rehabilitation HospitalNagasakiJapan The Japanese Red Cross Nagasaki Genbaku HospitalNagasakiJapan Unit of Rehabilitation Nagasaki University HospitalNagasakiJapan

Motor imagery is defined as an act wherein an individual contemplates a mental action of motor execution without apparent *** practice executed by repetitive motor imagery can improve motor performance without simultaneous sensory input or overt *** aimed to investigate cerebral hemodynamics during motor imagery and motor execution of a self-feeding activity using *** study included 21 healthy right-handed *** self-feeding activity task comprised either motor imagery or motor execution of eating sliced cucumber pickles with chopsticks to examine eight regions of interest:pre-supplementary motor area,supplementary motor area,bilateral prefrontal cortex,premotor area,and sensorimotor *** mean oxyhemoglobin levels were detected using near-infrared spectroscopy to reflect cerebral *** mean oxyhemoglobin levels during motor execution were significantly higher in the left sensorimotor cortex than in the supplementary motor area and the left premotor ***,significantly higher oxyhemoglobin levels were detected in the supplementary motor area and the left premotor area during motor imagery,compared to motor *** motor area and premotor area had important roles in the motor imagery of self-feeding ***,the activation levels of the supplementary motor area and the premotor area during motor execution and motor imagery are likely affected by intentional cognitive *** of cerebral activation differed in some areas during motor execution and motor imagery of a self-feeding *** study was approved by the Ethical Review Committee of Nagasaki University(approval No.18110801)on December 10,2018.

关键词： Activities of Daily Living brain function hemodynamics imagery(psychotherapy) mental practice motor cortex near-infrared neuroimaging neuroscience rehabilitation spectroscopy

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Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 659-661页

作者： Hirotsugu Maruyama Kazunari Tominaga Kunihiro Kato Satoshi Sugimori Masatsugu Shiba toshio Watanabe Yasuhiro fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine 1-4-3 Asahimachi Abeno-ku Osaka 545-8585 Japan

To the Editor:Biliary drainage is most frequently performed among endoscopic procedures using pancreatobiliary endoscopy.A large-diameter metallic stent can significantly extend the patency period rather than a plastic stent for extrahepatic biliary stricture.;However,the optimal drainage for the hilar biliary obstruction is still controversial.

关键词： Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction

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A method for using video presentation to increase the vividness and activity of cortical regions during motor imagery tasks

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Neural Regeneration Research 2021年第12期16卷 2431-2437页

作者： Kengo fujiwara Masatomo Shibata Yoshinaga Awano Koji Shibayama Naoki Iso Moemi Matsuo Akira Nakashima Takefumi Moriuchi Wataru Mitsunaga toshio Higashi Department of Clinical Services Nagasaki Rehabilitation HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan Department of Rehabilitation Faculty of Health SciencesTokyo Kasei UniversityTokyoJapan

In recent years,mental practice(MP)using laterally inverted video of a subject’s non-paralyzed upper limb to improve the vividness of presented motor imagery(MI)has been shown to be effective for improving the function of a paralyzed upper ***,no studies have yet assessed the activity of cortical regions engaged during MI task performance using inverse video presentations and neurophysiological *** study sought to investigate changes in MI vividness and hemodynamic changes in the cerebral cortex during MI performance under the following three conditions in near-infrared spectroscopy:MI-only without inverse video presentation(MI-only),MI with action observation(AO)of an inverse video presentation of another person’s hand(AO+MI(other hand)),and MI with AO of an inverse video presentation of a participant’s own hand(AO+MI(own hand)).Participants included 66 healthy right-handed adults(41 men and 25 women;mean age:26.3±4.3 years).There were 23 patients in the MI-only group(mean age:26.4±4.1 years),20 in the AO+MI(other hand)group(mean age:25.9±5.0 years),and 23 in the AO+MI(own hand)group(mean age:26.9±4.1 years).The MI task involved transferring 1 cm×1 cm blocks from one plate to another,once per second,using chopsticks held in the non-dominant *** on a visual analog scale(VAS),MI vividness was significantly higher in the AO+MI(own hand)group than in the MI-only group and the AO+MI(other hand)group.A main effect of condition was revealed in terms of MI vividness,as well as regions of interest(ROIs)in certain brain areas associated with motor *** data suggest that inverse video presentation of a person’s own hand enhances the MI vividness and increases the activity of motor-related cortical areas during *** study was approved by the Institutional Ethics Committee of Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121303)on January 18,2019.

关键词： action observation cortical activity inverse video presentation mental practice motor imagery motor palsy paralysis recovery rehabilitation stroke

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Management of gastric fundal varices without gastro-renal shunt in 15 patients

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World Journal of Gastroenterology 2008年第3期14卷 448-453页

作者： Natsuhiko Kameda Kazuhide Higuchi Masatsugu Shiba Kaori Kadouchi Hirohisa Machida Hirotoshi Okazaki Tetsuya Tanigawa toshio Watanabe Kazunari Tominaga Yasuhiro fujiwara Kenji Nakamura Tetsuo Arakawa Department of Gastroenterology Graduate School of Medicine Osaka City University Osaka 569-8686 Japan Second Department of Internal Medicine Osaka Medical College Osaka 569-8686 Japan Department of Radiology Graduate School of Medicine Osaka City University Osaka 569-8686 Japan

AIM:To examine the portal hemodynamics of gastric fundal varices (GV) without gastro-renal shunt (GRS), and to retrospectively investigate the effects of various kinds of treatment on eradication. METHODS: Ninety-four liver cirrhosis patients at high- risk of GV were treated in our hospital and enrolled in this study. We retrospectively examined their characteristics, liver function, and portal hemodynamics of GV. We performed balloon-occluded retrograde transvenous obliteration (BRTO) at first. If it was not technically possible to perform BRTO, endoscopic injection sclerotherapy using α-cyanoacrylate glue (CA) or percutaneous transhepatic obliteration (PTO) was performed. RESULTS: Among the 94 patients, a GRS was present in 79 (84.0%), and absent in the remaining 15 (16.0%). The subphrenic vein was connected to the inferior vena cava as the drainage vein in 13 (86.7%) out of the 15 cases without GRS. We performed BRTO in 6 patients, CA in 4 patients and PTO in 5 patients. The eradication rate was 100% for each procedure, but the rate of early recurrence within 6 mo was 16.7% for BRTO, 50.0% for CA and 40.0% for PTO, respectively. CONCLUSION: We should examine the hemodynamics before treatment of GV irrespective of the existence of GRS. If this hemodynamic examination reveals that the drainage vein connects directly to the inferior vena cava in GV without GRS, BRTO may be an effective treatment for GV with GRS.

关键词： Gastric fundal varices Gastro-renal shunt Balloon-occluded retrograde transvenous obliteration

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A case of mucosa-associated lymphoid tissue lymphoma forming multiple lymphomatous polyposis in the small intestine

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World Journal of Gastroenterology 2007年第9期13卷 1453-1457页

作者： Naoto Hirata Kazunari Tominaga Kensuke Ohta Kaori Kadouchi Hirotoshi Okazaki Tetsuya Tanigawa Masatsugu Shiba toshio Watanabe Yasuhiro fujiwara Shiro Nakamura Nobuhide Oshitani Kazuhide Higuchi Tetsuo Arakawa Department of Gastroenterology Osaka City University Graduate School of Medicine 1-4-3 Asahimachi Abeno-ku Osaka 545-8585 Japan Department of Hematology Osaka City University Graduate School of Medicine1-4-3 Asahimachi Abeno-kuOsaka 545-8585 Japan Department of Gastroenterology Rinku General Medical Center 2-3 Rinkuouraikita Izumisano Osaka 598-0048Japan

A 50-year old woman suffering from diabetes had a CT scan that revealed a diffuse thickening of small intestinal wall and swollen paraaortic lymph nodes. An esophago gastroduodenoscopy (EGD) confirmed multiple polypoid lesions in the duodenum and small intestine, and conventional histological testing revealed non-specific inflammatory changes. Further examinations including the immunohistochemical profiles of the biopsied specimens led us to diagnose the lesion as a marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type, forming multiple lymphomatous polyposis sequentially spreading from duodenal bulb to terminal ileum. According to Lugano’s classification, its staging was clinically diagnosed as stage Ⅱ. Two courses of a standard CHOP (cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and predonisolone) regimen with rituximab reduced the lesion and the patient had a almost complete response. A 5-year follow- up EGD and histological examinations detected no recurrence of the disease.

关键词： Intestinal lymphoma Hucosa-associated lymphoid tissue lymphoma Hultiple lymphomatous polyposis

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Successful treatment of giant rectal varices by modified percutaneous transhepatic obliteration with sclerosant:Report of a case

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World Journal of Gastroenterology 2006年第33期12卷 5408-5411页

作者： Hirotoshi Okazaki Kazuhide Higuchi Masatsugu Shiba Shirou Nakamura Tomoko Wada Kazuki Yamamori Ai Machida Kaori Kadouchi Akihiro Tamori Kazunari Tominaga toshio Watanabe Yasuhiro fujiwara Kenji Nakamura Tetsuo Arakawa Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan Department of Gastroenterology Osaka City University Graduate School of Medicine Osaka Japan Department of Radiology Osaka City University Graduate School of Medicine Osaka Japan

We present a female patient with continuous melena, diagnosed with rectal variceal bleeding. She had a history of esophageal varices, which were treated with endoscopic therapy. Five years after the treatment of esophageal varices, continuous melena occurred. Since colonoscopy showed that the melena was caused by giant rectal varices, we thought that they were not suitable to receive endoscopic treatment. We chose the modified percutaneous transhepatic obliteration with sclerosant, which is one of the interventional radiology techniques but a new clinical procedure for rectal varices. After the patient received this therapy, her condition of rectal varices was markedly improved.

关键词： Rectal varices Modified percutaneoustranshepatic obliteration with sclerosant

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Preventive Effect of Lactococcus lactis subsp. lactis JCM 5805 Yogurt Intake on Influenza Infection among Schoolchildren

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Health 2017年第4期9卷 756-762页

作者： Kiyomi Sakata Yumie Sasaki Kenta Jounai toshio Fujii Daisuke fujiwara Department of Hygiene and Preventive Medicine Iwate Medical University School of Medicine 2-1-1 Nishitokuta Yahaba-cho Shiwa-gun Iwate Japan Technical Development Center Koiwai Dairy Products Co. Ltd. 1254 Kamihirose Sayama-shi Saitama Japan Central Laboratories for Key Technologies Kirin Co. Ltd. 1-13-5 Fukuura Kanazawa-ku Yokohama Japan

Objective: A community-based intervention study was conducted to examine the effect of consumption of JCM 5805 yogurt on influenza incidence rates and the cumulative incidence rates among schoolchildren in Iwate Prefecture, Japan. Methods: Schoolchildren and their parents in Shizukuishi town were told of the purpose, frequency and duration of JCM 5805 yogurt administration. The number of elementary schoolchildren in Shizukuishi town was 780 while that of junior high school students in Shizukuishi town numbered 475. The number of elementary schoolchildren in neighboring town A was 208 and that of junior high school students in town A was 121. JCM 5805 yogurt was delivered three times a week to all elementary schools and junior high schools in Shizukuishi town from January 16 through March 18, 2015. The incidence rate was calculated every week as the maximum case number divided by the number of schoolchildren in each school. The cumulative incidence rate was calculated as the total case number during the period when JCM 5805 yogurt was delivered divided by the number of schoolchildren in each school. Results: JCM 5805 yogurt intake was associated with a two-thirds reduction in influenza incidence rates in Shizukuishi town schoolchildren compared with those of town A. Furthermore, the cumulative incidence rates of the elementary school and combined data from the elementary school and junior high school were significantly lower than those of neighbor town A. Conclusion: JCM 5805 yogurt intake reduced both the incidence rates and cumulative incidence rates of influenza.

关键词： Lactococcus lactis JCM 5805 Plasmacytoid Dendritic Cells Influenza Interferon-α Yogurt

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