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Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer

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Cancer Biology & Medicine 2020年第2期17卷 444-457页

作者： Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno Ana Ramirez de Molina1 Enrique Casado5Maria Sereno5 XIMDEA Food InstituteCEI UAM+CSICMadrid 28702Spain 12 de Octubre University Hospital Madrid 28041Spain Gregorio Maranon University Hospital Madrid 28009Spain Ramon y Cajal University Hospital Madrid 28034Spain Infanta Sofia University Hospital San Sebastian De Los ReyesMadrid 28702Spain Fundacion Alcorcon University Hospital AlcorconMadrid 28922Spain Prlncipe de Asturias University Hospital Alcala De HenaresMadrid 28805Spain La Paz University Hospital Madrid 28046Spain University Hospital of Torrejon Torrejon De ArdozMadrid 28850Spain Clinico San Carlos University Hospital Madrid 28040Spain Parque Cientifico de Madrid Foundation Madrid 28049Spain

Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with *** are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the *** this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular ***:In the first step,we conducted a clinical-pathological characterization of the ***,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the ***:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of *** obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)***,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes.

关键词： Long-term survivors non-small cell lung cancer surfactant proteins

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Phosphoprotein Phosphatase 1 Isoforms Alpha and Gamma Respond Differently to Prodigiosin Treatment and Present Alternative Kinase Targets in Melanoma Cells

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Journal of Biophysical Chemistry 2014年第2期5卷 67-77页

作者： Margarida Fardilha Joao Figueiredo Margarita Espona-Fiedler Juliana Felgueiras Luis Korrodi-Gregorio Sara L.C.Esteves Sandra Rebelo Odete A.B.da cruz Silva Edgar da cruz e Silva ricardo Perez-Tomas Laboratory of Signal Transduction Centre for Cell BiologyBiology Department and Health Sciences DepartmentUniversity of AveiroAveiroPortugal Department of Pathology and Experimental Therapeutics Cancer Cell Biology Research GroupUniversity of BarcelonaBarcelonaSpain Laboratory of Neuroscience Centre for Cell BiologyBiology Department and Health Sciences DepartmentUniversity of AveiroAveiroPortugal

Reversible protein phosphorylation is a central regulatory mechanism of cell function. Deregulation of the balanced actions of protein kinases and phosphatases has been frequently associated with several pathological conditions, including cancer. Many studies have already addressed the role of protein kinases misregulation in cancer. However, much less is known about protein phosphatases influence. Phosphoprotein Phosphatase 1 (PPP1) is one of the major serine/threonine protein phosphatases who has three catalytic isoforms: PPP1CA, PPP1CB, and PPP1CC. Its function is achieved by binding to regulatory subunits, known as PPP1-interacting proteins (PIPs), which may prefer a catalytic isoform. Also, some inhibitors/enhancers may exhibit isoform specificity. Here we show that, prodigiosin (PG), a molecule with anticancer properties, promotes the formation of PPP1CA-AKT complex and not of PPP1CC-MAPK complex. Both, AKT and MAPK, are well-known PIPs from two pathways that crosstalk and regulate melanoma cells survival. In addition, the analysis performed using surface plasmon resonance (SPR) technology indicates that PPP1 interacts with obatoclax (OBX), a drug that belongs to the same family of PG. Overall, these results suggest that PG might, at least in part, act through PPP1C/PIPs. Also, this study is pioneer in demonstrating PPP1 isoform-specific modulation by small molecules.

关键词： Phosphoprotein Phosphatase 1 Catalytic Subunit Surface Plasmon Resonance Mitogen-Activated Protein Kinase V-Akt Murine Thymoma Viral Oncogene Glycogen Synthase Kinase 3

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Population Dynamics of Colonizing Fauna and Its Effect on Growth Rates of the Farmed Red Alga Alsidium triquetrum (S. G. Gmelin) Trevisan

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Natural Science 2022年第2期14卷 42-55页

作者： Ruben Cabrera Arsenio J. Areces Jhoana Díaz-Larrea Sunil Kumar Sahu Juan ricardo cruz-Aviña Laura G. Nuñez García Gabinete de Arqueología Oficina del Historiador de la Ciudad Habana Vieja Cuba Instituto de Geografía Tropical Ministerio de Ciencia Tecnología y Medio Ambiente Municipio Playa Ciudad Habana Cuba Departamento de Hidrobiología Universidad Autónoma Metropolitana Unidad Iztapalapa CBS Cd de México México State Key Laboratory of Biocontrol Guangdong Key Laboratory of Plant Resources School of Life Science Sun Yat-Sen University Guangzhou China Facultad de Medicina Veterinaria y Zootecnia BUAP Laboratorio de Medicina de la Conservación Licenciatura en Medicina Veterinaria y Fauna Silvestre Km. 7.5 Carretera Ca&ntilde ada Morelos El Salado Tecamachalco Puebla Mexico

Herbivores can drastically alter the morphology of macroalgae by directly consuming tissue and by inflicting structural wounds. Macroalgae host abundant and diverse epibiont communities, the dynamics of which tend to be mostly unknown in space and time. As the cultivation of macroalgae gains momentum worldwide, it is key to measure how epibionts could affect algal performance. We examined the epibiont community associated with farmed Alsidium triquetrum, a red macroalga with growing pharmacological interest. Measurements were conducted over two independent 60-day periods, one in summer and one in winter. Epibionts showed different patterns of succession in both seasons. Crustaceans, mainly amphipods, showed the highest overall density, with deleterious effects on daily growth rates of A. triquetrum in winter. Adverse effects as a function of epibionts were not detected in summer. A. triquetrum is a perennial alga. However, its performance as a crop in the nearshore can be significantly affected by the epibiont community structure that persists in winter. Amphipods and ascoglossan molluscs were risk factors in the mariculture of this agarophyte. In winter, they can destroy plants when they reach more than five individuals per gram of fresh biomass. Results highlight that commercial farming of A. triquetrum would be successful if grown throughout the summer.

关键词： Cultivation Epifauna Macroalgae Macroinvertebrates Seaweed Mariculture

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Fractional Square Functions and Potential Spaces, Ⅱ

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Acta Mathematica Sinica,English Series 2015年第11期31卷 1759-1774页

作者： Jorge J.BETANCOR Juan C.FARIA Lourdes RODRIGUEZ-MESA ricardo TESTONI Jos L.TORREA Departamento de Anlisis Matemtico Universidad de La Laguna Campus de Anchieta Avda.Astrofísico Francisco Snchez 38271 La Laguna (Sta.Cruz de Tenerife) Spain Departamento de Matemtica Universidad Nacional del Sur Avda. Alem 1253 8000 Bahía BlancaBuenos Aires Argentina Departamento de Matem'aticas Universidad Autónoma de Madrid ICMAT-CSIC-UAM-UCM-UC3MCiudad Universitaria de Canto Blanco 28049 Madrid Spain

In this paper, we study fractional square functions associated with the Poisson semigroup for SchrSdinger operators. We characterize the potential spaces in the SchrSdinger setting by using vertical, area and gλ, fra... 详细信息

关键词： g-function Schrodinger operator potential space

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Perspectives of Waste Electrical and Electronic Equipment in Tampico, Mexico

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Journal of Environmental Protection 2014年第12期5卷 1266-1276页

作者： René Bernardo Elías Cabrera-cruz María Esther Bautista-Vargas Julio César Rolón-Aguilar ricardo Tobías-Jaramillo Alberto José Gordillo-Martínez Division of Postgraduate Studies and Research Faculty of Engineering “Arturo Narro Siller” Autonomous University of Tamaulipas Tamaulipas Mexico Center for Chemical Research Autonomous University of the State of Hidalgo Pachuca Mexico

Waste electrical and electronic equipment (WEEE) has brought negative effects to the environment produced by the materials that compose them. The proper implementation of management plans of WEEE should integrate measures to prevent, mitigate and correct these affectations. As an initial step, it is necessary to make a diagnosis of the current situation of WEEE management which is the objective of this work. The studied zone was composed by the municipalities of Tampico, Ciudad Madero and Altamira located in southeast Tamaulipas, Mexico. The descriptive analysis of technical and regulatory aspects of the current management system in the study area was developed, including generation rates and analysis of waste streams. Among the main results, the generation of WEEE was estimated in 2040.38 tons/year for 2013, distributed in the municipalities of Tampico with 830.93 tons/year, Altamira with 650.18 tons/year, and Ciudad Madero with 559.27 tons/year. This calculation was estimated using Mexico’s WEEE generation indicators. The analysis of waste streams includes five categories of WEEE, Televisions with 61% of the total generation, followed by sound devices with 18%, personal computers with 17%;mobile phones with 2% as well as fixed phones with 1%. In the study area, reports of Tampico’s municipality indicated that 96 tons of WEEE was collected in the city of Tampico in 2013. In México, the national legislation considers WEEE in the category of waste requiring special handling (WRSH), however, it exists an inadequacy in the environmental laws about the specific classification of this kind of debris that makes their effective management more difficult. No companies who provide a management or treatment operations for WEEE are reported in Tampico, or in the near region. In addition, despite an initial interest for the municipality to attend the WEEE problematic, it exists a lack of sensibility of the population in the absence of environmental education programs.

关键词： WEEE Management Tampico EIA

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Epidemiological Patterns of AIDS in a Reference Center from Catanduva,Sao Paulo State,Brazil

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Open Journal of Medical Microbiology 2012年第3期2卷 47-53页

作者： Arlindo Schiesari Jr. Katia Jaira Galisteu Luciana Ventura Cardoso Vanessa Maria Brogio Schiesari Adriana Antonia da cruz Furini Andrea Regina Baptista Rossit ricardo Luiz Dantas Machado Integrated College Padre Albino CatanduvaBrazil STD/AIDS Municipal Program CatanduvaBrazil Department of Dermatology Parasitic and Infectious DiseasesMedicine School in Sao Jose do Rio PretoSao Jose do Rio PretoBrazil Rio Preto University Center Sao Jose do Rio PretoBrazil Biomedical Institute Microbiology and Parasitical Diseases from Fluminense Federal UniversityNiteroiBrazil

Objective: Hereby we present the epidemiological and clinical profile of HIV-infected population before and during the highly active antiretroviral therapy (HAART) era from a tertiary care hospital in the Southeastern region of Brazil. Methods: A retrospective, cross-sectional and descriptive study was carried out, this involved the analysis of the medi-cal records of patients diagnosed with HIV-1/AIDS admitted to Hospital Escola Emílio Carlos, located in the munici-pality of Catanduva, State of S?o Paulo, Brazil. Results: In both pre-HAART and HAART periods, HIV-1 infection was more prevalent in men. Heterosexuality and secondary education were associated with AIDS in the HAART period. Statistically significant association was only observed for co-infection with HIV-1/Hepatitis C in the pre-HAART era and the number of patients with opportunistic infection (OI) was lower in the HAART period. Among all OI it is worth mentioning pulmonary pneumocystosis, which despite being common in two periods, its occurrence was considerably greater in the pre-HAART era. Concerning the distribution of OIs according to the HIV-1 viral load and serial count of T CD4+ lymphocytes, a significant association was observed. The association between the number of deaths by OIs and death in the 1st year of diagnosis in the HAART treatment was significant. Conclusions: The clinical and epidemiological profile of a specialized HIV-1/AIDS center in Catanduva, Southeastern Brazilian region, is consistent with the epidemiology of AIDS in the country.

关键词： HIV-Infected Population Antiretroviral Therapy Highly Active Brazil

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New Sulfonamides Derived from Carvacrol: Compounds with High Antibacterial Activity against Resistant Staphylococcus aureus Strains

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Journal of Biosciences and Medicines 2016年第7期4卷 105-114页

作者： Aldo Sena de Oliveira Luana Canzian Llanes Inês Maria Costa Brighente ricardo José Nunes Rosendo Augusto Yunes Nilton Máximo Junior Ana Milda Karsten Baumgart Anays Noumeh Aust Alexandre Bella cruz Department of Chemistry Federal University of Santa Catarina Florianópolis Brazil Graduate Program in Pharmaceutical Sciences University of Valley of ltajaí Itajaí Brazil

Nine new sulfonamides derived from carvacrol were prepared through a reaction between 4-hydroxy-2-isopropyl-5-methyl benzene sulfonyl chloride with various amines in excellent yields (76% - 92%). The sulfonamides were characterized using spectrometric and spectroscopic methods. Among these compounds, three derivatives showed excellent results in antibacterial activity against resistant S. aureus strains, with MIC values ranging from 3.9 to 62.50 ppm. The sulfonamide derivative of 4-methylaniline (SULF-1) had the best performance for all tested strains of bacteria (MIC = 3.9 to 15.62 ppm). Furthermore, the sulfonamide derivative of 4-fluoro aniline (SULF-3), which also presented promising results, was found to have a synergistic effect when combined with tetracycline and partial synergistic effect when combined with ampicillin, exhibiting an FIC index between 0.50 and 0.75. The sulfonamide derivative of 4-methylaniline had a synergistic effect in combination with erythromycin exhibiting an FIC index of 0.37. Carvacrol in association with the antibiotics tested did not have a synergistic effect.

关键词： Sulfonamides Carvacrol Antibacterial Staphylococcus aureus Synergism

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Failure in Fuel Injector Nozzles Used in Diesel Engines

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Journal of Mechanics Engineering and Automation 2015年第4期5卷 237-240页

作者： Jose Costa de Macedo Neto Marina Anunciacao Brito de Oliveira Eduardo Rafael Barreda del Campo ricardo Wilson Aguiar Da cruz Nayra Reis do Nascimento Joao Evangelista Neto Department of Materials Engineering School of Engineering Amazonas State University Manaus 69065-020 Brazil Department of Mechanical Engineering School of Engineering Amazonas State University Manaus 69065-020 Brazil Department of Materials Engineering and Bioprocess Faculty of Chemical Engineering University of Campinas Sao Paulo13083-852 Brazil Department of Electrical Engineering Faculty of Technology University Federal of Amazonas Manaus 69077-000 Brazil

This paper aims to conduct a study of the problems associated with the wear of the needles and fuel injection nozzles utilized in diesel engines. The wear found on the needles is mainly associated to impurities in the fuel oil and microcavitation occurred due to high pressure in the phase of the air compression for combustion of the combustible fluid. These pressures associated with the temperature and the fluid velocity results in the occurrence of vaporization, which releases shock waves that cause damage to the affected surface. The impurities solid particles from the fuel oil cause problems inside the nozzles as obstruction of the holes and wear on the needle tip and nozzle seat surface. These failures affect in the atomization of the fuel, since the deterioration of the internal passages of the nozzles interferes in the spray formation and in the end passage of the fluid. For the execution of this study it will be used digital microscopic analysis in specimens that suffered damage, in order to investigate the effects of fuel property, and the temperature conditions and pressure in the formation of the wear on the needles and injector nozzle.

关键词： Fuel injector nozzle injector needles wear.

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Developing Ontology Systems as a Base of an Environmental Quality Management Model in México

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Journal of Environmental Protection 2015年第9期6卷 1084-1093页

作者： René Bernardo Elías Cabrera-cruz Erika Alarcón-Ruiz Julio César Rolón-Aguilar Salvador W. Nava-Díaz Elena María Otazo-Sánchez ricardo Pérez Aviléz Division of Postgraduate Studies and Research Faculty of Engineering “Arturo Narro Siller” Autonomous University of Tamaulipas Tamaulipas Mexico Center for Chemical Research Autonomous University of Hidalgo State Hidalgo Mexico Institute of Sciences Autonomous University of Puebla Puebla Mexico

The process of identifying the attributes and relationships considered in an ontology is a complex task because there are many factors involved in the deterioration of environmental quality, the diversity of sources and data dispersion. This work presents an ontology that integrates the data required by an Environmental Quality Synoptic System (EQSS), which to date scatters in different Internet sites and concentrates by different agencies for example INEGI, CONABIO, SEMARNAT, CNA, among others. The methodology process consists of the collection of environmental information in Mexico through the application of computational techniques resulting ontology with environmental knowledge that will be processed by the system EQSS. Among the main advantages is than the selection and structure of information allow the automated generation of results in an environmental statement. The ontology proposal is based on knowledge of EQSS system that is based on the architecture of expert systems and through this important information for decision-making in regard to environmental quality and interaction with Geographic Information System (GIS) is obtained.

关键词： Ontology Software Knowledge Modeling Environmental Quality EIA

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Big data in healthcare:Conceptual network structure,key challenges and opportunities

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数字通信与网络:英文版 2023年第4期9卷 856-868页

作者： Leonardo B.Furstenaua Pedro Leivas Michele Kremer Sott Michael S.Dohan Jose ricardo Lopez-Robles Manuel J.Cobo Nicola Luigi Bragazzi Kim-Kwang Raymond Choo Post-Graduate Program in Industrial Engineering Federal University of Rio Grande Do SulPorto Alegre90035-190Brazil University of Santa cruz Do Sul Av.Independencia 2293Santa Cruz Do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Faculty of Business Administration Lakehead UniversityThunder BayOntarioCanada Autonomous University of Zacatecas Av.Ramon Lopez Velarde Col.CentroZacatecas98000Mexico Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain York University ON M3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Big data is a concept that deals with large or complex data sets by using data analysis tools(e.g.,data mining,machine learning)to analyze information extracted from several sources *** data has attracted wide attention from academia,for example,in supporting patients and health professionals by improving the accuracy of decision-making,diagnosis and disease *** research aimed to perform a Bibliometric Performance and Network Analysis(BPNA)supported by a Scoping Review(SR)to depict the strategic themes,thematic evolution structure,main challenges and opportunities related to the concept of big data applied in the healthcare *** this goal in mind,4857 documents from the Web of Science covering the period between 2009 to June 2020 were analyzed with the support of SciMAT *** bibliometric performance showed the number of publications and citations over time,scientific productivity and the geographic distribution of publications and research *** strategic diagram yielded 20 clusters and their relative importance in terms of centrality and *** thematic evolution structure presented the most important themes and how it changes over ***,we presented the main challenges and future opportunities of big data in healthcare.

关键词： Big data Healthcare digitalization Bibliometric Strategic intelligence Co-word analysis SciMAT

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