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Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane

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The Crop Journal 2023年第6期11卷 1805-1815页

作者： ricardo JoséGonzaga Pimenta Alexandre Hild Aono Roberto Carlos Villavicencio Burbano Marcel Fernando da Silva Ivan Antônio dos Anjos Marcos Guimarães de Andrade Landell Marcos Cesar Gonçalves Luciana Rossini Pinto Anete Pereira de Souza Centre for Molecular Biology and Genetic Engineering University of CampinasCampinasBrazil Gustavo Galindo Velasco Campus Littoral Polytechnic Superior SchoolGuayaquilEcuador Advanced Centre for Technological Research in Sugarcane Agribusiness Agronomic Institute of CampinasRibeirão PretoBrazil Plant Protection Research Centre Biological InstituteSão PauloBrazil department of Plant Biology Institute of BiologyUniversity of CampinasCampinasBrazil

Sugarcane mosaic virus(SCMV)is the main etiological agent of sugarcane mosaic disease,which affects sugarcane and other grass *** the extensive characterization of quantitative trait loci controlling resistance to SCMV in maize,the genetic basis of this trait in sugarcane is largely ***,a genome-wide association study was performed and machine learning coupled with feature selection was used for genomic prediction of resistance to SCMV in a diverse sugarcane *** single-nucleotide polymorphisms(SNPs)explained up to 29.9%of the observed phenotypic variance and a 73-SNP set predicted resistance with high accuracy,precision,recall,and F1 scores(the harmonic mean of precision and recall).Both marker sets were validated in additional sugarcane genotypes,in which the SNPs explained up to 23.6%of the phenotypic variation and predicted resistance with a maximum accuracy of 69.1%.Synteny analyses suggested that the gene responsible for the majority of SCMV resistance in maize is absent in sugarcane,explaining why this major resistance source has not been identified in this ***,using sugarcane RNA-Seq data,markers associated with resistance to SCMV were annotated,and a gene coexpression network was constructed to identify the predicted biological processes involved in *** network allowed the identification of candidate resistance genes and confirmed the involvement of stress responses,photosynthesis,and the regulation of transcription and translation in resistance to *** results provide a practical marker-assisted breeding approach for sugarcane and identify target genes for future studies of SCMV resistance.

关键词： Saccharum SCMV GWAS Machine learning RNA-Seq

Social Rights and Work on Digital Platforms in Brazil:The Case of“Breque dos Apps”

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Sociology Study 2023年第3期13卷 126-140页

作者： Raphaela Magnino Rosa Portilho ricardo JoséLeite de sousa University of the State of Rio de Janeiro(UERJ) Brazil

The movement known as“Breque dos Apps”was a social movement of a striker nature,which took place in Brazil in July *** movement was organized by workers which provided services to delivery apps(like iFood,Loggi,Uber Eats and Rappi).They demanded better working conditions and social protection measures,since they were out of the protection of the Brazilian legal *** reason for this lies in the fact that there is a debate about the classification of these workers-the maximum expression of the gig economy-as employees under Brazilian *** a result,and with the exponential growth in the use of these applications due to the Covid-19 pandemic,thousands of workers were left on the fringes of any social *** study aims to analyze the aforementioned movement and its demands within the paradigm of social rights,especially the ones regarding collective representation,which are guaranteed by the Brazilian *** terms of methodology,the content analysis method will be applied,considering that the established objective presupposes the study of theoretical and legal texts that allow the structuring of concepts applicable to the *** research technique to be adopted will be the analysis of indirect documentation,that is,literature review,to be carried out through bibliographic and documentary research,focused on literature and legal texts related to the topic.

关键词： Breque dos Apps strike delivery apps digital platform workers social rights

Multifunctional Nanostructured Materials Applied in Controlled Radiopharmaceuticals Release

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Journal of Biomaterials and Nanobiotechnology 2012年第2期3卷 163-168页

作者： Raquel Cristina de sousa Azevedo Daniel Crístian Ferreira Soares ricardo Geraldo de sousa Edésia Martins Barros de sousa Centro de desenvolvimento da Tecnologia Nuclear(CDTN)/CNEN Serviço de NanotecnologiaBelo HorizonteBrazil departa-mento de Engenharia Química Universidade Federal de Minas GeraisBelo HorizonteBrazil

The metaiodobenzylguanidine (MIBG) radiopharmaceutical, an analogue of norepinephrine, has been used to diagnose certain diseases in the cardiovascular system when radiolabeled with 123I. This radiopharmaceutical can also be used to treat tumors, such as neuroblastomas and pheochromocytomas, when radiolabeled with 131I. Its clinical use is often accompanied by a slow intravenous administration, where a significant dose of radiation can directly affect workers in nuclear medicine services. To overcome this problem, the incorporation and controlled release of radiopharmaceuticals from the matrix of mesoporous systems based on silica, such as SBA-15 and hybrid [SBA-15/P(N-iPAAm)], can lead to a significant reduction in radiation doses received by workers. In the present study, silica matrices SBA-15 and hybrid [SBA-15/P(N-iPAAm)] containing the radiopharmaceutical MIBG were prepared and physicochemically characterized through FTIR, SEM, and small angle X-ray diffraction techniques. The release profiles of MIBG from SBA-15 and [SBA-15/P(N-iPAAm)] were studied in a simulated body fluid (SBF) to evaluate their potential application as vehicles for controlled releases. Furthermore, in vitro studies were performed to assess the cytotoxicity of matrices as compared to human lung fibroblast cells (MRC-5). The results revealed that the amount of MIBG incorporated within the studied matrices was indeed quite different, showing that only the hybrid [SBA-15/P(N-iPAAm)] system allowed for a more adequate release profile of MIGB. Taking all results into consideration, it can be concluded that the hybrid matrix [SBA-15/P(N-iPAAm)] can be considered a potential alternative material for the controlled release delivery of radio-pharmaceuticals.

关键词： SAB-15 Hybrid[SBA-15/P(N-iPAAm)] MIGB Radiopharmaceutical Drug Release

The role of exercise in brain DNA damage

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Neural Regeneration Research 2020年第11期15卷 1981-1985页

作者： Thais Cereser Vilela Vanessa Moraes de Andrade Zsolt Radak ricardo Aurino de Pinho Laboratory of Translational Biomedicine Graduate Program of Health SciencesUniversity of Southern Santa Catarina–UNESCCriciumaSCBrazil Research Institute of Sport Science University of Physical EducationBudapestHungary Laboratory of Exercise Biochemistry in Health Graduate Program in Health SciencesSchool of MedicinePontificia Universidade Catolica do ParanaCuritibaPRBrazil

Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA,which leads to neuronal *** this way,DNA damage has been implicated in the pathogenesis of neurological disorders,cancer,and *** factors,such as physical exercise,are neuroprotective and increase brain function by improving cognition,learning,and memory,in addition to regulating the cellular redox *** mechanisms are associated with the effects of exercise in the brain,such as reduced production of oxidants,up-regulation of antioxidant capacity,and a consequent decrease in nuclear DNA ***,physical exercise is a potential strategy for further DNA damage ***,the neuroplasticity molecules that respond to different aspects of physical exercise remain *** this review,we discuss the influence of exercise on DNA damage and adjacent mechanisms in the *** discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.

关键词： aerobic exercise apoptosis brain-derived neurotrophic factor brain DNA damage DNA repair neurodegenerative disease oxidative stress physical exercise strength exercise

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana Rufino Ribeiro ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Labor Motivation and Its Influence on Workers’Productivity-A Secondary Publication

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Proceedings of Business and Economic Studies 2024年第1期7卷 210-217页

作者： ricardo Molinar University of Panama Panama

The productivity of an institution is achieved,in large part,by creating a harmonious environment that reflects the satisfaction,empowerment,and collaborative spirit of each *** this perspective,management will consider upgrades using all tactics that allow for the achievement of these goals,including direct effort and the involvement of all *** objective of this study was to examine the relationship between work motivation and the productivity of workers in the communal board of the Barrio Sur corregimiento in the province of Coló*** the questionnaire as an instrument,as well as the descriptive method,allowed for the report and evaluation of the characteristics of the workers,indicating interpersonal deficits and distancing in the motivations that drive administrative *** incorporating different approaches previously analyzed and developed by different authors familiar with the subject,it was possible to achieve substantial results,such as the need to implement administrative strategies that harmoniously incorporate workers,showing that,despite motivation problems,the work environment where one works is very important in the performance of their *** to motivate the direct participation of the workers selected as part of the sample,who showed full satisfaction with the results framed within the framework of individual improvement and,above all,the commitment to the institution to improve its work.

关键词： Work motivation Productivity Workers Work environment

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深海之王

商业周刊（中文版） 2024年第9期 54-63页

作者： Kit Chellek Olivia Solon Jonathan Browning ricardo Rey(插图) 杨飞(译) 不详

多年来,世界上最厉害的深海沉船猎人一直在与各国政府及竞争对手争夺海底的财富。他把自己的身份隐藏得很好,一直到现在。冰岛海岸警卫队的官员们在控制室的显示屏上注视着这艘船——在广阔的蓝色海图上,它只是一个孤点。2017年4月,这... 详细信息

多年来,世界上最厉害的深海沉船猎人一直在与各国政府及竞争对手争夺海底的财富。他把自己的身份隐藏得很好,一直到现在。冰岛海岸警卫队的官员们在控制室的显示屏上注视着这艘船——在广阔的蓝色海图上,它只是一个孤点。2017年4月,这个小点在离岸120英里(约193公里)的地方盘旋了好几天,任何理智的水手都不会在当时那种恶劣的天气里闲逛。接近飓风等级的狂风呼啸着穿越凶涌的大海;天空中雨雪交加。

关键词：海岸警卫队控制室显示屏竞争对手

Sustainable transit vehicle tracking service,using intelligent transportation system services and emerging communication technologies:A review

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 729-747页

作者： ricardo Salazar-Cabrera álvaro Pachón de la Cruz Juan Manuel Madrid Molina Telematics Engineering Research Group(GIT) Telematics DepartmentUniversidad del CaucaPopayanColombia Information Technology and Telecommunications Research Group(I2T) ICT DepartmentUniuersidad IcesiCaliColombia

The most salient problems of transit vehicle service in Latin American intermediate cities include:the high number of passengers involved in traffic accidents;traffic congestion caused by transit vehicles,and pollution generated by these vehicles,which increases in high congestion *** improve upon this situation,a research was conducted on the transit vehicle tracking service,which is a basic service for implementing mobility solutions for the aforementioned problems,the most relevant characteristics of this service for the context of Latin American intermediate cities were identified,and an implementation was *** paper presents the four stages of the study:(a)a review of the state-of-the-art of services or systems related to vehicle tracking,including wireless communications technologies,implemented sustainability approaches,usage of special algorithms for efficiency improvement,and the intelligent transportation system(ITS)architecture used as a basis;(b)the process of identifying relevant characteristics of the service for a given context;(c)proposal of an ITS architecture for this service in an intermediate city,its requirements and the suggested technologies;and(d)development of experiments for validating usage of the key suggested *** review allowed to identify the main service characteristics,with regard to vehicle positioning technologies,the recommended wireless communication technology(long range,LoRa),energy consumption considerations,and use of artificial intelligence(AI)to calculate waiting time of users at bus ***,an ITS architecture for the city of Popayan(Colombian city)considering the aforementioned characteristics is proposed,and the experiments related to the use of these technologies are described in detail.

关键词： Transportation engineering Intelligent transportation systems Transit vehicle ITS architecture Tracking Long range

Urethane Modified Hydrophobic Compact Wood Pulp Paper for Oil Spill Cleanup: A Preliminary Study

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Journal of Renewable Materials 2020年第10期8卷 1257-1268页

作者： Gustavo de Souza ricardo K.Kramer Antonio J.F.Carvalho department of Materials Engineering Sao Carlos School of Engineering(EESC)University of São Paulo(USP)São PauloBrazil

Oil spills and oil/water wastewater are among the great concerns regarding oil *** technologies face many limitations and in some cases are responsible for causing secondary pollution,therefore there is as seek for environmental friendly ***,from which celluloses are highlighted,are being employed for oil/water separation or oil absorbents ***,these membranes are obtained by freeze drying of CNF(cellulose nano-fibrils)suspensions followed by chemical modification for hydrophobization,which involves expensive process as chemical vapor deposition and expensive reactants as sylanes,turning these processes hardly ***,we produced a natural porous structure paper from eucalyptus pulp fibers modified by a dipping and heating process in a blocked diisocyanate *** the surface treatment,contact angle with water reached 144°and water absorption reduced seven times,keeping the good oil *** chemical modification process is simple to be performed and use a very low quantity of reactant estimated to be less than 0.1 wt%based on *** good mechanical properties of the material allows its use in non usual conditions which can be of great importance depending on the environmental conditions.

关键词： Cellulose oil removal hydrophobization water repellency blocked isocyanates