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Meta-analysis of combined therapy for adult hepatitis B virus-associated glomerulonephritis

World Journal of Gastroenterology 2012年第8期18卷 821-832页

作者： Xiao-Yong zheng ri-Bao Wei Li Tang Ping Li Xiao-Dong zheng Department of Nephrology General Hospital of Chinese PLA Beijing 100853 China Department of Ophthalmology Ehime University School of Medicine Ehime 791-0295 Japan

AIM: To investigate the efficacy and safety of combined antiviral and immunosuppressant therapy in adult hepatitis B virus-associated glomerulonephritis (HBVGN) patients. METHODS: A computerized literature search was carried out in the PubMed database, Embase, the Cochrane Library, Chinese BioMedical Literature on disc, Chinese Medical Current Contents, Chinese National Knowledge Infrastructure, Wanfang and VIP (Chinese Technological Journal of Database) to collect articles between June 1980 and December 2010 on therapy with immunosuppressants, e.g., glucorticosteroids, mycophenolate mofetil and leflunomide, combined with antivirals, e.g., interferon, lamivudine, entecavir and adefovir dipivoxil, in adult HBV-GN patients. The primary outcomes were remission of proteinuria, clearanceof HBV e-antigen, and elevation of serum albumin. The secondary outcomes were blood levels of alanine aminotransferase, serum creatinine, and HBV-DNA titer. Meta-analysis was performed using Review Manager 5.1. Fixed or random effect models were employed to combine the results after a heterogeneity test. The effects of the combined therapy were analyzed for different doses of glucorticosteroid and different types of HBV-GN. RESULTS: Twelve clinical trials with 317 patients were included. A significantly higher incidence of HBV-GN was found in male patients (relative risk = 2.40, 95% CI: 1.98-2.93). Combined therapy reduced the proteinuria significantly with a mean difference of 4.19 (95% CI: 3.86-4.53) and increased the serum albumin concentration significantly with a mean difference of -11.95 (95% CI: -12.97-10.93) without significant alterations of liver function (mean difference: 4.62, 95% CI: -2.55-11.79) and renal function (mean difference: 10.29, 95% CI: 0.14-20.45). No signif icant activation of HBV-DNA replication occurred (mean difference: 0.12, 95% CI: -0.37-0.62). There was no significant difference between the high dose glucorticosteroid group and the low dose glucorticosteroi

关键词： Meta-analysis hepatitis B virus-associatedglomerulonephritis Glucocorticoids Immunosuppressant Antiviral drug

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Experimental observation of spontaneous symmetry breaking in a quantum phase transition

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 34-39页

作者： Wen Ning ri-Hua zheng Jia-Hao Lu Fan Wu Zhen-Biao Yang Shi-Biao zheng Fujian Key Laboratory of Quantum Information and Quantum Optics College of Physics and Information EngineeringFuzhou UniversityFuzhou 350108China hefei National Laboratory Hefei 230088China

Spontaneous symmetry breaking(SSB)plays a central role in understanding a large variety of phenomena associated with phase transitions,such as superfluid and *** far,the transition from a symmetric vacuum to a macroscopically ordered phase has been substantially *** process bridging these two distinct phases is critical to understanding how a classical world emerges from a quantum phase transition,but so far remains unexplored in *** here report an experimental demonstration of such a process with a quantum Rabi model engineered with a superconducting *** move the system from the normal phase to the superradiant phase featuring two symmetry-breaking field components,one of which is observed to emerge as the classical *** results demonstrate that the environment-induced decoherence plays a critical role in the SSB.

关键词： quantum phase transition Rabi model spontaneous symmetry breaking superconducting circuit Schrodinger cat states

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Effect of rheo-diecast process on the mechanical properties of A390 alloy by serpentine channel

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International Journal of Minerals,Metallurgy and Materials 2016年第10期23卷 1177-1186页

作者： Kunhyok ri Wei-min Mao Zhi-kai zheng Myongsik Kim Yongho Sin School of Materials Science and Engineering University of Science and Technology Beijing School of Material Engineering Pyongyang Machinery University

In this paper, the effects of rheo-diecast process parameters and T6 heat treatment on the microstructure and mechanical properties of the rheo-diecasting（RDC） semi-solid A390 alloy prepared through pure copper serpentine channel were investigated. The results indicate that the mechanical properties of the RDC samples change with the pouring temperature and injection pressure. In this case, a lower pouring temperature results in better tensile strength and elongation of the RDC A390 alloy; however, the tensile strength and elongation decrease when the pouring temperature decreases to 660°C. Higher injection pressures result in the improved mechanical properties of the RDC A390 alloy. To some extent, T6 heat treatment improves the tensile strength and ductility of the RDC A390 alloy compared to those of the non-heat treated alloy. However, when the pouring temperature and injection pressure are greater than 670°C and 70 MPa, respectively, the mechanical properties are sharply diminished.

关键词： aluminum alloys diecasting rheo-casting microstructure mechanical properties

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Mechanism of colluvial landslide induction by rainfall and slope construction:A case study

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Journal of Mountain Science 2021年第4期18卷 1013-1033页

作者： ZHOU Zhou SheN Jun-hui LI Ying DUAN Wei-feng YANG ri-chang SHU Jun-cheng LI he-wei TAO Sheng-yu zheng Sheng-zhe State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Environment-geology and Civil Engineering Chengdu-University of TechnologyChengdu 610059China Power China Huadong Engineering Corporation Limited Hangzhou 310000China

The landslide hazards occurring in the complex geological genesis accumulation body are usually controlled by the coupling action of many internal and external ***,this paper takes the dam-front Danbo accumulation body landslide of Yangfanggou hydropower station on the Yalong river as the geological prototype,and discusses the process and mechanism of slope stability degradation under the combined action of rainfall and slope *** on the detailed understanding of the basic characteristics of the accumulation body,the development characteristics of the landslide and the construction situation of the slope engineering,the study conducted correlation analysis between rainfall and landslide displacement,the physical and mechanical tests of all types of rocksoil masses,and the numerical simulation testing of seepage field variation of the landslide *** is found that the special slope structure and material composition of the old landslide accumulation layer on the upper part of the Danbo accumulation body are the internal factors for the occurrence of thrust loadinduced landslide,and the construction of the slope engineering not only creates free space conditions for sliding,but also provides channels for the infiltration of rainfall into the slope after confluence,which is an external factor that caused the mechanical properties of the sliding zone soil to gradually weaken from the trailing edge to the leading *** geomechanical model of such landslide is that the active section of the trailing edge produces the"source of force",the transition section of the middle section affects the occurrence of sliding,and the anti-sliding section of the leading edge controls the occurrence of landslide *** results of this research provide not only a useful supplement to the theory of landslide formation mechanisms but also a scientific basis for guiding the prevention and control of similar hazards.

关键词： Colluvial landslide Slope construction Rainfall Induction mechanism Weakening pattern Geomechanical model

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Self-reduction Mechanism of Coal Composite Stainless Steel Dust Hot Briquette

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Journal of Iron and Steel Research International 2016年第4期23卷 314-321页

作者： Sok-chol ri Man-sheng CHU Shuang-yin CheN zheng-gen LIU Hun HONG School of Metallurgy Northeastern University School of Metallurgical Engineering Kim Chaek University of Technology

To efficiently recycle valuable metals such as chromium and nickel in stainless steel dust, self-reduction ex- periments were carried out to study the reduction mechanism of metal oxides in coal composite stainless steel dust hot briquette, which is defined as a CCSB here. Self-reduction of CCSB is proceeded by volatile matter and fixed carbon contained within CCSB. Experiments were performed to study the effects of temperature and carbon to oxygen （C/OCoal） ratio on self reduction of CCSB. At 1400 and 1450℃, volatile matter in coal used for experiment could take the place of about 40℃ of fixed carbon in coal. Under the present experimental conditions, reduction product of chromium appears as FeCr2O2, Cr2O3, Cr7C3 , and [Cr] in turn during reduction. To evaluate the formation of met al nuggets in self reduction process of CCSB, metal nuggets containing chromium and nickel were observed in outside of reduction products under various conditions, and thermodynamic equilibrium calculation was carried out for possi hie products and formation of molten metal by fixed carbon. SEM and EDS analyses were made for metal nugget and slag in reduced product. The results reveal that it is reasonable to achieve the metal nuggets at 1450℃, 0.8 of C/OCoal ratio and 20 min of reduction time. The nugget formation can indicate one innovative process for comprehensive utilization of stainless steel dust.

关键词： stainless steel dust coal composite hot briquette self reduction metal nugget

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Debris flow impact on flexible barrier: effects of debrisbarrier stiffness and flow aspect ratio

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Journal of Mountain Science 2019年第7期16卷 1629-1645页

作者： SONG Dong-ri ZHOU Gordon G.D CHOI Clarence Edward zheng Yun Key Laboratory of Mountain Hazards and Earth Surface Process/Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China Department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina The HKUST Jockey Club Institute for Advanced Study Hong Kong SARChina

Conventionally,flexible barriers are rated based on their ability to resist a free-falling boulder with a particular input ***,there is still no well-accepted approach for evaluating performance of flexible barrier under debris flow *** this study,a large-nonlinear finite-element model was used to back-analyze centrifuge tests to discern the effects of impact material type,barrier stiffness,and flow aspect ratio(flow height to flow length)on the reaction force between the impacting medium and flexible *** show that,in contrast to flexible barriers for resisting rockfall,the normal impact force induced by the highly frictional and viscous debris is insensitive to barrier *** is because the elongated distributions of kinetic energy are mainly dissipated by the internal and boundary shearing,and only a small portion is forwarded to the ***,a new stiffness number is proposed to characterize the equivalent stiffness between a debris flow or a boulder,and a flexible *** the circumstance of an extremely elongated debris flow event,i.e.,low aspect ratio,the load on a barrier is dominated by the static component and thus not sensitive to the barrier stiffness.

关键词： Debris flow Flexible barrier Impact Stiffness Flow aspect ratio

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Electro-generation of TGA by Ni-mSA-mCS bipolar membrane

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Chinese Chemical Letters 2007年第11期18卷 1411-1415页

作者： Zhen Xia Huang Xi zheng ri Yao Chen Xiao Chen Zhen Chen Experiment Center College of Chemistry and Materials Science Fujian Normal University Fuzhou 350007 China

Ni-mSA-mCS bipolar membrane （BM） was prepared by sodium alginate （SA） and chitosan （CS）, which were modified by Ca^2＋ and glutaraldehyde as linking reagents, respectively, mSA-mCS membrane was characterized by FTIR, SEM, TG and used as a separator in the electrolysis cell to produce thioglycolic acid （TGA）. The experiment results show that TGAwas prepared effectively by electro-reduction of dithiodiglycolic acid （DTDGA） with the mixture of TGA and DTDGA in the cathodic chamber. The current efficiency was up to 66.7% at the room temperature （25 ℃） during the current density of 10 mA/cm^2. Compared with the traditional metal reduction method, the electro-reduction technology saves the zinc powder and eliminates the pollution to environment.

关键词： Bipolar membrane Modified sodium alginate Modified chitosan Thioglycolic acid Dithiodiglycolic acid

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Dynamic hydraulic jump and retrograde sedimentation in an open channel induced by sediment supply: experimental study and SPH simulation

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Journal of Mountain Science 2019年第8期16卷 1913-1927页

作者： zheng Xiao-gang CheN ri-dong LUO Min KAZEMI Ehsan LIU Xing-nian State Key Laboratory of Hydraulics and Mountain river Engineering Sichuan UniversityChengdu 610065China Zienkiewicz Centre for Computational Engineering College of EngineeringSwansea UniversitySA1 8ENUK Department of Civil and Structural Engineering University of SheffieldSheffield S1 3JDUnited Kingdom

Mountainous torrents often carry large amounts of loose materials into the rivers, thus causing strong sediment transport. Experimentally it was found for the first time that when the intensive sediment motion occurs downstream over a gentle slope, the siltation of the riverbed is induced and the sediment particles can move upstream rapidly in the form of a retrograde sand wave, resulting in a higher water level along the river. To further study the complex mechanisms of this problem, a sediment mass model in the framework of the Smoothed Particle Hydrodynamics(SPH) method was presented to simulate the riverbed evolution, sediment particle motion, and the generation and development of dynamic hydraulic jump under the condition of sufficient sediment supply over a steep slope with varying angles. Because the sediment is not a continuous medium, the marker particle tracking approach was proposed to represent a piece of sediment with a marked sediment particle. The twophase SPH model realizes the interaction between the sediment and fluid by moving the bed boundary particles up and down, so it can reasonably treat the fluid-sediment interfaces with high CPU efficiency. The critical triggering condition of sediment motion, the propagation of the hydraulic jump and the initial siltation position were all systematically studied. The experimental and numerical results revealed the extra disastrous sediment effect in a mountainous flood. The findings will be useful references to the disaster prevention and mitigation in mountainous rivers.

关键词： Dynamic hydraulic jump Retrograde sedimentation Sediment supply Mountainous river Smoothed Particle Hydrodynamics Marked sediment particle

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Rubratoxin C,a new nonadride derivative from an endophytic fungus Penicillium sp.F-14

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Chinese Chemical Letters 2014年第9期25卷 1308-1310页

作者： ri-Dao Chen zheng Yan Jian-Hua Zou Nan Wang Jun-Gui Dai State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaPeking Union Medical College & Chinese Academy of Medical Sciences

One new nonadride derivative rubratoxin C （1） together with a known compound rubratoxin B （2） were isolated from an endophytic fungus Penicillium sp. F-14. Their structures were elucidated by various spectroscopic methods. Bioassays showed that 2 had moderate cytotoxic effect against HCT-8, BEL-7402, Ketr3, A2780, MCF-7 and BGC-823 human cancer cell lines, and 1 exhibited weak activity.

关键词： Nonadride derivative Endophytic fungus Natural products Cytotoxic activity

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BoxCox multi-output linear regression for 10.7 cm solar radio flux prediction

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Research in Astronomy and Astrophysics 2021年第4期21卷 225-234页

作者： Rui-Fei Cui Ya-Guang Zhu Huan Zhang ri-Wei Zhang Hong-Yu Zhao zheng-Lian Li State Key Laboratory of Astronautic Dynamics Xi’an 710043China Beijing Information and Communication Research Center Beijing 100840China

We consider the problem of predicting the mid-term daily 10.7 cm solar radio flux(F10.7),a widely-used solar activity index.A novel approach is proposed for this task,in which BoxCox transformation with a proper parameter is first applied to make the data satisfy the property of homoscedasticity that is a basic assumption of regression models,and then a multi-output linear regression model is used to predict future F10.7 *** experiment shows that the BoxCox transformation significantly improves the predictive performance and our new approach works substantially better than the prediction from the US Airforce and other alternative methods like Auto-regressive Model,Multi-layer Perceptron,and Support Vector Regression.

关键词： Sun:radio radiation methods:data analysis methods:statistical

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