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World Journal of Gastrointestinal Endoscopy 2024年第4期16卷 206-213页

作者： Hai-Bin Dong Tao Chen Xiao-Fei Zhang Yu-tang Ren bo Jiang Department of Gastroenterology Beijing Tsinghua Changgung HospitalBeijing 102218China Center for Medical Data Science Beijing Tsinghua Changgung HospitalBeijing 102218China

BACKGROUND No studies have yet been conducted on changes in microcirculatory hemody-namics of colorectal adenomas in vivo under *** microcirculation of the colorectal adenoma could be observed in vivo by a novel high-resolution magnification endoscopy with blue laser imaging(BLI),thus providing a new insight into the microcirculation of early colon *** To observe the superficial microcirculation of colorectal adenomas using the novel magnifying colonoscope with BLI and quantitatively analyzed the changes in hemodynamic *** From October 2019 to January 2020,11 patients were screened for colon adenomas with the novel high-resolution magnification endoscope with *** images were recorded and processed with Adobe Premiere,Adobe Photoshop and Image-pro Plus *** microcirculation parameters:Microcirculation vessel density(MVD),mean vessel width(MVW)with width standard deviation(WSD),and blood flow velocity(BFV),were calculated for adenomas and the surrounding normal *** A total of 16 adenomas were *** with the normal surrounding mucosa,the superficial vessel density in the adenomas was decreased(MVD:0.95±0.18 vs 1.17±0.28μm/μm2,Pboth *** slowed in the adenomas(709.74±213.28 vs 1256.51±383.31μm/s,P<0.05).CONCLUSION The novel high-resolution magnification endoscope with BLI can be used for in vivo study of adenoma superficial *** vessel density was decreased,more irregular,with slower blood flow.

关键词： Adenoma Microcirculation High-resolution magnification endoscopy Blue laser imaging

Black holes as the source of dark energy:A stringent test with high-redshift JWST AGNs

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 181-188页

作者： Lei Lei Lei Zu Guan-Wen Yuan Zhao-Qiang Shen Yi-Ying Wang Yuan-Zhu Wang Zhen-bo Su Wen-Ke Ren Shao-Peng tang Hao Zhou Chi Zhang Zhi-Ping Jin Lei Feng Yi-Zhong Fan Da-Ming Wei Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China

Studies have proposed that there is evidence for cosmological coupling of black holes(BHs)with an index of k≈3;hence,BHs serve as the astrophysical source of dark ***,the data sample is limited for the redshifts of≤*** recent years,the James Webb Space Telescope(JWST)has detected many high-redshift active galactic nuclei(AGNs)and *** the JWST NIRSpec-/NIRCam-resolved AGNs,three are determined to be in early-type host galaxies with a redshift of z~***,their M_(*)and MBH are in tension with the predicted cosmological coupling of black holes with k=3 at a confidence level of~2σ,which challenges the hypothesis that BHs serve as the origin of dark *** work on high-redshift AGNs using the JWST will further assess such a hypothesis by identifying more early-type host galaxies in the higher mass range.

关键词： dark energy supermassive black hole active galactic nuclei James Webb Space Telescope

Three types of promising functional building units for designing metal halide nonlinear optical crystals

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Chinese Journal of Structural Chemistry 2024年第6期43卷 8-11页

作者： Jiajing Wu Ru-Ling tang Sheng-Ping Guo School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou225002PR China Yunnan Key Laboratory of Electromagnetic Materials and Devices National Center for International Research on Photoelectric and Energy MaterialsSchool of Material and EnergyYunnan UniversityKunming650000PR China

Nonlinear optical(NLO)crystal materials greatly extend the tunable range of laser by frequency conversion,which promotes the rapid development of laser technology and plays an important role in many civil and military *** excellent and famous NLO crystals from the ultraviolet(UV)to visible to near infrared(NIR)regions have been developed,such as borates(KBe_(2)bo_(3)F_(2),β-BaB_(2)O_(4)),phosphates(KH_(2)PO_(4),KTiOPO_(4)),chalcogenides(AgGaS_(2),AgGaSe_(2))and so on[1,2].

关键词： optical tunable designing

Measurement of the neutron-induced total cross sections of ^(nat)Pb from 0.3 eV to 20 MeV on the Back-n at CSNS

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Nuclear Science and Techniques 2024年第2期35卷 85-93页

作者： Jie-Ming Xue Song Feng Yong-Hao Chen Han Yi Min Xiao Pin-Jing Cheng Xin-Xiang Li Rong Liu Yi-Wei Yang Zi-Jie Han Da-Jun Zhao Hao-Qiang Wang Bao-Qian Li Ji-Rong Zhao Lei-Xun tang Wen Luo bo Zheng School of Nuclear Science and Technology University of South ChinaHengyang 421001China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China

The neutron-induced total cross sections of natural lead have been measured in a wide energy range(0.3 eV-20 MeV)on the back-streaming white neutron beamline(Back-n)at the China Spallation Neutron *** energy was determined by the neutron total cross-section spectrometer using the time-of-flight technique.A fast multi-cell fission chamber was used as the neutron detector,and a 10-mm-thick high-purity natural lead sample was employed for the neutron transmission *** on-beam background was determined using Co,In,Ag,and Cd *** excitation function of ^(nat)Pb(n,tot)reaction below 20 MeV was calculated using the TALYS-1.96 nuclear-reaction modeling *** present results were compared with previous results,the evaluated data available in the five major evaluated nuclear data libraries(i.e.,ENDF/B-VIII.0,JEFF-3.3,JENDL-5,CENDL-3.2,and BROND-3.1),and the theoretical calculation *** agreement was found between the new results and those of previous experiments and with the theoretical curves in the corresponding *** measurement obtained the neutron total cross section of natural lead with good accuracy over a wide energy range and added experimental data in the resonance energy *** provides more reliable experimental data for nuclear engineering design and nuclear data evaluation of lead.

关键词： Neutron-induced total cross section Natural lead Time-of-flight TALYS-1.96 CSNS Back-n white neutron beamline

Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4244-4263页

作者： Xiao-Wei Wang Yu-Xing tang Fu-Xi Li Jia-Le Wang Gao-Peng Yao Da-Tong Zeng Yu-Lu tang Bang-Teng Chi Qin-Yan Su Lin-Qing Huang Di-Yuan Qin Gang Chen Zhen-bo Feng Rong-Quan He Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Red Cross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChi Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Computer Science and Technology School of Computer and Electronic InformationGuangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatocellular carcinoma(HCC)is a major health challenge with high incidence and poor survival rates in *** therapies,particularly tyrosine kinase inhibitors(TKIs),are the first-line treatment for advanced HCC,but resistance is *** Rho GTPase family member Rho GTPase activating protein 12(ARHGAP12),which regulates cell adhesion and invasion,is a potential therapeutic target for overcoming TKI resistance in ***,no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been *** To unveil the expression of ARHGAP12 in HCC,its role in TKI resistance and its potential associated *** This study used single-cell RNA sequencing(scRNA-seq)to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment *** was used to investigate focal adhesion(FA)pathway *** integrated bulk RNA data(RNA-seq and microarray),immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels,correlating with clinical *** assessed ARHGAP12 expression in TKI-resistant HCC,integrated conventional HCC to explore its mechanism,identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and *** ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate *** malignant hepatocytes in high-score FA groups,MDK-[integrin alpha 6(ITGA6)+integrinβ-1(ITGB1)]showed specificity in ligand-receptor ***12 mRNA and protein were upregulated in bulk RNA,immunohistochemistry and proteomics,and higher expression was associated with a worse ***12 was also found to be a TKI resistance gene that regulated the FA ***1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk *** expression of ARHGAP12 was associated with adverse reactions to sorafenib,cabozantinib and regorafenib,but not to *** ARHGAP12 expre

关键词： Hepatocellular carcinoma Focal adhesion Tyrosine kinase inhibitor Rho GTPase activating protein 12 Drug resistance Molecular mechanism Biomarker

Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges Disaster effects of climate change in High Mountain Asia:State of art and scientific challenges

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Advances in Climate Change Research 2024年第3期15卷 367-389页

作者： Hao WANG Bin-Bin WANG Peng CUI Yao-Ming MA Yan WANG Jian-Sheng HAO Yu WANG Ya-Mei LI Li-Jun SUN Jiao WANG Guo-Tao ZHANG Wei-Mo LI Yu LEI Wen-Qing ZHAO Jin-bo tang Chao-Yue LI Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China China‒Pakistan Joint Research Center on Earth Sciences Chinese Academy of SciencesIslamabad 45320Pakistan College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China College of Atmospheric Science Lanzhou UniversityLanzhou 730000China National Observation and Research Station for Qomolongma Special Atmospheric Processes and Environmental Changes Dingri 858200China

High Mountain Asia(HMA)shows a remarkable warming tendency and divergent trend of regional precipitation with enhanced meteorological *** rapid thawing of the HMA cryosphere may alter the magnitude and frequency of nature *** reviewed the influence of climate change on various types of nature hazards in HMA region,including their phenomena,mechanisms and *** reveals that:1)the occurrences of extreme rainfall,heavy snowfall,and drifting snow hazards are escalating;accelerated ice and snow melting have advanced the onset and increased the magnitude of snowmelt floods;2)due to elevating trigger factors,such as glacier debuttressing and the rapid shift of thermal and hydrological regime of bedrock/snow/ice interface or subsurface,the mass flow hazards including bedrock landslide,snow avalanche,ice-rock avalanches or glacier detachment,and debris flow will become more severe;3)increased active-layer detachment and retrogressive thaw slumps slope failures,thaw settlement and thermokarst lake will damage many important engineering structures and infrastructure in permafrost region;4)multi-hazards cascading hazard in HMA,such as the glacial lake outburst flood(GLOF)and avalanche-induced mass flow may greatly enlarge the destructive power of the primary hazard by amplifying its volume,mobility,and impact force;and 5)enhanced slope instability and sediment supply in the highland areas could impose remote catastrophic impacts upon lowland regions,and threat hydropower security and future water *** future,ongoing thawing of HMA will profoundly weaken the multiple-phase material of bedrock,ice,water,and soil,and enhance activities of nature *** and cascading hazards of high magnitude will prevail in *** the glacier runoff overpasses the peak water,low flow or droughts in lowland areas downstream of glacierized mountain regions will became more frequent and *** escalating hazards in the HMA region requires tackling s

关键词： High Mountain Asia Climate change Cryosphere degradation Nature hazards Disaster risk

基于脉冲序列重构的雷达Pri调制类型智能识别算法研究

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信号处理 2024年第2期40卷 263-271页

作者：黄中瑞唐波国防科技大学电子对抗学院安徽合肥230037

雷达脉冲重复间隔(Pri)是雷达信号的关键参数,对于雷达性能发挥起着至关重要的作用。研判雷达Pri调制类型能够为雷达识别和性能分析提供重要支撑,是电子对抗领域的关键研究内容。针对现有Pri调制类型识别准确率受脉冲丢失影响较大的问题... 详细信息

雷达脉冲重复间隔(Pri)是雷达信号的关键参数,对于雷达性能发挥起着至关重要的作用。研判雷达Pri调制类型能够为雷达识别和性能分析提供重要支撑,是电子对抗领域的关键研究内容。针对现有Pri调制类型识别准确率受脉冲丢失影响较大的问题,本文提出了一种基于脉冲序列重构的雷达Pri调制类型智能识别算法。首先,基于到达时间(TOA)多阶差分序列实现了Pri调制周期的初步估计;其次,根据Pri调制周期重构了不同脉冲序列样本;再次,对重构样本进行去均匀值预处理,并以此为输入搭建了卷积神经网络(CNN)识别Pri调制类型,该方法能够减弱人工提取特征的局限性,不仅可以获取Pri序列的深层特征,而且具有更强的环境适用性;最后,仿真实验表明了所提方法的有效性。在脉冲丢失率小于60%时,所提方法对于所有Pri调制类型的识别准确率均在92%以上,平均识别准确率大于98%,在脉冲丢失率小于80%时,平均识别准确率在81%以上。

关键词：脉冲丢失 Pri调制周期卷积神经网络 Pri调制类型识别

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不同沿岸输沙率计算公式对比分析

水科学进展 2024年第1期35卷 123-131页

作者：王宁舸唐磊孙波辛文杰南京水利科学研究院江苏南京210029

经历近100 a的发展,沿岸输沙率计算公式研究领域已形成许多代表性成果,系统研判各计算公式的预测精度对于快速准确判断研究区域沿岸输沙能力具有重要意义。依据使用率高、公式结构简洁、考虑参数相对全面等标准,选择了国内外7个沿岸输... 详细信息

经历近100 a的发展,沿岸输沙率计算公式研究领域已形成许多代表性成果,系统研判各计算公式的预测精度对于快速准确判断研究区域沿岸输沙能力具有重要意义。依据使用率高、公式结构简洁、考虑参数相对全面等标准,选择了国内外7个沿岸输沙率计算公式,采用现场原型沙、室内原型沙和室内轻质沙等多种实测资料,对各公式的计算准确程度和适用范围进行了定量检验。结果表明,CERC公式和Kamphuis公式适用于现场原型沙预测,但对室内轻质沙预测的偏离程度较大;MH-Kamphuis公式和van rijn公式对各种实测资料的预测均总体偏小;赵今声公式和Bayram公式的预测精度最低,预测偏小程度较大。经比较,孙林云公式对各项实测资料的符合程度总体较高,预测精度提高了36%~73%,具有更广泛的适用范围,推荐用于推导沙质海岸沿岸输沙模型相似律比尺关系。

关键词：沿岸输沙率计算公式原型沙轻质沙

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沟槽表面液滴动力学的格子玻尔兹曼模拟

东南大学学报（自然科学版） 2024年第2期54卷 495-502页

作者：唐志文许波王鑫陈振乾东南大学能源与环境学院南京210096

针对液滴在微结构表面上的润湿行为及各向异性浸润行为,采用格子玻尔兹曼方法模拟研究了沟槽表面尺寸、液滴尺寸及重力场对液滴动力学行为的影响.结果表明,垂直接触角大于平行接触角,且与肋板宽度成反比,随沟槽宽度的增加先增大后减小,... 详细信息

针对液滴在微结构表面上的润湿行为及各向异性浸润行为,采用格子玻尔兹曼方法模拟研究了沟槽表面尺寸、液滴尺寸及重力场对液滴动力学行为的影响.结果表明,垂直接触角大于平行接触角,且与肋板宽度成反比,随沟槽宽度的增加先增大后减小,平行接触角则与沟槽表面尺寸无关.液滴半径、液滴接触角和壁面固体分数相互关联,且壁面固体分数、液滴半径和重力系数与液滴变形比成正相关关系.液滴沿垂直沟槽方向上的铺展运动具有较大的能量壁垒,呈现各向异性浸润行为.液滴半径的增大和重力场的增强均可削弱液滴的各向异性浸润行为,并可通过改变壁面固体分数达到改变液滴状态的目的.

关键词：格子玻尔兹曼方法液滴润湿态各向异性

源-荷-储协同优化的配电网平衡能力提升方法

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中国电机工程学报 2024年第13期44卷 5097-5108,I0007页

作者：顾光荣杨鹏汤波王丁来鑫上海电力大学电气工程学院上海市杨浦区200090 国网河南省电力公司信阳供电公司河南省信阳市464000 上海理工大学机械工程学院上海市杨浦区200092

在新型电力系统建设背景下,针对分布式新能源和柔性负荷大量接入导致配电网供需情况日益复杂、功率和能量平衡愈加困难等问题,该文提出一种源-荷-储协同优化的配电网平衡能力提升方法,从经济性与用能低碳性等方面提高配电网运行水平。首... 详细信息

在新型电力系统建设背景下,针对分布式新能源和柔性负荷大量接入导致配电网供需情况日益复杂、功率和能量平衡愈加困难等问题,该文提出一种源-荷-储协同优化的配电网平衡能力提升方法,从经济性与用能低碳性等方面提高配电网运行水平。首先,建立多场景下的源荷不确定性模型,在有效量化配电网源荷不确定性的基础上提取典型运行场景;其次,提出一种基于信息熵理论的源荷功率时序平衡度量化评估方法;最后,建立源-荷-储协同的两阶段优化模型,第1阶段通过事件驱动机制深入挖掘用户参与需求响应的潜力,第2阶段在储能系统建模时引入平衡度约束以促进新能源消纳,进而使配电网的平衡能力得到最大程度提升。通过浙江某地区电网实例验证所提方法对提升配电网平衡能力和新能源消纳能力的科学性和实用性。

关键词：源-荷-储协同配电网平衡能力源荷不确定性信息熵理论事件驱动

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