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Proteomic Profiling and Protein-Protein Interaction Network Reveal the Molecular Mechanisms of Susceptibility to Drought Stress in Canola(Brassica napus L.)

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Phyton-International Journal of Experimental Botany 2022年第7期91卷 1403-1417页

作者： reza shokri-gharelo Ali Bandehagh Mohammad Anwar Hossain Department of Plant Breeding and Biotechnology University of TabrizTabriz51368Iran Department of Genetics and Plant Breeding Bangladesh Agricultural UniversityMymensingh2202Bangladesh

Drought stress is one of the most important abiotic stresses that plants face frequently in *** drought conditions,many morphological,physiological,and molecular aspects of plants are changed and as a result plants experience a remarkable reduction in growth,yield,and *** expand our understanding of the molecular basis of the plant response to drought stress,the proteomic profile and protein-protein network of canola(Brassica napus L.)were *** focus was to show molecular mechanisms related to canola susceptibility to drought *** experiment used a completely randomized design,implemented in a hydroponic system under greenhouse *** impose drought stress,plants were exposed to Hoagland’s solution supplemented with polyethylene glycol(PEG)6000 for 7 *** drought stress resulted in 161reproducible protein spots in twodimensional electrophoresis of canola *** t-student test showed 21 differentially abundant proteins(DAP),of which 2 and 19 were up and down accumulated,*** spots identified as 1-aminocyclopropane-1-carboxylate oxidase and D-2-hydroxyglutarate dehydrogenase showed an increased abundance of 2.11 and 1.77,*** extended protein-protein interaction of differentially abundant proteins and KEGG analysis showed 47 pathways directly and indirectly associated with canola response to drought *** with increased abundance were associated with amino acid and signaling processes,whereas DAPs with decreased abundance were mostly connected with pathways responsible for energy *** results of the study will help to elucidate further the molecular events associated with the susceptibility to drought stress in canola.

关键词： Abiotic stress differentially abundant protein molecular function proteomics susceptibility

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Selective harmonic elimination method for wide range of modulation indexes in multilevel inverters using ICA

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Journal of Central South University 2014年第4期21卷 1329-1338页

作者： Ali Ajami Mohammad reza Jannati Oskuee Ataollah Mokhberdoran Hossein shokri Electrical Engineering Department Azarbaijan Shahid Madani University

Selective harmonic elimination(SHE) in multilevel inverters is an intricate optimization problem that involves a set of nonlinear transcendental equations which have multiple local minima. A new advanced objective function with proper weighting is proposed and also its efficiency is compared with the objective function which is more similar to the proposed one. To enhance the ability of the SHE in eliminating high number of selected harmonics, at each level of the output voltage, one slot is created. The SHE problem is solved by imperialist competitive algorithm(ICA). The conventional SHE methods cannot eliminate the selected harmonics and satisfy the fundamental component in some ranges of modulation indexes. So, to surmount the SHE defect, a DC-DC converter is applied. Theoretical results are substantiated by simulations and experimental results for a 9-level multilevel inverter. The obtained results illustrate that the proposed method successfully minimizes a large number of identified harmonics which consequences very low total harmonic distortion of output voltage.

关键词： selective harmonic elimination DC-DC converter imperialist competitive algorithm(ICA)

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Hepatitis C virus core protein modulates several signaling pathways involved in hepatocellular carcinoma

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World Journal of Gastroenterology 2019年第1期25卷 42-58页

作者： Shahab Mahmoudvand Somayeh shokri reza Taherkhani Fatemeh Farshadpour Department of Virology School of Medicine Ahvaz Jundishapur University of Medical Sciences Department of Medical Virology School of MedicineHamadan University of Medical Sciences The Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences

Hepatocellular carcinoma(HCC) is the fifth most common cancer, and hepatitis C virus(HCV) infection plays a major role in HCC development. The molecular mechanisms by which HCV infection leads to HCC are varied. HCV core protein is an important risk factor in HCV-associated liver pathogenesis and can modulate several signaling pathways involved in cell cycle regulation, cell growth promotion, cell proliferation, apoptosis, oxidative stress and lipid metabolism. The dysregulation of signaling pathways such as transforming growth factor β(TGF-β), vascular endothelial growth factor(VEGF), Wnt/β-catenin(WNT), cyclooxygenase-2(COX-2) and peroxisome proliferator-activated receptor α(PPARα) by HCV core protein is implicated in the development of HCC. Therefore, it has been suggested that this protein be considered a favorable target for further studies in the development of HCC. In addition, considering the axial role of these signaling pathways in HCC, they are considered druggable targets for cancer therapy. Therefore, using strategies to limit the dysregulation effects of core protein on these signaling pathways seems necessary to prevent HCV-related HCC.

关键词： Hepatitis C virus Core protein Transforming growth factorβ Vascular endothelial growth factor Wnt/β-catenin Cyclooxygenase-2 Peroxisome proliferatoractivated receptorα Hepatocellular carcinoma

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Weak gravity conjecture from conformal field theory:a challenge from hyperscaling violating and Kerr-Newman-AdS black holes

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Chinese Physics C 2023年第1期47卷 225-233页

作者： Jafar Sadeghi Mehdi shokri Mohammad reza Alipour Saeed Noori Gashti Department of Physics University of MazandaranP.0.Box 47416-95447BabolsarIran School of Physics Damghan UniversityP.0.Box ***DamghanIran Department of Physics University of TehranNorth Karegar Ave.Tehran 14395-547ran Canadian Quantum Research Center 204-300232 Avenue Vernon British Columbia V1T 2L7Canada

We search for a possible relationship between weak gravity conjecture(WGC)and conformal field theory(CFT)in hyperscaling violating and Kerr-Newman-AdS black *** deal with the critical points of the black hole systems using the correlation function introduced in CFT and discuss WGC conditions using the imaginary part of the energy obtained from the critical points and their *** the assumptions z=1,d=1,andθ→0-,we link WGC to hyperscaling violating black holes owing to the existence of rHvalues larger and smaller than *** the second black hole system,we study the conditions of WGC for Kerr-Newman-AdS black holes using rotation and radius ***,we show that the conditions of WGC are satisfied when the charged particle near the hyperscaling violating and Kerr-Newman black holes is 1/a with a ratio a/l《1.

关键词： weak gravity conjecture Kerr-Newman-AdS black holes hyperscaling violating black holes conformal field theory

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Immunomodulatory effects of astragalus polysaccharide on Human peripheral blood mononuclear cells co-cultured with cervical cancer cell lineImmunomodulatory effects of astragalus polysaccharide on Human peripheral blood mononuclear cells co-cultured with cervical cancer cell line

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Journal of Traditional Chinese Medicine 2021年第5期41卷 684-694页

作者： Elham Shokati Mohammad-reza shokri Kobra Entezami Samaneh Khorrami Mona Amani Morteza Motallebnezhad Elahe Safari Immunology Research Center Institute of Immunology and Infectious DiseasesIran University of Medical SciencesTehran ***Iran Department of Immunology Faculty of Medical SciencesIran University of Medical SciencesTehran ***Iran Department of Immunology School of Public HealthTehran University of Medical SciencesTehran ***Iran

OBJECTIVE:To investigate immunomodulatory effects of Astragalus polysaccharides(APS)on the co-culture of peripheral blood mononuclear cells(PBMCs)with He La cervical cancer cell ***:To assess the proliferation of PBMCs,carboxyfluorescein succinimidyl ester(CFSE)-labeled PBMCs were co-cultured with He La cells and treated with different concentrations of *** of cell culture were collected for cytokines assay via enzyme-linked immunosorbent assay(ELISA).The impact of APS on the proliferation of PBMCs,induction of regulatory T cells(Tregs),and myeloid-derived suppressor cells(MDSCs)was carried out by flow ***:It was observed that APS could increase the proliferation of PBMCs co-cultured with He La cells(P0.05).Furthermore,ELISA results demonstrated that APS could decrease IL-10 and TGF-βconcentration(P<0.05).CONCLUSION:The above-mentioned characteristics showed that APS might be able to modulate immune responses and improve anti-tumor effects through increasing the proliferation of PBMCs and decreasing inhibitory cytokines secretion as critical mediators of immune suppression in the tumor microenvironment.

关键词： Astragalus polysaccharides uterine cervical neoplasms HeLa cells coculture techniques cytokines T-lymphocytes,regulatory

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Effect of Ion Concentrations on the Characteristics of a Multi-Component Magnetized Plasma Sheath

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Plasma Science and Technology 2009年第6期11卷 642-646页

作者： M.M.HATAMI B.shokri Laser-Plasma Research Institute of Shahid Beheshti University G.C.EvinTehranIran Physical Department and Laser-Plasma Research Institute of Shahid Beheshti University G.C.EvinTehranIran

A hydrodynamic approach is used to investigate a three-component magnetized plasma sheath which consists of electrons and two species of positive ions. Assuming a phase space of one-dimensional spatial coordinate system and three-dimensional velocity coordinate system, the effect of different concentrations of positive ion species on some characteristics of the plasma sheath such as the velocity and density distribution of positive ion species and the electrostatic potential of this region is investigated. The calculated results show that the increase in the density ratio of positive ion species causes a decrease in both the ion velocities and the electrostatic potential of the sheath region. Also, it is shown that in the sheath region of a magnetized plasma consisting of only one positive ion species the bumps of the net density of charged particles disappears much faster. In addition, three-dimensional velocity of each positive ion species in the sheath region is plotted for different concentrations of positive ion species.

关键词： magnetized plasma plasma and electropositive plasma sheath hydrodynamic equations multi-component sheath

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Evolution of the Piranshahr pull-apart basin at releasing stepovers of the strike-slip fault systems in Northwest of Iran:Insights from twodimensional numerical modeling

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Journal of Mountain Science 2024年第12期21卷 4282-4298页

作者： shokri Parisa ALAVI Seyed Ahmad GHASSEMI Mohammad reza GANJIANI Seyed Mehdi Department of Sedimentary and Oil Basins Faculty of Earth SciencesShahid Beheshti UniversityTehran ***Iran Research Institute for Earth Sciences Geological Survey of IranTehran ***Iran Department of Mechanical Engineering University of TehranTehran ***Iran

The Piranshahr pull-apart basin,situated in the northwestern part of the Zagros Main Recent Fault(MRF),is characterized by two right-stepping segments of the dextral ***,a combination of finite element modeling techniques,especially twodimensional numerical modeling using ABAQUS software,along with field-based structural geological methods are used to assess the geometry and evolution of the pull-apart along the releasing stepovers in this strike-slip *** utilized numerical approach applies two-dimensional(2D)finite-element modeling related to elastic Newtonian rheology to evaluate the distribution of stress and localization of strain within the pull-apart *** study provides valuable insights into the factors controlling the shape,as well as exploring the interaction between the pre-existing structures in this right-lateral strike-slip releasing stepover,pull-apart basin development in strike-slip systems,and stress-strain behavior by studying the impact of boundary conditions and fault overlap on the deformation *** models consider three representative geometries of fault segment interactions,including underlapping,neutral,and overlapping stepovers,positioned at angles of 30°,45°,and 60°.The results indicate that increased overlap creates an extensive and elongated deformation pattern,while decrease overlap leads to block rotation and a narrow deformation *** addition,the degree of overlapping between parallel strike-slip faults influences the stress and *** mean normal stress within the transtensional basin,located between the fault segments,exhibits an extensional nature,while the region outside the stepover experiences general compressive mean normal *** Piranshahr transtensional pull-apart basin exemplifies the progressive evolution of underlapping stepovers,resulting in displaying an elongated rhomboidal to trapezoidal-shaped geometry over time.

关键词： Main Recent Fault Piranshahr pull-apart basin Releasing Stepover Finite element method ABAQUS software

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Recent tectonic activity in Central Alborz Mountain,Iran:morphometric analysis and knickpoint identification

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Journal of Mountain Science 2020年第12期17卷 3137-3161页

作者： Parisa shokri Maryam DEHBOZORGI Saeid HAKIMI ASIABAR Department of Earth Science Kharazmi UniversityTehran15719-14911Iran Department of Geology Lahijan BranchAzad UniversityGilan1616Iran

Alborz,as part of the Alpine-Himalayan orogeny belt,has been the result of the convergence of the Central Iranian and Eurasian plate since the late *** study area located in Central Alborz encompasses different Quaternary ***,the present study aimed to evaluate the effect of faults on river landforms through morphotectonic indices and the causes of knickpoints and knickzones in the Bedrock Rivers in part of Central *** this end,six morphometric indices such as longitudinal gradient(SL),hierarchical anomaly(Δα),the bifurcation index(R),hypsometric integral and hypsometric curve(Hi-Hc),relative relief(Bh),and basin shape(Bs) were calculated and analyzed in38 sub-basins of the ***,the area was divided into extremely high,high,medium,and low tectonic activity areas using the relative tectonic activity(IAT).Normalized steepness and concavity indices along with the longitudinal profiles of the streams were obtained using Matlab and Arc GIS *** on the findings,the existence of slope-break knickpoints at the mountain piedmont at the outlet of large rivers through active faults demonstrated that most of these landforms were created by movements along the main faults such as Khazar,Nusha,Soheil,Deylaman,Kashachal,representing high tectonic activity in the central and southern parts of the study ***,the values of these indices were extremely low and indicated low tectonic activity in the northern parts located in the embayment part of the Caspian ***,the findings revealed that these classes correspond well to the areas with landforms such as V-shaped and narrow valleys,gorges,deflected and offset streams,deformed Neogene,and Quaternary units that indicate the post-Neogene activity.

关键词： Morphotectonic Bedrock rivers Knickpoint Quaternary Fault Uplift Central Alborz

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Lattice Boltzmann simulation of natural convection in open end cavity with inclined hot wall

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Applied Mathematics and Mechanics(English Edition) 2015年第4期36卷 523-540页

作者： M.NAZARI H.shokri A.A.MOHAMAD Department of Mechanical Engineering Shahrood University of Technology Department of Mechanical Engineering Schulich School of EngineeringCentre for Environmental Engineering for Research and EducationUniversity of Calgary

Natural convection in an open end cavity with a hot inclined wall is simulated based on the lattice Boltzmann method （LBM）. The physics of flow and energy transfer in open end cavities are addressed when the hot wall is inclined. The combination of the two topics （open cavity and inclined walls） is the main novelty of the present study. The effects of the angle of the hot inclined wall on the flow field and heat transfer are thoroughly investigated. The Prandtl number is fixed to 0.71 （air）. The Rayleigh number and the angle of the hot inclined wall are varied in the range of 10^4 to 10^6 and 60° to 85°, respectively. The results are presented for two different aspect ratios, i.e., A = 1 and 2. The results obtained with the LBM are also compared with those of the finite volume method （FVM）. The predicted results of the LBM conform to those of the FVM. The results show that by increasing the angle of the hot inclined wall and the aspect ratio of the cavity, the average Nusselt number decreases. The trend of the local Nusselt number on the inclined wall is also discussed.

关键词： lattice Boltzmann method (LBM) natural convection open end cavity,inclined wall

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Antimycotic efficacy of Iranian medicinal plants towards dermatophytes obtained from patients with dermatophytosis

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中国天然药物 2013年第1期11卷 43-48页

作者： Ali reza Khosravi Hojjatollah shokri[ Zohreh Farahnejat reza Chalangari Martis Katalin Mycology Research Center Faculty of Veterinary Medicine University of Tehran Tehran lran Faculty of Veterinary Medicine University of Mazandaran Amol lran Department of Medical Mycology and Parasitology Artesh University of Medical Sciences Tehran lran Dermatology Clinic Imam Khomeini Hospital Tehran University of Medical Sciences Tehran lran

从 Artemisia sieberi， Cuminum cyminum， Foeniculum vulgare， Heracleum persicum， Menta spicata， Nigella sativa， Rosmarinus officinalis， Zataria multiflora 和 Ziziphora 瞄准九植物香精油(曙光女神) ，包括那些 clinopodioides，为他们的 anti-dermatophytic 性质被评估。测试皮藓菌包括了 Trichophyton mentagrophytes (号码 32 ) 的方法， T。rubrum (号码 29 ) ， Epidermophyton floccosum (号码 19 ) ， Microsporum gypseum (号码 11 ) 和 M。canis (号码 42 ) 。植物油的危险性测试被由临床的实验室标准协会描述了的肉汤 microdilution 技术以最小的禁止的集中(MIC ) 和最小的杀菌剂集中(MFC ) 执行。所有曙光女神学习了的结果对皮藓菌是活跃的。MIC 为测试的植物油记录了从 0.25 ～ 4 mg ‰ ? 娠潨杮潺杮?? € 楑 ???????????? 丠??? ? ㈠吗？？

关键词： Antifungal activity Iranian herbal plants Artemisia sieberi Essential oil Dermatophytes.

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