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Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

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Genes & Diseases 2024年第1期11卷 189-204页

作者： Ebrahim H.Maleki Ahmad reza Bahrami Maryam M.Matin Department of Biology Faculty of ScienceFerdowsi University of Mashhad*** MashhadIran Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University31-007 KrakowPoland Doctoral School of Exact and Natural Sciences Jagiellonian University30-348 KrakowPoland Industrial Biotechnology Research Group Institute of BiotechnologyFerdowsi University of Mashhad*** MashhadIran Novel Diagnostics and Therapeutics Research Group Institute of BiotechnologyFerdowsi University of Mashhad***MashhadIran Stem Cell and Regenerative Medicine Research Group Iranian Academic Center for EducationCulture and Research(ACECR)Khorasan Razavi Branch917751376 MashhadIran

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology,as it represents a major obstacle to effective cancer *** tumor cells are highly diverse at genetic,epigenetic,and phenotypic levels,intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects,and recurrence of the *** on the role of heterogeneous subpopulations of cancer cells with varying cell-cycle dynamics and behavior during cancer progression and treatment;herein,we aim to establish a comprehensive definition for adaptation of neoplastic cells against *** discuss two parallel and yet distinct subpopulations of tumor cells that play pivotal roles in reducing the effects of chemotherapy:"resistant"and"tolerant"***,this review also highlights the impact of the quiescent phase of the cell cycle as a survival mechanism for cancer *** understanding the mechanisms under-lying the quiescence,it provides an insightful perspective on cancer stem cells(CsCs)and their dual and intertwined functions based on their cell cycle state in response to ***-over,CSCs,epithelial-mesenchymal transformed cells,circulating tumor cells(CTCs),and disseminated tumor cells(DTCs),which are mostly in a quiescent state of the cell cycle are proved to have multiple biological links and can be implicated in our viewpoint of cell cycle heterogeneity in ***,increasing our knowledge of cell cycle heterogeneity is a key to identifying new therapeutic solutions,and this emerging concept may provide us with new opportunities to prevent the dreadful cancer recurrence.

关键词： Cancer stem cells(CSCs) Carcinoma Cell cycle heterogeneity Quiescence Therapy resistance Therapy tolerance Tumor dormancy

Numerical and Performance Analysis of one row Transonic Rotor with Sweep and Lean angle

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Journal of Thermal Science 2014年第5期23卷 438-445页

作者： Seyed reza razavi Masoud Boroom Aerospace Engineering Department AmirKabir University of Technology

In this study,aerodynamic behaviors of swept and leaned blades were *** and tangential blade curvatures impacts on compressor's operating parameters were analyzed separately.A commercial CFD program which solves the Reynolds-averaged Navier-Stokes equations was used to find out the mentioned impact and the complicated flow field of transonic *** CFD method that was used for solving flow field's equation was validated by experimental data of NASA Rotor *** results showed that the compressor with curved rotors had higher efficiency,rotor pressure ratio and stable operating range compared to the compressor with un-curved *** curved rotors mostly had higher impact on the overall stable operating range compared to the other operating *** range involves choking point and stall point that were changed separately by using of bended *** finding the detailed impact of sweep and lean angle on transonic blades,various forms of lean and sweep angles were exerted to basic *** was found that sweep angles increased overall operating range up to 30%,efficiency up to 2%and pressure ratio up to 1%.Leaning the blades increased the safe operating range,the pressure ratio and efficiency by 14%,4%and 2%respectively.

关键词：弯曲转子跨音速 Navier-Stokes方程性能分析扫描转子压缩机 CFD方法数值

2-Amino-4-(4-aminophenyl)thiazole application as an ionophore in the construction of a Lu(Ⅲ) selective membrane sensor

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Chinese Chemical Letters 2012年第3期23卷 343-346页

作者： Mohammad reza Pourjavid Taherehsadat razavi NFCRS Nuclear Science&Technology Research InstituteAEOIP.O.Box 11365-8486TehranIran Instrumental Analysis Department Research Institute of Petroleum Industry(RIPI)P.O.Box 14665-137TehranIran

A derivative of thiazole（AAT） has been explored as a sensing material for preparation a selective Lu（III） PVC-based membrane *** proposed sensor exhibits a Nernstian response over a wide concentration range from 1.0×10^（-6） to 1.0×10^（-1） mol/L of Lu（Ⅲ） and the detection limit is 5.7×10^（-7） mol/*** sensor response is independent of pH of the solution in the range 3.2-8.8 and possesses the advantages of fast response time（～6） and in particular,good selectivity to the lutetium ions with regard to most common metal ions,and especially all lanthanide ions.

关键词： Membrane sensor Lu(Ⅲ) selective Thiazole derivative PVC Potentiometry

Weldability and liquation cracking behavior of ZhS6U superalloy during electron-beam welding

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International Journal of Minerals,Metallurgy and Materials 2019年第2期26卷 251-259页

作者： Arash Khakzadshahandashti Mohammad reza Rahimipour Kourosh Shirvani Mansour razavi Department of Ceramic Materials and Energy Research Center Department of Material and Renewal Energy Iranian Research Organization for Science and Technology (IROST)

The weldability of the ZhS6U nickel-based superalloy, which is prone to solidification cracking during electron-beam welding(EBW) repair processes, was investigated. The effects of two different pre-weld heat-treatment cycles on the final microstructure before and after welding were examined. Welds were made on flat coupons using an EBW machine, and the two heat-treatment cycles were designed to reduce γ′ liquation before welding. Microstructural features were also examined by optical and scanning electron microscopy. The results showed that the change in the morphology and size of the γ′ precipitates in the pre-weld heat-treatment cycles changed the ability of the superalloy to release the tensile stresses caused by the matrix phase cooling after EBW. The high hardness in the welded coupons subjected to the first heat-treatment cycle resulted in greater resistance to stress release by the base alloy, and the concentration of stress in the base metal caused liquation cracks in the heat-affected zone and solidification cracks in the weld area.

关键词： weldability ZhS6U superalloy electron beam welding heat-affected zone liquation cracking pre-weld heat treatment

Genotype×tillage interaction and the performance of winter bread wheat genotypes in temperate and cold dryland conditions

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Journal of Integrative Agriculture 2022年第11期21卷 3199-3215页

作者： Ebrahim ROOHI reza MOHAMMADI Abdoul Aziz NIANE Javad VAFABAKHSH Mozaffar ROUSTAEE Mohammad reza JALAL KAMALI Shahriar SOHRABI Shahriar FATEHI Hossain TARIMORADI Horticulture and Crop Science Research Department Kurdistan Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation and Extension Organization(AREEO)Sanandaj 66169-36311Iran Dry Land Agricultural Research Institute(DARI) Sararood CampusAREEOKermanshah 67441-61377Iran International Center for Agriculture Research in the Dry Area(ICARDA) Dubai 13979United Arab Emirates Seed and Plant Improvement Research Department Khorasan Razavi Agricultural and Natural Resources Research and Education CenterAREEOMashhad 91859-86111Iran Cereal Research Department DARIAREEOMaragheh 119Iran International Maize and Wheat Improvement Center(CIMMYT) Karaj 31585-4119Iran Kurdistan Jehade Agricultural Organization Sanandaj 66169-35383Iran

Growing concerns for food security and the alleviation of hunger necessitate knowledge-based crop management technologies for sustainable crop *** this study,13 winter bread wheat genotypes(old,relatively old,modern,and breeding lines)were evaluated under three different tillage systems,i.e.,conventional tillage(CT,full tillage with residue removed),reduced tillage(RT,chisel tillage with residue retained)and no-tillage(NT,no-tillage with residue retained on the soil surface)in farmer’s fields under rainfed conditions using strip-plot arrangements in a randomized complete block design with three replications in the west of Iran(Kamyaran and Hosseinabad locations)over two cropping seasons(2018–2019 and 2019–2020).The main objectives were to investigate the effects of tillage systems and growing conditions on the agronomic characteristics,grain yield and stability performance of rainfed winter bread wheat ***(P<0.01)genotype×tillage system interaction effects on grain yield and agronomic traits suggested that the genotypes responded differently to the different tillage *** number of grains per spike and plant height were positively(P<0.0)associated with grain yield under the NT system,so they may be considered as targeted traits for future wheat *** statistical models,the modern cultivars(“Sadra”and“Baran”)were identified as high yielding and showed yield stability across the different tillage *** per each tillage system,genotype“Sadra”followed by“Zargana-6//Dari 1-7 Sabalan”exhibited higher adaption to CT;while cultivars“Jam”and“Azar2”showed better performance under the RT system;and cultivars“Varan”and“Baran”tended to have better performance expression in the NT *** increased grain yields achieved in combination with lower costs and greater profits from conservation agriculture suggest that adapted cultivar and NT systems should be evaluated and promoted more widely to farmers in the west of Iran as an a

关键词： bread wheat no-tillage reduced tillage grain yield yield stability

Computational fluid dynamics(CFD) simulation of effect of baffles on separation in mixer settler

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International Journal of Mining Science and Technology 2012年第5期22卷 703-706页

作者： Mohsen Ostad Shabani Ali Mazahery Mehdi Alizadeh Ali Asghar Tofigh Mohammad reza Rahimipour Mansour razavi Alireza Kolahi Materials and Energy Research Center(MERC) TehranIran

The main ideas in the development of the solvent extraction mixer settler focused on achieving clean phase separation,minimizing the loss of the reagents and decreasing the surface area of the *** role of baffles in a mechanically agitated vessel is to ensure even distribution,reduce settler turbulence,promote the stability of power drawn by the impeller and to prevent swirling and vortexing of liquid,thus,greatly improving the mixing of *** insertion of the appropriate number of baffles clearly improves the extent of liquid ***,excessive baffling would interrupt liquid mixing and lengthen the mixing *** fluid dynamics(CFD) provides a tool for determining detailed information on fluid flow(hydrodynamics) which is necessary for modeling subprocesses in mixer settler.A total of 54 final CFD runs were carried out representing different combinations of variables like number of baffles,density and impeller *** data shows that amount of separation increases with increasing baffles number and decreasing impeller speed.

关键词：计算流体动力学 CFD 相分离调音台挡板定居混合澄清槽液体混合

Iran supports a great share of biodiversity and floristic endemism for Fritillaria spp.(Liliaceae)：A review

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Plant Diversity 2017年第5期39卷 245-262页

作者： Mahmoud Kiani Shirin Mohammadi Alireza Babaei Fatemeh Sefidkon Mohamad reza Naghavi Mojtaba Ranjbar Seyed Ali razavi Keramatollah Saeidi Hadi Jafari Davoud Asgari Daniel Potter Department of Biotechnology & Medicinal Plants Amol University of Special Modem Technologies Amol Iran Department of Horticultural Science Shiraz University Shiraz lran Department of Horticultural Sdence Tarbiat Modares Umverslty lenran lrand Research Institute of Forests and Rangelands Tehran lrane Department of Agronomy and Plant Breeding Faculty of Agriculture University of Tehran Karaj lran Department of Horticulture Faculty of Agriculture Shahre Kord University Shahre Kord lrang Department of Physiology & Breeding of Ornamental Plants Engineering Faculty of Horticulture Sciences University of Tehran Karaj Iranh Department of Plant Sciences University of California-Davis Davis USA

Iran supports a great share of exotic and/or endemic plant genera and species. The genus Fritillaria(Liliaceae) is a precious part of this botanical richness with 19 species, of which 10 are endemic to the country. However, signs are mounting that the country is truly at a crossroads when it comes to preservation of this national wealth. In this regard, an effective conservation strategy should thoroughly consider the classification of Fritillaria, as conservation practices are compromised by knowledge gaps in systematics and taxonomy. As published studies on Fritillaria in Iran have been sporadic and limited in scope, the aim of this review is to provide information necessary to help bridge these information *** objective is to facilitate increased understanding of the geographic, taxonomic, cytogenetic and phylogenetic status of Iranian Fritilloria, which is vital to meeting the goal of sustainable conservation of the genus in Iran and neighboring areas.

关键词： Conservation Ecosystem Endemic Phylogenetic Middle East Taxonomy

Ⅱ期人工晶状体植入术后102例患者视力的分析(英文)

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国际眼科杂志 2008年第11期8卷 2161-2163页

作者： Abolghasem Rastegar Mohammad reza Besharati Mohammad reza shoja Shahid Sadoughi大学眼科伊朗亚兹德

目的:评价分析无晶状体眼Ⅱ期植入前房型和后房型人工晶状体的效果。进行Ⅱ期人工晶状体植入的最常见原因是无晶状体眼眼镜矫正不满意或不耐受及不愿意佩戴隐形眼镜。方法:前瞻性,非随机对照实验研究,伊朗亚兹德Sadoughi医院眼科,1995/2... 详细信息

目的:评价分析无晶状体眼Ⅱ期植入前房型和后房型人工晶状体的效果。进行Ⅱ期人工晶状体植入的最常见原因是无晶状体眼眼镜矫正不满意或不耐受及不愿意佩戴隐形眼镜。方法:前瞻性,非随机对照实验研究,伊朗亚兹德Sadoughi医院眼科,1995/2005年。根据之前进行的白内障手术的类型,后房型人工晶状体植入62眼(60.78%),前房型人工晶状体植入40眼(39.21%)。根据随访期间的病历记录分析患者基本资料和临床资料。结果:患者102例,其中女42例(41.18%),男60例(58.82%),在1995/2005年期间进行了II期人工晶状体植入术。年龄在48 ～72(平均62.6)岁,平均随访时间20.2mo(6 ～72mo)。术中及术后并发症少,手术及拆线后3mo视力状况如下:视力20/20的有48例(47.05%),视力20/40以上的有51例(50%),视力下降(snellens视力表中3行)的有3例(2.95%)。结论:Ⅱ期人工晶状体植入术的短期并发症并不比I期白内障摘除并人工晶状体植入多,视力结果与术前最佳矫正视力相同,因此II期人工晶状体植入术可以安全有效的治疗无晶状体眼。

关键词： Ⅱ期人工晶状体无晶状体眼复明

圆锥角膜患者健康同胞的角膜地形图变化(英文)

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国际眼科杂志 2010年第2期10卷 212-214页

作者： Mohammad reza Besharati Mohammad reza shoja Masoud reza Manaviat Maryam kheirandish Maasome Zare Rad 伊朗亚兹德Shahid Sadoughi大学眼科

目的:描述圆锥角膜(KCN)患者亲属的受累角膜地形图。方法:对75名KCN患者的150名同胞的300只眼睛在角膜诊所进行了研究,经过完整的裂隙灯,屈光检查并由角膜摄影视频图片提供角膜地形图。进行方差分析,Fisher精确测试和卡方检验比较结果... 详细信息

目的:描述圆锥角膜(KCN)患者亲属的受累角膜地形图。方法:对75名KCN患者的150名同胞的300只眼睛在角膜诊所进行了研究,经过完整的裂隙灯,屈光检查并由角膜摄影视频图片提供角膜地形图。进行方差分析,Fisher精确测试和卡方检验比较结果。结果:在150个同胞中,女56%,男44%,平均年龄21(15-39)岁。诊断KCN和可疑KCN的分别为12.3%和6.6%。KCN患者中央角膜曲率(CK)为46.50±4.51(D)而可疑KCN患者为45.66±1.52(D)。KCN患者角膜下方与上方平均屈光度差值(I-S)为3.51±2.50(D)而在可疑KCN患者为1.56±1.22(D)。在KCN状态椭圆型为67.6%(25例)而圆型为32.4%(12例)。在可疑KCN分别为90%和10%。KCN屈光不正为-7.50至1.25(-1.25±1.83)D,可疑KCN为0.45至-4.2(-0.68±0.76)D而健康组为2.75至-7.5(-0.6±1.12)D。KCN和可疑KCN中22.7%为轻度散光,18.3%为中度散光。结论:KCN患者健康同胞中KCN情况增加显示出需要筛选检查以早期诊断并在这些个体中谨慎实施屈光性角膜手术或隐形眼镜治疗。

关键词：圆锥角膜地形测量同胞可疑KCN