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Calcium phosphate cements for bone engineering and their biological properties

Bone Research 2017年第4期5卷 286-304页

作者： Hockin Hk Xu Ping Wang Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A reynolds Department of Endodontics Periodontics and ProsthodonticsUniversity of Maryland School of DentistryBaltimoreMD 21201USA Center for Stem Cell Biology and Regenerative Medicine University of Maryland School of MedicineBaltimoreMD 21201USA University of Maryland Mariene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMD 21201USA Mechanical Engineering Department University of Maryland Baltimore CountyBaltimoreMD 21250USA State key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduSichuan 610041China VIP Integrated Department Stomatological Hospital of Jilin UniversityChangchunJilin 130011China Volpe Research Center American Dental Association FoundationNational Institute of Standards&TechnologyGaithersburgMD 20899USA Department of Orthopaedic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Calcium phosphate cements （CPCs） are frequently used to repair bone defects. Since their discovery in the 1980s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability, bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs, including 3D printing, injectability, stem cell delivery, growth factor and drug delivery, and pre- vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis.

关键词： CPC BMSCs Calcium phosphate cements for bone engineering and their biological properties

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Lincoln's selected writings

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作者： edited by David S. reynolds the Graduate Center of the City University of New York.

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Role of Oxidative Stress in Cardiac Allograft Vasculopathy

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Open Journal of Organ Transplant Surgery 2013年第2期3卷 36-41页

作者： Nandini Nair Enrique Gongora Joshua reynolds Department of Cardiology and Cardiothoracic Surgery Scott & White Healthcare Temple USA Department of Cardiothoracic Surgery Drexel University College of Medicine/Hahnemann University Hospital Philadelphia USA

Cardiac Allograft Vasculopathy, an accelerated form of arterial occlusive disease, is the major cause of death in the long-term after heart transplantation. Multiple factors influence the initiation and progression of CAV. These include ischemia-reperfusion, dyslipidemia, insulin resistance, and hypertension due to the use of immunosuppressive agents, the direct effects of immunosuppressive agents on endothelial function, and viruses (CMV). Impaired endothelial function reflects abnormalities in the production or activity of several vasoactive substances. Disruption of the nitric oxide synthase (NOS) pathway leads to changes in vascular reactivity, structure, and interaction with circulating blood components. Since endothelium-derived nitric oxide (NO) suppresses vascular cell proliferation and vascular inflammation, a deficit in vascular NO facilitates development of CAV. The link between oxidative stress and CAV largely exists in the balance between free radical superoxide generation and NO production. This review focuses on identifying the oxidative stress factors affecting CAV.

关键词： Cardiac Allograft Vasculopathy Oxidative Stress Asymmetric Dimethyl Arginine Cyto Megalo Virus Transplantation

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Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation

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Journal of Animal Science and Biotechnology 2013年第4期4卷 287-293页

作者： Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P reynolds Joel S Caton kimberly A Vonnahme Center for Nutrition and Pregnancy Department of Animal Sciences North Dakota State University

Background： Objectives were to examine the effects of selenium （Se） supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes （n = 84） were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se （adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BVV]） and nutritional plane （60% IRES], 100% [CON], or 140% [EXC]）. At parturition, lambs were removed and 42 ewes （7/treatment） were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present （P 〈 0.05）, least squares means from the highest-order interaction are presented. Results： Final body weight of ewes was least （P 〈 0.002） in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy （parturition or d 20 of lactation）. In ewes necropsied at parturition, mammary glands were heavier （P = 0.02） in EXC compared to RES, with CON intermediate. Concentration of RNA （rag/g） was decreased （P= 0.01） in EXC compared to CON at parturition. There was a tendency （P= 0.07） for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater （P_〈 0.02） number of proliferating cells then all other treatments. Mammary vascular area tended （P = 0.08） to be affected by a Se by nutrition interaction where ASe-CON had less （P= 0.007） vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased （P 〈- 0.05） in RES compared to CON and EXC-fed ewes. Conclusions： Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland develo

关键词： Mammary gland Nutrition Proliferation Selenium Vascularity

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Dynamic Modelling and Design of a Servomechanism for Hydraulic Directional-Control Valves

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河北工业大学学报 1997年第A1期26卷 58-75页

作者： Tan Runbua and A. J. reynolds

This paper analyses a control strategy applicable in heaVy-duty hydraulic Systems,namely, the introduction of a servovalve to achieve smoother operation of direCtional-control valves that serve also as flow-control valves over two fanges of operating conditions. A mathematical model of the dynamics of the System is etallished and design criteria are obtained from a linearised form of that model. The influence of variations in tile axial force on the spool of the main valve is investigated, and the use of the resultS in the design of systems of the proposed kind is discussed.

关键词： Hydraulic System Dynamic Performance Servomechnaism Flow-Control Valve Directional-Control Valve.

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Our Angry Age

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语言教育 1996年第11期 43-44页

作者： reynolds Dodson 张江云

Recently my college-age daughter said,“I hate modem classi-cal *** always sounds so angry.”I had never thought of modern music that way,but as soon asshe said it,I knew what she meant.I’ve often criticized rap forthat reason.“It’s not like jazz or early rock,”I’d say.“Thosewere *** you hear rap blasting from a passing car,youwonder what the driver’s so mad at.”I submit that historians will lable our times The Age

关键词： college happy daughter modem blasting never submit Our Angry Age meant popularity

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APPLICATION OF HIGH PRESSURE LIQUID CHROMATOGRAPHY AND MICROSEQUENCING METHODOLOGY IN THE STRUCTURAL ANALYSIS OF HUMAN HEMOGLOBIN VARIANTS

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Science China Chemistry 1983年第8期26卷 836-849页

作者：曾溢滔,黄淑帧,A.reynolds,H.LAM,B.B.WEBBER,J.B.WILSON,T.H.J.HUISMAN Laboratory of Medical Genetics Shanghai Children's Hospital Shanghai People's Republic of China Laboratory of Medical Genetics Shanghai Children's Hospital Shanghai People's Republic of China Laboratory of Protein Chemistry Comprehensive Sickle Cell Center Department of Cell and Molecular Biology Medical Collge of Georgia Augusta Ga 30912 U. S. A. Laboratory of Protein Chemistry Comprehensive Sickle Cell Center Department of Cell and Molecular Biology Medical Collge of Georgia Augusta Ga 30912 U. S. A. Laboratory of Protein Chemistry Comprehensive Sickle Cell Center Department of Cell and Molecular Biology Medical Collge of Georgia Augusta Ga 30912 U. S. A. Laboratory of Protein Chemistry Comprehensive Sickle Cell Center Department of Cell and Molecular Biology Medical Collge of Georgia Augusta Ga 30912 U. S. A. Laboratory of Protein Chemistry Comprehensive Sickle Cell Center Department of Cell and Molecular Biology Medical Collge of Georgia Augusta Ga 30912 U. S. A.

This paper reports the results of the analyses of 17 different Hb variants which were observed in 37 families. High pressure liquid chromatography (HPLC) was used to separate tryptic and thermolytic peptides of globin chains. The double coupling microsequencing technique can successfully be used for sequencing small or larger peptides.

关键词： APPLICATION OF HIGH PRESSURE LIQUID CHROMATOGRAPHY AND MICROSEQUENCING METHODOLOGY IN THE STRUCTURAL ANALYSIS OF HUMAN HEMOGLOBIN VARIANTS HPLC

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演说之禅

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作者： (美)Garr reynolds

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演说之禅

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作者： (美)Garr reynolds

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水硅铀矿及其他常见铀矿的铀浸出动力学比较（英文）

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Transactions of Nonferrous Metals Society of China 2018年第10期28卷 2135-2142页

作者： H.S.reynolds R.RAM M.I.POWNCEBY Y.YANG M.CHEN J.TARDIO L.JONES S.k.BHARGAVA Centre for Advanced Materials and Industrial Chemistry(CAMIC) School of Applied SciencesRMIT UniversityGPO Box 2476Melbourne VIC 3001Australia School of Earth Atmosphere and Environment Monash University9 Rainforest WalkClaytonVictoria 3800Australia CSIRO Mineral Resources Private Bag 10 Clayton SouthVictoria 3169Australia

水热合成并表征水硅铀矿,在此基础上对水硅铀矿在硫酸体系中的浸出过程进行研究,并将结果与其他相关的合成U^(4+)矿物如氧化铀(UO_2)和钛铀矿(UTi_2O_6)在类似条件下的浸出速率和浸出率进行比较。浸出时间对铀溶出影响的研究表明,水硅... 详细信息

水热合成并表征水硅铀矿,在此基础上对水硅铀矿在硫酸体系中的浸出过程进行研究,并将结果与其他相关的合成U^(4+)矿物如氧化铀(UO_2)和钛铀矿(UTi_2O_6)在类似条件下的浸出速率和浸出率进行比较。浸出时间对铀溶出影响的研究表明,水硅铀矿在36~48 h被完全浸出,该反应的活化能为38.4 kJ/mol。与水硅铀矿相比,氧化铀矿的溶出速率明显较快,可以在3 h内达到完全溶出(E_a=42~84 kJ/mol)。比较而言,合成钛铀矿的浸出速率较水硅铀矿的明显更低,其144 h铀的最大浸出率只有18%。上述3种矿物溶出速率和提取率的显著区别与文献报道相符合,即矿物的可溶出性为氧化铀>水硅铀矿>钛铀矿。在天然水硅铀矿中,由于杂质的存在,其可溶出性可能会被进一步抑制。

关键词：水硅铀矿铀钛铀矿浸出动力学

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