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Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard reynolds Anna M.Barron Chih Hung Lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

Maternal Group B Streptococcus Infection Correlates Inversely With Preeclampsia in Pregnant African American Women

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Maternal-Fetal Medicine 2024年第1期6卷 23-28页

作者： keun Soo kwon Tzu Hsuan Cheng Simone A。reynolds Jordan Zhou Huchong Cai Sharon Lee Ivan Velickovic Mudar Dalloul David Wlody Ming Zhang Department of Anesthesiology State University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Epidemiology and Biostatistics School of Public HealthState University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Obstetrics and Gynecology State University of New York-Downstate Health Sciences UniversityNew York 11203USA

Objective:To determine whether an association exists between group B Streptococcus(GBS)colonization and preeclampsia among pregnant Black ***:This retrospective cross-sectional study involved Black women who gave birth at State University of New York Downstate Hospital between January 2010 and December *** were collected from the Obstetric Department,including delivery date,time,mode of delivery,age of the mother,weeks of gestation at delivery,and antepartum *** GBS test results were originally determined using the eSwab transport *** was defined based on the American College of Obstetricians and Gynecologists criteria for the periods 2010–2012 and 2013–*** primary outcome was whether GBS was associated with the outcome of preeclampsia in the population of Black ***,including smoking status,gestational age,parity,body mass index,maternal age,and presence of herpes simplex virus(HSV)and human immunodeficiency virus(HIV)were examined as potential ***-squared test and logistic regression model were used,presenting odds ratios with 95%confidence intervals(Pk women included in this study,GBS-positive women(n=977)had a 53%reduction in the likelihood of being diagnosed with preeclampsia compared to GBS-negative women(adjusted odds ratio,0.47;95%confidence interval,0.32–0.70).We did not find evidence of differences in the distribution of smoking habits(P=0.783)or maternal age(P=0.107)between GBS-positive and GBS-negative ***,the GBS-positive women tended to be less likely to have a preterm delivery(9.62%(94/977)vs.24.24%(1707/7042),Pkely to be nulliparous(33.37%(326/977)vs.37.87%(2667/7042),P=0.006),and less likely to be obese(51.38%(502/977)vs.55.30%(3894/7042),Pkely to have a comorbid infecti

关键词： Pregnancy outcome Preeclampsia GBS colonization African American Afro-Caribbean

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中华高血压杂志(中英文) 2023年第1期 100-100页

作者： Akinyelure OP Hubbard D Sakhuja S Hardy ST Oparil S Cherrington AL reynolds k Wozniak G Muntner P 林沁郑武洪

在过去1年中未就诊的高血压患者血压失控的可能性更大。本研究人员使用2013—2018年美国国家健康和营养调查数据(n=5985),检查了过去1年美国成人高血压患者未就诊的相关因素。高血压定义为收缩压≥140和/或舒张压≥90mm Hg(1mm Hg=0.133... 详细信息

在过去1年中未就诊的高血压患者血压失控的可能性更大。本研究人员使用2013—2018年美国国家健康和营养调查数据(n=5985),检查了过去1年美国成人高血压患者未就诊的相关因素。高血压定义为收缩压≥140和/或舒张压≥90mm Hg(1mm Hg=0.133k Pa)或使用抗高血压药物。通过自我报告获取受试者过去1年的就诊情况,发现7.0%的美国成年高血压患者在过去1年中未曾就诊。与过去1年曾就诊的患者相比,

关键词：成人高血压国家健康

为歌剧盛装打扮去听高音演唱一定要穿高级时装?

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空中英语教室（高级版．彭蒙惠英语） 2024年第8期 14-15,41,42页

作者： Jeremy reynolds 不详

在英国皇家歌剧院看到的观众和观赏匹兹堡歌剧团表演的观众有所不同。在英国皇家歌剧院,处处充斥着浮华光鲜的贵气。在灯光的映衬下,燕尾服的缎面翻领和钻石耳环耀眼夺目,多层大厅无处不在的玻璃和镜子闪闪发亮——这里就是一个看与被... 详细信息

在英国皇家歌剧院看到的观众和观赏匹兹堡歌剧团表演的观众有所不同。在英国皇家歌剧院,处处充斥着浮华光鲜的贵气。在灯光的映衬下,燕尾服的缎面翻领和钻石耳环耀眼夺目,多层大厅无处不在的玻璃和镜子闪闪发亮——这里就是一个看与被看的炫耀空间。

关键词：高级时装闪闪发亮耀眼夺目看与被看翻领燕尾服匹兹堡钻石

Oxidative Stress in Collegiate Cross Country Skiers in Mid- and Post-Seasons

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Journal of Biosciences and Medicines 2024年第5期12卷 99-110页

作者： Scott P. Jerome kriya L. Dunlap Ava M. Parrish Matthew L. Lowman Emily M. Shipman Lawrence k. Duffy Arleigh J. reynolds Department of Chemistry & Biochemistry University of Alaska Fairbanks Fairbanks AK USA Institute of Arctic Biology University of Alaska Fairbanks Fairbanks AK USA Department of Biology & Wildlife University of Alaska Fairbanks Fairbanks AK USA Department of Veterinary Medicine University of Alaska Fairbanks Fairbanks AK USA

Purpose: The oxidative stress (OS) hypothesis of overtraining syndrome argues that increased production of free radicals through exercise cause muscle fatigue and damage resulting in lower athletic performance. Several studies have investigated OS immediately before and after exercise bouts in a training macrocycle. Our study aimed to compare OS of endurance athletes between a competition macrocycle and the immediate post-season recovery macrocycle. In addition, we aimed to identify athletes who experienced an unexplainable drop in athletic performance during the competition season in order to compare their OS to those who experienced no drop in performance. Methods: Fifteen members of the University of Alaska Fairbanks cross country ski team volunteered for this study. Blood samples were taken in early February (“mid-season”) and late April (“post-season”). Participants completed questionnaires regarding physical activity and athletic performance at the time of the blood draws. Plasma was analyzed for 4-hydroxynonenal (HNE), nitrotyrosine, nitric oxide (NOX), and superoxide dismutase (SOD). Significance was determined by Wilcoxon and Mann-Whitney tests. Results: Participants displayed significantly higher (p Conclusion: Signs of oxidative stress and mitigation during the post-season recovery macrocycle were higher in athletes who reported experiencing a drop in athletic performance during the competition season macrocycle.

关键词： Oxidative Stress 4-Hydroxynonenal Superoxide Dismutase Athletic Performance Training Macrocycle

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世界主要央行正在等待合适时机降息

商业周刊（中文版） 2024年第2期 6-7页

作者： Chris Anstey Enda Curran Garfield reynolds 易语(译) 不详

将之称作转折之年吧,在经历了四十年来最激进的一轮加息后,世界主要央行2024年将会转而开始下调借贷成本。现在的关键问题是,未来几个月的通,胀数据是否能让决策者以足够快的速度启动这一转变,从而减弱过去紧缩政策带来的影响,并避免经... 详细信息

将之称作转折之年吧,在经历了四十年来最激进的一轮加息后,世界主要央行2024年将会转而开始下调借贷成本。现在的关键问题是,未来几个月的通,胀数据是否能让决策者以足够快的速度启动这一转变,从而减弱过去紧缩政策带来的影响,并避免经济硬着陆。投资者预期新的一年中会发生这种转变,其所依赖的是令人鼓舞的消费者价格数据。

关键词：借贷成本投资者预期经济硬着陆降息紧缩政策加息央行价格数据

来自美国综合医疗保健系统的高血压患者824650例中，血管紧张素转换酶抑制药或血管紧张素受体阻滞药的使用与新型冠状病毒疾病2019发生率的关系

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中华高血压杂志(中英文) 2021年第4期29卷 399-399页

作者：刘青练桂丽 An J Wei R Zhou H Luong TQ Gould Mk Mefford MT Harrison TN Creekmur B Lee MS Sim JJ Brettler JW Martin JP Ong-Su AL reynolds k

先前报告认为使用血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)或血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能上调血管紧张素转换酶2受体,显著加重严重急性呼吸综合征冠状病毒2的感染性。...

先前报告认为使用血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)或血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能上调血管紧张素转换酶2受体,显著加重严重急性呼吸综合征冠状病毒2的感染性。研究者评估了高血压患者使用ACEI或ARB和新型冠状病毒疾病2019(coronavirus disease 2019,COVID-19)感染性之间的相关性。方法和结果:研究者于2020年3月1日从南加州凯萨医疗机构中选择高血压患者。

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Chemical exposures and suspected impacton Gulf War Veterans

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Military Medical Research 2023年第5期10卷 577-586页

作者： Rami Elhaj Joseph M.reynolds Center for Cancer Biology Immunology and InfectionChicago Medical SchoolRosalind Franklin University of Medicine and ScienceNorth ChicagoIL 60064USA

Gulf War Illness(GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War(1990–1991). There are several hypothesized factors believed to contribute to GWI, including(but not limited to)exposures to chemical agents and a foreign environment(e.g., dust, pollens, insects, and microbes). Moreover, the inherent stress associated with deployment and combat has been associated with GWI. While the etiology of GWI remains uncertain, several studies have provided strong evidence that chemical exposures, especially neurotoxicants,may be underlying factors for the development of GWI. This mini style perspective article will focus on some of the major evidence linking chemical exposures to GWI development and persistence decades after exposure.

关键词： Gulf War Illness(GWI) Sarin Neuroinfammation Organophosphate(OP)

随诊间血压变异性与心血管疾病和全因死亡率的关系

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中华高血压杂志 2014年第9期22卷 816-816页

作者：戴伦叶鹏 Diaz kM Tanner RM Falzon L Levitan EB reynolds k Shimbo D Muntner P

随诊间血压变异性与血压、心血管疾病（cardiovascular disease,CVD）、死亡率之间的相互关系仅在一些,但不是所有的研究中得到证实。该文对研究随诊间血压变异性与血压、CVD、全因死亡率之间相互关系的文献进行系统回顾与荟萃分析。方... 详细信息

随诊间血压变异性与血压、心血管疾病（cardiovascular disease,CVD）、死亡率之间的相互关系仅在一些,但不是所有的研究中得到证实。该文对研究随诊间血压变异性与血压、CVD、全因死亡率之间相互关系的文献进行系统回顾与荟萃分析。方法：搜索医学研究数据库截至2014年6月4日的资料文献,纳入的研究需符合下列入选标准：以成人为研究对象;随访中测量血压≥3次;随访CVD、冠状动脉性心脏病（冠心病）及脑卒中的发生或死亡率;随访结果需要通过数据库或死亡证明或事件鉴定委员会确认;对混杂因素进行调整。

关键词：血压变异性全因死亡率心血管疾病随诊冠状动脉性心脏病随访结果鉴定委员会荟萃分析