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Immune response to H pylori

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World Journal of Gastroenterology 2006年第35期12卷 5593-5598页

作者： Giovanni Suarez Victor E reyes Ellen J Beswick Department of Pediatrics University of Texas Medical Branch Galveston TX 77555 United States Department of Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555United StatesDepartment of Microbiology and Immunol-ogy University of Texas Medical Branch Galveston TX 77555 United States

The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While the extreme pH of this environment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, Hpylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the infiltration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associated pathogenesis. Here, we review the host responses involved during infection with Hpylori and how they are influenced by this bacterium.

关键词： H pylori Immune response T cell Dendritic cells

H pylori and host interactions that influence pathogenesis

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World Journal of Gastroenterology 2006年第35期12卷 5599-5605页

作者： Ellen J Beswick Giovanni Suarez Victor E reyes Departments of Pediatrics Microbiology and Immunology University of Texas Medical Branch Galveston TX 77555 United States

H py/ori is probably the most prevalent human pathogen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I carcinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduodenal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory response that becomes chronic, along with a detectable adaptive immune response, these responses are ineffective in clearing the infection. Hpylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they interact with the host epithelium to influence pathogenesis.

关键词： H pylori Gastric cancer Immune response Vacuolating cytotoxin

Nutritional Supplement Ocoxin® Combined with Gemcitabine-Based Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma

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Open Journal of Gastroenterology 2024年第8期14卷 267-287页

作者： Mayté Lima-Pérez Jorge Luis Soriano-García Masiel González-Meisozo Jorge Luis Soriano-Lorenzo Vilma Fleites-Calvo Dunia Morales-Morgado Carlos Domínguez-Álvarez Iván Ramón-Concepción Raidel Rodríguez-Barrios Alicia Tarinas-reyes Ivis Mendoza-Hernández Rolando Uranga-Piña Clinical Oncology Department Ameijeiras Hospital Havana Cuba Clinical Pathology Department Ameijeiras Hospital Havana Cuba Clinical Section National Coordinating Centre for Clinical Trials Havana Cuba Biostatistics Section National Coordinating Centre for Clinical Trials Havana Cuba

Background: the quality of life (QoL) of patients with pancreatic ductal adenocarcinoma (PDAC), with its limited survival, can be affected by chemotherapy-induced toxicity. The main objective was to evaluate the effect of introducing ocoxin oral solution (OOS) in combination with standard therapy on quality of life. Methods: Thirty patients were enrolled in an exploratory, prospective, single-centre clinical trial in the oncology department of “Hermanos Ameijeiras” University Hospital in Havana, Cuba. Quality of life was measured using the EORTC QLQ-C30 questionnaire and toxicity was assessed using the NCI-CTC-AE classification version 5.0. Results: There was stability in the scores over time for overall QoL and the functional scale criteria, while in terms of symptoms, fatigue, pain and loss of appetite were reduced. No grade 3 - 4 adverse events (AEs) were recorded, and only 14.9% of toxicities were classified as grade 2, and these were considered to be unrelated to OOS. Biochemical and nutritional parameters were normalised at 12 months compared to the baseline values. Conclusions: This clinical study is the first report of the use of OOS in patients with advanced pancreatic cancer, and demonstrates that it is able to maintain optimal quality of life with reduced severity of toxicity during and after combination treatment with gemcitabine-based chemotherapy.

关键词： EORTC QLQ-C30 Ocoxin Chemotherapy Pancreatic Cancer Quality of Life

A New Alternative Method for the Generation of Acoustic Filters, Modulating Acoustic Impedance: Theoretical Model

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Open Journal of Acoustics 2017年第3期7卷 39-51页

作者： Jesús Madrigal-Melchor Agustín enciso-Muñ oz David Armando Contreras-Solorio Xochitl Saldañ a-Saldañ a Raúl Alberto reyes-Villagrana Unidad Académica de Física Universidad Autónoma de Zacatecas Zacatecas México Instituto de Física Benemérita Universidad Autónoma de Puebla Puebla México CONACYT-Universidad Autónoma de Chihuahua Chihuahua México

Using the transfer matrix method we calculate the frequency dependence of the transmission of longitudinal elastic waves for a layered structure where the specific acoustic impedance of the layers with odd numbering follows a Gaussian distribution, while the inserted even layers have the same impedance as the propagation medium. The structure presents intervals of low-pass, band-stop, and band-pass. The characteristics of the bands depend on the number of layers, on the contrast between the maximum and minimum impedances of the structure, and on the ratio of the width of the inserted layers to the width of the layers with a Gaussian distribution of impedances.

关键词： Acoustic Transmission Acoustic Impedance Modulation Gaussian Profile

Pacing profiles and tactical behaviors of elite runners

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Journal of Sport and Health Science 2021年第5期10卷 537-549页

作者： Arturo Casado Brian Hanley Pedro Jimenez-reyes Andrew Renfree Faculty of Health Sciences Isabel I UniversityBurgos 09003Spain Carnegie School of Sports Leeds Beckett UniversityLeeds LS63QSUK Centre for Sport Studies Rey Juan Carlos UniversityMadrid 28943Spain Institute of Sport and Exercise Science University of WorcesterWorcester WR26AJUK

The pacing behaviors used by elite athletes differ among individual sports,necessitating the study of sport-specific pacing ***,pacing behaviors adopted by elite runners differ depending on race ***“all-out”strategy,characterized by initial rapid acceleration and reduction in speed in the later stages,is observed during 100 m and 200 m events;400 m runners also display positive pacing patterns,which is characterized by a reduction in speed throughout the ***,800 m runners typically adopt a positive pacing strategy during paced“meet”***,during championship races,depending on the tactical approaches used by dominant athletes,pacing can be either positive or negative(characterized by an increase in speed throughout).A U-shaped pacing strategy(characterized by a faster start and end than during the middle part of the race)is evident during world record performances at meet races in 1500 m,5000 m,and 10,000 m *** a parabolic J-shaped pacing profile(in which the start is faster than the middle part of the race but is slower than the endspurt)can be observed during championship 1500 m races,a negative pacing strategy with microvariations of pace is adopted by 5000 m and 10,000 m runners in championship *** cross country and marathon championship races are characterized by a positive pacing strategy;whereas a U-shaped pacing strategy,which is the result of a fast endspurt,is adopted by 3000 m steeplechasers and half *** contrast,recent world record marathon performances have been characterized by even pacing,which emphasizes the differences between championship and meet races at distances longer than 800 *** reviewed suggest further recommendations for *** the whole race,800 m runners should avoid running wide on the *** turn,during major championship events,1500 m,5000 m,and 10,000 m runners should try to run close to the inside of the track as much as possible during t

关键词： Athletics Distance running Pacing Sprinting

Leaching kinetics in cyanide media of Ag contained in the industrial mining-metallurgical wastes in the state of Hidalgo, Mexico

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International Journal of Mining Science and Technology 2014年第5期24卷 689-694页

作者： Juan Hernandez Francisco Patino Isauro Rivera Iván Alejandro reyes Misrael Uriel Flores Julio Cesar Juarez Martín reyes Research Centre in Materials and Metallurgy Autonomous University of Hidalgo Pachuca 42184 Mexico

The leaching kinetics in cyanide media of the silver contained in the Dos Carlos waste tailings at the City of Pachuca de Soto, Hidalgo State, Mexico were carried out. The used material contained the following chemical composition: 56 10-6of Ag, 0.6 10 6of Au and 70.43%(by weight) of SiO2; 7.032%(by weight) of Al2O3; 2.69%(by weight) of Fe; 0.46%(by weight) of Mn; 3.98%(by weight) of K2O; 3.34%(by weight) of CaO; 2.50%(by weight) of Na2O; 0.04%(by weight) of Zn; 0.026%(by weight) of Pb. The mineralogical phases present were the following: Silica, albite, argentite, berlinite, orthoclase, potassium jarosite, and natrojarosite. In the leaching kinetics in cyanide media, and under the studied conditions,the effect of the CN concentration on the reaction rate has no effect on the whole process of alkaline cyanidation, of which the reaction order is n 0. Temperature has an effect on the cyanidation rate of the reaction, with an activation energy of 47.9 KJ/mol. At the same time, when the particle size decreases there is an increase in the reaction rate, which is inversely proportional to the particle diameter; when increasing the NaOH concentration there is an increase in the reaction rate Kexp, with a reaction order(n) of 0.215 under the studied ranges.

关键词： Silver Waste tailings Cyanidation Leaching

One Decade of Development and Evolution of MicroRNA Target Prediction Algorithms

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 254-263页

作者： Paula H.reyes~Herrera Elisa Ficarra School of Electronic and Biomedical Engineering Universidad Antonio Narino Department of Control and Computer Engineering Politecnico di Torino

Nearly two decades have passed since the publication of the first study reporting the discovery of microRNAs （miRNAs）. The key role of miRNAs in post-transcriptional gene regulation led to the performance of an increasing number of studies focusing on origins, mech- anisms of action and functionality of miRNAs. In order to associate each miRNA to a specific functionality it is essential to unveil the rules that govern miRNA action. Despite the fact that there has been significant improvement exposing structural characteristics of the miRNA-mRNA interaction, the entire physical mechanism is not yet fully understood. In this respect, the development of computa- tional algorithms for miRNA target prediction becomes increasingly important. This manuscript summarizes the research done on miRNA target prediction. It describes the experimental data currently available and used in the field and presents three lines of compu tational approaches for target prediction. Finally, the authors put forward a number of considerations regarding current challenges and future directions.

关键词： MicroRNAs MicroRNA recognition elements Target prediction

Analysis and parameter extraction of memristive structures based on Strukov's non-linear model

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Journal of Semiconductors 2018年第12期39卷 106-113页

作者： A.Avila Garcia L.Ortega reyes Centro de Investigacion y de Estudios Avanzados del Instituto Polit6cnico Nacional Departamento de Ingenieria ElectricaSeccion de Electronica del Estado SolidoMexico 07360Mexico

Diverse models have been proposed for explaining the electrical performance of memristive devices. In principle, the behavior of internal variables associated to each one could be extracted from experimental results. In a former work, thermally grown TiOmemristive structures were built and characterized to obtain the constitutive relationship(magnetic flux versus charge). The aim of this work is to continue that analysis by determining the microscopic parameters within the frame of a simple model. We use the already obtained memristance dependence of time and the basic expressions from the non-linear model proposed by Strukov et al. to compute the state-variable,the mobility of the doping species, the speed of the boundary between the doped and the undoped regions, the voltages and the electric fields on the distinct regions. The power dissipation and its time evolution are also presented. Moreover, a quite different window function from those formerly proposed, which was estimated from experimental data, is also determined. This information provides a straightforward picture of the ionic transport during one cycle of a square voltage waveform within the framework of this simple model. Finally, a quality factor is proposed as the key parameter for actual memristors viewed under the same model.

关键词： memristors parameter extraction non-linear model experimental window function

Identification and evaluation of enzymatic ability of fungal endophytes from Citrofortunella microcarpa(Bunge)Wijnands

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Studies in Fungi 2021年第1期6卷 460-468页

作者： reyes RDC Parayao AM Waing KGD Department of Biological Sciences College of ScienceCentral Luzon State University3120 Science City of MuñozNueva EcijaPhilippines

Citrofortunella microcarpa locally known as“kalamansi”belongs to the family Rutaceae is one of the most important marketable fruit crops grown in the *** from being a fruit crop,the plant also houses various endophytic microorganisms which exhibit various symbiotic ***,this study isolated fungal endophytes from *** stem and leaves and were identified culturally and *** identities of the fungal species were confirmed using ITS1 and ITS4 *** identified fungal endophytes were tested for their ability to produce fungal enzymes such as amylase,cellulase,laccase and *** 11 fungal endophytes were isolated from stem and leaves of *** namely,Colletotrichum fructicola,Colletorichum gloeosporioides,Colletotrichum siamense,Fusarium oxysporum,Lasiodiplodia theobromae,Nigrospora oryzae,Nigrospora rubi,Nodulisporium indicum,Phomopsis azadirachtae,Phyllosticta capitalensis,and an unidentified species under the Order *** the identified endophytic fungal species showed production of *** the cellulose assay,four species namely ***,***,***,and the unidentified species had potential for cellulose *** oxysporum and *** were found to be producers of ***,only the unidentified species showed extracellular protease activity.

关键词： enzymes extracellular ITS primers Pleosporales