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A facile design for multifunctional AIEgen based on tetraaniline derivatives

Science China Chemistry 2019年第6期62卷 732-738页

作者： Beibei Liu Wei He Hao Lu Kun Wang Mingming Huang Ryan Tsz kin Kwok Jacky Wing Yip lam Longcheng Gao Jiping Yang Benzhong Tang Key laboratory of Aerospace Advanced Materials and Performance Ministry of Education School of Materials Science and EngineeringBeihang University Department of Chemistry HKUST Jockey Club Institute for Advanced Study Institute of Molecular Functional Materials Division of Biomedical Engineering State Key Laboratory of Molecular Neuroscience Division of Life Science The Hong Kong University of Science and Technology Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education Key Laboratory of Beijing Energy School of Chemistry and Environment Beihang University

Aniline oligomers have been widely used in many fields due to their excellent physicochemical properties. Owing to strong intermolecular interactions, their emission is always weakened or quenched when they are in high concentration or aggregated state, which greatly limits their fluorescent applications. Inspired by the concept of aggregation-induced emission(AIE), herein we introduced large steric groups onto the aniline oligomer to prevent the formation of packing structure. In particular, diphenyl vinyl group was bonded with oligomeric tetraaniline by a facile synthetic procedure with high yield. The obtained aniline oligomer derivative exhibited typical AIE features, which was also confirmed by density functional theoretical calculation. More importantly, this AIE oligomer was able to detect Fe^(3+) ions selectively and quantitatively. The fluorescence intensity decreased linearly along with the increment of Fe^(3+) concentration. Moreover, we demonstrated that this AIE oligomer could stain live bacteria, such as E. coli and S. aureus efficiently. All these results suggest that such a readily accessible and multifunctional tetraaniline derivative provides a new platform for the construction of fluorescent materials.

关键词： tetraaniline aggregation-induced emission Fe3+ ion detection bacteria imaging

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一种基于自样本学习的人脸图像超分辨率复原算法

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高技术通讯 2009年第4期19卷 377-381页

作者：李晓光沈兰荪 lam kin Man 王素玉北京工业大学信号与信息处理研究室北京100124 香港理工大学电子及资讯工程学系

针对人脸图像超分辨率复原问题,提出了一种新的基于自样本学习的超分辨率复原算法。该算法从输入图像本身提取训练样本库,并采用矢量量化的方法对训练样本进行分类。再利用并行设计的多类预测器对每类样本进行学习训练,指导高频信息的... 详细信息

针对人脸图像超分辨率复原问题,提出了一种新的基于自样本学习的超分辨率复原算法。该算法从输入图像本身提取训练样本库,并采用矢量量化的方法对训练样本进行分类。再利用并行设计的多类预测器对每类样本进行学习训练,指导高频信息的估计重建。对来自输入图像本身的自样本训练集合和来自特定训练图像库的特定训练样本集合进行了对比研究。实验结果表明提出算法在图像重建质量和实现速度上都有很好的表现。

关键词：超分辨率复原人脸图像放大示例学习自样本多类预测器

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Influences of fiber length and water film thickness on fresh properties of basalt fiber-reinforced mortar

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第5期22卷 344-356页

作者： Leo Gu LI Yi OUYANG pui-lam NG Kai-long ZENG Albert Kwok Hung KWAN Department of Civil Engineering Guangdong University of TechnologyGuangzhou 510006China Department of Civil Engineering The University of Hong KongHong Kong 999077China Mott MacDonald(Hong Kong)Ltd. Hong Kong 999077China China Jinmao Holdings Group Ltd. Guangzhou 510030China

In plain mortar,the water film thickness(WFT)has been found to play a key role in the fresh ***,in fiber-reinforced mortar,the role of WFT has not been investigated *** this research,basalt fibers of different lengths were added to the mortar,and the dynamic and static flowability,cohesiveness,adhesiveness,and packing density were tested to study the effects of fiber length on the packing density and WFT,and the combined effects of fiber length and WFT on the fresh *** results showed that in fiber-reinforced mortar,the WFT also plays a key role,whereas the fiber length exerts its influences through the indirect effects on the packing density and WFT and the direct effect on fiber-mortar ***,an increase in fiber length decreases the packing density and WFT,decreases the dynamic and static flowability needed for placing,increases the cohesiveness needed for avoiding segregation,and,quite unexpectedly,decreases the adhesiveness needed for rendering and spraying *** analysis yielded good correlation of the fresh properties to fiber length and WFT,and best-fit formulas for the mix design for basalt fiber-reinforced mortar were obtained.

关键词： Basalt fiber Fiber-reinforced mortar Fresh properties Water film thickness(WFT)

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一种基于GVF各向异性扩散模型的图像放大算法

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电子学报 2008年第9期36卷 1755-1758页

作者：李晓光沈兰荪 lam kin-Man 王素玉北京工业大学信号与信息处理研究室北京100124 Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityHong Kong

提出了一种基于梯度向量流各向异性扩散模型的图像放大方法.首先低分辨率图像插值放大作为高分辨率图像的初始估计,然后利用基于GVF的平均曲率扩散模型和高斯移动平均低分辨率模型约束进行迭代复原.GVF是一种有旋场,作为外力场用来描述... 详细信息

提出了一种基于梯度向量流各向异性扩散模型的图像放大方法.首先低分辨率图像插值放大作为高分辨率图像的初始估计,然后利用基于GVF的平均曲率扩散模型和高斯移动平均低分辨率模型约束进行迭代复原.GVF是一种有旋场,作为外力场用来描述图像的边缘特征,能够将初始图像中斜向边缘锯齿效应表示为流线型.采用GVF外力场约束平均曲率扩散过程,能够有效去除边缘锯齿现象并保持纹理结构.高斯移动平均模型提供了图像数据保真度约束,使结果更接近理想图像.实验结果表明,本文算法能够有效提高放大图像的主观视觉质量和客观PSNR.

关键词：图像放大梯度向量流各向异性扩散超分辨率复原

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Long-Term and Immediate Impacts of Health Emergency and Disaster Risk Management(Health-EDRM) Education Interventions in a Rural Chinese Earthquake-Prone Transitional Village

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International Journal of Disaster Risk Science 2018年第3期9卷 319-330页

作者： Emily Ying Yang Chan Janice Ying-en Ho Zhe Huang Jean Hee Kim Holly Ching Yu lam Phoebe pui Wun Chung Carol Ka Po Wong Sida Liu Sharon Chow Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health & Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC) Wu Zhi Qiao (Bridge to China) Charitable Foundation

Ma'an Qiao Village, a Dai and Yi ethnic minority-based community in Sichuan Province, China sustained complete infrastructure devastation during the 2008 Panzhihua earthquake. Health emergency and disaster risk management(Health-EDRM) education intervention programs were implemented in 2010 and 2011. This serial cross-sectional survey study aimed to examine the immediate and long-term impacts of the Health-EDRM interventions in this remote rural community. The findings demonstrate knowledge improvement in areas of water and sanitation, food and nutrition, and disaster preparedness immediately after the Health-EDRM education interventions. Temporal stability of knowledge retention was observed in household hygiene and waste management and smoking beliefs in 2018, 7 years after the *** important findings include knowledge uptake pattern differences of oral rehydration solution(ORS) between earthquake-prone and flood-prone communities. Usage of Internet and mobile technology for accessing disaster-related information was found to be independent of gender and income. Overall, this study demonstrated the knowledge improvement through Health-EDRM education interventions in a remote rural community. Promoting behavioral changes through interventions to raise awareness has the potential to reduce health risks in transitional post-disaster settings. Future programs should aim to identify evidence-based practices and explore how technology can support Health-EDRM education among vulnerable subgroups.

关键词： Earthquake Transitional community Disaster preparedness kit Disaster risk reduction Health emergency and disaster risk management Rural China Sichuan

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Risk Perception and Knowledge in Fire Risk Reduction in a Dong Minority Rural Village in China: A Health-EDRM Education Intervention Study

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International Journal of Disaster Risk Science 2018年第3期9卷 306-318页

作者： Emily Ying Yang Chan Holly Ching Yu lam Phoebe pui Wun Chung Zhe Huang Tony Ka Chun Yung Kelvin Wai Kit Ling Gloria Kwong Wai Chan Cheuk Pong Chiu Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health and Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC)

Fire is one of the major disasters in rural communities but evidence of the effectiveness of education interventions against fire risks is limited. This was a 2-year study assessed the effectiveness of face-to-face Health Emergency and Disaster Risk Management(HealthEDRM) education interventions for raising fire risk reduction knowledge in a fire-prone rural ethnic minority community. The study was conducted in various pre-set time points of an intervention-based project in a Dongbased community in Nanjiang Village, Guizhou Province in 2015 and 2016 to increase knowledge among the villagers about how to reduce general-and electrical-fire risks. Pre-and post-intervention questionnaires were used to evaluate the effectiveness of increasing fire risk-related knowledge through these interventions, immediately after the 2015 and 2016 interventions, and 17 months after the 2015 intervention. The knowledge of using fire blanket,recalling the correct emergency telephone number,unplugging unused electrical appliances, and not using water to extinguish electrical fires had immediately improved after the interventions. Subjects demonstrated a better understanding that fire blankets can fight a blaze if used appropriately, and that knowledge was sustained for 17 months. The interventions were effective in improving fire prevention and response knowledge. Targeted interventions should be organized according to communities' culture, the evolution of economic prosperity and lifestyle practices.

关键词： Dong village Fire risk education Fire risk perception Fire risk reduction Health education Rural China Health-EDRM

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Clinical factors affecting rejection rates in liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第4期14卷 367-373页

作者： kin Pan Au See-Ching Chan Kenneth Siu-Ho Chok William Wei Sharr Wing-Chiu Dai Sui-Ling Sin Tiffany Cho-lam Wong Chung-Mau Lo Department of Surgery the University of Hong Kong Medical Center Queen Mary Hospital

With improvements in survival, liver trans- plant recipients now suffer more morbidity from long-term immunosuppression. Considerations were given to develop individualized immunosuppression based on their risk of re- jection. METHOD： We retrospectively analyzed the data of 788 liver transplants performed during the period from October 1991 to December 2011 to study the relationship between acute cel- lular rejection （ACR） and various clinical factors. RESULTS： Multivariate analysis showed that older age （P=0.04, OR=0.982）, chronic hepatitis B virus infection （P=0.005, OR= 0.574）, living donor liver transplantation （P=0.02, OR=0.648） and use of interleukin-2 receptor antagonist on induction （P〈0.001, OR=0.401） were associated with fewer ACRs. Patients with fulminant liver failure （P=.004, OR=4.05） were more likely to develop moderate to severe grade ACR. CONCLUSIONS： Liver transplant recipients with older age, chronic hepatitis B virus infection, living donor liver trans- plantation and use of interleukin-2 receptor antagonist on in- duction have fewer ACR. Patients transplanted for fulminant liver failure are at higher risk of moderate to severe grade ACR. These results provide theoretical framework for developing individualized immunosuppression.

关键词： liver transplantation acute rejection immunosuppression

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人脸检测研究进展

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计算机工程与应用 2003年第28期39卷 5-9,21页

作者：刘党辉沈兰荪 kin-Man lam 北京工业大学信号与信息处理研究室北京100022 Centrefor Multimedia Signal Processing The Hong Kong Polytechnic UniversityHongKong

人脸检测在人脸识别、基于内容的检索、自动监控、人机交互等方面有着广泛的应用。文章主要从特征和原理方面对已有方法进行分析,表明了人脸检测技术的特点、存在的问题以及发展现状等,也给出了一些新的研究方向和发展前景。

关键词：人脸检测基于知识的方法基于统计的方法

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Structural Chemical Shifts of Adenine in Deoxyribonucleic Acids

Structural Chemical Shifts of Adenine in Deoxyribonucleic Ac...

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第十四届全国波谱学学术会议

作者： Sik Lok lam kin Fung Lai Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong. Department of Chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong.

＜正＞Simple structure-chemical shift relationships are present in *** these relationships have not been observed in nucleic ***,reliable sets of random coil proton,carbon and phosphorus DNA chemical shifts have been ...

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三陰乳腺癌PD-L1(SP142)與CTLA-4、PTEN表達的關係研究

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镜湖医学 2024年第1期24卷 20-23,F0003页

作者：韋潔貞林文華冼麗芳陳建勇黃香婷肖剛文劍明澳門鏡湖醫院病理科中国

目的探討三陰乳腺癌PD-L1(SP142)與CTLA-4、PTEN表達的關係和意義。方法收集鏡湖醫院2008年1月~2018年6月間病理科136例乳腺癌標本,按乳腺癌分子分型分為三陰乳腺癌(TNBC)、管腔A型、管腔B型及HER2型乳腺癌,採用免疫組化檢測各型乳腺癌P... 详细信息

目的探討三陰乳腺癌PD-L1(SP142)與CTLA-4、PTEN表達的關係和意義。方法收集鏡湖醫院2008年1月~2018年6月間病理科136例乳腺癌標本,按乳腺癌分子分型分為三陰乳腺癌(TNBC)、管腔A型、管腔B型及HER2型乳腺癌,採用免疫組化檢測各型乳腺癌PD-L1(SP142)、CTLA-4和PTEN表達情況,並分析它們之間的關係。結果136例乳腺癌中,32.4%的病例PD-L1(SP142)陽性,其中48%(24/50)TNBC、11.9%(5/42)管腔A型、20%(3/15)管腔B型和41.4%(12/29)HER2型PD-L1(SP142)陽性;43.4%的病例CTLA-4陽性,其中52.0%(26/50)TNBC、31.0%(13/42)管腔A型、33.3%(5/15)管腔B型和50.9%(15/29)HER2型CTLA-4陽性;28.0%的病例PTEN陽性,其中52.0%(26/50)TNBC、31.0%(13/42)管腔A型、33.3%(5/15)管腔B型和50.9%(15/29)HER2型PTEN陽性。TNBC的PD-L1(SP142)表達與CTLA-4表達呈正相關(Spearman=0.409,P<0.05),與PTEN表達呈負相關(Spearman=-0.318,P<0.05)。結論TNBCPD-L1(SP142)與CTLA-4表達的正相關關係,提示聯合免疫治療可能使TNBC患者獲益,而TNBCPD-L1(SP142)與PTEN表達的負相關關係,提示TNBC同時遭受免疫逃逸和基因突變的雙重打擊,因此適合免疫治療和靶向PTEN聯合治療。

关键词：三陰乳腺癌 PD-L1(SP142) CTLA-4 PTEN

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