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Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth

Neural Regeneration Research 2021年第6期16卷 1121-1126页

作者： Jia-Jian Liang Yu-Fen Liu Tsz kin Ng Ci-Yan Xu Mingzhi Zhang Chi pui Pang Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or ***,the effects and mechanisms of macrophage activation on neuronal survival remain *** the present study,we co-cultured adult Fischer rat retinas with primary peritoneal macrophages or zymosan-treated peritoneal macrophages for 7 *** analysis revealed that peritoneal macrophages reduced retinal ganglion cell survival and neurite outgrowth in the retinal explant compared with the control *** addition of zymosan to peritoneal macrophages attenuated the survival and neurite outgrowth of retinal ganglion *** media from peritoneal macrophages also reduced retinal ganglion cell survival and neurite *** result suggests that secretions from peritoneal macrophages mediate the inhibitory effects of these *** addition,increased inflammationand oxidation-related gene expression may be related to the enhanced retinal ganglion cell degeneration caused by zymosan *** summary,this study revealed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth,and that macrophage activation further aggravated retinal ganglion cell *** study was approved by the Animal Ethics Committee of the Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong,Shantou,Guangdong Province,China,on March 11,2014(approval ***20140311(2)-P01).

关键词： in vitro inflammation macrophages model neurite outgrowth optic nerve retinal ganglion cells survival

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Revisiting oral fluoropyrimidine with cetuximab in metastatic colorectal cancer: Real-world data in Chinese population

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World Journal of Gastrointestinal Oncology 2019年第11期11卷 1031-1042页

作者： Ka-On lam Man-Chi Fu kin-Sang Lau Kam-Mo lam Cheuk-Wai Choi Wan-Hang Chiu Cheng-Man Yuen Lai-Han Kwok Fong-Kit Tam Wing-Lok Chan Sum-Yin Chan pui-Ying Ho To-Wai Leung Ho-Fun Lee Department of Clinical Oncology LKS Faculty of MedicineThe University of Hong KongHong KongChina Department of Clinical Oncology Queen Mary HospitalHong KongChina Clinical Oncology Centre The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Pharmacy Queen Mary HospitalHong KongChina Department of Diagnostic Radiology LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Cetuximab in combination with oral fluoropyrimidine(FP)remains controversial in metastatic colorectal cancer(mCRC).In view of the regional variation in the tolerability of FP,we conducted a retrospective analysis to compare oral FP with infusional FP in combination with cetuximab in Chinese *** To compare the efficacy and safety profile of cetuximab in combination with oral FP and infusional FP in Chinese population in the real-world *** A retrospective cohort study was done to analyse consecutive patients with Kras wild-type mCRC who received first-line treatment with cetuximab and FP-based chemotherapy in our unit from January 2010 to December ***-five eligible patients were *** median follow-up of our cohort was 65.0 *** The median progression-free survival(mPFS)and median overall survival(mOS)of the entire cohort were 9.66 mo(95%CI:7.72–12.5)and 25.8 mo(95%CI:18.7–35.6),*** oral FP and infusional FP,there was no statistical significant difference in the mPFS[9.79 mo(95%CI:7.49–12.7)vs 9.63 mo(95%CI:6.34–13.4);P=0.72]and mOS[25.8 mo(95%CI:15.2–35.6)vs 26.3 mo(95%CI:18.7–41.2);P=0.63].Grade 3 or above adverse events were reported in 28.4%of patients,being similar with oral and infusional FP,and included 10.5%of neutropenia and 2.1%of diarrhoea *** The current analysis demonstrates comparable efficacy and safety profiles of cetuximab in combination with oral and infusional FP in Chinese *** results expand treatment options for Chinese patients and invite revision of existing treatment guidelines to incorporate oral FP-based chemotherapy plus cetuximab.

关键词： Capecitabine 5-Fluorouracil Cetuximab Metastatic colorectal cancer Chinese

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Optimization and evaluation of reduced graphene oxide hydrogel composite as a demulsifier for heavy crude oil-in-water emulsion

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Chinese Journal of Chemical Engineering 2021年第5期34卷 297-305页

作者： kin Kit Fong Inn Shi Tan Henry Chee Yew Foo Man Kee lam Adrian Chiong Yuh Tiong Steven Lim Department of Petroleum Engineering Faculty of Engineering and ScienceCurtin UniversityCDT 25098009 MiriSarawakMalaysia Department of Chemical Engineering Faculty of Engineering and ScienceCurtin UniversityMiri 98009Malaysia Chemical Engineering Department Universiti Teknologi PETRONASSeri Iskandar 32610Malaysia HICoE-Centre for Biofuel and Biochemical Research Institute of Self-Sustainable BuildingUniversiti Teknologi PETRONASSeri Iskandar 32610Malaysia Department of Chemical Engineering Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul RahmanKajang 43000Malaysia Centre for Photonics and Advanced Materials Research Universiti Tunku Abdul RahmanKajang 43000Malaysia

The rising production of produced water from oilfields had been proven to bring detrimental environmental *** this study,an efficient,recyclable,and environmental-friendly reduced graphene oxide immobilizedκ-Carrageenan hydrogel composite(κCaGO)was fabricated as an alternative sorbent for crude oil-in-water ***(PEI)was employed to form a stable hydrogel *** conditions for the immobilization of graphene oxide(GO)on PEI-modifiedκ-Carrageenan(κC)beads were optimized *** immobilization yield of 77%was attained at 2%PEI,2 h immobilization activation time,and pH ***,the synthesizedκCaGO is capable of demulsification with an average demulsification efficiency of 70%.It was found that the demulsification efficiency increases with salinity andκCaGO dosage,and it deteriorates under alkaline *** phenomena can be attributed to the interfacial interactions betweenκCaGO and the ***,theκCaGO can be recycled to use for up to six cycles without significant leaching and *** such,the synthesizedκCaGO could be further developed as a potential sorbent substitute for the separation of crude oil from produced water.

关键词： Graphene oxide κ-Carrageenan Adsorbents Demulsification Composites Waste water

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混凝土应力状态对碳化深度的影响

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建筑结构学报 2018年第S1期39卷 397-404页

作者：王健 NG pui-lam 苏瀚杜进生北京交通大学土木建筑工程学院北京100044 维尔纽斯皇家理工大学土木工程学院维尔纽斯10223

为考虑混凝土应力状态对碳化深度的影响,在混凝土碳化深度模型中增加了应力影响系数。利用已有文献的试验数据,进一步研究了应力影响系数随混凝土应力比变化的规律,并分别建立了应力影响系数随混凝土拉、压应力比变化的计算式。将建立... 详细信息

为考虑混凝土应力状态对碳化深度的影响,在混凝土碳化深度模型中增加了应力影响系数。利用已有文献的试验数据,进一步研究了应力影响系数随混凝土应力比变化的规律,并分别建立了应力影响系数随混凝土拉、压应力比变化的计算式。将建立的应力影响系数计算式与既有的3组典型计算式进行了对比,结果表明,建立的应力影响系数计算式较合理,具有较高的预测精度。对规范中的应力影响系数计算式进行了评价,结果表明,在混凝土拉应力状态下,应力影响系数取值偏于不安全;相反,在混凝土压应力状态下,取值偏于保守,因此可将文中所提计算式作为规范中应力影响系数的修正式。

关键词：混凝土碳化深度模型应力状态应力影响系数

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Interactions Between Arbuscular Mycorrhizae and Plants in Phytoremediation of Metal-Contaminated Soils: A Review

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Pedosphere 2013年第5期23卷 549-563页

作者： LEUNG Ho-Man WANG Zhen-Wen YE Zhi-Hong YUNG kin-lam PENG Xiao-Ling CHEUNG Kwai-Chung Department of Biology Hong Kong Baptist University School of Biological Science and Technology Yangzhou University State Key Laboratory for Bio-control and School of Life Sciences Sun Yat-sen University Division of Science and Technology BNU-HKBU United International College Department of Applied Sciences Hong Kong Institute of Vocational Education (Chai Wan)

Metal contamination in the environment is a global concern due to its high toxicity to living organisms and its worldwide distribution. The principal goal of this review is to examine the current strategies and technologies for the remediation of metal- contaminated soils by metal-accumulating plants and assess the roles of arbnscular mycorrhizal （AM） fungi in remediation of soils under hyperaccumulator or non-accumulator plants. The use of plants to remove metals from the environment or reduce the toxicity, known as phytoremediation, is an environmentally sustainable and low cost remediation technology. The mechanisms of the use of hyperaccumulator plants for phytoremediation included solubilization of the metal in the soil matrix, the plant uptake of the metal, detoxification/chelation and sequestration, and volatilization. Recently, some ecologists have found that phytoremediation with the aids of mycorrhizae can enhance efficiency in the removal of toxic metals. AM fungi can facilitate the survival of their host plants growing on metal-contaminated land by enhancing their nutrient acquisition, protecting them from the metal toxicity, absorbing metals, and also enhancing phytostabilization and phytoextraction. Such information may be useful for developing phytoremediation program at metal-contaminated sites.

关键词： AM fungi heavy metals hyperaccumulator plant phytoextraction phytostabilization

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基于感兴趣区的图像编码与渐进传输

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电子学报 2004年第3期32卷 411-415页

作者：卓力沈兰荪 lam kin-man 北京工业大学信号与信息处理研究室北京100022 Department of Electronic & Information Engineering HongKong Polytechnic University

本文采用一种任意形状的整型或非整型小波变换 ,结合高效的SPIHT(SetPartitioningInHierarchicalTrees)图像编码算法 ,分别实现了任意形状感兴趣区的无损压缩和非感兴趣的有损压缩算法 .另外本文还提出了两种感兴趣区优先编码策略 ,可... 详细信息

本文采用一种任意形状的整型或非整型小波变换 ,结合高效的SPIHT(SetPartitioningInHierarchicalTrees)图像编码算法 ,分别实现了任意形状感兴趣区的无损压缩和非感兴趣的有损压缩算法 .另外本文还提出了两种感兴趣区优先编码策略 ,可以保证在极低的码率下感兴趣区的重建质量远远好于非感兴趣区的重建质量 ,满足用户快速、个性化的浏览需求 .这些方法得到的压缩码流都具有嵌入的特点。

关键词：适形小波编码提升小波 SPHT算法感兴趣区渐进传输图像编码图像传输

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Packing and film thickness theories for the mix design of high-performance concrete

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第10期17卷 759-781页

作者： pui-lam NG Albert Kwok-Hung KWAN Leo Gu LI Department of Civil Engineering The University of Hong Kong Pokfulam Hong Kong China Faculty of Civil Engmeering Vilnius Gediminas Technical University Vilnius Lithuania Schoo of Cicil and Transportation Engmeering Guangdong University of Technology Guangzhou 510006 China

A high-performance concrete （HPC） is required to have superior performance in various aspects such as workability,strength, durability, dimensional stability, segregation stability, and passing ability. The mix design of HPC is rather complicatedbecause the number of ingredients in HPC is usually more than those in conventional concrete and some of the required propertiesare conflicting with each other in the sense that improvement in one property would at the same time cause impairment of anotherproperty. However, there is still lack of understanding regarding how the various mix parameters should be optimised forachieving best overall performance. Most practitioners are still conducting mix design primarily through trial concrete mixing,which is laborious, ineffective, and often unable to timely respond to fluctuations in the properties of raw materials. To addressthese issues, the authors have been developing the packing and film thickness theories of concrete materials, in order to revamp themix design philosophy of HPC in terms of the water film thickness （WFT）, paste film thickness （PFT）, and mortar film thickness（MFT） in the concrete. Based on the findings from an extensive experimental programme, suitable ranges ofWFT, PFT, and MFThave been recommended.

关键词： Concrete mix design, Concrete science, Film thickness, High-performance concrete, Packing density, Sustainability

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Total Ginsenoside Extract from Panax ginseng Enhances Neural Stem Cell Proliferation and Neuronal Differentiation by Inactivating GSK-3β

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Chinese Journal of Integrative Medicine 2022年第3期28卷 229-235页

作者： LIN Kai-li ZHANG Ji CHUNG Hau-lam WU Xin-yi LIU Bin ZHAO Bo-xin SZE Stephen Cho-wing ZHOU Ping-zheng YUNG Ken kin-lam ZHANG Shi-qing School of Public Health Guangzhou Medical UniversityGuangzhou(511436)China Department of Biology Hong Kong Baptist University(HKBU)Hong Kong Special Administrative Region(999077)China HKBU Shenzhen Research Institute and Continuing Education ShenzhenGuangdong Provinee(518057)China Department of Plastic Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou(510515)China Guangzhou Institute of Cardiovascular Disease the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou(510260)China Department of Pharmacy Nan fang HospitalSouther n Medical Un iversityGuan gzhou(510515)China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou(510515)China

Objective:To study the effects of total ginsenosides(TG)extract from Panax ginseng on neural stem cell(NSC)proliferation and differentiation and their underlying ***:The migration of NSCs after treatment with various concentrations of TG extract(50,100,or 200μg/mL)were *** proliferation of NSCs was examined by a combination of cell counting kit-8 and neurosphere *** differentiation mediated by TG extract was evaluated by Western blotting and immunofluorescence staining to monitor the expression of nestin and microtubule associated protein 2(MAP2).The GSK-3β/β-catenin pathway in TG-treated NSCs was examined by Western blot *** NSCs with constitutively active GSK-3βmutant were made by adenovirus-mediated gene transfection,then the proliferation and differentiation of NSCs mediated by TG were further ***:TG treatment significantly enhanced NSC migration(P<0.01 or P<0.05)and increased the proliferation of NSCs(P<0.01 or P<0.05).TG mediation also significantly upregulated MAP2 expression but downregulated nestin expression(P<0.01 or P<0.05).TG extract also significantly induced GSK-3βphosphorylation at Ser9,leading to GSK-3βinactivation and,consequently,the activation of the GSK-3β/β-catenin pathway(P<0.01 or P<0.05).In addition,constitutive activation of GSK-3βin NSCs by the transfection of GSK-3βS9 A mutant was found to significantly suppress TG-mediated NSC proliferation and differentiation(P<0.01 or P<0.05).Conclusion:TG promoted NSC proliferation and neuronal differentiation by inactivating GSK-3β.

关键词： ginsenoside neural stem cell proliferation neuronal differentiation GSK-3β

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一种基于分形码和模型约束的图像放大算法

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电子学报 2006年第3期34卷 433-436页

作者：张晓玲沈兰荪 lam kin-Man 北京工业大学信号与信息处理研究室北京100022 香港理工大学电子与资讯工程系

图像放大技术在众多研究领域中有着重要的应用.本文提出一种基于分形码和模型约束的图像放大算法,分形码能够包含图像的空间信息和图像本身的自相似信息,模型约束能够有效的限制放大引入的误差.我们首先对图像采用多种值域块分割方案计... 详细信息

图像放大技术在众多研究领域中有着重要的应用.本文提出一种基于分形码和模型约束的图像放大算法,分形码能够包含图像的空间信息和图像本身的自相似信息,模型约束能够有效的限制放大引入的误差.我们首先对图像采用多种值域块分割方案计算得到多组分形码,并由此得到多个放大图像,然后对放大图像进行平均,从而降低编码误差,最后采用约束模型对放大图像进行修正.实验结果表明,利用本文的方法可以大大提高放大图像的PSNR.

关键词：图像放大分形编码模型约束

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Investigation of the genetic etiology in male infertility with apparently balanced chromosomal structural rearrangements by genome sequencing

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Asian Journal of Andrology 2022年第3期24卷 248-254页

作者： Matthew Hoi kin Chau Ying Li Peng Dai Mengmeng Shi Xiaofan Zhu Jacqueline pui Wah Chung Yvonne K Kwok Kwong Wai Choy Xiangdong Kong Zirui Dong Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong KongChina Shenzhen Research Institute The Chinese University of Hong KongShenzhen 518057China Hong Kong Hub of Paediatric Excellence The Chinese University of Hong KongHong KongChina Genetics and Prenatal Diagnosis Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Chinese University of Hong Kong-Baylor College of Medicine Joint Center for Medical Genetics Hong KongChina

Apparently balanced chromosomal structural rearrangements are known to cause male infertility and account for approximately 1%of azoospermia or severe ***,the underlying mechanisms of pathogenesis and etiologies are still largely ***,we investigated apparently balanced interchromosomal structural rearrangements in six cases with azoospermia/severe oligospermia to comprehensively identify and delineate cryptic structural rearrangements and the related copy number *** addition,high read-depth genome sequencing(GS)(30-fold)was performed to investigate point mutations causative of male ***-pair GS(4-fold)revealed additional structural rearrangements and/or copy number changes in 5 of 6 cases and detected a total of 48 ***,the breakpoints caused truncations of 30 RefSeq genes,five of which were associated with ***,the breakpoints disrupted 43 topological-associated *** disruptions or potential dysregulations of genes,which play potential roles in male germ cell development,apoptosis,and spermatogenesis,were found in all cases(n=6).In addition,high read-depth GS detected dual molecular findings in case MI6,involving a complex rearrangement and two point mutations in the gene ***,our study provided the molecular characteristics of apparently balanced interchromosomal structural rearrangements in patients with male *** demonstrated the complexity of chromosomal structural rearrangements,potential gene disruptions/dysregulation and single-gene mutations could be the contributing mechanisms underlie male infertility.

关键词： azoospermia balanced structural rearrangements genome sequencing male infertility severe oligospermia

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