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2型糖尿病患者血小板脱颗粒与颈总动脉内膜中膜增厚进展相关

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中国动脉硬化杂志 2005年第5期13卷 661-661页

作者： Fateh-Moghadam S Li Z Ersel S reuter t Htun P Plockinger U 阳辉

Electrosorption at metal surfaces from first principles

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npj Computational Materials 2020年第1期6卷 517-526页

作者： Nicolas G.Hörmann Nicola Marzari Karsten reuter Chair of theoretical Chemistry and Catalysis Research Center Technische Universität MünchenGarching 85748Germany theory and Simulation of Materials(tHEOS) and National Centre for Computational Design and Discovery of Novel Materials(MARVEL)École Polytechnique Fédérale de LausanneLausanne 1015Switzerland Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6Berlin 14195Germany

Electrosorption of solvated species at metal electrodes is a most fundamental class of processes in interfacial ***,we use its sensitive dependence on the electric double layer to assess the performance of ab initio thermodynamics approaches increasingly used for the first-principles description of *** show analytically that computational hydrogen electrode calculations at zero net-charge can be understood as a first-order approximation to a fully grand canonical ***,higher-order terms in the applied potential caused by the charging of the double layer include contributions from adsorbate-induced changes in the work function and in the interfacial *** contributions are essential to yield prominent electrochemical phenomena such as non-Nernstian shifts of electrosorption peaks and non-integer electrosorption *** illustrate this by calculating peak shifts for H on Pt electrodes and electrosorption valencies of halide ions on Ag electrodes,obtaining qualitative agreement with experimental data already when considering only second order *** results demonstrate the agreement between classical electrochemistry concepts and a first-principles fully grand canonical description of electrified interfaces and shed new light on the widespread computational hydrogen electrode approach.

关键词： sorption principles canonical

toward diagnostic relevance of theαVβ5,αVβ3,andαVβ6 integrins in OA:expression within human cartilage and spinal osteophytes

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Bone Research 2020年第4期8卷 458-472页

作者： Edith Charlier Céline Deroyer Sophie Neuville Zelda Plener Olivier Malaise Federica Ciregia Philippe Gillet Gilles reuter Mallory Salvé Nadia Withofs Roland Hustinx Dominique de Seny Michel G.Malaise Laboratory of Rheumatology GIGA-I3CHULiègeULiègeLiègeBelgium Department of Orthopaedic Surgery CHULiègeLiègeBelgium Department of Neurosurgery CHULiègeLiègeBelgium Department of Nuclear Medicine CHULiègeLiègeBelgium

We previously reported 18FPRGD2 uptake by the coxofemoral lining,intervertebral discs and facet joint osteophytes in OA using PEt/SCAN ***,the molecular mechanism by which the PRGD2 tracer interacts with joint tissues and osteophytes in OA remains *** PRGD2 ligands are expected to belong to the RGD-specific integrin family,the purpose of this study was(i)to determine which integrin complexes display the highest affinity for PRGD2-based ligands,(ii)to analyze integrin expression in relevant tissues,and(iii)to test integrin regulation in chondrocytes using OA-related stimuli to increase the levels of fibrosis and ossification *** this end,the affinity of PRGD2-based ligands for five heterodimeric integrins was measured by competition with *** situ analyses were performed in human normal *** cartilage and spinal *** were characterized by(immuno-)histological *** subunit expression was tested in chondrocytes undergoing dedifferentiation,osteogenic differentiation,and inflammatory *** integrinsαVβ5,αVβ3,andαVβ6 presented the highest affinity for PRGD2-based *** situ,the expression of these integrins was significantly increased in OA compared to normal *** osteophytes,the mean integrin expression score was significantly higher in blood vessels,fibrous areas,and cells from the bone lining than in osteocytes and cartilaginous *** vitro,the levels of integrin subunits were significantly increased during chondrocyte dedifferentiation(except forβ6),fibrosis,and osteogenic differentiation as well as under inflammatory *** conclusion,anatomical zones(such as OA cartilage,intervertebral discs,and facet joint osteophytes)previously reported to show PRGD2 ligand uptake in vivo expressed increased levels ofαVβ5,αVβ3,andβ6 integrins,whose subunits are modulated in vitro by OA-associated conditions that increase fibrosis,inflammation,and osteogenic differentiation.t

关键词： cartilage inflammation femoral

Cell Cycle-based myocardial repair

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Cell Cycle-based myocardial repair

Multimodality imaging using proton magnetic resonance spectroscopic imaging and ^(18)F-fluorodeoxyglucose-positron emission tomography in local prostate cancer

2012年中美临床和转化医学国际论坛心脑血管病分会论坛（延吉）暨第十二届全国心血管药理学术会议和中俄药理国际研讨会

作者： Loren Field Mark Soonpaa Sean reuter Gerd Hasenfuss Karl toischer Krannert Institute of Cardiology/Department of Medicine Indiana UniversityIndianapolisUSA Herz Zentrum Gttingen/Department of Cardiology and Pneumology Georg-August-UniversittGttingenGermany

Progressive cardiomyocyte loss is a unifying theme in congestive heart *** in humans and mice revealed remarkably similar albeit low levels of cardiomyocyte cell cycle activity in un-injured *** injury can result in a transient increase in cardiomyocyte cell cycle induction,which in some cases results in increased cardiomyocyte multi-nucleation and/or ploidy in the absence of an overt increase in cardiomyocyte *** potential theraputic value of cell cycle induction is evident in

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World Journal of Radiology 2017年第3期9卷 134-142页

作者： Amita Shukla-Dave Cecilia Wassberg Darko Pucar Heiko Schoder Debra A Goldman Yousef Mazaheri Victor E reuter James Eastham Peter t Scardino Hedvig Hricak Department of Radiology Memorial SloanKettering Cancer Center Department of Medical Physics Memorial Sloan-Kettering Cancer Center Department of Diagnostic Radiology Karolinska University Hospital Department of Radiology Augusta University Department of Epidemiology-Biostatistics Memorial Sloan-Kettering Cancer Center Department of Pathology Memorial SloanKettering Cancer Center Department of Urology Memorial Sloan-Kettering Cancer Center

AIM to assess the relationship using multimodality imaging between intermediary citrate/choline metabolism as seen on proton magnetic resonance spectroscopic imaging(1H-MRSI) and glycolysis as observed on ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG-PEt/Ct) in prostate cancer(PCa) patients. MEtHODS the study included 22 patients with local PCa who were referred for endorectal magnetic resonance imaging/1HMRSI(April 2002 to July 2007) and ^(18)F-FDG-PEt/Ct and then underwent prostatectomy as primary or salvage treatment. Whole-mount step-section pathology was used as the standard of reference. We assessed the relationships between PEt parameters [standardized uptake value(SUVmax and SUVmean)] and MRSI parameters [choline + creatine/citrate(CC/Cmax and CC/Cmean) and total number of suspicious voxels] using spearman's rank correlation, and the relationships of PEt and 1H-MRSI index lesion parameters to surgical Gleason *** Abnormal intermediary metabolism on 1H-MRSI was present in 21/22 patients, while abnormal glycolysis on ^(18)F-FDG-PEt/Ct was detected in only 3/22 patients. Specifically, index tumor localization rates were 0.95(95%CI: 0.77-1.00) for 1H-MRSI and 0.14(95%CI: 0.03-0.35) for ^(18)F-FDG-PEt/Ct. Spearman rank correlations indicated little relationship(ρ =-0.36-0.28) between 1H-MRSI parameters and ^(18)F-FDG-PEt/Ct parameters. Both the total number of suspicious voxels(ρ = 0.55, P = 0.0099) and the SUVmax(ρ = 0.46, P = 0.0366) correlated weakly with the Gleason score. No significant relationship was found between the CC/Cmax, CC/Cmean or SUVmean and the Gleason score(P = 0.15-0.79). CONCLUSION the concentration of intermediary metabolites detected by 1H MRSI and glycolytic flux measured ^(18)F-FDG PEt show little correlation. Furthermore, only few tumors were FDG avid on PEt, possibly because increased glycolysis represents a late and rather ominous event in the progression of PCa.

关键词： Proton magnetic resonance spectroscopic imaging ^(18)F-fluorodeoxyglucose-positron emission tomography Prostate cancer

Association of Genetic Variation in the Promoter Region of OXtR with Differences in Social Affective Neural Processing

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Journal of Behavioral and Brain Science 2012年第1期2卷 60-66页

作者： Garret O’Connell Heather C. Whalley Prerona Mukherjee Andrew C. Stanfield Christian Montag Jeremy Hall Martin reuter Center for Economics and Neuroscience University of Bonn Bonn Germany Department of Psychology University of Bonn Bonn Germany Division of Psychiatry University of Edinburgh Scotland UK

Evidence supports the involvement of oxytocin in social behavior. the oxytocin receptor gene (OXtR) has been associated with differences in social brain function and risk for autism. Motivated by recent work, we investigated the effect of variation in the common functional rs2268498 t/C polymorphism in the promoter region of OXtR on neural responses to fear expressions. 46 healthy subjects were divided into genotype groups of C carriers (n = 32) and tt ho-mozygous (n = 14) and neural activity was measured during the recognition of fear and neutral expressions. Results showed that during the recognition of fear expressions, the tt genotype group exhibited increased responding in the inferior occipital gyrus, considered important for face processing, compared to carriers of the C allele (P ter corrected for whole brain), an effect not found for neutral faces. these results indicate the impact of this OXtR genetic variant on individual differences in social affective neural processing.

关键词： OXtR Promoter Region Inferior Occipital Gyrus fMRI Emotional Facial Processing

tFEB扩增性肾细胞癌:是一种异常表达黑素细胞标志物和形态学异质性的具有侵袭性分子亚型的肾细胞癌

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临床与实验病理学杂志 2017年第1期33卷 3-3页

作者： Argani P reuter V E Zhang L 魏建国刘勇浙江省绍兴市人民医院病理科绍兴312000 江西省人民医院病理科南昌330006

伴t（6；11）（p21；q12）染色体易位的肾细胞癌（RCC）是一种常发生于年轻患者的低级别RCC。肿瘤通常具有不同寻常的双相型形态学，其特征为大的上皮样细胞巢围绕着管腔内聚集的小细胞簇，且管腔周有基膜物质围绕。t（6；11）（p21；q1... 详细信息

伴t（6；11）（p21；q12）染色体易位的肾细胞癌（RCC）是一种常发生于年轻患者的低级别RCC。肿瘤通常具有不同寻常的双相型形态学，其特征为大的上皮样细胞巢围绕着管腔内聚集的小细胞簇，且管腔周有基膜物质围绕。t（6；11）（p21；q12）易位使Alpha（MALAtl）基因与tFEB转录因子基因融合，导致tFEB表达上调，进而驱动黑素细胞标志物异常表达，其是该肿瘤的特征性标志。

关键词：细胞标志物肾细胞癌异常表达形态学分子亚型黑素侵袭性异质性

Precision health: A nursing perspective

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International Journal of Nursing Sciences 2020年第1期7卷 5-12页

作者： Mei R.Fu Emma Kurnat-thoma Angela Starkweather Wendy A.Henderson Ann K.Cashion Janet K.Williams Maria C.Katapodi Karin reuter-Rice Kathleen t.Hickey Veronica Barcelona de Mendoza Kathleen Calzone Yvette P.Conley Cindy M.Anderson Debra E.Lyon Michael t.Weaver Pamela K.Shiao Rose E.Constantino Shu-Fen Wung Marilyn J.Hammer Joachim G.Voss Bernice Coleman William F.Connell School of Nursing Boston CollegeChestnut HillMAUSA National Institute of Nursing Research National Institutes of HealthBethesdaMDUSA School of Nursing and Health Studies Georgetown UniversityWashingtonDCUSA School of Nursing University of ConnecticutStorrsCTUSA School of Nursing The University of IowaIowa CityIAUSA Nursing Science University of BaselBaselSwitzerland School of Nursing Duke UniversityDurhamNCUSA School of Nursing Columbia UniversityNew YorkNYUSA School of Nursing Yale UniversityOrangeCTUSA National Cancer Institute Center for Cancer ResearchGenetic BranchBethesdaMDUSA School of Nursing University of PittsburghPittsburghPAUSA College of Nursing The Ohio State UniversityOHUSA University of Florida Gainesville FLUSA Center for Biotechnology and Genomic Medicine Medical College of GeorgiaAugusta UniversityAugustaGAUSA College of Nursing the University of Arizona TucsonAZUSA Dana-Farber Cancer Institute 450 Brookline AvenueLW523BostonMAUSA Frances Payne Bolton School of Nursing Case Western Reserve UniversityClevelandOHUSA Nursing Research and Development Cedars-Sinai Medical CenterLos AngelesUSA

Precision health refers to personalized healthcare based on a person's unique genetic,genomic,or omic composition within the context of lifestyle,social,economic,cultural and environmental influences to help individuals achieve well-being and optimal *** health utilizes big data sets that combine omics(*** sequence,protein,metabolite,and microbiome information)with clinical information and health outcomes to optimize disease diagnosis,treatment and prevention specific to each *** implementation of precision health requires interprofessional collaboration,community outreach efforts,and coordination of care,a mission that nurses are well-positioned to *** the surge of interest and attention to precision health,most nurses are not well-versed in precision health or its implications for the nursing *** on a critical analysis of literature and expert opinions,this paper provides an overview of precision health and the importance of engaging the nursing profession for its *** topics reviewed in this paper include big data and omics,information science,integration of family health history in precision health,and nursing omics research in symptom *** paper concludes with recommendations for nurse leaders in research,education,clinical practice,nursing administration and policy settings for which to develop strategic plans to implement precision health.

关键词： Nurses Genomics Omics Precision medicine Precision health

the role of polysulfide-saturation in electrolytes for high power applications of real world Li-S pouch cells

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Nano Research 2023年第6期16卷 8313-8320页

作者： tom Boenke Sebastian Kirchhoff Florian Sreuter Florian Schmidt Christine Weller Susanne Dörfler Kai Schwedtmann Paul Härtel thomas Abendroth Holger Althues Jan J.Weig Stefan Kaskel technische Universität Dresden Chair of Inorganic Chemistry IBergstr.6601069 DresdenGermany Fraunhofer Institute for Material and Beam technology(IWS) Winterbergstr.2801277 DresdenGermany technische Universität Dresden Chair of Inorganic Molecular ChemistryMommsenstraße 401069 DresdenGermany

the lithium-sulfur(Li-S)technology is the most promising candidate for next-generation batteries due to its high theoretical specific energy and steady progress for applications requiring lightweight batteries such as aviation or heavy electric *** these applications,however,the rate capability of Li-S cells requires significant *** electrolyte formulations in Li-S batteries enable new pathways for cell development and adjustment of all ***,their rate capability at pouch cell level is often neither evaluated nor compared to state of the art(SOtA)LitFSI/dimethoxyethane/dioxolane(LItFSI:lithium-bis(trifluoromethylsulfonyl)imide)***,the combination of the sparingly polysulfide(PS)solvating hexylmethylether/1,2-dimethoxyethane(HME/DME)electrolyte and highly conductive carbon nanotube Buckypaper(CNt-BP)with low porosity was evaluated in both coin and pouch cells and compared to dimethoxyethane/dioxolane reference *** advanced sulfur transfer melt infiltration was employed for cathode production with *** Li+ion coordination in the HME/DME electrolyte was investigated by nuclear magnetic resonance(NMR)and Raman ***,ionic conductivity and viscosity was investigated for the pristine electrolyte and a polysulfide-statured *** electrolytes,DME/DOL-1/1(DOL:1,3-dioxolane)and HME/DME-8/2,are then combined with CNt-BP and transferred to multi-layered pouch *** study reveals that the ionic conductivity of the electrolyte increases drastically over state of(dis)charge especially for DME/DOL electrolyte and lean electrolyte regime leading to a better rate capability for the sparingly polysulfide solvating *** evaluation in prototype cells is an important step towards bespoke adaption of Li-S batteries for practical applications.

关键词： lithium-sulfur pouch cell polysulfide solubility electrolyte characterization high power