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The cycloaddition reaction using visible light photoredox catalysis

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Science China Chemistry 2016年第2期59卷 161-170页

作者： Yu Liu renjie song Jinheng Li Department of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang 414005China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineer ingHunan UniversityChangsha 410082China

In recent years, visible light photoredox catalysis has emerged as an important research area in synthesis. In this review, we describe the recent progress in the visible light induced cycloaddition reactions, including [2+2], [3+2], [4+2] and [2+2+2] cycloadditions, for the construction of four-, five- or six-membered cycles and polycycles. Furthermore, the mechanisms for these transformations are also discussed, in which the formation of the radicals is initiated by a visible light photoredox catalysis process.

关键词： cycloaddition annulation visible light photoredox

Redox-triggered hydroarylation of o-(hydroxyalkyl)arylalkynes with arylsulfonyl chlorides using visible light catalysis

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Science China Chemistry 2016年第2期59卷 184-189页

作者： renjie song Jiadong Xia Jiangxi Yu Jinheng Li State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China Key Laboratory of Functional Organometallic Materials of College of Hunan Province College of Chemistry and Material Science Hengyang Normal University Hengyang 421008 China

A new radical-mediated method for the synthesis of 1-(2-(1,2-diarylvinyl)phenyl)ethan-1-ones by the redox hydroarylation of o-(hydroxyalkyl)arylalkynes with arylsulfonyl chlorides is described. This visible light catalysis method proceeds via a sequence of the radical addition of aryl group across the C?C triple bond, protonation and redox reaction, and represents a new redox transformation reaction directed by a neighboring hydroxyl group.

关键词： hydroarylation redox visible light catalysis alkynes arylsulfonyl chlorides

The RNA m^(6)A demethylase ALKBH5 drives emergency granulopoiesis and neutrophil mobilization by upregulating G-CSFR expression

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Cellular & Molecular Immunology 2024年第1期21卷 6-18页

作者： Yang Liu renjie song Zhike Lu Lu Zhao Xinyi Zhan Yini Li Xuetao Cao Department of Immunology Center for ImmunotherapyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical SciencesBeijingChina Suzhou Institute of Systems Medicine Chinese Academy of Medical SciencesSuzhouChina Frontier Research Center for Cell Response Institute of ImmunologyCollege of Life SciencesNankai UniversityTianjinChina School of Life Sciences Westlake UniversityHangzhouChina

Emergency granulopoiesis and neutrophil mobilization that can be triggered by granulocyte colony-stimulating factor(G-CSF)through its receptor G-CSFR are essential for antibacterial innate ***,the epigenetic modifiers crucial for intrinsically regulating G-CSFR expression and the antibacterial response of neutrophils remain largely unclear.N6-methyladenosine(m^(6)A)RNA modification and the related demethylase alkB homolog 5(ALKBH5)are key epigenetic regulators of immunity and inflammation,but their roles in neutrophil production and mobilization are still *** used cecal ligation and puncture(CLP)-induced polymicrobial sepsis to model systemic bacterial infection,and we report that ALKBH5 is required for emergency granulopoiesis and neutrophil ***5 depletion significantly impaired the production of immature neutrophils in the bone marrow of septic *** addition,Alkbh5-deficient septic mice exhibited higher retention of mature neutrophils in the bone marrow and defective neutrophil release into the circulation,which led to fewer neutrophils at the infection site than in their wild-type *** bacterial infection,ALKBH5 imprinted production-and mobilization-promoting transcriptome signatures in both mouse and human ***,ALKBH5 erased m^(6)A methylation on the CSF3R mRNA to increase the mRNA stability and protein expression of G-CSFR,consequently upregulating cell surface G-CSFR expression and downstream STAT3 signaling in *** RIP-qPCR results confirmed the direct binding of ALKBH5 to the CSF3R mRNA,and the binding strength declined upon bacterial infection,accounting for the decrease in G-CSFR expression on bacteria-infected *** these results collectively,we define a new role of ALKBH5 in intrinsically driving neutrophil production and mobilization through m^(6)A demethylation-dependent posttranscriptional regulation,indicating that m^(6)A RNA modification in neutrop

关键词： Emergency granulopoiesis Neutrophil mobilization ALKBH5 m^(6)A RNA modification G-CSF receptor

m^(6)A demethylase ALKBH5 is required for antibacterial innate defense by intrinsic motivation of neutrophil migration

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2608-2622页

作者： Yang Liu renjie song Lu Zhao Zhike Lu Yini Li Xinyi Zhan Fengjiao Lu Jiang Yang Yamei Niu Xuetao Cao Department of Immunology Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences100005 BeijingChina Frontier Research Center for Cell Response Institute of ImmunologyCollege of Life SciencesNankai University300071 TianjinChina School of Life Sciences Westlake University310024 HangzhouChina Department of Pathology Institute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences100005 BeijingChina.

Neutrophil migration into the site of infection is necessary for antibacterial innate defense,whereas impaired neutrophil migration may result in excessive inflammation and even *** neutrophil migration directed by extracellular signals such as chemokines has been extensively studied,yet the intrinsic mechanism for determining neutrophil ability to migrate needs further investigation.N6-methyladenosine(m^(6)A)RNA modification is important in immunity and inflammation,and our preliminary data indicate downregulation of RNA m^(6)A demethylase alkB homolog 5(ALKBH5)in neutrophils during bacterial *** m^(6)A modification and ALKBH5 might intrinsically modulate neutrophil innate response remain *** we report that ALKBH5 is required for antibacterial innate defense by enhancing intrinsic ability of neutrophil *** found that deficiency of ALKBH5 increased mortality of mice with polymicrobial sepsis induced by cecal ligation and puncture(CLP),and Alkbh5-deficient CLP mice exhibited higher bacterial burden and massive proinflammatory cytokine production in the peritoneal cavity and blood because of less neutrophil ***5-deficient neutrophils had lower CXCR2 expression,thus exhibiting impaired migration toward chemokine ***,ALKBH5-mediated m^(6)A demethylation empowered neutrophils with high migration capability through altering the RNA decay,consequently regulating protein expression of its targets,neutrophil migration-related molecules,including increased expression of neutrophil migration-promoting CXCR2 and NLRP12,but decreased expression of neutrophil migration-suppressive PTGER4,TNC,and *** findings reveal a previously unknown role of ALKBH5 in imprinting migrationpromoting transcriptome signatures in neutrophils and intrinsically promoting neutrophil migration for antibacterial defense,highlighting the potential application of targeting neutrophil m^(6)A modification in controlling bacterial infec

关键词： neutrophil impaired immunity

Daily Visibility and Hospital Admission in Shanghai, China

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Biomedical and Environmental Sciences 2011年第2期24卷 117-121页

作者： GE WenZhen CHEN renjie song WeiMin KAN HaiDong School of Public Health and Key Lab of Public Health Safety of the Ministry of Education Fudan University Shanghai 200032 China

Objective The study is to investigate the associations between visibility, major air pollutants and daily counts of hospital admission in Shanghai, China. Methods Daily data on hospital admission, visibility, and air pollution during 2005‐2008 were obtained from the Shanghai Insurance Bureau （SHIB）, Shanghai Meteorological Bureau, and Shanghai Environmental Monitoring Center, respectively. The generalized additive model （GAM） with penalized splines was used to examine the associations between daily visibility and hospital admission. Results Among various pollutants, PM 2.5 showed strongest correlation with visibility. Decreased visibility was significantly associated with increased risk of hospital admission in Shanghai. An inter‐quartile range decrease in the 2‐day （L01） moving average of visibility corresponded to 3.66% （95%CI： 1.02%, 6.31%）, 4.06% （95%CI： 0.84%, 7.27%）, and 4.32% （95%CI： 1.67%, 6.97%） increase of total, cardiovascular, and respiratory hospitalizations, respectively. Conclusion Our analyses provide the first piece of evidence in China, demonstrating that decreased visibility has an effect on hospital admission, and this finding strengthens the rationale for further limiting air pollution levels in Shanghai.

关键词： Air pollution Hospital admission Visibility

基于感兴趣区域的高性能视频编码帧内预测优化算法

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电子与信息学报 2020年第11期42卷 2781-2787页

作者：宋人杰张元东东北电力大学计算机学院吉林132012

针对高性能视频编码(HEVC)帧内预测编码算法复杂度较高的问题,该文提出一种基于感兴趣区域的高性能视频编码帧内预测优化算法。首先,根据图像显著性划分当前帧的感兴趣区域(ROI)和非感兴趣区域(NROI);然后,对ROI基于空域相关性采用提出... 详细信息

针对高性能视频编码(HEVC)帧内预测编码算法复杂度较高的问题,该文提出一种基于感兴趣区域的高性能视频编码帧内预测优化算法。首先,根据图像显著性划分当前帧的感兴趣区域(ROI)和非感兴趣区域(NROI);然后,对ROI基于空域相关性采用提出的快速编码单元(CU)划分算法决定当前编码单元的最终划分深度,跳过不必要的CU划分过程;最后,基于ROI采用提出的预测单元(PU)模式快速选择算法计算当前PU的能量和方向,根据能量和方向确定当前PU的预测模式,减少率失真代价的相关计算,达到降低编码复杂度和节省编码时间的目的。实验结果表明,在峰值信噪比(PSNR)损失仅为0.0390 dB的情况下,所提算法可以平均降低47.37%的编码时间。

关键词：高性能视频编码感兴趣区域编码单元划分预测单元模式选择

Intermolecular Radical Difunctionalization of Alkenes

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Intermolecular Radical Difunctionalization of Alkenes

基于虚拟DPU技术的DCS流程动态数学模型仿真

中国化学会第二届全国有机自由基化学会议

作者： Xuanhui Ouyang Yang Li renjie song Jinheng Li Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong University

＜正＞The difunctionalization of alkenes, the simultaneous addition of two functional groups across a C=C bond, has become a powerful technique for functionalizing alkenes. Such methods are generally achieved via a transition-metal-catalyzed process or a radical process, which remain essentially limited by the use of nucleophilic reagents to terminate these events. Very recently, we developed a new oxidative radical strategy for achieving various difunctionalization of alkenes.1

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高电压技术 2006年第1期32卷 91-93页

作者：宋人杰王晓东东北电力学院信息工程系吉林132012

用虚拟DPU技术对TDC3000集散控制系统实现了DCS流程动态数学模型仿真,该法将实际分散控制单元中的DPU功能移植到虚拟DPU软件上,脱离硬件而采用软件仿真实现DPU工作过程的模拟。其中虚拟DPU算法块在VISUAL C++高级评议环境中开发,虚拟DP... 详细信息

用虚拟DPU技术对TDC3000集散控制系统实现了DCS流程动态数学模型仿真,该法将实际分散控制单元中的DPU功能移植到虚拟DPU软件上,脱离硬件而采用软件仿真实现DPU工作过程的模拟。其中虚拟DPU算法块在VISUAL C++高级评议环境中开发,虚拟DPU通过DDE通讯接口、OPC服务器接口与仿真操作界面通讯。该法既保证了DCS系统的仿真精度又增强了系统的可移植性和可扩充性。

关键词：发电厂集散控制系统虚拟分散处理单元流程动态数学模型仿真

Epigenetic and metabolic regulation of host-pathogen interaction

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Epigenetic and metabolic regulation of host-pathogen interac...